Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer by Ai Sato, Kiyoshi Takagi, Mio Yamaguchi-Tanaka, Jotaro Okushima, Yuto Yamazaki, Akihiro Ito, Takashi Suzuki

“…However, the clinical and biological significance of MMP3 has not been well elucidated.We therefore immunolocalized MMP3 in prostate cancer tissues (n = 117) and demonstrated that MMP3 immunoreactivity was correlated with aggressive phenotype of prostate cancer, including higher proliferation/invasion ability, and shorter disease-free survival. In addition, subsequent in vitro analysis revealed that overexpression of MMP3 significantly increased the proliferative and migratory abilities of PC-3 and DU-145 prostate cancer cell lines, depending on conditioned media from WMPY-1 prostate stromal cells.It was concluded that MMP3 might contribute to prostate cancer progression by modifying the ECM surrounding prostate cancer cells and could serve as a potent prognostic factor in prostate cancer.…”
Get full text

Functional Outcome (Short Term) of Modular Cementless Bipolar HemiArthroplasty (Hydroxyapatite-Coated Stem) for Fracture Neck of Femur in the Elderly by Navin K. Shukla, Lata Keshkar, Jayanta Mukherjee, Ratnesh Kumar, Shivendra Singh, Alok C. Agrawal

“…Twenty-seven patients (62%) were absolutely pain-free. There were no dislocations, revisions, or additional surgeries in any patients. …”
Get full text

Nutritional assessment using subjective global assessment identifies energy malnutrition and predicts mortality in patients with liver cirrhosis by Takao Miwa, Tatsunori Hanai, Kayoko Nishimura, Sachiyo Hirata, Shinji Unome, Yuki Nakahata, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu

“…Multivariable analysis indicated that both SGA-B (odds ratio, 3.59; 95% confidence interval [CI], 1.59–8.10) and SGA-C (odds ratio, 19.70; 95% CI, 3.46–112.00), along with free fatty acids (FFA), were independently linked to energy malnutrition. …”
Get full text

Development of Nutrient-Rich Injera Using Amaranthus Leaf/Grain and Teff Flours: A Study on Nutritional Value, Sensory Characteristics, and Storage Stability by Betelhem Abera, Ramesh Duraisamy, Tewodros Birhanu, Beyene Gurbo, Ketemaw Salelign

“…It has substantial national and global recognition due to its nutraceutical benefits and its gluten-free nature. Flatbread, a functional food for health promotion, can be enhanced with less mineral-rich crops like Amaranthus, which are often underutilized, to increase its nutritional and mineral content. …”
Get full text

Serum Zinc Levels in Women with Polycystic Ovarian Syndrome are Lower as Compared to Those without Polycystic Ovarian Syndrome: A Cohort Study by Swati Dhar, Reena Yadav, Akash Tomar

“…Background: Zinc is an essential micronutrient, a vital stabiliser and a cofactor in many enzymes such as superoxide dismutase and phospholipase C and also acts as an antioxidant by protecting the sulfhydryl groups of different proteins and enzymes against free radicals. It is unclear if serum zinc levels are correlated with polycystic ovary syndrome (PCOS) and its pathophysiology, although relation between diabetes and insulin resistance has been established. …”
Get full text

Exploring the microbiota-gut-brain axis: impact on brain structure and function by Lidya K. Yassin, Mohammed M. Nakhal, Alreem Alderei, Afra Almehairbi, Ayishal B. Mydeen, Amal Akour, Mohammad I. K. Hamad

“…Subsequently, we will examine the technical strategies employed to study MGBA interactions, including using germ-free (GF) animals, probiotics, fecal microbiota transplantation (FMT), and antibiotics-induced dysbiosis. …”
Get full text

A comprehensive global mapping of offshore lighting by C. D. Elvidge, T. Ghosh, N. Chatterjee, N. Chatterjee, M. Zhizhin, M. Zhizhin, P. C. Sutton, M. Bazilian

“…The product merges two operational nighttime light products: VIIRS boat detection (VBD) data and VIIRS cloud-free nighttime light (VNL) data. The two products are spatially complementary, making it possible to fill gaps through a merger. …”
Get full text

Effect of double-induced on whey protein isolate nanoparticle formation and stabilized food-grade Pickering emulsions: Stability and gastrointestinal digestion by Shenghua He, Yonghui Wang, Guanghui Li, Xueli Gao, Zhiyan Chen, Weiyun Guo, Jihong Huang

“…PEs stabilized by double-induced WPINs showed a slower release rate of free fatty acid during gastrointestinal digestion. …”
Get full text

KNOWLEDGE, ATTITUDES AND PRACTICES TOWARDS OPEN EDUCATIONAL RESOURCES IN HIGHER EDUCATION INSTITUTIONS IN THE PHILIPPINES by Liezel G. Mohillo, Angie R. Jalandoon, Dave E. Marcial

“…With the update in education and the shift in learning modality a great need for educational resources - free and open to the public increases, especially in the outrage of the pandemic. …”
Get full text

A foundation systematic review of natural language processing applied to gastroenterology & hepatology by Matthew Stammers, Balasubramanian Ramgopal, Abigail Owusu Nimako, Anand Vyas, Reza Nouraei, Cheryl Metcalf, James Batchelor, Jonathan Shepherd, Markus Gwiggner

“…Conclusion NLP can unlock substantial clinical information from free-text notes stored in EPRs and is already being used, particularly to interpret colonoscopy and radiology reports. …”
Get full text

Translation, cross-cultural adaptation and validation of the composite physical function scale in Chinese community-dwelling older adults by Jiaying Qi, Jing Xu, Hui Zhang, Mingshuai Feng, Hongyan Meng, Li Wang

