Fabrication and evaluation of a portable and reproducible quartz crystal microbalance immunochip for label-free detection of β-lactoglobulin allergen in milk products by Mingfei Pan, Liping Hong, Jingying Yang, Xiaoqian Xie, Kaixin Liu, Shuo Wang

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Repetitive Transcranial Magnetic Stimulation for the Treatment of Complex Regional Pain Syndrome: A Pilot Study by Foglia SD, Drapeau CC, Ramdeo KR, Adams FC, Soppitt DB, Rehsi RS, Shanthanna H, Nelson AJ

“…Stevie D Foglia,1 Chloe C Drapeau,2 Karishma R Ramdeo,2 Faith C Adams,2 Daniel B Soppitt,2 Ravjot S Rehsi,2 Harsha Shanthanna,1,3 Aimee J Nelson1,2 1School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada; 2Department of Kinesiology, McMaster University, Hamilton, ON, Canada; 3Department of Anesthesia, McMaster University, Hamilton, ON, CanadaCorrespondence: Aimee J Nelson, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, Tel +1 905-525-9140 x28053, Fax +1 905-523-6011, Email nelsonaj@mcmaster.caPurpose: Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition characterized by sensory, motor, and autonomic dysfunction with a world-wide prevalence of 26.2 per 100,000 people per year and is 3 to 4 times more prevalent in females. …”
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Suitability of Measures of Pharmacy-Based Medication Adherence for Routine Clinical Use Among Patients with Chronic Diseases: A Systematic Review by Jannah W, Khoiry QA, Alfian SD, Abdulah R

“…Raya Jatinangor, KM 21, Jatinangor, Sumedang, Indonesia, Tel/Fax +62-022-7796200, Email sofa.alfian@unpad.ac.idPurpose: To identify the suitability of pharmacy-based measures for determining medication adherence in routine clinical use.Methods: Data were obtained through PubMed and Scopus databases up to December 2023 without publication year restrictions. …”
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Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy by Gao Y, Li L, Zhao F, Cheng Y, Jin M, Xue FS

“…Ying Gao,1 Lu Li,1 Fang Zhao,1 Yi Cheng,1 Mu Jin,2 Fu-Shan Xue1,3 1Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, People’s Republic of ChinaCorrespondence: Mu Jin, Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 An-Zhen Road, Chao-Yang District, Beijing, 100029, People’s Republic of China, Tel +86-13366600987, Email jinmu0119@hotmail.com Fu-Shan Xue, Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-An Road, Xi-Cheng District, Beijing, 100050, People’s Republic of China, Tel +86-13911177655, Fax +86-591-88217841, Email xuefushan@aliyun.com; xuefushan@mail.ccmu.edu.cnPurpose: This study aimed to assess the protective effect of a clinical dose esketamine on cerebral ischemia/reperfusion (I/R) injury and to reveal the potential mechanisms associated with microglial polarization and autophagy.Methods: Experimental cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in adult rats and simulated by oxygen-glucose deprivation (OGD) in BV-2 microglial cells. …”
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Evaluation of the Effectiveness of Standard Precaution Training on Disposition of Occupational Blood Exposure Among Healthcare Trainees: A Pre-Post Intervention Study by Zhang X, Li H, Li N, Li Y, Kong L, Zhang M, Wang P, Ma Y, Ni L, Liu L, Meng X

“…Xing Zhang,1 Hongwei Li,2 Ning Li,1 Yusen Li,1 Li Kong,1 Min Zhang,1 Peng Wang,1 Yonghui Ma,1 Leiping Ni,2 Lili Liu,1 Xiujuan Meng1 1Healthcare-Associated Infection Control Department, Affiliated Hospital of Jining Medical University, Jining, Shandong, People’s Republic of China; 2Medical Education Center, Affiliated Hospital of Jining Medical University, Jining, Shandong, People’s Republic of ChinaCorrespondence: Xiujuan Meng, Healthcare-associated infection control department, Affiliated Hospital of Jining Medical University, Jining, Shandong, People’s Republic of China, Tel +86 537 2903180, Fax +86 537 2213030, Email mxj0324@163.comIntroduction: Blood-borne occupational exposure (OBE) is one of the major public health problem for healthcare workers globally. …”
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Preferences and Attitudes Towards Digital Communication and Symptom Reporting Methods in Clinical Trials by McDowell B, Dumais KM, Gary ST, de Gooijer I, Ward T

