Valproic acid intoxication – The importance of toxicological analysis and correct management: A case report by André Valle de Bairros, Karol Andriely de Vargas Paier, Leonardo Corrêa Cardoso, Fernanda Ziegler Reginato, Gustavo Andrade Ugalde, Ivy Bauer Lovatel, Miguel Roehrs

“…Introduction: Valproic acid (VPA) is an anticonvulsant widely used in treating epilepsy which can occur cases of poisoning in overdose situations. …”
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Congenital malformations in children of epileptic pregnant women in the Cienfuegos province (2008-2018) by María Soledad Vilches León, Carmen Niurka Piña Loyola, Maylé Santos Solís, Vivian Rosa Vázquez Martínez, Cristóbal Jorge Torres González, Niurys Gonzales Cano

“…<p><strong>Background</strong>: in pregnant women, epilepsy is one of the most frequent neurological disorders, considered high risk due to the complications it produces. …”
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Neuroborreliosis with encephalitis: a broad spectrum of clinical manifestations by Dominica Hudasch, Franz Felix Konen, Nora Möhn, Lea Grote-Levi, Ulrich Wurster, Gabriel Welte, Josef Conzen, Nima Mahmoudi, Thomas Skripuletz, Philipp Schwenkenbecher

“…Conclusion Neuroborreliosis can present with symptoms that mimic various neurological disorders, such as dementia, movement disorders, and epilepsy. Radiculitis, peripheral facial palsy or meningitis are an additional hint for this infectious disease. …”
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Patient-Independent Epileptic Seizure Detection with Reduced EEG Channels and Deep Recurrent Neural Networks by Nadine El-Dajani, Tim Friedrich Lutz Wilhelm, Jan Baumann, Rainer Surges, Bernd T. Meyer

“…Electroencephalography (EEG) is widely used to diagnose epilepsy and detect seizures. Automatic detection and documentation of epileptic seizures using EEG signals would help neurologists evaluate the course of disease of each patient individually. …”
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Effect of γ-ethyl-γ-phenyl-butyrolactone (EFBL), anticonvulsant and hypnotic drug, on mouse brain catecholamine levels by Rasgado Lourdes A. Vega, Villanueva Iván, Díaz Fernando Vega

“…The results support the role of DA and NA in regulating seizure activity in the brain and indicate that EFBL offers a potential treatment for refractory epilepsy without complementary drugs and Parkinson’s disease, without the drawbacks of oral therapies.…”
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Cannabis sativa subsp. sativa's pharmacological properties and health effects: A scoping review of current evidence. by Xin Yi Lim, Terence Yew Chin Tan, Siti Hajar Muhd Rosli, Muhammad Nor Farhan Sa'at, Syazwani Sirdar Ali, Ami Fazlin Syed Mohamed

“…There was also evidence suggesting benefits in cannabis dependence, epilepsy, and anxiety disorders. Pre-clinically, hemp derivatives showed potential anti-oxidative, anti-hypertensive, anti-inflammatory, anti-diabetic, anti-neuroinflammatory, anti-arthritic, anti-acne, and anti-microbial activities. …”
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Subdural empyema in patient with SARS-CoV-2 positivity: A rare case report of 3 patients by Hamidreza Aghadoost, MD, Ghazaleh Salehabadi, MD-MPH, Esmaeil Fakharian, MD

“…The third one is a 47-year-old gentleman with a known case of epilepsy, who presented with a 2-day history of headache and fever and an event of Generalized Tonic Colonic (GTC) seizure on the day of admission. …”
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Exploring the Effectiveness of Machine Learning and Deep Learning Techniques for EEG Signal Classification in Neurological Disorders by Souhaila Khalfallah, William Puech, Mehdi Tlija, Kais Bouallegue

“…This study explores the use of machine learning (ML) and deep learning (DL) techniques in processing Electroencephalography (EEG) signals to detect various neurological disorders, including Epilepsy, Autism Spectrum Disorder (ASD), and Alzheimer&#x2019;s disease. …”
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Multiple intracerebral hematomas during SEEG recording and intradural hemorrhage after spinal tap: A case report prompting more research on collagen IV gene mutation and oral nicot... by Markus Leitinger, Serena Broggi, Mathias Spendel, Gudrun Kalss, Ivan Petrović, Herbert Krainz, Fabio Rossini, Julia Höfler, Andreea Toma, Giorgi Kuchukhidze, Matthias Mauritz, Kai‐Nicolas Poppert, Bernardo Crespo‐Pimentel, Pilar Bosque‐Varela, Anna Pleyers, Patricia Ganger, Dieter Kotzot, Davor Lessel, Christoph J. Griessenauer, Eugen Trinka

“…We present a 20+ year‐old man with drug‐resistant epilepsy who underwent stereo‐EEG with 17 depth electrodes. …”
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Acute metabolic decompensation after liver transplant in a patient with maple syrup urine disease by Shao Ching Tu, Marium Khan, Katie Wolfe, Sakil S. Kulkarni, Elizabeth Toolan, Dorothy K. Grange

