3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications by Shanshan Han, Kexin Nie, Jingchao Li, Qingqing Sun, Xiaofeng Wang, Xiaomeng Li, Qian Li

“…Electrospun nanofibers have been frequently used for tissue engineering due to their morphological similarities with the extracellular matrix (ECM) and tunable chemical and physical properties for regulating cell behaviors and functions. …”
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Monocarboxylate Transporters: Role and Regulation in Corneal Diabetes by Pawan Shrestha, Amy E. Whelchel, Sarah E. Nicholas, Wentao Liang, Jian-Xing Ma, Dimitrios Karamichos

“…In this study, we investigated the regulation of MCT1, 2, 4, 5, 8, and 10, in corneal DM, using established 3D self-assembled extracellular matrix (ECM) in vitro models. Primary stromal corneal fibroblasts were isolated from healthy (HCFs), type I (T1DMs), and type II (T2DMs) DM donors. …”
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Electrospun short fibers: a new platform for cancer nanomedicine applications by Yifan Huang, Mengsi Zhan, Mingwu Shen, Lili Zhang, Xiangyang Shi

“…With the continuous development of nanomaterials, nanofibers prepared by electrospinning have gradually occupied people’s vision because of their unique advantages, such as crisscross network and extracellular matrix-mimicking structure, high drug loading efficiency, and sustained release kinetics. …”
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Extracellular Vesicles Derived from Adipose Mesenchymal Stem Cells Promote Peritoneal Healing by Activating MAPK-ERK1/2 and PI3K-Akt to Alleviate Postoperative Abdominal Adhesion by Manyu Shi, Hengchen Liu, Tingting Zhang, Mingzhao Zhang, Xin Tang, Zenan Zhang, Wenjun Lu, Shulong Yang, Zhitao Jiang, Qingbo Cui, Zhaozhu Li

“…The expression of extracellular matrix-related indexes and peritoneal healing were observed using immunohistochemistry. …”
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Binding and cleavage of pro-urokinase by a tegument extract of Fasciola hepatica newly excysted juveniles activate the host fibrinolytic system by Judit Serrat, María Torres-Valle, Carolina De Marco Verissimo, Mar Siles-Lucas, Javier González-Miguel

“…Abstract Plasmin, the final product of fibrinolysis, is a broad-spectrum serine protease that degrades extracellular matrix (ECM) components, a function exploited by multiple pathogens for dissemination purposes. …”
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Histological and Immunohistochemical Evaluation of Autologous Cultured Bone Marrow Mesenchymal Stem Cells and Bone Marrow Mononucleated Cells in Collagenase-Induced Tendinitis of E... by Antonio Crovace, Luca Lacitignola, Giacomo Rossi, Edda Francioso

“…Both cBMSC and BMMNCS grafts resulted in a qualitatively similar heling improvement of tendon extracellular matrix, in terms of the type I/III collagen ratio, fiber orientation, and COMP expression.…”
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Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation by Günseli Çubukçuoğlu Deniz, Serkan Durdu, Yeşim Doğan, Esra Erdemli, Hilal Özdağ, Ahmet Ruchan Akar

“…QRT-PCR analysis confirmed that AFib persistence was associated with increased expression molecular changes underlying a transition to heart failure (NPPB, P=0.002; ANGPTL2, P=0.002; IGFBP2, P=0.010), structural remodeling including changes in the extracellular matrix and cellular stress response (COLQ, P=0.003; COMP, P=0.028; DHRS9, P=0.038; CHGB, P=0.038), and cellular stress response (DNAJA4, P=0.038). …”
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MAIP1-Related Tumor Immune Infiltration: As a Potential Prognostic Biomarker for Esophageal Cancer by Xiaoyu He, Fu Gan, Yongjian Lin, Guoqing Liu, Yunhua Lin, Dongxu Chen

“…Enrichment analysis revealed that the differential genes (DEGs) between high and low group are involved in biological functions such as extracellular matrix and organization extracellular structure. …”
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MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models by Beatriz Aparecida Fioruci-Fontanelli, Luiz Gustavo A. Chuffa, Leonardo O. Mendes, Patricia Fernanda F. Pinheiro, Flávia Karina Delella, Cilmery S. Kurokawa, Sérgio Luis Felisbino, Francisco Eduardo Martinez

“…These important findings demonstrate that chronic ethanol intake impairs the physiological balance of the prostate extracellular matrix turnover, through downregulation of MMPs, which may contribute to the development of prostatic diseases. …”
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Evaluating the antifibrotic potential of naringenin, asiatic acid, and icariin using murine and human precision‐cut liver slices by Ke Luo, Yana Geng, Dorenda Oosterhuis, Vincent E. deMeijer, Peter Olinga

