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    MODIFICATION OF BREAST CANCER CELLS' SENSITIVITY TO METFORMIN DUE TO CO-CULTIVATION WITH B. ANIMALIS by T.P. Kozak, O.O. Lykhova, P.A. Virych, V.F. Chekhun

    Published 2025-04-01
    Subjects: “…intracellular lactate dehydrogenase activity). cell viability was evaluated using the trypan blue exclusion test. results. co-cultivation of bc cells with b. animalis leads to enhanced glycolysis in malignant cells. these metabolic phenotype changes are accompanied by alterations in the sensitivity of bc cells to metformin. only in mcf-7 cells treated with b. animalis was a significant enhancement of the antitumor effects of metformin observed compared to cells incubated with either metformin or b. animalis alone. conclusions. exposure of mcf-7 cells to b. animalis increases their sensitivity to the anti-proliferative effects of metformin…”
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