Impact of 17-alpha ethinyl estradiol (EE2) and diethyl phthalate (DEP) exposure on microRNAs expression and their target genes in differentiated SH-SY5Y cells by Agnese Graziosi, Camilla Corrieri, Giulia Sita, Luca Ghelli, Sabrina Angelini, Roberta d’Emmanuele di Villa Bianca, Emma Mitidieri, Raffaella Sorrentino, Patrizia Hrelia, Fabiana Morroni

“…Our results show that both EDCs downregulated specific miRNAs—miR-18b-5p, miR-200a-3p, and miR-653-5p—affecting key processes such as cell proliferation, survival, and apoptosis. Gene expression analysis revealed the upregulation of EGFR, IGF1R, BTG2, and SH3BP4, implicating these miRNAs in the regulation of the Ras and PI3K/Akt/mTOR pathways. …”
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Weighted gene co-expression network analysis reveals key stromal prognostic markers in pancreatic cancer by G. Mantini, A. Agostini, M. Tufo, S. Rossi, M. Kulesko, C. Carbone, L. Salvatore, G. Tortora, G. Scambia, L. Giacò

“…We investigated the gene expression profile and clinical information of 140 pancreatic ductal adenocarcinoma patients from TCGA. …”
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The extraction of effective components and an antioxidant activity study of Tulipa edulis by Doudou Zhang, Dong Xiao, Tingting Yin, Shuangzhi Zhao, Olena Zhur, Xun Xiao, Hailun He, Leilei Chen

“…Moreover, F2 can play a strong antioxidant protective role in HUVEC cells. Meanwhile, the gene expression of heme oxygenase 1 (HO-1), γ-glutamyl cysteine ligase catalytic subunit (GCLC) and NAD(P)H quinone oxidoreductase-1 (NQO1) in HUVEC cells was up-regulated after treated with F2. …”
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IL-17 Is a Key Regulator of Mucin-Galectin-3 Interactions in Asthma by Manoj J. Mammen, Jamil Ali, Amita Aurora, Umesh C. Sharma, Ravikumar Aalinkeel, Supriya D. Mahajan, Mark Sands, Stanley A. Schwartz

“…Increased mucus secretion from increased mucin gene expression in the airway epithelium is associated with poor prognosis and mortality. …”
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Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis by Chuchun Fang, Xuewei Liu, Chen Yu, Songlin Li, Xueying Liu, Shifeng Qiu, Hongbin Liang, Caiwen Ou, Jiancheng Xiu

“…Genetic instruments for drug target gene expression were extracted from the eQTLGen consortium (31684 individuals, 37 cohorts). …”
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Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning by Jianhui Chen, Qun Li, Xiaofang Liu, Fang Lin, Yaling Jing, Jiayan Yang, Lianfang Zhao

“…This study aims to investigate the potential biomarkers and immune infiltration in EMs and RPL, providing a basis for early detection and treatment of the two diseases.MethodsTwo RPL and six EMs transcriptomic datasets from the Gene Expression Omnibus (GEO) database were used for differential analysis via limma package, followed by weighted gene co-expression network analysis (WGCNA) for key modules screening. …”
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Stryphnodendron adstringens have a modulatory effect on inflammatory cytokines markers of in vitro activated macrophages by Ivana Beatrice Mânica da Cruz, Cibele Ferreira Teixeira, Neida Luiza Pellenz, Moisés Henrique Mastella, Verônica Farina Azzolin, Euler Esteves Ribeiro, Fernanda Barbisan

“…Extracts at concentrations of 0.49 mg/mL and 0.99 mg/mL decreased the protein and gene expression of pro-inflammatory cytokines, exhibiting the opposite effect concerning IL-10. …”
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Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas by Yanguo Li, Jiawei Fan, Zhuo Shen, Jun Zhang, Xuemei Yin, Fang Han, Wenfei Li

“…This study aimed to explore the role and mechanisms of this prognostic signature in patients with low-grade gliomas (LGGs).Method: A total of 217 patients with LGGs were retrospectively obtained from the Chinese Glioma Genome Atlas as the training group, whereas an additional 190 cases (GSE107850) were collected from the Gene Expression Omnibus as validation data. The Kaplan–Meier method evaluated the overall survival (OS) between the high IGFBP2 and low IGFBP2 expression groups. …”
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Single-cell sequencing uncovers the mechanistic role of DAPK1 in glioma and its diagnostic and prognostic implications by Tian-Hang Yu, Yan-Yu Ding, Yan-Yu Ding, Si-Guo Zhao, Jie-Hui Zhao, Yu Gu, Dong-Hui Chen, Fang Zhang, Wen-Ming Hong, Wen-Ming Hong

“…However, the precise role and underlying mechanisms of DAPK1 in gliomas remain inadequately understood.MethodsWe performed analyses on RNA-seq and microarray datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), in addition to single-cell RNA sequencing (scRNA-seq) data from glioma patients available in GEO. …”
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Differential effects of structurally different lysophosphatidylethanolamine species on proliferation and differentiation in pre-osteoblast MC3T3-E1 cells by Fumiaki Makiyama, Shiori Kawase, Aoi William Omi, Yusuke Tanikawa, Taishi Kotani, Teruki Shirayama, Naoyuki Nishimura, Taiga Kurihara, Naoto Saito, Jun Takahashi, Takeshi Uemura

“…Interestingly, 18:0 LPE suppressed osteogenic differentiation, reducing mineralization, alkaline phosphatase activity, and osteogenic gene expression, whereas 16:0 LPE and 18:1 LPE had no such effects. …”
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Epigenetically Mediated Pathogenic Effects of Phenanthrene on Regulatory T Cells by Jing Liu, Luhua Zhang, Lisa C. Winterroth, Marco Garcia, Shannon Weiman, Jillian W. Wong, John B. Sunwoo, Kari C. Nadeau