“…Bryan McDowell,1 Kelly M Dumais,2 Sarah Tressel Gary,2 Ingeborg de Gooijer,2 Tomás Ward3 1eCOA Science, Clario, Geneva, Switzerland; 2eCOA Science, Clario, Philadelphia, PA, USA; 3Insight Science Foundation Ireland Research Centre for Data Analytics, Dublin City University, Dublin, IrelandCorrespondence: Bryan McDowell, eCOA Science, Clario, Chemin Louis-Hubert 2, Petit-Lancy, Geneva, 1213, Switzerland, Tel +41 22 879 91 00, Fax +41 22 879 91 01, Email bryan.mcdowell@clario.comPurpose: With the growing use of digital health technologies (DHT) in clinical trials, the opportunity to use technology to promote greater patient centricity and inclusivity has emerged. …”
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Hydrophobic and Hydrophilic IOLs in Patients with Uveitis – A Randomised Clinical Trial by Pålsson S, Schuborg C, Sterner B, Andersson Grönlund M, Zetterberg M

“…Sara Pålsson,1,2 Claes Schuborg,2,3 Bertil Sterner,1,2 Marita Andersson Grönlund,1,4 Madeleine Zetterberg1,2 1Department of Clinical Neuroscience/Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 2Region Västra Götaland, Sahlgrenska University Hospital, Department of Ophthalmology, Mölndal, Sweden; 3Guldhedskliniken, Gothenburg, Sweden; 4Department of Ophthalmology, Faculty of Medicine and Health, Örebro University, Örebro, SwedenCorrespondence: Madeleine Zetterberg, Sahlgrenska University Hospital, Department of Ophthalmology, Mölndal, SE 431 80, Sweden, Tel +46 31 33 43 31 50, Fax +46 31 41 29 04, Email madeleine.zetterberg@vgregion.sePurpose: To compare inflammatory response, visual acuity, and complications of two intraocular lenses (IOLs) in patients with and without uveitis.Setting: Tertiary referral centre at Sahlgrenska University Hospital/Mölndal, Sweden.Design: Prospective randomised controlled trial.Patients and Methods: Patients with and without uveitis eligible for cataract surgery were randomised to receive a hydrophobic or a hydrophilic square-edged intraocular lens (IOL). …”
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Functional Remediation Improves Serum BDNF and TrkB Levels in Euthymic Patients with Bipolar Disorder: A Randomized Trial Study by Li R, Li J, Ji SS, Li D, Chu L, Zhang J, Sun X, Luo X, Zhang Y

“…Ru Li,1,* Jiaxin Li,1,* Shiyi Suzy Ji,2 Dazhi Li,1 Lijun Chu,1 Jian Zhang,1 Xia Sun,1 Xingguang Luo,3 Yong Zhang1 1Unit of Bipolar Disorder, Tianjin Anding Hospital, Tianjin, People’s Republic of China; 2Department of Counseling and Clinical Psychology, Teachers College, Columbia University, NY, New York, USA; 3Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA*These authors contributed equally to this workCorrespondence: Yong Zhang, Unit of Bipolar Disorder, Tianjin Anding Hospital, 13 Liulin Road, Hexi District, Tianjin, 300222, People’s Republic of China, Tel/Fax +86 22 8818 8258, Email zhangyong@tjmhc.comPurpose: We aimed to verify the impact of functional remediation (FR) on serum brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) levels, to explore the biomechanism of FR intervention in patients with euthymic bipolar disorder (BD).Patients and Methods: This is a randomized controlled, 12-week intervention study with participants randomized into the FR group (n=39) and the treatment as usual group (TAU, n=42) at the 1∶1 ratio. 17-Hamilton Depression Rating Scale-17 (HDRS-17), Young Mania Rating Scale (YMRS), and Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) were used to assess affective symptoms and cognitive functioning both at baseline and week 12, respectively. …”
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Effects of Lupeol on Intestinal Anastomosis After Experimental Intestinal Ischemia-Reperfusion Injury in Rats by Kaya C, Kapisiz A, Eryilmaz S, Karabulut R, Turkyilmaz Z, Inan MA, Aydin GY, Celik MA, Sonmez K

