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Pharmacodynamics of interspecies interactions in polymicrobial infections
Published 2025-01-01“…Understanding the complex eco-evolutionary dynamics of PMIs and their impact on antimicrobial treatment response represents a step towards developing improved treatment strategies for PMIs. …”
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New technologies for future living. A proposal for 2100s Milan
Published 2020-12-01“…Evolutionary dynamics and the current environmental, social and economic emergencies envisage new urban visions requiring designers to shift the reference time’s horizon towards long-period scenarios. …”
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23
Paradigm shifters: tricksters and cultural science
Published 2010-12-01“…The disciplinary purpose of the paper is to try to bridge two otherwise disconnected domains – cultural studies and evolutionary economics – by showing that the traditional methods of the humanities (e.g. anthropological, textual and historical analysis) have explanatory force in the context of economic actions and complex-system evolutionary dynamics. The objective is to understand creative innovation as a general cultural attribute rather than one restricted only to accredited experts such as artists; thus to theorise creativity as a form of emergence for dynamic adaptive systems. …”
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24
Evolutionary Network Games: Equilibria from Imitation and Best Response Dynamics
Published 2017-01-01“…We consider games of strategic substitutes and complements on networks and introduce two evolutionary dynamics in order to refine their multiplicity of equilibria. …”
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25
A multiscale model of the bone marrow and hematopoiesis
Published 2011-03-01“…Our goal is the development of a spatially-explicit in silico model of the bone marrow to understand both its normal function and the evolutionary dynamics that govern the emergence of bone marrow malignancy.Here we introduce a multiscale computational model of the bone marrow that incorporates three distinct spatial scales, cell, hematopoietic subunit, whole marrow.Our results, using parameter estimates from literature, recapitulates normal bone marrow function and suggest an explanation for the fractal-like structure of trabeculae and sinuses in the marrow, which would be an optimization of the hematopoietic function in order to maximize the number of mature blood cells produced daily within the volumetric restrictions of the marrow.…”
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The Interplay Between Viral Infection and Cell Death: A Ping-Pong Effect
Published 2025-01-01“…This study emphasizes the importance of investigating the mechanisms by which viruses control the host’s PCD machinery to gain insight into the evolutionary dynamics of host-pathogen interactions and to develop new approaches for predicting and managing viral threats. …”
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Differential impact of sickle cell trait on symptomatic and asymptomatic malaria
Published 2012-09-01“…To examine the differential impact of the sickle cell trait on symptomatic and asymptomatic malaria, we developed a mathematical model of malaria transmission that incorporates the evolutionary dynamics of $S$-gene frequency. Our model indicates that the fitness of sickle cell trait is likely to increase with the proportion of symptomatic malaria infections. …”
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28
Short tandem repeats delineate gene bodies across eukaryotes
Published 2024-12-01“…These results suggest that the hypermutability inherent to STRs is canalized along the genome sequence and contributes to regulatory and eco-evolutionary dynamics in all eukaryotes.…”
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29
Evolution of infectious diseases induced by epidemic prevention publicity and interaction between heterogeneous strains
Published 2024-08-01“…Thus, we first establish an evolutionary dynamics Susceptible-Infected- Recovered (SIR) model which considers the interaction between heterogeneous strains. …”
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30
Evolution of parasite transmission dispersion
Published 2025-01-01“…We develop a mathematical model using a Price equation framework to address this question that follows the epidemiological and evolutionary dynamics of a general host–parasite system. …”
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31
Agent-Based Modeling and Simulation for the Bus-Corridor Problem in a Many-to-One Mass Transit System
Published 2014-01-01“…When each commuter has a limited memory, some fluctuations exist in the evolutionary dynamics of the system, and hence an ideal equilibrium can hardly be reached. …”
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Fitness landscapes of human microsatellites.
Published 2024-12-01“…The heterogeneity in fitness landscapes we report suggests that genome-scale analyses like those used to assess selection targeting single nucleotide variants run the risk of oversimplifying the evolutionary dynamics of microsatellites. Moreover, our fitness landscapes provide a valuable visualization of the selective dynamics navigated by microsatellites.…”
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The genetic architecture of local adaptation in a cline
Published 2023-02-01“…We also show that changing the fitness function relating trait to fitness has a strong impact on the overall evolutionary dynamics and resulting architecture. …”
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34
The Anthropocene and the biodiversity crisis: an eco-evolutionary perspective
Published 2025-01-01“…This crisis does not only affect the ecological dynamics of biodiversity, but also its evolutionary dynamics, including genetic diversity, an aspect that is generally neglected. …”
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The tetracycline resistome is shaped by selection for specific resistance mechanisms by each antibiotic generation
Published 2025-02-01“…This suggests mechanism-specific selection by each tetracycline generation; however, the evolutionary dynamics of this remain unclear. Here, we evaluate 24 recombinant Escherichia coli strains expressing tetracycline resistance genes from each mechanism (efflux pumps, ribosomal protection proteins, and enzymatic inactivation) in the context of each tetracycline generation. …”
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Geographic variation in abundance and diversity of Acinetobacter baumannii Vieuvirus bacteriophages
Published 2025-01-01“…Specifically, Vieuvirus-related phages were frequently identified in isolates from Thailand, Mexico, China, and South Korea, which show the geographic prevalence of A. baumannii prophages.DiscussionThis study highlights the importance of considering geographic factors to fully understand prophage diversity and their significant role in the evolutionary dynamics of A. baumannii.…”
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From threats to solutions: A literature review of climate adaptation in anadromous salmon and trout
Published 2025-01-01“…In conclusion, our findings identify strengths and gaps in the research investigating the role of evolutionary dynamics in the face of climate change. By capitalizing on new tools for sequencing, genomic analysis, and automated field data collection, we can establish baselines for tracking evolutionary responses to climate change. …”
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Differential Evolutionary Constraints in the Evolution of Chemoreceptors: A Murine and Human Case Study
Published 2014-01-01“…We have analyzed the functional networks of these genes, their orthologs distribution, and performed phylogenetic analyses in order to investigate their evolutionary dynamics. We have modeled the chemosensory networks and compared the evolutionary constraints of their genes in Mus musculus, Homo sapiens, and Rattus norvegicus. …”
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Chromosome-level genome assembly and annotation of Japanese anchovy (Engraulis japonicus)
Published 2025-01-01“…However, the lack of genomic resources hampers our understanding of its genetic diversity and differentiation, as well as the evolutionary dynamics. Here, we firstly report a complex chromosome-level genome assembly of E. japonicus with a large size of 1.4 Gb, with features of high repetitive sequences (54.9%), high heterozygosity (2.3%) and a number of protein-coding genes (24,405). …”
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Revisiting Key Entry Routes of Human Epidemic Arboviruses into the Mainland Americas through Large-Scale Phylogenomics
Published 2018-01-01“…Here, we applied robust phylogenomic methods to trace the evolutionary dynamics of these arboviruses with special focus on Brazil, the epicenter of these triple epidemics. …”
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