Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection by Amanda R. Loehr, Dennis M. Timmerman, Michelle Liu, Ad J. M. Gillis, Melia Matthews, Jordana C. Bloom, Peter K. Nicholls, David C. Page, Andrew D. Miller, Leendert H. J. Looijenga, Robert S. Weiss

“…Here, we report that miRNAs in the mouse miR-290-295 cluster, homologs of the human miR-371-373 cluster, were detectable in serum from mice with malignant TGCTs but not from tumor-free control mice or mice with benign teratomas. miR-291-293 were expressed and secreted specifically by pluripotent EC cells, and expression was lost following differentiation induced by the drug thioridazine. …”
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Bubble connectivity in experimentally-sheared crystal-bearing silicic melts by Daffos, Camille, Martel, Caroline, Arbaret, Laurent, Champallier, Rémi

“…The samples were deformed in torsion at a temperature of 650 °C (crystal-free) or 750 °C (crystal-bearing), confining pressure of 50 MPa, constant moderate shear rate of $2 \times 10^{-4}~\mathrm{s}^{-1}$, and low strains ($\gamma < 2$). …”
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Growth, Yield and Quality of Maize under Ozone and Carbon Dioxide Interaction in North West India by Achchhelal Yadav, Arti Bhatia, Sudesh Yadav, Archana Singh, Ritu Tomer, Ramesh Harit, Vinod Kumar, Bhupinder Singh

“…To understand how the growth and nutritional quality of maize will be affected under elevated carbon dioxide (CO2) and tropospheric ozone (O3) interaction, a field experiment was conducted under free air O3 and CO2 enrichment rings (FAOCE) growing HQPM-1 and PMH-1 maize cultivars at New Delhi, India. …”
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Factors determining primary or delayed surgery for unilateral, non-metastatic Wilms tumor: a multicentric Egyptian study by Ahmed Elgendy, Amr Abdelhamid AbouZeid, Mohamed El-Debeiky, Shaimaa Abdelsattar Mohammad, Marwa Romeih, Ahmed Ebeed, Mohamed Abouheba, Mohammed Hamada Takrouney, Mahmoud Mostafa, Ahmed Khairi, Osama El-Naggar, Sameh Shehata

“…The 3-year overall and event-free survival for all patients were 91% and 89%, respectively. …”
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The Combination of D-TACE-HAIC, Lenvatinib, and PD-1 Inhibitors Shows Significant Clinical Efficacy in Patients with Unresectable Hepatocellular Carcinoma by Wu Y, Zhu J, Zhang H, Xia N

“…The median progression-free and overall survival (PFS and OS) of patients in Group A were 13.2 and 28.8 months, with both being significantly higher than the corresponding intervals in Group B (5.7 and 10.8 months, respectively). …”
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Network Pharmacology and Experimental Validation of the Therapeutic Effect of Baji Capsule on LPS-Induced Osteoporosis by Li Q, Li D, Tian C, Liu X, Wang H, Liu H

“…The therapeutic effect of Baji capsule was evaluated by high-resolution micro-computed tomography (Micro-CT) and tissue section staining, serum inflammatory factor levels were assessed by ELISA, serum oxidative stress-related marker levels were determined by kits, and finally the mechanism was explored by network pharmacology and then verified by immunohistochemistry.Results: Micro-CT results showed that Baji capsule attenuated LPS-induced inflammatory bone loss.Baji capsule also reduced serum inflammatory factor levels and oxygen free radical production. Target screening by network pharmacology yielded a total of 236 active ingredients of Baji capsule, as well as 278 common targets after taking the intersection of Baji capsule active ingredient targets and osteoporosis disease-related targets.Conclusion: Baji capsule can treat osteoporosis by reducing inflammation and oxidative stress. …”
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Associations of the Need for Surgery in Emergency Department Patients with Small Bowel Obstructions by Daniel J. Berman, Alexander W. Mahler, Ryan C. Burke, Andrew E. Bennett, Nathan I. Shapiro, Leslie A. Bilello

“…We identified seven independent associations for the decision of surgery: abdominal distension (OR 0.27, 95% CI 0.10–0.62); gastrografin (OR 0.41, 95% CI 0.20–0.81); previous SBO (OR 0.42, 95% CI 0.26–0.66); higher Charlson Comorbidity Index score (OR 0.87, 95% CI 0.80–0.95); nasogastric decompression (OR 2.04, 95% CI 1.25–3.39), initial systolic blood pressure <100 mm Hg (OR 2.65, 95% CI 1.05–6.53); free fluid or volvulus/closed-loop obstruction on computed tomography (OR 7.95, 95% CI 4.25–15.39), with the AUC for the predictive model equaling 0.73. …”
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Gut microbial subtypes and clinicopathological value for colorectal cancer by Shuwen Han, Jing Zhuang, Yifei Song, Xinyue Wu, Xiaojian Yu, Ye Tao, Jian Chu, Zhanbo Qu, Yinhang Wu, Shugao Han, Xi Yang

“…Clinical information (e.g., free fatty acids and total cholesterol) and CRC pathological information (e.g., tumor depth) varied among gut microbial subtypes. …”
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Differentiated approach at the choice of chronic hepatitis C antiviral therapy mode (real clinical practice experience) by I. Yu. Pirogova, N. B. Kovaleva, E. P. Patlusov, E. S. Radchenko

“…As administration of interferon-free treatment modes for most of patients is limited due to financial considerations, application of IFN-based modes of treatment in clinical practice is still actual. …”
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Electrochemically-driven solid oxide tubular membrane reactor for efficient separation of oxygen and argon by Yuanhui Tang, Yutao Hu, Sisi Wen, Song Lei, Yakai Lin, Li Ding, Haihui Wang

