Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines by Kyle K. L. Phua

“…In this brief report, we will discuss established conjugation strategies that have been successfully applied to both polymeric and liposomal gene delivery systems. We will also briefly describe promising DC surface receptors amenable for targeting mRNA nanoparticles. …”
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Cardiovascular Activities of of the bradykinin system by Jagdish N. Sharma

“…The ability of kallikrein gene delivery to produce a wide spectrum of beneficialeffects makes it a promising candidate in treating hypertension and cardiovascular andrenal diseases. …”
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Genetics of Cerebral Vasospasm by Travis R. Ladner, Scott L. Zuckerman, J Mocco

“…In our review, we summarize the most recent research involving key areas within the genetics and vasospasm discussion: (1) Prognostic role of genetics—risk stratification based on gene sequencing, biomarkers, and polymorphisms; (2) Signaling pathways—pinpointing key inflammatory molecules responsible for downstream cellular signaling and altering these mediators to provide therapeutic benefit; and (3) Gene therapy and gene delivery—using viral vectors or novel protein delivery methods to overexpress protective genes in the vasospasm cascade.…”
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Biomaterials in Guided Bone and Tissue Regenerations: An Update by Reza Abdollahi Namanloo, Maedeh Ommani, Kamyar Abbasi, Mostafa Alam, Ashkan Badkoobeh, Mahdi Rahbar, Hadi Kokabi Arasteh, Emran Hajmohammadi, Reza Sayyad Soufdoost, Seyed Ali Mosaddad

“…Secondly, biomaterials are examined for their therapeutic uses such as growth factors, stem cells, and gene delivery vehicles. Conclusion. If a tooth has been extracted or if the gums have been infected with periodontal disease, guided bone regeneration procedures may be used to restore the lost bone. …”
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Evaluation and Prediction of the HIV-1 Central Polypurine Tract Influence on Foamy Viral Vectors to Transduce Dividing and Growth-Arrested Cells by Sergey Shityakov, Carola Förster, Axel Rethwilm, Thomas Dandekar

“…Retroviral vectors are potent tools for gene delivery and various biomedical applications. To accomplish a gene transfer task successfully, retroviral vectors must effectively transduce diverse cell cultures at different phases of a cell cycle. …”
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Gene Carriers and Transfection Systems Used in the Recombination of Dendritic Cells for Effective Cancer Immunotherapy by Yu-Zhe Chen, Xing-Lei Yao, Yasuhiko Tabata, Shinsaku Nakagawa, Jian-Qing Gao

“…This paper describes the recent progress in gene delivery systems including viral vectors and nonviral carriers for DC-based genetically engineered vaccines. …”
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Nanoparticle Therapy Is a Promising Approach in the Management and Prevention of Many Diseases: Does It Help in Curing Alzheimer Disease? by Lamyaa M. Kassem, Nada A. Ibrahim, S. Ayesha Farhana

“…Nanotechnology offers various forms of nanoparticles, and these nanoparticles have brain-targeted and long-acting properties with minimal systemic adverse effects and motor complications. Gene delivery vehicles and nanocarriers including neurotrophic factors are promising therapeutics for many NDDs, and they can modulate neuronal survival and synaptic connectivity. …”
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Phytonanoparticles as novel drug carriers for enhanced osteogenesis and osseointegration by Nandita Suresh, Nebu George Thomas, Matti Mauramo, Tuomas Waltimo, Timo Sorsa, Sukumaran Anil

“…Looking ahead, we identify key research directions, including developing personalized therapies, combination approaches with stem cells or gene delivery, and long-term safety assessments. By harnessing the power of plant-derived nanomaterials, phytonanoparticles represent an innovative approach to addressing the complex challenges of bone regeneration, with potential applications spanning dental, orthopedic, and maxillofacial surgery. …”
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scFv Antibody: Principles and Clinical Application by Zuhaida Asra Ahmad, Swee Keong Yeap, Abdul Manaf Ali, Wan Yong Ho, Noorjahan Banu Mohamed Alitheen, Muhajir Hamid

“…Alternatively, antibody fragments could also be applied in the construction of immunotoxins, therapeutic gene delivery, and anticancer intrabodies for therapeutic purposes. …”
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Ultrasound Microbubble-Mediated microRNA-505 Regulates Cervical Cancer Cell Growth via AKT2 by Leilei Xu, Qin Zhang, Changhua Li, Fu Hua, Xiaoping Liu