“…While most of our patients have not had documented encephalopathy, one of the patients with epilepsy had a seizure during a gastrointestinal illness. …”
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Identification of Potential Clusters of Signs and Symptoms to Prioritize Patients’ Eligibility for AADCd Screening by 3-OMD Testing: An Italian Delphi Consensus by Carlotta Spagnoli, Roberta Battini, Filippo Manti, Duccio Maria Cordelli, Andrea Pession, Melissa Bellini, Andrea Bordugo, Gaetano Cantalupo, Antonella Riva, Pasquale Striano, Marco Spada, Francesco Porta, Carlo Fusco

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Modulation of Motor Cortical Activities by Action Observation and Execution in Patients with Stroke: An MEG Study by Jun-Ding Zhu, Chia-Hsiung Cheng, Yi-Jhan Tseng, Chien-Chen Chou, Chih-Chi Chen, Yu-Wei Hsieh, Yu-Hsien Liao

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Diffused Multi-scale Generative Adversarial Network for low-dose PET images reconstruction by Xiang Yu, Daoyan Hu, Qiong Yao, Yu Fu, Yan Zhong, Jing Wang, Mei Tian, Hong Zhang

“…Compared to other methods, the synthesized full-dose PET image generated by our method exhibits a more accurate voxel-wise metabolic intensity distribution, resulting in a clearer depiction of the epilepsy focus. Conclusions The proposed method demonstrates improved restoration of original details from low-dose PET images compared to other models trained on the same datasets. …”
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The Development of Methods of BLOTCHIP^®-MS for Peptidome: Small Samples in Tuberous Sclerosis by Kunio Yui, George Imataka, Kotaro Yuge, Hitomi Sasaki, Tadashi Shiohama, Kyoichi Asada, Hidehisa Tachiki

“…Neurological manifestations mainly include epilepsy and autism spectrum disorder (ASD). ASD is the presenting symptom (25–50% of patients). …”
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Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia by Renshi Kawakatsu, Kenjiro Tadagaki, Kenta Yamasaki, Yasumichi Kuwahara, Tatsushi Yoshida

“…Valproic acid (VPA), commonly used for epilepsy, has also been studied for potential applications in AML treatment. …”
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Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus by Yan Yang, Chao Yuan, Shu-qun Shen, Xue-er Wang, Qing-hua Mei, Wen-qing Jiang, Qin Huang

“…N-Methyl-D-aspartate (NMDA) receptors are a subgroup of the glutamate receptor family, whose NR2A subunit was found on neuronal cells (anti-NR2A) in NPSLE patients with different types of epilepsy. The present study was conducted to determine the serum levels of anti-NR2A antibodies in a large group of SLE patients, to investigate the possible correlation between the presence of the NR2A specific antibodies and NPSLE-related seizure disorders. …”
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Determination of Levetiracetam in Human Plasma by Dispersive Liquid-Liquid Microextraction Followed by Gas Chromatography-Mass Spectrometry by Greyce Kelly Steinhorst Alcantara, Leandro Augusto Calixto, Luiz Alberto Beraldo de Moraes, Regina Helena Costa Queiroz, Anderson Rodrigo Moraes de Oliveira, Cristiane Masetto de Gaitani

“…Levetiracetam (LEV) is an antiepileptic drug that is clinically effective in generalized and partial epilepsy syndromes. The use of this drug has been increasing in clinical practice and intra- or -interindividual variability has been exhibited for special population. …”
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Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex by Jason S. Hauptman, Joseph Antonios, Gary W. Mathern, Michael S. Levine, Carlos Cepeda

“…These findings have potential implications for the treatment of neurological disorders associated with mTOR pathway dysfunction, such as epilepsy and autism.…”
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Whole Exome Sequencing Reveals Compound Heterozygosity for Ethnically Distinct PEX7 Mutations Responsible for Rhizomelic Chondrodysplasia Punctata, Type 1 by Jessie C. Jacobsen, Emma Glamuzina, Juliet Taylor, Brendan Swan, Shona Handisides, Callum Wilson, Michael Fietz, Tessa van Dijk, Bart Appelhof, Rosamund Hill, Rosemary Marks, Donald R. Love, Stephen P. Robertson, Russell G. Snell, Klaus Lehnert

“…We describe two brothers who presented at birth with bone growth abnormalities, followed by development of increasingly severe intellectual and physical disability, growth restriction, epilepsy, and cerebellar and brain stem atrophy, but normal ocular phenotypes. …”
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Protective effects of wogonin in the treatment of central nervous system and degenerative diseases by Qingan Fu, Qingyun Yu, Hongdan Luo, Zhekang Liu, Xiaowei Ma, Huijian Wang, Zhijuan Cheng

“…This review elucidates the pharmacological mechanisms underlying the protective effects of wogonin in CNS diseases, including ischemic stroke, hemorrhagic stroke, traumatic brain injury, epilepsy, anxiety, neurodegenerative diseases, and CNS infections. …”
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