The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis by Matteo Massara, Michelle Ballabio, Bastien Dolfi, Golnaz Morad, Vladimir Wischnewski, Eleni Lamprou, Joao Lourenco, Stéphanie Claudinot, Hector Gallart-Ayala, Rui Santalla Méndez, Annamaria Kauzlaric, Nadine Fournier, Ashish V. Damania, Matthew C. Wong, Julijana Ivanisevic, Nadim J. Ajami, Jennifer A. Wargo, Johanna A. Joyce

“…Toward this goal, we explored the contribution of the gut microbiome to BrM development by using in vivo breast-BrM models under germ-free conditions or antibiotic treatment. This revealed a detrimental role of gut microbiota in fostering BrM initiation. …”
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The development of a nurse-led preoperative anaesthesia screening tool by Delphi consensus by M B Nejthardt, P Alexandris, S Bechan, M F A Bijli, S Chetty, J M Dippenaar, M Gibbs, M Johnson, H Kluyts, R Llewellyn, M Motiang, P Mogane, P Motshabi, B Mrara, F Roodt, U Singh, S Spijkerman, E Turton, J van der Westhuizen, B Biccard

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Aspergillus terreus variant TB21 wet biomass optimized by in-situ transesterification for biodiesel production by Rashmi K. Bed, V. Ravi Kumar, Ameeta RaviKumar

“…Physico-chemical properties of TB21-derived biodiesel were determined, namely, density(0.88 g cm−3), kinematic viscosity (4.1 mm s−2), iodine value (96.82), cetane number (55.31), free fatty acid content (0.15%), total acid number (0.3 NaOH mg g−1), meeting international (ASTM D6751, EN 14214) and Indian (IS 15607) standards. …”
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Developing an activated biochar-mineral supplement for reducing methane formation in anaerobic fermentation by Sara Tahery, Mariano C. Parra, Paul Munroe, David R. G. Mitchell, Sarah J. Meale, Stephen Joseph

“…A high surface area, a high concentration of oxygen-containing functional groups, and a high concentration of free radicals, associated with O and Fe unpaired electrons, assisted the supplement with catalysing the oxidation of methane. …”
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Insecticide-treated nets utilization and influencing factors on middle school students in Southeast Nigeria. A cross-sectional study by Egbobe JohnPaul Otuomasiri, Magnus Michael Sichalwe, Ezaka Ephraim Ibeabuchi

“…The positive link between knowledge and ITN use highlights the need for effective health education. Additionally, free distribution significantly boosts consumption, underscoring the importance of tailored interventions for vulnerable populations. …”
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Theologen van de twintigste eeuw en de christologie by A. van de Beek

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Reducing the effective dose of doxycycline using chitosan silver nanocomposite as a carriers on gram positive and gram-negative bacteria by Elham M. Mostafa, Y. Badr, M. M. Hashem, K. Abo-EL-Sooud, Amna H. Faid

“…The antibacterial effect of Doxy/AgNPs nanocomposite was found to be twice effect of free doxy, suggesting a synergistic interaction between the two components. …”
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Dentinal Crack Formation and Quality of Obturation Using Two Single File Systems and Two Obturation Techniques: A micro-CT Study. by Shaban Shaban Omar, Bahar Jafaar Selivany

“…None of the root canal filling procedures yield fillings that are void-free. …”
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Blood-based biomarkers in patients with non-small cell lung cancer treated with immune checkpoint blockade by Yo-Ting Tsai, Jeffrey Schlom, Renee N. Donahue

“…These investigations have unveiled compelling correlations between the peripheral immune status of patients both before and during ICI therapy and patient outcomes, which include response rates, progression-free survival, and overall survival. There is need for rigorous validation and standardization of these blood-based assays for broader clinical application. …”
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Higher-dimensional Willmore energy as holographic entanglement entropy by Giorgos Anastasiou, Ignacio J. Araya, Pablo Bueno, Javier Moreno, Rodrigo Olea, Alejandro Vilar Lopez

“…The new functional involves an integral over the doubled RT surface of a linear combination of three quartic terms in extrinsic curvatures and is free from ultraviolet divergences by construction. …”
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Cost Effectiveness Analysis of Eribulin Mesylate as a Treatment for Metastatic Breast Cancer in Spain: Management in the Later Line of Therapy by Gabriel Tremblay, Unnati Majethia, Ilias Kontoudis, Jesús De Rosendo

“…Model inputs were overall survival, progression-free survival and costs relating to chemotherapies, grade 3/4 adverse events and healthcare utilization. …”
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Lipotoxicity and metabolic disorders at obesity by V. T. Ivashkin, M. V. Mayevskaya