“…The application of ultrasound and microbubbles (USMB-) mediated microRNA (miR) is a promising approach of gene delivery for cancer treatment. We aimed to discuss the effects of USMB-miR-505 on cervical cancer (CC) development. miR-505 mediated by USMB was prepared. …”
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Employing the Oncolytic Vesicular Stomatitis Virus in Cancer Virotherapy: Resistance and Clinical Considerations by Alaa A. Abdelmageed, Stephen Dewhurst, Maureen C. Ferran

“…Vesicular Stomatitis Virus (VSV) has emerged as a promising candidate for various clinical applications, including vaccine development, virus pseudotyping, and gene delivery. Its broad host range, ease of propagation, and lack of pre-existing immunity in humans make it ideal for therapeutic use. …”
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Amphiphiles Self-Assembly: Basic Concepts and Future Perspectives of Supramolecular Approaches by Domenico Lombardo, Mikhail A. Kiselev, Salvatore Magazù, Pietro Calandra

“…While amphiphiles self-assembly has attracted considerable attention for decades due to their extensive applications in material science, drug and gene delivery, recent developments in nanoscience stimulated the combination of the simple approaches of amphiphile assembly with the advanced concept of supramolecular self-assembly for the development of more complex, hierarchical nanostructures. …”
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Blood-Brain Barrier Abnormalities Caused by HIV-1 gp120: Mechanistic and Therapeutic Implications by Jean-Pierre Louboutin, David S. Strayer

“…Thus, (1) HIV-envelope gp120 disrupts the BBB; (2) this occurs via lesions in brain microvessels, MMP activation and degradation of vascular basement membrane and vascular tight junctions; (3) NMDAR-1 activation plays a role in this BBB injury; and (4) antioxidant gene delivery as well as NMDAR-1 antagonists may protect the BBB.…”
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Immunocompatibility of Bacteriophages as Nanomedicines by Tranum Kaur, Nafiseh Nafissi, Olla Wasfi, Katlyn Sheldon, Shawn Wettig, Roderick Slavcev

“…Recently, phages have been employed as gene-delivery vectors (phage nanomedicine), for nearly half a century as tools in genetic research, for about two decades as tools for the discovery of specific target-binding proteins and peptides, and for almost a decade as tools for vaccine development. …”
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Pancreatic Cancer: Molecular, Biochemical, Chemopreventive, and Therapeutic Aspects by Juan Iovanna, José Luis Neira

“…The bioavailability of compounds such as antisense oligonucleotides and siRNAs in humans remains a big hurdle, which will require further improvement of gene-delivery strategies. Finally, the long-term goal of the therapy individualization for patients is possible if factors that predict treatment response, such as biological markers, could be determined accurately. …”
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Highly Effective Ex Vivo Gene Manipulation to Study Kidney Development Using Self-Complementary Adenoassociated Viruses by Tie-Lin Chen, Hong-Lian Wang, Yun-Hong Liu, Yin Fang, Rui-Zhi Tan, Pu-Hui Zhou, Qin Zhou, Xiao-Yan Lv

“…We for the first time employed and validated scAAV as a gene delivery tool in cultured kidney. Conclusions. These findings are expected to expedite the use of the ex vivo embryonic kidney cultures for kidney development research. …”
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Three-dimensional linkage analysis with digital PCR for genome integrity and identity of recombinant adeno-associated virus by Tam Duong, Michele Firmo, Chien-Ting Li, Bingnan Gu, Peng Wang

“…Abstract Recombinant adeno-associated virus (rAAV) has emerged as the vector of choice for in vivo gene delivery, with numerous clinical trials underway for the treatment of various human diseases. …”
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DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells by Maria Cristina Grimaldi, Sara Bozzer, Dick J. Sjöström, Dick J. Sjöström, Linnea I. Andersson, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Luca De Maso, Federico Riccardi, Michele Dal Bo, Daniele Sblattero, Paolo Macor

“…This strategy has the advantage of minimizing off-target effects by restricting gene delivery to the desired cell population. However, the nanoplatform must guarantee both the local production of the protein and the safety of the treatment to allow an effective therapy with reduced systemic toxicity.MethodsIn order to ensure a selective delivery of nucleic acids, we developed poly(lactic-co-glycolic acid) (PLGA)-poly(vinyl alcohol) (PVA) NPs loaded with an Enhanced Green Fluorescent Protein (EGFP)-coding plasmid and covalently coated with antiCD19 recombinant antibody as a targeting mechanism. …”
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