“…Cem Kaya,1 Alparslan Kapisiz,1 Sibel Eryilmaz,1 Ramazan Karabulut,1 Zafer Turkyilmaz,1 Mehmet Arda Inan,2 Gizem Yaz Aydin,3 Mert Alperen Celik,4 Kaan Sonmez1 1Department of Pediatric Surgery, Faculty of Medicine, Gazi University, Yenimahalle, Ankara, Turkey; 2Department of Pathology, Faculty of Medicine, Gazi University, Yenimahalle, Ankara, Turkey; 3Department of Biochemistry, Faculty of Medicine, Gazi University, Yenimahalle, Ankara, Turkey; 4Faculty of Medicine, Gazi University, Yenimahalle, Ankara, TurkeyCorrespondence: Cem Kaya, Medical Faculty, Gazi University, Department of Pediatric Surgery, Emniyet Mahallesi, Mevlana Bulvarı, No: 29, Yenimahalle, Ankara, 06500, Turkey, Tel +90 312 2026213, Fax +90 312 2230528, Email drcemkaya61@gmail.comBackground: Intestinal ischemia/reperfusion (I/R) injury can occur in a wide variety of diseases and surgeries. …”
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Predictive value of MMP-2, MMP-9, TIMP-1 in surgical treatment of localized renal cell cancer by A. I. Tarasenko, A. N. Rossolovskiy, O. L. Berezinets, D. A. Durnov, E. B. Popyhova, V. M. Popkov

“…All patients being in the early (7-10th day) and long-term postoperative period (after 1 and 2 years) by solid-phase ELISA, on a StatFax 4200 analyzer using eBiosence and Cloud-Clone Corp reagent kits, a study was made on the basis of the concentration in the blood serum of markers of oncogenesis MMP‑2, MMP‑9 and TIMP‑1 metalloproteinase inhibitor.Results. …”
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Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice With Mitoxantrone-Induced Cardiotoxicity by Zhang Q, Liang D, Zhang C, Ye L, Sun P, Zhu H, Zhao Y, Li Y, Guan Y, Zhang H

“…Qing Zhang,1 Deshuai Liang,2 Chengfang Zhang,3 Ling Ye,4 Ping Sun,4 Hongli Zhu,4 Yongqin Zhao,4 Yuewen Li,4 Yun Guan,4 Haiguo Zhang4 1College of Clinical Medicine, Jining Medical University, Jining, 272013, People’s Republic of China; 2Department of Pharmacy, Jining NO. 1 People’s Hospital, Jining, 272000, People’s Republic of China; 3Department of Clinical Laboratory, Jining NO. 1 People’s Hospital, Jining, 272000, People’s Republic of China; 4Department of Hematology, Jining NO. 1 People’s Hospital, Jining, 272000, People’s Republic of ChinaCorrespondence: Haiguo Zhang; Yun Guan, Jining NO. 1 People’s Hospital, 6 Jiankang Road, Jining Shandong, 272000, People’s Republic of China, Tel/Fax +86-0537 2257626 ; +86-0537 2087093, Email wfmchero@126.com; gyuanun1989@163.comPurpose: Mitoxantrone (MTX) is largely restricted in clinical usage due to its significant cardiotoxicity. …”
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Localized Drug Delivery in Different Gastrointestinal Cancers: Navigating Challenges and Advancing Nanotechnological Solutions by Hasan AM, Cavalu S, Kira AY, Hamad RS, Abdel-Reheim MA, Elmorsy EA, El-kott AF, Morsy K, AlSheri AS, Negm S, Saber S

