Multiomics identify the gene expression signature of the spinal cord during aging process by Lintao Xu, Jingyu Wang, Jinjie Zhong, Weiwei Lin, Gerong Shen, Ning He, Xingjia Mao, Chunyan Fu, Zhaobo Huang, Fengdong Zhao, Xin Ye, Yongjian Zhu, Mingzhi Zheng, Hui Li, Lin-lin Wang, Kai Zhong, Lijun Zhu, Ying-ying Chen

“…Flow cytometry reveals increased accumulation of free Fe2+ and ROS in senescent mixed glial cells; however, CCK-8 assays reveal that these cells are resistant to ferroptosis. …”
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Clinical outcomes of nephroureterectomy with bladder cuff excision or radical cystectomy for distal ureteral carcinoma invaded muscle of the ureteral orifice by Pan Li, Suoshi Jing, Yindong Kang, Bin Feng, Yunxin Zhang, Hui Ding, Juan Wang, Yingru Wang, Li Yang, Zhilong Dong, Junqiang Tian, Zhiping Wang, Zizhen Hou

“…Methods This multicenter study retrospectively studied the demographics and perioperative outcomes of 59 patients who underwent NU-BCE or NU-RC between 2003 and 2024. Relapse-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) were presented using Kaplan–Meier curves. …”
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Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy by Atsushi Musha, Nobuteru Kubo, Hidemasa Kawamura, Naoko Okano, Masahiro Onishi, Takeru Ohtaka, Midori Tamura, Osamu Nikkuni, Yuichi Tomidokoro, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno

“…The 5-year rates for local control (LC), progression-free survival (PFS), and overall survival (OS) were 67.6 %, 47.7 %, and 79.0 %, respectively. …”
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Audit Sistem Informasi pada Sistem Manajemen Layanan Satu Atap (SIMANTAP) Menggunakan Kerangka COBIT 5.0 (Studi Kasus: Bank Indonesia Provinsi Bengkulu) by Arie Vatresia, Pieters N.P Tambunan, Aan Erlanshari

“…Abstract Bank Indonesia is the central bank of the Republic of Indonesia and an independent state institution, free from interference from the government or other parties. …”
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Response of Soil Respiration to Snowfall in a Kubuqi Salix Plantation Forest of During Freeze-thaw Period by WANG Jixuan, LAN Xiaozhen, PEI Zhiyong, ZHANG Junyao, WANG Xinping, LI Ying, WANG Haichao, SUN Xiaotian, SUN Kai

“…[Methods] Soil respiration rates of salix plantations that were untouched and unlevelled stubble (ww), untouched and levelled stubble (wp), untouched and unlevelled stubble (zw), and levelled and levelled stubble (zp) were measured in the snow-free treatment by using the Li-6800 soil-carbon-water flux measurement chamber in the Salix Forest Germplasm Resource Bank of the Dalate Banner, Ordos, Inner Mongolia, and the atmospheric temperature, soil temperature and humidity were measured simultaneously. …”
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Fabrication of Nano-Silver Composite Using Amomum longiligulare Fruit Polysaccharides and Their Biological Activities by Lian Y, Ma N, Cheng Q, Luo M, Xu Z, He F, Zhou X, Zhang Y, Jin D, Kong Y, Wang Y, Wei N

“…Finally, the in vitro antioxidant activity, antibacterial activity and anticancer activity of the nano-silver composite were evaluated.Results: Single-factor experiments identified the optimal synthesis conditions for ALP(D)-AgNPs as a reaction time of 180 min, a temperature of 100 °C, and a 10:1 volume ratio of silver nitrate to ALP-D. The free radical scavenging activity of ALP(D)-AgNPs against DPPH and ABTS was significantly enhanced compared with that of ALP-D. …”
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Comparison of different drying processes of Morchella sextelata: Changes in volatile and non-volatile components, color and texture by Yaxuan Liao, Mengdi Xin, Hao Dong, Yuxing Liu, Lingling Li, Xinyong Guo, Shaobo Cheng, Guogang Chen

“…In addition, the equivalent umami concentration (1293.20 g MSG/100 g) and total aroma compound content (2,533,403 μg/kg) for HAD-MVD were significantly higher than that for VFD, and the content of non-volatile substances such as soluble sugars, 5′-nucleotides, and total free amino acids were also high. Therefore, HAD-MVD represents an economic and more environmentally benign solution for the commercial processing of M. sextelata.…”
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Barriers and facilitators to maternal healthcare in East Africa: a systematic review and qualitative synthesis of perspectives from women, their families, healthcare providers, and... by Manaye Yihune Teshale, Agegnehu Bante, Abebe Gedefaw Belete, Rik Crutzen, Mark Spigt, Sarah E. Stutterheim

“…Key facilitators identified included improved healthcare understanding and women's self-efficacy at the individual level, family support and positive social influences at the interpersonal level, high-quality services, reliable transportation, compassionate care, and health education at the health facility level, community initiatives, gender equality, and maternity waiting homes at the community level, as well as free maternity services and health extension programs at the policy level. …”
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Effects of high-pressure homogenization on phenolics profile, antioxidant activity, α-glucosidase inhibitory activity, and insulin resistance of peach juice during simulated gastro... by Yijin Peng, Shenke Bie, Shengbao Cai, Linyan Zhou, Chaofan Guo

“…The bioactivities of peach juice were significantly improved, as evidenced by enhanced antioxidant activity, with DPPH and ABTS free radical scavenging capacities rising by 8.58 % - 26.68 %, and α-glucosidase inhibition improving by 21.40 % - 32.98 %. …”
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Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

