Monoclonal antibody development and antigenic epitope identification of chicken pro-IL-1β by Mengmeng Xu, Mengmeng Huang, Guodong WANG, Jingzhe HAN, Xinxin NIU, Jinze HAN, Hangbo YU, Yulong ZHANG, Runhang LIU, Ziwen WU, Hongyu Cui, Yanping Zhang, Suyan Wang, Yongzhen Liu, Yuntong Chen, Yulu Duan, Liuan Li, Yulong Gao, Xiaole Qi

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In silico design of a multi-epitope vaccine against Mycobacterium avium subspecies paratuberculosis by Weiqi Guo, Weiqi Guo, Xinyu Wang, Jiangang Hu, Beibei Zhang, Luru Zhao, Luru Zhao, Guangdong Zhang, Jingjing Qi, Zuzhang Wei, Yanqing Bao, Mingxing Tian, Shaohui Wang

Subjects: “…multi-epitope vaccine…”
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Mapping of Minimal Motifs of B-Cell Epitopes on Human Zona Pellucida Glycoprotein-3 by Wan-Xiang Xu, Ya-Ping He, Jian Wang, Hai-Ping Tang, Hui-Juan Shi, Xiao-Xi Sun, Chao-Neng Ji, Shao-Hua Gu, Yi Xie

“…In this direction, it is imperative to map minimal motifs of the B cell epitopes (BCEs) so as to avoid ZP-specific oophoritogenic T cell epitopes (TCEs) in the ZP3-based immunogens. …”
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The trend of phylogenetic and epitope variations of SARS-CoV-2 Omicron sub-lineages in Iran by Mehdi Shabani, Ahmad Nejati, Jila Yavarian, Jila Yavarian, Kaveh Sadeghi, Sevrin Zadheidar, Akram Sadat Ahmadi, Monire Ghadirali, Arghavan Zebardast, Adel Abedi, Mohammad Hossein Najmi, Nazanin-Zahra Shafiei-Jandaghi, Talat Mokhtari-Azad

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Purification, Physicochemical Properties, and Epitope Analysis of Sarcoplasmic Calcium-Binding Protein from Penaeus vannamei by CHEN Wei, ZHOU Junjun, CHEN Yachun, JIA Yingmin, MA Aijin

Subjects: “…penaeus vannamei; sarcoplasmic calcium-binding protein; stability; epitope…”
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Purification and immunoglobulin E epitopes identification of low molecular weight glutenin: an allergen in Chinese wheat by Yanbo Wang, Yihang Tong, Jinru Zhou, Dong Yang, Linglin Fu

“…In addition, 8 peptides were predicted efficiently by 5 immunological tools, among which five peptides showed significant immunoglobulin E (IgE) binding abilities. Two specific epitopes were found to be in the non-conserved region of the amino acid sequence of LMW-GS, which was speculated to be the specific epitope of Chinese wheat. …”
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Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping by Yan Lu, Yajun Wang, Zhen Zhang, Jingliang Huang, Meicun Yao, Guobin Huang, Yuanyuan Ge, Peichun Zhang, Huaxin Huang, Yong Wang, Huiliang Li, Wen Wang

“…IgY-S exhibited high immunoreactivity against SARS-CoV-2 S, and by epitope mapping, we found five linear epitopes of IgY-S in SARS-CoV-2 S, two of which are cross-reactive with SARS-CoV S. …”
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Identification of fine antigenic epitopes of Tamdy virus glycoprotein Gn fragment and establishment of ELISA detection method by Yujiao Fu, Liping Liu, Beibei Zhang, Xiaoshan Chao, Junxia Jin, Ying Wang, Juntao Ding

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IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex by Tae Sik Goh, Yuna Jo, Byunghyuk Lee, Geona Kim, Hyunju Hwang, Eunhee Ko, Seung Wan Kang, Sae-Ock Oh, Sun-Yong Baek, Sik Yoon, Jung Sub Lee, Changwan Hong

“…We demonstrate here that 4G3, TUGm2, and 3E12 epitope masking of γc protein are induced in the presence of IL-7, indicating that the epitope alteration is induced by IL-7 binding to the preassembled receptor core. …”
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A Full GMP Process to Select and Amplify Epitope-Specific T Lymphocytes for Adoptive Immunotherapy of Metastatic Melanoma by N. Labarriere, A. Fortun, A. Bellec, A. Khammari, B. Dreno, S. Saïagh, F. Lang