“…Abstract Liver fibrosis is an exaggerated wound healing response defined by the excessive accumulation of extracellular matrix. This study investigated the antifibrotic potential of naringenin (NRG), asiatic acid (AA), and icariin (ICA) using murine and human precision‐cut liver slices (PCLS). …”
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Redefining bladder cancer treatment: innovations in overcoming drug resistance and immune evasion by Peng Huang, Jie Wang, Zongze Yu, Jiaan Lu, Zhou Sun, Zhigui Chen

“…TME, comprising cancer-associated fibroblasts (CAFs), immunosuppressive cells, and different components of the extracellular matrix (ECM), orchestrates a setting that fosters tumor growth and immune evasion and confers resistance on any therapeutic regime that might be used. …”
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Pilot study: Initial investigation suggests differences in EMT-associated gene expression in breast tumor regions by Kylie L. King, Hamed Abdollahi, Zoe Dinkel, Alannah Akins, Homayoun Valafar, Heather Dunn

“…The development of breast cancer is highly associated with interactions between tumor cells and the extracellular matrix (ECM), and recent research suggests that cellular components of the ECM vary between racial groups. …”
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New therapies in pulmonary arterial hypertension: Recent insights by Giulia Guglielmi, Konstantinos Dimopoulos, S. John Wort

“…Current therapies primarily focus on pulmonary vasodilation; however, novel approaches that target the underlying pathophysiological mechanisms—such as TGF-β signalling, epigenetic alterations, growth factors, inflammation, and extracellular matrix remodelling—are promising alternatives for improving treatment outcomes. …”
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Cell autonomous TLR4 signaling modulates TGF-β induced activation of human cardiac fibroblasts by Gayathri Vijayakumar, Anisha Latha, Aiswaria P. Anil, Yogini Surve, Aiswarya R, Bipin G. Nair, Indulekha CL. Pillai

“…TGF-β treated cardiac fibroblastss show enhanced cytokine expression, and inhibition of TLR4 signaling reduces the expression of cytokines, thereby reducing TGF-β targets such as extracellular matrix genes. Thus, our data demonstrate that TLR4 and other signaling molecules downstream of TLR4 are expressed in cardiac fibroblast, and inhibition of TLR4 modulates fibrotic changes in vitro.…”
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Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors by Gianna Dipalma, Angelo Michele Inchingolo, Valeria Colonna, Pierluigi Marotti, Claudio Carone, Laura Ferrante, Francesco Inchingolo, Andrea Palermo, Alessio Danilo Inchingolo

“…Conclusion: The findings of the reviewed studies underscore the potential of the CGF in enhancing bone regeneration through stimulating cell proliferation, angiogenesis, and extracellular matrix mineralization. Autologous materials have also demonstrated promising results due to their biocompatibility and capacity for seamless integration with natural bone tissue. …”
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Uniaxial Cyclic Tensile Stretching at 8% Strain Exclusively Promotes Tenogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells by Hui Yin Nam, Belinda Pingguan-Murphy, Azlina Amir Abbas, Azhar Mahmood Merican, Tunku Kamarul

“…The tenogenic, osteogenic, adipogenic, and chondrogenic differentiation potential of hMSCs were evaluated using biochemical assays, extracellular matrix expressions, and selected mesenchyme gene expression markers; and were compared to primary tenocytes. …”
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CRYβB2 alters cell adhesion to promote invasion in a triple-negative breast cancer cell line by Amr A. Waly, London Harper, Jodie M. Fleming, Lindsey M. Costantini

“…RNA sequencing analysis indicated that CRYβB2 overexpression modulated cell-cell adhesion and extracellular matrix organization pathways, which are critical to invasion of cancer cells. …”
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Mesothelial cell responses to acute appendicitis or small bowel obstruction reactive ascites: Insights into immunoregulation of abdominal adhesion. by Melissa A Hausburg, Kaysie L Banton, Christopher D Cassidy, Robert M Madayag, Carlos H Palacio, Jason S Williams, Raphael Bar-Or, Rebecca J Ryznar, David Bar-Or

“…Select rA caused MCs to form clusters of fibroblastic cells, extracellular matrix fibers (FIB), and secretion of GCX. …”
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Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway by Chunxue Li, Rongrong Zhang, Yating Zhan, Jianjian Zheng

“…Liver fibrosis, which results from chronic liver injury due to factors such as chronic alcohol consumption, hepatitis virus infections, and immune attacks, is marked by excessive deposition of extracellular matrix (ECM). Resveratrol (Res), a polyphenol phytoalexin, has been demonstrated to show anti-inflammatory, antioxidative, antiproliferative, and chemopreventive activities. …”
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IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A by Xiuxia Wang, Yating Yang, Xianyu Zhou, Shun Yu, Xusong Luo, Lin Lu, Zhen Gao, Jun Yang

“…Moreover, keloid SPOCD1 deficiency attenuates KFs progression and extracellular matrix (ECM) deposition. Reducing IFNγ and SPOCD1 simultaneously can increase the positive rate of reactive oxygen species (ROS) and promote mitochondrial shrinkage. …”
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