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2261
Prioritization of biological processes based on the reconstruction and analysis of associative gene networks describing the response of plants to adverse environmental factors
Published 2021-09-01“…The prioritization results indicate that fundamental processes, such as gene expression, post-translational modifications, protein degradation, programmed cell death, photosynthesis, signal transmission and stress response play important roles in the common molecular genetic mechanisms for plant response to various adverse factors. …”
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2262
Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat
Published 2016-01-01“…We have also examined gene expression and surface marker profiles in a predictive model to identify cells with enhanced chondrogenic potential. …”
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2263
Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases
Published 2025-01-01“…However, these studies detected the gene expression of all cells in fibrotic skin diseases and did not enrich immune cells. …”
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2264
Effects of Light Spectra on Nutritional Composition in Juvenile Sinonovacula constricta (Lamarck 1818) and Transcriptomic Analysis
Published 2024-01-01“…The results indicate that the light spectrum has a significant impact on the growth, biochemical composition, and gene expression of juvenile S. constricta. Specifically, culturing S. constricta under the yellow light led to improved growth rate (1.09 ± 0.03%/day), higher levels of carbohydrate (26.27% ± 0.49%), crude lipid (11.99% ± 0.23%), energy contents (14,611.34 ± 1,067.01 kJ/kg), and essential amino acids (15.22 ± 0.01 g/kg), as well as increased proportions of polyunsaturated fatty acids (12.38 ± 0.31 µg/mg). …”
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2265
Identification of the Key Genes and Pathways in Esophageal Carcinoma
Published 2016-01-01“…Methods. 5 microarray datasets of EC were downloaded from Gene Expression Omnibus. Differentially expressed genes (DEGs) were screened by bioinformatics analysis. …”
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2266
Chloroplast Vesiculation and Induced Chloroplast Vesiculation and Senescence‐Associated Gene 12 Expression During Tomato Flower Pedicel Abscission
Published 2025-01-01“…This study highlights the deleterious effects of abscission on chloroplast ultrastructure in the cells of the tomato flower pedicel abscission zone, revealing spatiotemporal differential gene expression and key transcriptional networks involved in chloroplast vesiculation during abscission. …”
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2267
Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB...
Published 2025-02-01“…DOR and MOR also differentially modulated microglia in APP/PS1 mice and in vitro AD cell model with a DOR-mediated inhibition on the excessive activation of microglia and the release of pro-inflammatory cytokines in AD pathologies. Gene expression profiling further revealed that the alternations in DOR/MOR are closely associated with microglial homeostatic signatures and high mobility group protein B1 (HMGB1) in AD. …”
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2268
The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas
Published 2015-01-01“…Background. Gene expression profiles of 181 breast cancer samples were analyzed to identify prognostic features of nuclear receptors NR5A1 and NR5A2 based upon their associated transcriptional networks. …”
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2269
INFORMACINIS GENOMAS, INDIVIDO IR POPULIACIJOS GENOMAI
Published 2002-01-01“…However, because of the different gene expression during differentation the cells become different in form and in function. …”
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2270
Unveiling the mechanism of micro-and-nano plastic phytotoxicity on terrestrial plants: A comprehensive review of omics approaches
Published 2025-01-01“…This literature review synthesizes current findings regarding MNPs-induced phytotoxicity, emphasizing alterations in gene expression, protein synthesis, metabolic pathways, and physiological disruptions as revealed through omics analyses. …”
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2271
Reactivation of mTOR signaling slows neurodegeneration in a lysosomal sphingolipid storage disease
Published 2025-01-01“…Tsc2 reduction also partially rescued aberrant synaptic function–related gene expression. These findings imply that enhancing mTOR signaling could be a potential therapeutic strategy for lysosomal-based neurodegenerative diseases.…”
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2272
IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy
Published 2025-01-01“…However, whether IL-33 is necessary for IL-10’s proinflammatory effects has not been examined.MethodsTo therefore determine the role of the IL-33/ST2 axis in this pathway, we assessed the effects of IL-10 on IgE-mediated MC activation and food allergy development in wild-type (WT) and ST2-/- mice.ResultsIL-10 stimulation significantly enhanced IL-33 gene expression, ST2 receptor expression, cytokine production, mMCP-1 secretion, and proliferation in IgE and antigen-activated bone marrow-derived MCs (BMMCs) from WT mice. …”
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2273
Anthracyclines disaggregate and restore mutant p63 function: a potential therapeutic approach for AEC syndrome
Published 2025-01-01“…Abstract Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome is a rare genetic disorder caused by mutations in the TP63 gene, which encodes a transcription factor essential for epidermal gene expression. A key feature of AEC syndrome is chronic skin erosion, for which no effective treatment currently exists. …”
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2274
Effect of Biofloc Culture on the Daily Rhythmicity of the Activity and Expression of Digestive Enzymes in Tilapia, Oreochromis niloticus
Published 2025-01-01“…The enzyme activity of trypsin (try), chymotrypsin (chy), leucine aminopeptidase (lap), alkaline proteases (alk), lipase (lip), and amylase (amy), along with the gene expression of trypsin (try), chymotrypsin (chy), pepsin (pep), amylase (amy), and phospholipase (pla) were measured throughout a daily cycle. …”
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2275
The Impact of DNA Methylation on IL6 mRNA Levels in Hematinic Deficiency and Atopy-Associated Recurrent Aphthous Stomatitis Patients
Published 2021-01-01“…The methylation levels of the IL6 promoter were assessed by a reverse transcriptase-polymerase chain reaction technique. The gene expression of RAS and the control group was analyzed by the 2−ΔΔCT method. …”
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2276
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling
Published 2025-01-01“…Confirming previous findings, gene expression of cholesterol biosynthesis genes was reduced via reduced ERK phosphorylation. …”
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2277
INFORMACINIS GENOMAS, INDIVIDO IR POPULIACIJOS GENOMAI
Published 2002-01-01“…However, because of the different gene expression during differentation the cells become different in form and in function. …”
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2278
A novel lncRNA AC112721.1 promotes the progression of triple-negative breast cancer by directly binding to THBS1 and regulating miR-491-5p/C2CD2L axis
Published 2024-12-01“…Abstract Triple-negative breast cancer (TNBC) seriously threatens women’s health, and long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in TNBC. This study aimed to identify lncRNAs that represent effective targets for the early diagnosis or treatment of TNBC. …”
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2279
Identification of Key Genes and Prognostic Value Analysis in Hepatocellular Carcinoma by Integrated Bioinformatics Analysis
Published 2019-01-01“…This study included 3 expression profiles (GSE45267, GSE74656, and GSE84402), which were obtained from the Gene Expression Omnibus (GEO). GEO2R was used to analyze the differentially expressed genes (DEGs) between HCC and normal samples. …”
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2280
Efficacy and compatibility mechanism of bear bile powder in Shexiang Tongxin dropping pills for acute myocardial infarction treatment
Published 2025-01-01“…Our findings suggested that combination treatment with CF and BBP synergistically attenuates AMI by altering gene expression, gut microbiota, and intestinal metabolite profiles. …”
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