“…We have previously described a sorting method of epitope-specific T lymphocytes that uses magnetic beads coated with HLA/peptide complexes and we suggested that this method could be applied to a clinical setting. …”
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Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis by Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu

“…First, three online software were used to predict HLA-A2-restricted epitopes. Then, the candidate epitopes were confirmed with the T2A2 cell binding affinity and peptide/MHC (pMHC) complex stability assays and in vitro immune activity experiments. …”
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Immunological Responses and Epitope Mapping by Tuberculosis-Associated Antigens within the RD1 Region in Japanese Patients by Hideaki Nagai, Maho Suzukawa, Yumi Sakakibara, Ken Ohta, Pedro A. Reche, Koichi Suzuki, Yoshihiko Hoshino

“…Results of the ELISPOT assay led to the discovery of specific epitopes within the early secreted antigenic target 6 kDa (ESAT-6) and culture filtrate protein 10 kDa (CFP-10) proteins. …”
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Design of a Multi-Epitope Vaccine against the Glycoproteins of Newcastle Disease Virus by Using an Immunoinformatics Approach by Natolotriniavo T. Randriamamisolonirina, Mirantsoa S. Razafindrafara, Olivier F. Maminiaina

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The Development of a Novel Broad-Spectrum Influenza Polypeptide Vaccine Based on Multi-Epitope Tandem Sequences by Song Zhao, Junhao Luo, Wenhui Guo, Li Li, Siyu Pu, Libo Dong, Wenfei Zhu, Rongbao Gao

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Immunoinformatics Identification of B- and T-Cell Epitopes in the RNA-Dependent RNA Polymerase of SARS-CoV-2 by Niti Yashvardhini, Amit Kumar, Deepak Kumar Jha

“…Among the predicted epitopes, 26 B-cell and 9 T-cell epitopes showed non-allergenic, non-toxic, and highly antigenic properties. …”
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Development of a recombinant infectious bronchitis virus vaccine expressing infectious laryngotracheitis virus multiple epitopes by Guanming Shao, Jun Fu, Yun Pan, Shiying Gong, Chaoyi Song, Sheng Chen, Keyu Feng, Xinheng Zhang, Qingmei Xie

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Computational design of multi-epitope vaccine against Hepatitis C Virus infection using immunoinformatics techniques. by Sara Zubair, Fahed Parvaiz, Turki Abualait, Khalid Al-Regaiey, Tasneem Anwar, Mahnoor Zafar, Imdad Kaleem, Shahid Bashir

“…In this study, we used an array of immunoinformatics approaches to design a multiepitope peptide-based vaccine against HCV by emphasizing 6 conserved epitopes from viral protein NS5B. The potential epitopes were examined for their possible antigenic combination with each other along with GPGPG linkers using structural modeling and epitope-epitope interaction analysis. …”
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Monovalent Lectin Microvirin Utilizes Hydropathic Recognition of HIV-1 Env for Inhibition of Virus Cell Infection by Bibek Parajuli, Kriti Acharya, Harry Charles Bach, Shiyu Zhang, Cameron F. Abrams, Irwin Chaiken

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Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands by Daniel Fallon, Ching-Shin Huang, Jingya Ma, Christopher Morgan, Zhaohui Sunny Zhou

“…In contrast, as we report herein, the agonistic antibody 2D3 binds NKG2D with a 2:1 stoichiometry of its antigen binding fragments to homodimeric NKG2D and a largely distinct epitope. This binding interaction, as compared to NKG2D natural ligands, suggests there may be unique mechanisms to engage this receptor while offering possible benefits when incorporated into an IgG-based therapeutic.…”
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In silico development of a multi-epitope-based vaccine against Burkholderia cepacia complex using reverse vaccinology by Donya Ghorbani, Donya Ghorbani, Masoumeh Beig, Masoumeh Beig, Narjes Noori Goodarzi, Mohammad Sholeh, Mohammad Sholeh, Behzad Shahbazi, Behzad Shahbazi, Yaser Moghaddam, Farzad Badmasti

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