TAp63γ is the primary isoform of TP63 for tumor suppression but not development by Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang

“…Additionally, loss of p63γ shortens the lifespan of tumor-free mice potentially via increased cellular senescence. …”
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Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites by Yun Teng, Chao Luo, Xiaolan Qiu, Jingyao Mu, Mukesh K. Sriwastva, Qingbo Xu, Minmin Liu, Xin Hu, Fangyi Xu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Maiying Kong, Zhanxu Liu, Xiang Zhang, Raobo Xu, Jun Yan, Michael L. Merchant, Craig J. McClain, Huang-Ge Zhang

“…An increased level of circulating DHA inhibits PD-L1 expression in tumor cells by binding the PD-L1 promoter and subsequently prevents c-myc-initiated transcription of PD-L1. Colonization of germ-free male mice with gut bacteria from anti-PD-L1 non-responding patients supplemented with DHA enhances the efficacy of anti-PD-L1 therapy compared to controls. …”
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Navigating the future of agri-food supply chain: A conceptual framework using bibliometric review by Abdul Kafi, Nizamuddin bin Zainuddin, Mohd Fitri Mansor, Mohamed Najib Bin Salleh, Adam bin Mohd Saifudin, Nurhaizal Azam Arif, Syairah Aimi Shahron, Ravi Ramasamy, Ibrahim Hassan mohamud

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Evaluation of taste quality of Keemun congou black tea during ripening and the effect of this quality on antioxidant capacity and in vitro inhibition of α-amylase and α-glucosidase... by Wenjing Huang, Zhibin Ye, Yida Wu, Tianzi Yu, Wei Zhao, Zihao Qi, Yanqun Jiang, Qiuyan Liu, Guofu Lu, Jingming Ning

“…Experiments regarding the inhibition of α-amylase and α-glucosidase activity and scavenging of 2,2-diphenyl-1-picrylhydrazyl radical revealed that ripening triggered the cascade reaction of polyphenols to form catechin polymers and flavonoid glycosides, thereby changing the dual biological functions of hypoglycaemia and free radical scavenging in vitro. Our study confirms the key role of ripening in enhancing the taste quality and potential health functional activities of KCBT.…”
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Pattern and Predictors of Maternal Healthcare Services Utilization among Women of Reproductive Age in Lagos, Nigeria by Esther Oluwakemi Oluwole, Alero Ann Roberts, Ifeoma Peace Okafor, Victoria Oluwasola Yesufu

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Structured reporting of neuroendocrine tumors in PET/CT using [18F]SiTATE - impact on interdisciplinary communication by Anna Hinterberger, Lukas Trupka, Sophia Kortbein, Ricarda Ebner, Nicola Fink, Matthias F. Froelich, Dominik Nörenberg, Carmen Wängler, Björn Wängler, Ralf Schirrmacher, Adrien Holzgreve, Matthias Brendel, Stefanie Corradini, Christoph Auernhammer, Johannes Rübenthaler, Freba Grawe

“…Abstract Our retrospective single-center study aims to evaluate the impact of structured reporting (SR) using a self-developed template on report quality compared to free-text reporting (FTR) in [18F]SiTATE Positron Emission Tomography/Computer Tomography (PET/CT) for the primary staging and therapy monitoring of patients diagnosed with neuroendocrine tumors (NET). …”
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GR-Athena++: General-relativistic Magnetohydrodynamics Simulations of Neutron Star Spacetimes by William Cook, Boris Daszuta, Jacob Fields, Peter Hammond, Simone Albanesi, Francesco Zappa, Sebastiano Bernuzzi, David Radice

“…The code correctly captures magnetic field instabilities in nonrotating stars with total relative violation of the divergence-free constraint of 10 ^−16 . It handles evolutions with a microphysical equation of state and black hole formation in the gravitational collapse of a rapidly rotating star. …”
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A qualitative study of community perceptions and practices relating to blood donation in Cameroon by Solange Dabou, Wilfred Ngwa, Ngo Valery Ngo, Constantine T Asahngwa, Ghyslaine Bruna Djeunang Dongho, Regina Sinsai, Evrard Kepgang, Odette D Kibu, Ronald Mbua Gobina, Denis Alemka Foretia

“…Some people do not want to donate blood due to: (1) fear of needles, donor-site pain or possible ritualistic use of donated blood, (2) certain religious beliefs, such as those held by Jehovah’s Witnesses, (3) local and cultural beliefs, (4) the perception that blood donation is a commercial activity for many health personnel and (5) lack of transparency from health personnel. The practice of free and voluntary donation, as well as donations specifically to family and friends, was common. …”
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SuessR: Regional corrections for the effects of anthropogenic CO2 on δ13C data from marine organisms by Casey T. Clark, Mattias R. Cape, Mark D. Shapley, Franz J. Mueter, Bruce P. Finney, Nicole Misarti

“…The Suess effect can be corrected for mathematically; however, a variety of disparate techniques are currently used, often resulting in corrections that differ substantially. SuessR is a free, user‐friendly tool that allows researchers to calculate and apply regional Suess corrections to δ13C data from marine systems using a unified approach. …”
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Factors Responsible For School Dropout At Different Levels of Education in Selected Academic Institutions in Kisoro Municipality Southern Division Kisoro District. by Kamahoro, Phionah

