17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease by Ferdinando Nicoletti, Ingrid Philippens, Paolo Fagone, Clarence N. Ahlem, Christopher L. Reading, James M. Frincke, Dominick L. Auci

“…HE3286 treatment significantly improved motor function compared to vehicle in the rotarod test (mean 58.2 sec versus 90.9 sec, P<0.0001), and reduced inflammatory mediator gene expression in the brain (inducible nitric oxide synthase, 20%, P=0.002; tumor necrosis factor α, 40%, P=0.038, and interleukin-1β, 33%, P=0.02) measured by reverse-transcriptase polymerase chain reaction. …”
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Tryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson’s disease and insomnia by Xin-Yu Li, Wen-Kai Yu, Jing-Hao Wu, Wen-Jun He, Yu-Nan Cheng, Kai Gao, Yi-Han Wei, Yu-Sheng Li

“…We analyzed datasets for PD (GSE100054) and insomnia (GSE208668) obtained from the Gene Expression Omnibus (GEO) database. TMRGs were obtained from the Molecular Signatures Database (MSigDB) and the Genecards database. …”
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The AMPK–mTOR Pathway Is Inhibited by Chaihu Shugan Powder, Which Relieves Nonalcoholic Steatohepatitis by Suppressing Autophagic Ferroptosis by Zheng Liang, Dajin Pi, Jianwei Zhen, Haizhen Yan, Chuiyang Zheng, July Liang Chen, Wen Fan, Qingliang Song, Jinyue Pan, Dongdong Liu, Maoxing Pan, Qinhe Yang, Yupei Zhang

“…Hence, the primary objective of this research is to examine the impacts and possible mechanisms of CSP on NASH through assessments of liver histopathology, lipidomic analysis, and gene expression. To induce a mouse model of NASH, we employed a diet which deficient in methionine and choline, known as methionine–choline deficient (MCD) diet. …”
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Endoplasmic reticulum protein TXNDC5 modulates thyroid eye disease TGF-β1-induced myofibroblast transdifferentiation by Albert Y Wu, Hsun-I Chiu, Shi-Bei Wu, Chieh-Chih Tsai

“…We would evaluate the role of thioredoxin domain containing 5 (TXNDC5), a fibroblast-enriched ER protein, in TGF-β1-induced myofibroblast transdifferentiation from TED orbital fibroblasts.Methods Orbital fibroblasts from patients with TED were treated with TGF-β1 to investigate ER stress-relative gene expression especially for TXNDC5. To determine if TXNDC5 is involved in TGF-β1-induced fibrosis, we transfected TED orbital fibroblasts by lentivirus with a small hairpin RNA of pLKO-TXNDC5 gene (shTXNDC5) to knockdown TXNDC5 protein expression levels. …”
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Metagenomic analysis of goat feces from Ogliastra (Sardinia, Italy) by Monica Rosaria Molotzu, Piera Angela Cabras, Lisa Di Marcantonio, Rossano Atzeni, Nicolò Pietro Paolo Macciotta, Antonella Canu

“…Variations in the composition and gene expression of the intestinal microbiota are associated with the risk of the onset of various pathologies of the gastrointestinal tract and chronic inflammatory intestinal diseases. …”
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Split Application of Potassium Reduces Rice Chalkiness by Regulating Starch Accumulation Process Under High Temperatures by Xinyue Zhang, Youfa Li, Junjie Dong, Yuanze Sun, Haowei Fu

“…Specifically, the split application of K fertilizer reduced the enzymatic activities of SuSy, ADPGase, and SBE by 3.17–34.20% at 5–10 DAA, and GBSS and SSS by 6.48–13.50% at 5 DAA, but enhanced them by 5.50–54.90% from 15 DAA and 2.07–97.10% from 10 DAA. Similarly, the gene expression levels of enzymes involved in this process were decreased by 3.52–24.12% at 5 DAA but increased by 8.61–30.00% at 20 DAA by the split application of K fertilizer. …”
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Influence of Different ECM-Like Hydrogels on Neurite Outgrowth Induced by Adipose Tissue-Derived Stem Cells by E. Oliveira, R. C. Assunção-Silva, O. Ziv-Polat, E. D. Gomes, F. G. Teixeira, N. A. Silva, A. Shahar, A. J. Salgado

“…Their impact on ASC survival, metabolic activity, and gene expression was also evaluated. Our results indicated that all hydrogels supported ASC survival and viability, being this more evident for the functionalized GG hydrogels. …”
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Age-related aspects of glioma: current understanding. Literature review by Serhii P. Luhovskyi, Tetiana Y. Kvitnytska-Ryzhova

“…A major distinction between aHGG and pHGG lies in mutations such as IDH 1/2, EGFR gene expression, TERT mutations, chromosome alterations (+7/-10), and TP53 mutations, all contributing to a poorer prognosis in HGG gliomas. …”
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PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response by Ling Cheng, Ian Meliala, Yidi Kong, Jingyuan Chen, Christopher G Proud, Mikael Björklund

“…Depletion of PEBP1 impaired mitochondrial ISR activation by reducing eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and subsequent ISR gene expression, which was independent of PEBP1’s role in inhibiting the RAF/MEK/ERK pathway. …”
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Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature by James Wood, Stuart J. Smith, Marcos Castellanos-Uribe, Anbarasu Lourdusamy, Sean T. May, David A. Barrett, Richard G. Grundy, Dong-Hyun Kim, Ruman Rahman