“…The resulting membrane reactor was compact, defect-free, and capable of producing Ar with a purity of 99.99 %. …”
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Development of High Dietary Fiber Cereal Bar as Emergency Food Product and The Chemical-Microbiological Properties and Nutritional Content by Ani Radiati, Sumarto Sumarto, Fahmi Hafid, Emma Kamelia, Lia Nurcahyani, Dini Mariani, Siti Badriah, Tjahja Muhandri

“…Results: The test showed that the mixed berry cereal bar contained 9.43% dietary fiber, exceeding BPOM standards. The product was free from heavy metal contamination (arsenic, cadmium, mercury, lead, and tin) and showed no trans fats. …”
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Out-of-field dose assessment for pencil beam scanning proton radiotherapy versus photon radiotherapy for breast cancer in pregnant women by Menke Weessies, Murillo Bellezzo, Britt J.P. Hupkens, Frank Verhaegen, Gloria Vilches-Freixas

“…Materials and methods: For breast cancer involving lymph node levels 1–4 and the intramammary lymph nodes, treatment plans were created for XRT (with Flattening Filter (FF) and FF-Free (FFF)) and PBS-PRT, prescribing 15 × 2.67 Gy(RBE). …”
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Complete metabolic response as early predictor of long-term efficacy after adoptive T cell therapy using tumor-infiltrating lymphocytes by Rikke Andersen, Troels Holz Borch, Eva Ellebaek, Inge Marie Svane, Helle Westergren Hendel, Kasper Madsen

“…Neither mOS (range 32.2–149.8+) nor median progression-free survival (mPFS; range 20.7–123.4+) were reached for patients with partial response (PR)/CMR (10 patients), whereas patients with PR/non-CMR (12 patients) had a mOS of 28.7 months (p=0.0016) and a mPFS of 7.8 months (p&lt;0.0001).Overall, not achieving a CMR was associated with a short mPFS of 3.2 months, and 97.9% (47/48) of all patients in this group progressed within 12 months.Conclusion: In conclusion, early CMR is a strong predictor of long-term survival after TIL therapy in metastatic melanoma patients. …”
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The effects of circuit hydraulic weight interval training on body composition and progression of resistance in recreationally exercising pre- and postmenopausal women: an 18-week q... by Małgorzata Socha, Paulina Ćwieląg, Waldemar Andrzejewski

“…Each participant from the CHWIT group took part in a total of 54 training sessions, developed for the Mrs.Sporty network, under the constant supervision of a qualified trainer.ResultsAfter 18 weeks of training in both intervention groups, ANCOVA demonstrated statistically significant (p &lt; 0.05) decreased body fat (%), reduced thigh and arm circumference, and increased muscle component (kg) as the main part of fat-free body mass. Additionally, premenopausal women decreased their body mass, BMI, and waist and hip circumferences. …”
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Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation by Jing Dong, Shahram Arsang-Jang, Tao Zhang, Zhongyuan Chen, Yung-Tsi Bolon, Stephen Spellman, Raul Urrutia, Paul Auer, Wael Saber

“…We evaluated the impact of donor mtDNA variants on recipients’ transplantation outcomes, including overall survival, relapse, relapse-free survival, and transplant-related mortality. …”
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Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients by Jae-Ghi Lee, Ilkyu Park, Hannah Lee, Seungyoon Nam, Jisup Kim, Won-Suk Lee, Myunghee Kang, Jung Ho Kim

“…It then assessed their 5-year event-free survival (EFS) and disease-specific survival (DSS) hazard ratios (HRs). …”
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Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease by María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez

“…Molecular docking and molecular dynamics simulations were performed to provide a comprehensive understanding of the interactions between LRRK2 and the inhibitors in the data set and best molecules of the screening. Free energy of binding calculation along with hydrogen bond occupancy analysis and RMSD of the ligand in the pocket show CRA_1801 as the best candidate to be repurposed as LRRK2 inhibitor.…”
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GAZE DIRECTION MONITORING MODEL IN COMPUTER SYSTEM FOR ACADEMIC PERFORMANCE ASSESSMENT by Olesia Barkovska, Yaroslav Liapin, Tetiana Muzyka, Ihor Ryndyk, Pavlo Botnar

“…The dynamic authentication based on the sequence of eye movements proposed in the model allows error-free user's eye area detection for further analysis of the test subject's behavior. …”
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Phenolic and amino acid profiles, and antioxidant properties of third generation snack foods adding Citrus mitis by-products and milk powder: impact of extrusion processing and mic... by Xóchitl Ariadna Ruiz-Armenta, Carlos Iván Delgado-Nieblas, José de Jesús Zazueta-Morales, Ernesto Aguilar-Palazuelos, Perla Rosa Fitch-Vargas, José Alberto Gallegos-Infante, José Ángel López-Valenzuela, María Fernanda Quintero-Soto

“…Sixteen phenolic acids, nine flavonoids, and a hydroxy acid were identified in free and bound extracts by UPLC coupled to ESI-MS. …”
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Case report: Bevacizumab-induced cerebrovascular events: a case series report and literature review by Ke Chen, Boyang Jiang, Boyang Jiang, Huiping Yan, Huiping Yan, Liu Yang, Liu Yang, Zheling Chen, Zheling Chen

“…In clinical use, bevacizumab has improved the overall survival (OS) and progression-free survival (PFS) of malignant solid tumors, and the safe use of bevacizumab has gradually become the mainstream direction of clinical, nursing and pharmaceutical research. …”
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