“…To determine specific effects on T cell populations by phenanthrene, primary human Treg were treated with Phe, TCDD, or FICZ and assessed for function, gene expression, and phenotype. Methylation of CpG sites within the FOXP3 locus reduced FOXP3 expression, leading to impaired Treg function and conversion of Treg into a CD4+CD25lo Th2 phenotype in Phe-treated cells. …”
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Exploring bio-remediation strategies by a novel bacteria Micrococcus sp. strain HX in Cr(VI)-contaminated groundwater from long-term industrial polluted by Yu Xia, Yujuan Wen, Yuesuo Yang, Xiaoming Song, Yunlong Wang, Zhipeng Zhang

“…Transcriptome analyses revealed oxidoreductase activity, ATP binding and the NAD(P) binding region protein-related gene expression were up-regulated. Binding reduction experiments indicated that most of the Cr(III) was detected extracellular, which suggests that the reduction of Cr(VI) by HX was mainly extracellular enzyme-catalyzed.…”
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Activation of PTGS2/NF‐κB signaling pathway enhances radiation resistance of glioma by Cheng Tan, Liang Liu, Xiaoyang Liu, Ling Qi, Weiyao Wang, Guifang Zhao, Libo Wang, Yimeng Dai

“…Methods We downloaded the microarray data from the Gene Expression Omnibus (GEO) database. We verified transfection successfully through QRT‐PCR analysis. …”
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Neuroprotective and Antiapoptotic Activity of Lineage-Negative Bone Marrow Cells after Intravitreal Injection in a Mouse Model of Acute Retinal Injury by Anna Machalińska, Dorota Rogińska, Ewa Pius-Sadowska, Miłosz P. Kawa, Edyta Paczkowska, Michał Rudnicki, Renata Lejkowska, Bartłomiej Baumert, Barbara Wiszniewska, Bogusław Machaliński

“…Moreover, global gene expression at day 7 was analyzed by RNA arrays. We observed that Lin−BMCs integrated into outer retinal layers improving morphological retinal structure and induced molecular changes such as downregulation of proapoptotic caspase-3 gene, a decrease in BAX/BCL-2 gene ratio, and significant elevation of BDNF expression. …”
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Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological funct... by Zhu Liu, Zhi-Qiang Ling

“…This analysis encompassed gene expression profiles across 33 cancer types, with a focus on PAQR11's expression patterns, prognostic significance, and immunological relevance. …”
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Melatonin Enhances Maize Germination, Growth, and Salt Tolerance by Regulating Reactive Oxygen Species Accumulation and Antioxidant Systems by Wei-Qing Li, Jia-Yu Li, Shao-Jie Bi, Jia-Yue Jin, Zhong-Ling Fan, Zi-Lin Shang, Yi-Fei Zhang, Yan-Jie Wang

“…Consequently, in this research, we utilized the maize cultivars Zhengdan 958 (ZD958) and Demeiya 1 (DMY1), which are extensively marketed in northeastern China’s high-latitude cold regions, to reveal the modulating effects of melatonin on maize salinity tolerance by determining the impacts of varying concentrations of melatonin on maize seedling growth characteristics, osmoregulation, antioxidant systems, and gene expression. The findings revealed that salt stress (100 mM NaCl) significantly inhibited maize seed germination and seedling development, which resulted in significant increases in the H₂O₂ and O₂⁻ content and decreases in the antioxidant enzyme activity and photosynthetic pigment content in maize seedlings. …”
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Genomic Characterization and Functional Validation of Six <i>cis</i>-Regulatory Sequences in Medicinal Plant <i>Andrographis paniculata</i> by Xingbin Lv, Hua Yang, Yufang Hu, Qi Liang, Shuyun Tian, Lang Yang, Mingkun Huang, Ling Zhang, Yanqin Xu

“…Plant <i>cis</i>-regulatory sequences (CRSs) are essential for gene expression and transcriptional regulation in plants. …”
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WNT3A promotes the cementogenic differentiation of dental pulp stem cells through the FOXO1 signaling pathway by Dongmei Cheng, Yang Bao, Xue Wang, Haidong Xiang, Tianyuan Guo, Yong Du, Zhiyong Zhang, Han Guo

“…Methods DPSC data set GSE138179 was retrieved from gene expression omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was employed to identify significant modules. …”
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L-Citrulline in Neonates: From Bench to Bed Side by Dwayne Mascarenhas, Atefeh Mohammadi, Randa Higazy, Julijana Ivanovska, Estelle Gauda, Bonny Jasani

“…Animal studies in lipopolysaccharide-induced models of chorioamnionitis and hyperoxia- and inflammation-induced BPD-PH in rodent lung models revealed that L-CIT supplementation significantly mitigated structural changes in the pulmonary vasculature, preserved alveolar growth, and increased vascular endothelial growth factor gene expression, highlighting the anti-inflammatory and antioxidant effects of L-CIT supplementation. …”
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Mitigation of doxorubicin-induced liver toxicity in mice breast cancer model by green tea and Moringa oleifera combination: Targeting apoptosis, inflammation, and oxidative stress by Abdulrahman H. Laftah, Nawfal Alhelfi, Sadeq K. Al Salait, Ammar B. Altemimi, Mohammad Reza Tabandeh, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

“…Additionally, the herbal treatment lowered pro-inflammatory cytokine levels and regulated apoptosis-related gene expression, lowering BAX and increasing BCL2, promoting cell survival, and reducing inflammation. …”
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