“…Hang Yin,1– 5,* Xiaoxing Li,6,* Dazhou Lu,1– 5,* Xin Zhao,7,* Zeyu Yang,1– 5 Zerui Wang,1– 5 Feng Xu,1– 5 Yuguo Chen,1– 5 Chuanbao Li1– 5 1Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 3Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 4Shandong Key Laboratory: Magnetic Field-Free Medicine & Functional Imaging (MF), Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 5NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 6Department of Geriatrics, Qilu Hospital, Shandong University, Jinan, Shandong, People’s Republic of China; 7Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuanbao Li; Yuguo Chen, Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China, Email bao2460@126.com; chen919085@sdu.edu.cnBackground: Aortic dissection (AD) is a life-threatening cardiovascular emergency and currently lacks effective drug treatment. …”
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Predicting Iran Cooperative Development Bank's Profit/Loss: Two-stage Collective Learning by Seyed Bagher Fattahi, Seyed Mozafar Mirbargkar, Ebrahim Chirani, Mohammadreza Vatanparast

“…These variables encompass interest-free loans and short-term deposits, deposit interest expenses, total customer deposits, income from facilities and investments, common income, cash balances, administrative expenses, long-term deposits, non-common income, asset depreciation expenses, and the bank's size. …”
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Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study by Taylor Roh, Sungeun Ju, So Young Park, Yeonghwan Ahn, Jiyun Chung, Miyako Nakano, Gyoungah Ryu, Young Jae Kim, Geumseo Kim, Hyewon Choi, Sung-Gwon Lee, In Soo Kim, Song-I Lee, Chaeuk Chung, Takashi Shimizu, Eiji Miyoshi, Sung-Soo Jung, Chungoo Park, Sho Yamasaki, Seung-Yeol Park, Eun-Kyeong Jo

“…Abstract Haptoglobin (Hp) scavenges cell-free hemoglobin and correlates with the prognosis of human sepsis, a life-threatening systemic inflammatory condition. …”
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Oncological outcomes following extreme oncoplastic breast conserving surgery (eOPBCS) for locally advanced breast cancer (LABC): A systematic review and meta-analysis by Megan Chua Wern Ee, Ashley Lee Shi Hui, Wong Hung Chew, Emmeline Elaine Cua-Delos Santos, Sean Li Siwei, Sng Ming Xian, Qin Xiang Ng, Serene Goh Si Ning

“…The primary outcomes were overall survival (OS), disease-free survival (DFS), and local recurrence rates (LRR). …”
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Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

“…Evidence suggests that myxozoans evolved from free-living ancestors to endoparasites around 600 million years ago and are likely one of the first metazoan parasites on Earth. …”
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Nonylphenol exposure increases the risk of Hirschsprung’s disease by inducing macrophage M1 polarization by Xuefeng Yang, Chengyan Tang, Daiwei Zhu, Xingrong Xia, Qing Du, Lu Huang, Jianguo Liu, Yuanmei Liu

“…Herein, we identified the content of NP and expression of lncRNA LINC00294/Inhibin Subunit Beta E (INHBE) axis in clinical samples and evaluated the crucial role of lncRNA LINC00294/INHBE axis in the neurogenic potential of neurons and the neurotoxicity effects of NP in the SH-SY5Y cells and female specific pathogen-free (SPF) rat model. Our results showed that NP concentration and LINC00294 were significantly associated with HSCR occurrence and macrophage polarization in human HSCR specimens. …”
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Large-scale high purity and brightness structural color generation in layered thin film structures via coupled cavity resonance by Wang Danyan, Ji Chengang, Li Moxin, Xing Zhenyu, Gao Hao, Li Xiaochan, Zhou Huixian, Hu Yuhui, Lin Zhelin, Zhang Cheng

“…Structural colors, resulting from the interaction of light with nanostructured materials rather than pigments, present a promising avenue for diverse applications ranging from ink-free printing to optical anti-counterfeiting. Achieving structural colors with high purity and brightness over large areas and at low costs is beneficial for many practical applications, but still remains a challenge for current designs. …”
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Characteristics, clinical manifestations and management of leprosy in KwaZulu-Natal, South Africa: A 20-year retrospective study by J S Sons, Z N Mkhize, N C Dlova, C Aldous, P R Bhat, A V Chateau

“…These findings emphasise the urgent need for enhanced patient and healthcare worker education, particularly in primary healthcare settings, to improve adherence to treatment, advocate for prophylactic measures and prevent new cases. Achieving leprosy-free status in SA requires the collaboration of many role-players to address these challenges and improve healthcare practices. …”
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Donafenib combined with sintilimab for advanced hepatocellular carcinoma: a single arm phase II trial by Xiaoyang Hong, Yongjian Guo, Wenbo Shi, Kangshun Zhu, Licong Liang, Liteng Lin, Ye Chen, Jingwen Zhou, Jingjun Huang, Jiabai Huang, Yaozhu Wu, Wensou Huang, Mingyue Cai

“…The primary endpoint of this study was progression-free survival (PFS) per mRECIST. Results 30 patients were enrolled. …”
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Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening by Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan

“…These High Quantity brain organoids (Hi-Q brain organoids) exhibit reproducible cytoarchitecture, cell diversity, and functionality, are free from ectopically active cellular stress pathways, and allow cryopreservation and re-culturing. …”
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Preference for HIV testing among community residents in Yunnan Province, China: results from a discrete choice experiment by Jingwen Yang, Chenquan Qiu, Renhai Tang, Wenbin Dong, Enlong Yao, Huyunzhao Wang, Shuwen Lin, Minyang Xiao, Zuyang Zhang, Jin Niu, Liru Fu, Lijun Song, Xuehua Li, Yuhua Shi, Xiaowen Wang

“…We also observed that having support services was preferable (β = 0.50, p < 0.01) to support services not being available. Free HIV testing was the most preferred cost attribute (β = 1.61, p < 0.001). …”
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