“…The researcher recommends that; Governments should plan some special policies to improve female education like introducing special stipends for female students and also making education free for them. Although some countries have already taken some steps in this regard, it is important to expand it further for other countries. …”
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First-line chemotherapy with selective internal radiation therapy for intrahepatic cholangiocarcinoma: The French ACABi GERCOR PRONOBIL cohort by Nicolas Adamus, Julien Edeline, Julie Henriques, Nadim Fares, Thierry Lecomte, Anthony Turpin, Dewi Vernerey, Mathilde Vincens, Brice Chanez, David Tougeron, Christophe Tournigand, Eric Assenat, Matthieu Delaye, Sylvain Manfredi, Olivier Bouché, Nicolas Williet, Angelique Vienot, Lorraine Blaise, Léo Mas, Cindy Neuzillet, Alice Boilève, Gaël S. Roth

“…The primary outcome was progression-free survival (PFS). Secondary outcomes were overall survival (OS), objective response rate (ORR) and tumor resection rate. …”
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Size distribution of extracellular vesicles in pretreatment ascites and plasma is correlated with primary treatment outcome in advanced high-grade serous carcinoma by Maruša Herzog, Ivan Verdenik, Borut Kobal, Katarina Černe

“…The correlations of the EV concentration and size distribution in ascites and plasma with treatment outcome, progression-free survival (PFS) and overall survival (OS) were analysed. …”
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Probing aspects of extracellular vesicle associated AAV allows increased vector yield and insight into its transduction and immune-evasive properties by Ming Cheng, Demitri de la Cruz, Adam V. Crain, Paula Espinoza, Carrie Ng, Zachary C. Elmore, Aravind Asokan, Casey A. Maguire

“…We used density gradient ultracentrifugation to separate EV-AAV from free AAV to determine the yields and functional activity of EV-AAV. …”
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Real-world data of dacomitinib as first-line treatment for patients with EGFR-mutant non-small-cell lung cancer by Ji Eun Shin, Hyun Ae Jung, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Byoung Yong Shim

“…This study assessed the objective response rate (ORR), progression-free survival (PFS), overall survival (OS), safety profile of dacomitinib, and subsequent treatments after dacomitinib failure. …”
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Predictive value of the perivascular fat attenuation index for MACE in young people suspected of CAD by Yani Yu, Dongkai Shan, Xi Wang, Zinuan Liu, Guanhua Dou, Junjie Yang, Yuqi Liu, Yundai Chen

“…K‒M survival analysis was conducted to assess the prognostic value of the perivascular FAI and improvement over traditional risk factor prediction methods. Results The event-free survival of patients in the high FAI group (FAI≥-75.2 HU) was significantly lower than that of patients in the low FAI group (FAI<-75.2 HU) at a median follow-up of 72.7 months (93.9% vs. 99.7%, P < 0.001). …”
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Virtual Joint Field Campaign: a framework of synthetic landscapes to assess multiscale measurement methods of water storage by T. Francke, C. Brogi, A. Duarte Rocha, M. Förster, M. Heistermann, M. Köhli, D. Rasche, M. Reich, P. Schattan, P. Schattan, L. Scheiffele, M. Schrön

“…</p> <p>In this study we suggest a synthetic virtual landscape that allows for an exact definition of all variables of interest and, consequently, constitutes the so-called “virtual truth” free of knowledge gaps. Such a landscape can be explored in various “virtual field campaigns” using “virtual sensors” that mimic the response and characteristics of actual devices. …”
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Penerapan Machine Learning untuk Mengendalikan Parameter Budidaya Tanaman Hidroponik Berbasis Edge dan Cloud Computing by Helmy Helmy, Arif Nursyahid, Thomas Agung Setyawan

“…Hydroponic plant cultivation has many advantages, including not requiring large land areas, being pesticide-free, producing more sterile plants, and being less susceptible to disease since it does not use soil. …”
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Tobacco Use, Risk Perceptions, and Characteristics of Adults Who Used a Heated Tobacco Product (IQOS) in the United States: Cross-Sectional Survey Study by Hui G Cheng, Brendan Noggle, Andrea R Vansickel, Edward G Largo, Pierpaolo Magnani

“… BackgroundThe Tobacco Heating System (THS; commercialized as IQOS) is a smoke-free heated tobacco product introduced in the United States in 2019 and authorized by the US Food and Drug Administration as a modified risk tobacco product (MRTP) in 2020. …”
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Acceptability of and experiences with menstrual hygiene cups among adolescent girls and young women aged 15–24 in two communities in Lusaka, Zambia: an exploratory study nested in... by Melleh Gondwe, Melvin Simuyaba, Mwelwa Phiri, Chisanga Mwansa, Albertus Schaap, Lucheka Sigande, Kwame Shanaube, Sian Floyd, Sarah Fidler, Helen Ayles, Musonda Simwinga, Bernadette Hensen

“…Conclusion Despite concerns, misconceptions and initial challenges, cups were acceptable among AGYW. Free distribution of cups provides an opportunity to address menstrual health challenges among AGYW. …”
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Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Furthermore, serum levels of free DNA gradually and significantly increased, further supporting the induction of NETosis following PTS. …”
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