“…Alexandru Madalin Hasan,1 Simona Cavalu,1 Ahmed Y Kira,2 Rabab S Hamad,3 Mustafa Ahmed Abdel-Reheim,4 Elsayed A Elmorsy,5 Attalla F El-kott,6,7 Kareem Morsy,6,8 Ali S AlSheri,6 Sally Negm,9 Sameh Saber10 1Department of Preclinical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, 410087, Romania; 2Department of Pharmaceutics, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt; 3Biological Sciences Department, College of Science, King Faisal University, Al Ahsa, 31982, Saudi Arabia; 4Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia; 5Department of Pharmacology and Therapeutics, College of Medicine, Qassim University, Buraidah, 51452, Saudi Arabia; 6Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia; 7Department of Zoology, Faculty of Science, Damanhour University, Damanhour, Egypt; 8Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt; 9Department of Life Sciences, College of Science and Art, Mahyel Aseer, King Khalid University, Abha, 62529, Saudi Arabia; 10Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, EgyptCorrespondence: Ahmed Y Kira, Department of Pharmaceutics, Faculty of Pharmacy, ‎Delta University for Science and Technology, Gamasa, Egypt, +11152, Tel +2 01026462867, Fax +2 0502770140, Email ahmed.kira@deltauniv.edu.eg Mustafa Ahmed Abdel-Reheim, Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia, Email m.ahmed@su.edu.saAbstract: Different types of cancers affect the gastrointestinal tract (GIT), starting from the oral cavity and extending to the colon. …”
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High-Grade Cervical Intraepithelial Neoplasia: Impact of Colposcopic Lesion Area on Systemic Immune Responses by Mantoani PTS, Micheli DC, Jammal MP, Vieira JH, Michelin MA, Ferreira CGX, Silva HN, Murta EFC, Nomelini RS

“…Getúlio Guaritá, s/n, Bairro Abadia, Uberaba, MG, 38025-440, Brazil, Tel +55 34 3318 5326, Fax +55 34 3318 5342, Email rosekeila@terra.com.brBackground: The progression of high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer is accompanied by a reduction in the immune response. …”
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Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization by Sun Z, Liu J, Ge P, Cao Y, Liu J, Wen H, Luo X, Pei B, Jin Z, Li H, Xun L, Luo Y, Yang Q, Chen H

“…Zhenxuan Sun,1– 3,* Jie Liu,1– 3,* Peng Ge,1– 3,* Yinan Cao,4 Jin Liu,1– 3 Haiyun Wen,1– 3 Xinyu Luo,1– 3 Boliang Pei,1– 3 Zuocang Jin,1,3 Huijuan Li,3 Lu Xun,1– 3 Yalan Luo,5 Qi Yang,6 Hailong Chen1– 3 1Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 2Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 3Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 4Day Surgery Center, Dalian Municipal Central Hospital, Dalian, Liaoning, 116033, People’s Republic of China; 5Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 6Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116023, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hailong Chen, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Zhongshan Road 222, Dalian, Liaoning, 116011, People’s Republic of China, Tel +86 411 83635963, Fax +86 411 83622844, Email chenhailong@dmu.edu.cnPurpose: Explore the therapeutic effect and molecular mechanism of rhein on severe acute pancreatitis associated acute lung injury (SAP-ALI).Methods: The SAP-ALI rat model was constructed by retrograde injection of 5% sodium taurocholate into the pancreaticobiliary duct, and pulmonary microvascular endothelial cell (PMVEC) injury model was induced by LPS. …”
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Hyperglycemia Is a Potential Prognostic Factor for Exacerbation in Severe Psoriasis with Diabetes or Prediabetes by Yongpisarn T, Thadanipon K, Suchonwanit P, Rattanakaemakorn P

“…Tanat Yongpisarn,1 Kunlawat Thadanipon,1,2 Poonkiat Suchonwanit,1 Ploysyne Rattanakaemakorn1 1Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Ploysyne Rattanakaemakorn, Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand, Tel +662-201-1141, Fax +662-201-1211, Email ploysyne@gmail.comBackground: Psoriasis is an immune-mediated skin disease with a chronic relapsing-remitting course. …”
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Application of Targeted Next-Generation Sequencing in Bronchoalveolar Lavage Fluid for the Detection of Pathogens in Pulmonary Infections by Dai X, Xu K, Tong Y, Li J, Dai L, Shi J, Xie H, Chen X

“…Xianning Dai,1 Kai Xu,1 Yu Tong,1 Jing Li,2 Liya Dai,1 Jianyou Shi,1 Haibin Xie,3 Xi Chen3 1Department of Clinical Laboratory, Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Care Hospital, Zhejiang, People’s Republic of China; 2Department of PCCM, Wenzhou People’s Hospital, Wenzhou Maternal and Child Health Care Hospital, Zhejiang, People’s Republic of China; 3Department of Immunization Planning, Prevention and Health Care, Centers for Disease Control of Luchen, Zhejiang, People’s Republic of ChinaCorrespondence: Xi Chen, Department of Immunization Planning, Prevention and health care,Centers for Disease Control of Luchen, No. 3320 Guojing Road, Wenzhou, Zhejiang, 325005, People’s Republic of China, Tel +86 577 56760657, Fax +86 577 56760654, Email cxbrook0577@163.comObjective: This study aims to evaluate the utility of targeted next-generation sequencing (tNGS) in bronchoalveolar lavage fluid (BALF) for hospitalized patients with pulmonary infections.Methods: A cohort of 358 patients who received diagnosis and treatment for respiratory infections in the department of Respiratory Medicine at Wenzhou People’s hospital from January 2023 to April 2024 were selected for this study. …”
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Non-Pharmaceutical Interventions May Attenuate Acute Exacerbations of Asthma: Experience During the COVID-19 Pandemic in Taiwan by Lin CY, Lin CH, Lo YL, Lo CY, Huang HY, Hsieh MH, Fang YF, Li TC, Lin SM, Huang YT, Chang PJ, Lin HC