“…It is possible to explain lipotoxicity phenomenon as follows: in conditions of insulin resistance glucose stops to be an energy source and is substituted by lipolysis, therefore a plenty of free fatty acids is formed, having potential of toxicity and realizing metabolic disorders in target organs: the liver, the pancreas, muscles. …”
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5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects by Liangliang Hu, Ting Meng, Davies Marabada, Zhichao Jin, Qing Huang, Shijie Wei, Zhizhong Wang

“…Pharmacokinetic analyses revealed that 5-FUSA-β-CD and 5-FUBA-β-CD were eliminated slowly and their half-lives were longer than that of free 5-FU. Distinct linkers were meticulously designed and synthesized to generate 5-Fluorouracil-β-Cyclodextrin conjugates that exhibit differential anti-colon cancer activity and half-lives. …”
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Effect of Motor Blockage on Transient Characteristics of Asymmetric Flow in a Double-suction Centrifugal Fan by S. Du, X. Wu, Z. Wang, W. Yang, Z. Yang, Z. Wang, W. Zhang

“…Numerical results reveal that compared with the baseline motor-free model, the motor blockage of the two models decreases the flow rate by 30.4% and 20.8%, respectively, at the obstructed inlet of the fan, and the inflow is non-uniform and presents a local reversed flow. …”
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Efficiency of a macroroughness block ramp in reducing the impact of low-head dams on riverine fish dispersion by Tomanova Sylvie, Courret Dominique, Richard Sylvain, Mercier Olivier, Guillemin Axel, Labedan Mathilde, Sagnes Pierre

“…Macroroughness ramps (e.g. with a rough bed and protruding blocks evenly distributed in staggered rows) are nature-like fishways offering a wide range of flow conditions and are expected to be very efficient tools to reduce the impact of weirs on the free movements of most life-stages of riverine fish species. …”
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Physical determinants of daily physical activity in older men and women. by Laura Karavirta, Timo Aittokoski, Katja Pynnönen, Timo Rantalainen, Kate Westgate, Tomas Gonzales, Lotta Palmberg, Joona Neuvonen, Jukka A Lipponen, Katri Turunen, Riku Nikander, Erja Portegijs, Taina Rantanen, Søren Brage

“…<h4>Methods</h4>In this cross-sectional study, a population-based cohort of 75, 80, and 85-year-old men and women (n = 409, 62% women) underwent laboratory-based assessment of walking speed, maximal knee extension strength, and body fat percentage. Free-living physical activity was assessed as total PAEE, and light (LPA) and moderate-to-vigorous physical activity (MVPA) using individually calibrated combined accelerometry and heart rate sensing. …”
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Plasma mcfDNA Sequencing May Improve Usual Care Diagnostics to Detect HHV-8 Among Outpatient People with Advanced HIV by Sarah Park, Brian Epling, Morgan Richey, Daniel Lupu, Mona Mughar, Irini Sereti

“…Methods: Pathogen-agnostic plasma microbial cell-free DNA sequencing was applied to banked samples from 116 outpatients included in 2 previous prospective studies of patients with antiretroviral treatment-naïve, advanced HIV (CD4 count ≤100 cells/µL). …”
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Treatment Interruption and Regimen Change in Firstgeneration versus Second-generation Tyrosine Kinase Inhibitors used as First-line Therapy for Chronic Myeloid Leukemia by Melea A. Ward, Gang Fang, Kristy L. Richards, Christine M. Walko, Stephanie R. Earnshaw, Laura E. Happe, Susan J. Blalock

“…**Background:** Research has shown that treatment interruptions are associated with worse failure-free survival in chronic myeloid leukemia (CML); however they are commonly used in clinical trials to manage adverse events. …”
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Beliefs about HIV cure: A qualitative study of people living with HIV in Soweto, South Africa by Fatima Laher, Naledi Mahlangu, Mbalenhle Sibiya

“…Thirdly, anticipated socio-behavioural effects: beliefs existed that cures might improve happiness, reduce emotional burdens of disclosure, facilitate HIV-free generations, increase risk behaviours, and reduce health checks, but not change societal attitudes to HIV. …”
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Phosphaturic mesenchymal tumor: Clinicopathological features with outcomes in 10 patients with review of literature by Vivek C. Parameshwar, Bharat Rekhi, Ashwini Duggad, Mukta Ramadwar

“…All those patients were free of disease until the last follow-up. Conclusion: This constitutes the first largest comprehensive study on these rare tumors from our country. …”
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