Risk of adverse cardiovascular events based on common genetic variants in 8-year follow-up of the LIPIDOGEN2015 population using the polygenic risk score (PRS): study design and me... by Maciej Banach, Martyna Fronczek, Tadeusz Osadnik, Agnieszka Gach, Dominik Strapagiel, Marcin Słomka, Mateusz Lejawa, Anna Goc, Ewa Boniewska-Bernacka, Anna Pańczyszyn, Gregory Y.H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Peter E. Penson, Jacek Jóźwiak

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The Pathology of T Cells in Systemic Lupus Erythematosus by Anselm Mak, Nien Yee Kow

“…Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed. …”
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tRNA-derived small RNAs: their role in the mechanisms, biomarkers, and therapeutic strategies of colorectal cancer by Bo Zhang, Yanru Pan, Zhe Li, Kefeng Hu

“…Their involvement in regulating translation, gene expression, reverse transcription, and epigenetics has gradually come to light. Emerging research has revealed dysregulation of tsRNAs in CRC, implicating their role in CRC initiation and progression, and highlighting their potential in early diagnosis, prognosis, and therapeutic strategies. …”
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Sex and gender differences in the molecular etiology of Parkinson’s disease: considerations for study design and data analysis by Samantha L. Schaffner, Kira N. Tosefsky, Amy M. Inskter, Silke Appel-Cresswell, Julia M. Schulze-Hentrich

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Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice by Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

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Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker by Hang Yi, Yiwen Lin, Yutong Li, Yeqi Guo, Ligong Yuan, Yousheng Mao

“…Methods including correlation analysis, Cox regression analysis, and Kaplan-Meier analysis were used to explore the expression pattern, prognosis, tumor infiltration pattern, genetics and epigenetics, and drug sensitivity of B4GALNT1 in pan-cancer patients from the above datasets. …”
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Osteoblast-Specific Overexpression of Nucleolar Protein NO66/RIOX1 in Mouse Embryos Leads to Osteoporosis in Adult Mice by Qin Chen, Krishna M. Sinha, Benoit de Crombrugghe, Ralf Krahe

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Concise Review: The Regulatory Mechanism of Lysine Acetylation in Mesenchymal Stem Cell Differentiation by Hong Yang, Yuexia Liu, Xuanchen Liu, Huihui Gu, Jing Zhang, Chao Sun

“…Nowadays, the use of MSCs has attracted considerable attention in the global science and technology field, with the self-renewal and multidirectional differentiation potential for diabetes, obesity treatment, bone repair, nerve repair, myocardial repair, and so on. Epigenetics plays an important role in the regulation of mesenchymal stem cell differentiation, which has become a research hotspot in the medical field. …”
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Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity by Saber Imani, Parham Jabbarzadeh Kaboli, Ali Babaeizad, Mazaher Maghsoudloo

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Genetic Variants Related to Increased CKD Progression—A Systematic Review by Filipe S. Mira, Bárbara Oliveiros, Isabel Marques Carreira, Rui Alves, Ilda Patrícia Ribeiro

“…Several genetic variants were identified in genes that encode proteins related to metabolic processes, oxidative stress, immune regulation, the renin–angiotensin–aldosterone pathway, and epigenetics, among others. These genetic alterations can affect protein function and lead to renal damage, impacting CKD development and progression. …”
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Mechanisms Underlying Aggressive Behavior Induced by Antiepileptic Drugs: Focus on Topiramate, Levetiracetam, and Perampanel by Cerine C. Hansen, Hanna Ljung, Eylert Brodtkorb, Arne Reimers

“…Other mechanisms involve hormones, epigenetics, and “alternative psychosis” and related phenomena. …”
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TOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway by Maria C. Arroyo López, M. A. Fernández-Mimbrera, E. Gollini, A. Esteve-Codina, A. Sánchez, Juan Alberto Marchal Ortega

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Decoding vascular aging: implications for atherosclerosis progression and clinical intervention by Silumbwe Ceaser Wankumbu, Xiao-Man Ji, Ming Xu

“…In the review, we highlighted five altered vascular mechanisms in cardiovascular models: genomic instability, neurohormonal deregulation, epigenetics, protein regulation, and the gut microbiome. …”
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Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome by Michael T. Zimmermann, Raul A. Urrutia, Patrick R. Blackburn, Margot A. Cousin, Nicole J. Boczek, Eric W. Klee, Colleen Macmurdo, Paldeep S. Atwal

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Changes in RNA Splicing: A New Paradigm of Transcriptional Responses to Probiotic Action in the Mammalian Brain by Xiaojie Yue, Lei Zhu, Zhigang Zhang

“…Most studies have primarily investigated how gut bacteria modulate host epigenetics and gene expression; their impact on host alternative splicing, particularly in the brain, remains largely unexplored. …”
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The importance of fungi and of mycology for a global development of the bioeconomy by L. Lange, L. Bech, P.K. Busk, M.N. Grell, Y. Huang, M. Lange, T. Linde, B. Pilgaard, D. Roth, X. Tong

“…This knowledge can be obtained by studying the fungal proteome and metabolome; the biology of fungal RNA and epigenetics; protein expression, homologous as well as heterologous; fungal host/substrate relations; physiology, especially of extremophiles; and, not the least, the extent of global fungal biodiversity. …”
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Phenotypic plasticity plays an essential role in the confrontation between plants and herbivorous insects by Xianzhong Wang, Jieyu Kang, Huizhong Wang, Shigui Wang, Bin Tang, Jiangjie Lu

“…Throughout this process, phenotypic plasticity has continuously helped both groups adapt to new environments and niches. Epigenetic changes play an important role in the formation of plastic phenotype. …”
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Osteoprotegerin as an Emerging Biomarker of Carotid Artery Stenosis? A Scoping Review with Meta-Analysis by Jerzy Chudek, Marta Pośpiech, Anna Chudek, Michał Holecki, Monika Puzianowska-Kuźnicka

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Methylation Status of Vitamin D Receptor Gene Promoter in Benign and Malignant Adrenal Tumors by Catia Pilon, Andrea Rebellato, Riccardo Urbanet, Vincenza Guzzardo, Rocco Cappellesso, Hironobu Sasano, Ambrogio Fassina, Francesco Fallo

“…Downregulation of VDR gene expression may result from epigenetics events, that is, methylation of cytosine nucleotide of CpG islands in VDR gene promoter. …”
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Emerging roles of circular RNAs on the regulation of production traits in chicken by Guishuang You, Hong Long, Xiaoxu Shen, Huadong Yin, Shibin Zhang

“…This performance is determined by various production traits that are primarily influenced by multiple factors, including epigenetics—a critical aspect of gene regulation. Circular RNAs (circRNAs), a unique class of non-coding RNAs, have emerged as key epigenetic regulators. …”
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