Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury by Anubhav Chakraborty, Pragasam Viswanathan

“…Over the years, the epigenetic landscape has grown increasingly complex. …”
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Methods of massive parallel reporter assays for investigation of enhancers by S. E. Romanov, D. A. Kalashnikova, P. P. Laktionov

“…The development of high-throughput genomic assays has made it possible to significantly accelerate the accumulation of information about the characteristic epigenetic properties of regulatory elements. In combination with high-throughput studies focused on the genome-wide distribution of epigenetic marks, regulatory proteins and the spatial structure of chromatin, this significantly expands the understanding of the principles of epigenetic regulation of genes and allows potential regulatory elements to be searched for in silico. …”
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Oxidative Stress and DNA Methylation in Prostate Cancer by Krishna Vanaja Donkena, Charles Y. F. Young, Donald J. Tindall

“…Epigenetics affects genetic regulation, cellular differentiation, embryology, aging, cancer, and other diseases. …”
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Chromatin Modifying Agents in the In Vitro Production of Bovine Embryos by Fabio Morato Monteiro, Clara Slade Oliveira, Letícia Zoccolaro Oliveira, Naiara Zoccal Saraiva, Maria Eugênia Zerlotti Mercadante, Flavia Lombardi Lopes, Daniel Robert Arnold, Joaquim Mansano Garcia

“…Therefore, proper knowledge of epigenetic reprogramming is necessary to prevent possible epigenetic errors and to improve efficiency and the use of in vitro fertilization and cloning technologies in cattle and other species.…”
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Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity by Dalia Ali, Elna P. Chalisserry, Muthurangan Manikandan, Rimi Hamam, Musaad Alfayez, Moustapha Kassem, Abdullah Aldahmash, Nehad M. Alajez

“…Herein, we investigated the epigenetic effect of romidepsin, a small molecule dual inhibitor targeting HDAC1 and HDAC2 identified through an epigenetic library functional screen. …”
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Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells by Adele Murrell

“…Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. …”
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Longitudinal genetic studies of cognitive characteristics by R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, S. B. Malykh, E. K. Khusnutdinova

“…The appropriate correction of epigenetic factors related to environmental differences in cognitive abilities requires to determine the mechanisms of chromatin modifications and variations in DNA methylation. …”
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IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma by Khuloud Bajbouj, Mahmood Y. Hachim, Rakhee K. Ramakrishnan, Huwaida Fazel, Jumana Mustafa, Shahed Alzaghari, Mahmoud Eladl, Jasmin Shafarin, Ronald Olivenstein, Qutayba Hamid

“…Asthma is one of the most common obstructive pulmonary diseases worldwide. Epigenetic alterations, including DNA methylation and histone modifications, have been reported to contribute to asthma pathogenesis. …”
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Adenine, a key player in biology and medicinal chemistry by Fillion, Alexandra, Vichier-Guerre, Sophie, Arimondo, Paola Barbara

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Allele-specific methylation of SSTR4 associated with aging and cognitive functions in patients with schizophrenia. by Rongrong Zhao, Huihui Shi, Yanqiu Wang, Tao Jiang, Yahui Xu

“…However, the role of genetic-epigenetic interactions involving SSTR4 in patients with schizophrenia remains unexplored. …”
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Long Noncoding RNAs, Chromatin, and Development by Daniel P. Caley, Ryan C. Pink, Daniel Trujillano, David R. F. Carter

“…This differential expression is regulated at the epigenetic level by chromatin modifications, such as DNA and histone methylation, which interact with structural and enzymatic proteins, resulting in the activation or silencing of any given gene. …”
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Assessing in-vitro models for microglial development and fetal programming: a critical review by Steven Schepanski, Steven Schepanski, Gonza B. Ngoumou, Gonza B. Ngoumou, Claudia Buss, Claudia Buss, Claudia Buss, Claudia Buss, Georg Seifert, Georg Seifert

“…Key factors such as scalability, genetic and epigenetic fidelity, and physiological relevance are highlighted. …”
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The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes? by Ruggero Ridolfi

“…Connecting links amongst the external environment, cellular microenvironment and functional epigenetic and genetic mutations promote carcinogenesis. …”
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Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running by Andrea T. U. Schaefers, Keren Grafen, Gertraud Teuchert-Noodt, York Winter

“…We examined if a similar epigenetic effect of rearing environment on adult neuroplastic responses can be found in mice (Mus musculus). …”
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Emerging Stem Cell Therapies: Treatment, Safety, and Biology by Joel Sng, Thomas Lufkin

“…The discovery of induced pluripotent stem cells has led to an improved understanding of the underlying epigenetic keys of pluripotency and carcinogenesis. …”
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Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases by Jiani Li, Jichao Sha, Liwei Sun, Dongdong Zhu, Cuida Meng

“…In this study, we highlighted the recent evidence on the contribution of epigenetic modifications in Treg cells to the pathogenesis of allergic diseases. …”
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Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming by James Spyrou, David K. Gardner, Alexandra J. Harvey

“…Significantly, relative nutrient availability impacts iPSC reprogramming efficiency, epigenetic regulation and cell fate, and differentially alters their ability to respond to physiological stimuli. …”
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Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells by Gregory M. Kelly, Mohamed I. Gatie

“…Another major focus is on the epigenetic regulation of ECCs and stem cells, and, towards that end, this review closes on what we see as a new frontier in combating aging and human disease, namely, how cellular metabolism shapes the epigenetic landscape and hence the pluripotency of all stem cells.…”
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Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia by Olivia M. Depies, Qianqian Guo, Yuan Gao, Sutapa Sinha, Zhenqing Ye, Weiguo Han, Kari G. Rabe, Mingma S. Hoel, Heather C. Darby, Chuanhe Yu, Esteban Braggio, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Zhiquan Wang

“…Abstract: Epigenetic alterations have been found in chronic lymphocytic leukemia (CLL), but the functional importance of these changes remains underexplored. …”
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QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration by Jayshree Advani, Puja A. Mehta, Andrew R. Hamel, Sudeep Mehrotra, Christina Kiel, Tobias Strunz, Ximena Corso-Díaz, Madeline Kwicklis, Freekje van Asten, Rinki Ratnapriya, Emily Y. Chew, Dena G. Hernandez, Sandra R. Montezuma, Deborah A. Ferrington, Bernhard H. F. Weber, Ayellet V. Segrè, Anand Swaroop

“…Abstract DNA methylation provides a crucial epigenetic mark linking genetic variations to environmental influence. …”
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