“…Here, we use liquid chromatography–mass spectrometry and gene expression microarray to profile integrated intratumour metabolic heterogeneity, as a direct functional readout of adaptive responses of subclones to the tumour microenvironment. …”
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Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet by Meirong Wu, Xiaobin Wu, Jiangxiong Zhu, Fanglan Li, Xinlin Wei, Yuanfeng Wang

“…Our results showed that GT and Se-GT supplementations significantly prevented the increase of blood pressure (BP), activated the phosphoinosmde-3-kinase/protein kinase B (PI3K/Akt) signaling pathway, and regulated the gene expression related to BP, as well as improved the tissue damage like heart, liver, and kidneys. …”
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Genome Mining and Characterization of Two Novel <i>Lacticaseibacillus rhamnosus</i> Probiotic Candidates with Bile Salt Hydrolase Activity by Gianluigi Agolino, Marianna Cristofolini, Amanda Vaccalluzzo, Davide Tagliazucchi, Alice Cattivelli, Alessandra Pino, Cinzia Caggia, Lisa Solieri, Cinzia Lucia Randazzo

“…However, BAs stress increased the <i>bsh</i> gene transcription in the VB1 strain but not in the VB4 strain, suggesting a partially nonlinear relationship between BSH activity and gene expression. In conclusion, despite the complexity of the BSH transcriptional system, the results support the VB4 strain as a promising BAs-deconjugating probiotic candidate.…”
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The temporal relationship between mitochondrial quality and renal tissue recovery following ischemia-reperfusion injury by Priyanka N. Prem, Harish Swaminathan, Gino A. Kurian

“…Results: Prolonging ischemia duration reduces bioenergetic function while disrupting the balance of mitochondrial fusion, fission, and mitophagy at the gene expression level while maintaining intact mitochondrial copy number. …”
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Mechanistic insights into pachymic acid’s action on triple-negative breast Cancer through TOP2A targeting by Ming Liu, Li Zheng, Yang Zhang, Jinhui Tian

“…We acquired Microarray data of TNBC from the Gene Expression Omnibus (GEO). The related targets of PA were predicted and screened using the following 6 databases: Swiss Target Prediction, HERB (Herbal Medicine Database), ETCM (Encyclopedia of Traditional Chinese Medicine), BATMAN (Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine), HIT (Herb Ingredients’ Targets Database), and PharmMapper. …”
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Analysis of Microarray-Identified Genes and MicroRNAs Associated with Idiopathic Pulmonary Fibrosis by Lichao Fan, Xiaoting Yu, Ziling Huang, Shaoqiang Zheng, Yongxin Zhou, Hanjing Lv, Yu Zeng, Jin-Fu Xu, Xuyou Zhu, Xianghua Yi

“…The microRNA microarray dataset GSE32538 and the mRNA datasets GSE32537, GSE53845, and GSE10667 were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed miRNAs (DE-miRNAs)/genes (DEGs) were screened with GEO2R, and their associations with IPF were analyzed by comprehensive bioinformatic analyses. …”
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Transcriptome Analysis Revealed the Molecular Mechanism of Acetic Acid Increasing <i>Monascus</i> Pigment Production in <i>Monascus ruber</i> CICC41233 by Yan Wang, Weiwei Wu, Xiaoshu Wu, Weiyu Li, Jingjing Cui, Chuannan Long

“…The transcriptomics data showed that the differentially expressed genes between <i>M. ruber</i> with acetic acid and without acetic acid were mainly involved in starch and sucrose metabolism, glycolysis/gluconeogenesis, pyruvate metabolism, TCA cycle, and oxidative phosphorylation, and that these differentially expressed genes were not involved in amino acid metabolism. Gene expression analysis showed that the relative expression levels of MP synthesis genes (<i>MpPKS5</i>, <i>MppA</i>, <i>MpFasB</i>, <i>MppB</i>, <i>MppD</i>, and <i>MppR2</i>) were significantly up-regulated under acetic acid conditions. …”
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Correlation of susceptibility to ortho-aminoazotolueneinduced hepatocarcinogenesis with Car and Ahr signaling pathway activation in mice by N. V. Baginskaya, E. V. Kashina, M. Yu. Shamanina, S. I. Ilnitskaya, V. I. Kaledin, V. A. Mordvinov

“…Mice were sacrificed on days 1 and 4 after the last OAT administration. Gene expression levels in the liver were determined by real-time PCR. …”
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Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential by Tohada M. AL-Noshokaty, Rehab Abdelhamid, Nourhan M. Abdelmaksoud, Aya Khaled, Mariam Hossam, Razan Ahmed, Toka Saber, Shahd Khaled, Shereen Saeid Elshaer, Ahmed I. Abulsoud

“…Also, microribonucleic acid (RNA) (miRNAs), critical regulators of gene expression, are introduced as potential modulators of GLP-1 signaling. …”
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Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma by Changyu Zhu, Heshu Liu, Zhixin Li, Yijun Shi, Jingyang Zhao, Yuping Bai, Qian Chen, Wei Li

“…Methods and Results In this study, we delved into the variations in gene mutation, methylation patterns, and expression levels of SERPINE1 in head and neck squamous cell carcinoma (HNSCC) and normal tissues, leveraging comprehensive analyses of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. The connection between the biological function of the gene and prognosis was scrutinized through immune infiltration and enrichment analyses. …”
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The biogenesis, regulation and functions of transitive siRNA in plants by Tan Huijun, Liu Yuelin, Guo Hongwei

“…Small RNA (sRNA)-mediated RNA interference (RNAi) is a sequence-specific gene silencing mechanism that modulates gene expression in eukaryotes. As core molecules of RNAi, various sRNAs are encoded in the plant genome or derived from invading RNA molecules, and their biogenesis depends on distinct genetic pathways. …”
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