“…Confirmatory factor analysis for a modified model provided an average fit index (chi-square/free ratio = 3.596, root mean square error of approximation = 0.099, normal fit index = 0.908, incremental fit index = 0.931, comparative fit index = 0.931 and Tucker–Lewis index = 0.909). …”
Get full text

Efficacy and safety of camrelizumab combined with chemotherapy as second-line treatment for locally advanced, recurrent, or metastatic esophageal squamous cell carcinoma by Yinfang Gu, Xiaofang Zou, Junlin Zhu, Guowu Wu

“…We evaluated short-term efficacy, including overall response rate (ORR) and disease control rate (DCR), as well as survival outcomes, including progression-free survival (PFS) and overall survival (OS). Safety was also assessed. …”
Get full text

The Managers' Perceptions of Telework Implementation Requirements in the Algerian Companies: A Post Covid-19 Assessment by Riad BENGHEBRID

“…Design/Method/Approach: We opted for an essentially qualitative approach field by conducting semi-structured interviews individually with 11 company managers from different sectors of activity in order for the interviewee to feel sufficiently free and to have as much transparency and credibility as possible, and to obtain in-depth information that is difficult to express quantitatively or statistically, with diversity of the sample in terms of (age, professional experience, sector of activity, legal form etc.). …”
Get full text

PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma by San-Chi Chen, Hsiang-Ling Ho, Chien-An Liu, Yi‑Ping Hung, Nai-Jung Chiang, Ming‑Huang Chen, Yee Chao, Muh-Hwa Yang

“…This association held for targeted therapies, immune checkpoint inhibitors, and chemotherapy. Progression-free survival (PFS) for the regression, stable, and progression groups was non-reached, 6.7, and 3.2 months (p = 0.0002), and overall survival (OS) was non-reached, non-reached, and 18.5 months (p = 0.02). …”
Get full text

Synthesis and Antioxidant Activity of Selenized Apigenin by Yawen GAO, Guopeng WU, Bo HAN, Rongwu WANG, Fangming LOU

“…The in vitro antioxidant results suggested that Se-AP exhibited a clearance rate of 93.82%±0.63% for ABTS+ radicals at a concentration of 400 mg/L, 39.53%±0.67% for DPPH radicals and 96.54%±0.77% for OH radicals at a concentration of 800 mg/L and the ability of scavenging DPPH free radicals was slightly enhanced, while the scavenging ability of ABTS+ and OH radicals was significantly increased (IC50 was 53.52±1.85 mg/L and 11.33±0.64 mg/L), and the scavenging ability was comparable to that of VC at 800 mg/L at the same concentration for Se-AP. …”
Get full text

Detection and decontamination of Mycoplasma in cultured cells and viral strains by Glaucia Prado de Andrade, Natália Hettwer Pedroso, Alice Becker, Vinicius Soares dos Santos, Juciane Bonella, José Valter Joaquim Silva Júnior, Rudi Weiblen, Eduardo Furtado Flores

“…After, a decontamination protocol of viral seeds was carried out, consisting of amplification in cell culture, centrifugation of the viral suspension, filtration, limiting dilution and culture in mycoplasma-free cells. The fourteen viral strains were decontaminated after 1 to 4 cycles of the protocol. …”
Get full text

Solubility and thermodynamic analysis of amlodipine besylate in mixtures of propylene glycol and 1-propanol from 293.2 to 323.2 K by Homa Rezaei, Fleming Martinez, William E. Acree Jr, Abolghasem Jouyban

“…In the realm of thermodynamics, the apparent parameters, namely enthalpy, entropy, and Gibbs free energy, pertinent to the dissolution processes of ADB were computed. …”
Get full text

Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma by Rina Nulianti, Hartanto Bayuaji, Mulyanusa Amarullah Ritonga, Tono Djuwantono, Dian Tjahyadi, Anita Rachmawati, Sri Ratna Dwiningsih, Aisyah Shofiatun Nisa, Putri Nadhira Adinda Adriansyah

“…Local bleeding and inflammation within endometriosis lesions, which occur in an environment rich in iron, reactive oxygen species (ROS), and free radicals, can disturb the balance of iron within the peritoneal cavity. …”
Get full text

Optimization of Enzymatic Hydrolysis Process, Structural Characterization and Antioxidant Activity Analysis of Gastrodia elata Polysaccharide by Yunfei HU, De ZHOU, Qinglan ZENG, Jinsong HE, Ming ZHAO, Qingyan TANG

“…In addition, the ABTS+ and DPPH free radical scavenging abilities in vitro were tested before and after enzymolysis. …”
Get full text

IMPLEMENTASI PENERAPAN PRINSIP KERJASAMA PERDAGANGAN BEBAS DALAM KEBIJAKAN NASIONAL TERKAIT TINDAKAN PENGAMANAN PERDAGANGAN (SAFEGUARD) by Mira Utami, Umar Aris

“…Hasil pembahasan penelitian ini diharapkan dapat digunakan untuk memecahkan masalah terkait perlindungan hukum atas ancaman kerugian akibat tidak maksimalnya  perlindungan negara kepada warga negaranya dari ancaman kerugian serius akibat serbuan produk luar negeri dalam rangka kerjasama ekonomi perdagangan bebas (Free Trade Area) antar negara maupun kumpulan negara, yang saat ini telah diratifikasi, sehingga perdagangan bebas ini tidak merugikan bangsa indonesia dan pengaturan akan safeguard di negara Indonesia sejalan dengan norma norma terkait safeguard yang telah diatur oleh WTO. …”
Get full text