“…Chun-Yu Lin,1,2 Chiung-Hung Lin,1,2 Yu-Lun Lo,1,2 Chun-Yu Lo,1,2 Hung-Yu Huang,1,2 Meng-Heng Hsieh,1,2 Yueh-Fu Fang,1,2 Tsu-Chuan Li,1,2 Shu-Min Lin,1,2 Yu-Tung Huang,3 Po-Jui Chang,1,2 Horng-Chyuan Lin1,2,4 1Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; 2College of Medicine Chang Gung University, Taoyuan, Taiwan; 3Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Department of Respiratory Therapy, Chang Gung Memorial Hospital at Linkou, Taoyuan, TaiwanCorrespondence: Horng-Chyuan Lin, Department of Thoracic Medicine, Chang Gung Memorial Hospital, 5 Fu-Hsing Street, Kweishan, Taoyuan, 33305, Taiwan, Tel +886-3-3281200 ext. 8470, Fax +886-3-3282474, Email lin53424@gmail.comBackground: Non-pharmaceutical interventions (NPIs) were widely used during the coronavirus disease 2019 (COVID-19) pandemic, however their impact on acute asthma exacerbations (AEs) is not well studied.Methods: We had retrospectively collected patients with asthma AEs between 2019 and 2020 and retrieved data from the Chang Gung Research Database, including clinical manifestations, medications, pulmonary function, clinic and emergency department visits and hospitalizations.Results: A total of 39,108 adult patients with asthma were enrolled, of whom 1502 were eligible for analysis. …”
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Comparative study on the weight loss and lipid metabolism by tea polyphenols in diet induced obese C57BL/6J pseudo germ free and conventionalized mice by Kashif Hussain, Yingying Yang, Jie Wang, Hengjuan Bian, Xi Lei, Junjie Chen, Qianying Li, Li Wang, Qingping Zhong, Xiang Fang, Yutao Wang, Hong Wei, Yigang Tong, Zhenlin Liao

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Economic Evaluation of Robotic-assisted Radical Prostatectomy: A Systematic Review and Meta-analysis by Tanan Bejrananda, Win Khaing, Sajesh K. Veettil, Therdpong Thongseiratch, Nathorn Chaiyakunapruk

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Comparison of IMO vifa24plus(1-2) and Humphrey Field Analyzer 24-2 by Takagi Y, Asano R, Yamashita K, Sakai Y, Yokoyama S, Ichikawa K, Ichikawa K

“…Yuki Takagi,1,2 Ryo Asano,1,3 Kanna Yamashita,2 Yukihiro Sakai,2 Sho Yokoyama,1 Kei Ichikawa,2 Kazuo Ichikawa2 1Department of Ophthalmology, Japan Community Healthcare Organization Chukyo Hospital, Nagoya, Aichi, Japan; 2Chukyo Eye Clinic, Nagoya, Aichi, Japan; 3Asano Eye Clinic, Nagoya, Aichi, JapanCorrespondence: Yuki Takagi, Department of Ophthalmology, Japan Community Healthcare Organization Chukyo Hospital, 1-1-10 Sanjo Minami-ku, Nagoya, Aichi, Japan, Tel +81-52-691-7151, Fax +81-52-692-5220, Email ytakagi@sanjogroup.jpPurpose: This study aimed to compare the results of the IMO vifa 24plus(1– 2) and HFA 24– 2 visual field tests.Patients and Methods: We included 52 patients (104 eyes) with glaucoma who visited Chukyo Eye Clinic between June 2023 and March 2024. …”
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