Comparative analysis of selected methods of carbapenemase determination among clinical Klebsiella pneumoniae. by Agata Pruss, Alicja Skierska, Paweł Kwiatkowski, Helena Masiuk, Joanna Jursa-Kulesza, Stefania Giedrys-Kalemba, Iwona Bilska, Monika Sienkiewicz, Maria V Melnyk, Barbara Dołęgowska

“…Klebsiella pneumoniae is a typical opportunistic pathogen that exhibits multiple virulence factors and antibiotic resistance conditioning mechanisms. Carbapenemases are enzymes that help bacteria to exhibit the strongest resistance against antibiotics. …”
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Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt. by Alyssa Hubal, Anusha Vendhoti, Charles N Shaffer, Sarah Vos, Yalitza Lopez Corcino, Carlos S Subauste

“…Blockade of Src triggered LC3 and LAMP-1 recruitment around the parasitophorous vacuole (PV) and parasite killing dependent on the autophagy protein, ULK1, and lysosomal enzymes. Src promoted PI3K activation and recruitment of activated Akt to the PV membrane. …”
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Phytocannabinoids: a new frontier in Alzheimer’s disease management by Jagadeesh S. Rao

“…The ECS consists of endocannabinoids, metabolic enzymes, and their receptors, CB1R and CB2R. Individuals have utilized therapeutic cannabis-derived remedies for medicinal purposes. …”
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Postcholecystectomy syndrome: the modern approach: resolution of Advisory council by V. T. Ivashkin, A. V. Okhlobystin, D. S. Bordin, E. Ya. Seleznyova, Yu. A. Kucheryavy, Ye. V. Bystrovskaya, O. C. Vasnev, M. F. Osipenko, G. H. Musayev, Yu. O. Shulpekova

“…Pharmacological treatment of sphincter of Oddi dysfunction that develop at GSD/PCS include following of dietary recommendations, intake of selective spasmolytics, digestive enzymes and ursodeoxycholic acid. Conclusions. Follow-up program for the patient of the cholecystectomy should include regular assessment of clinical symptoms for duly diagnostics of acute and/or severe complications and associated diseases, that may require surgical treatment. …”
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Megoura crassicauda promote the ability of Vicia faba L. to remediate cadmium pollution of water and soil by Sijing Wan, Shasha Wang, Yan Li, Yexin Xie, Qimei Li, Yinjie Fang, Zhenjuan Yin, Shigui Wang, Yifan Zhai, Bin Tang

“…We also found that prolonged Cd treatment increased the activities of stress-related antioxidant enzymes in fava beans, including superoxide dismutase, peroxidase, and malondialdehyde. …”
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Clinical diagnosis of Q fever by targeted next-generation sequencing for identification of Coxiella burnetii by Shaohua Zhan, Haoyuan Jin, Hanbing Ji, Xin Hou, Jing Li, Ye Zhang, Jiajia Zheng, Liyan Cui

“…Although blood cultures were negative, elevated infection markers (CRP, PCT, and ferritin) and liver enzymes (ALT, AST, GGT, ALP, and LDH) were observed. …”
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X-linked ubiquitin-specific peptidase 11 (USP11) increases susceptibility to Cushing’s disease in women by Tao Zhang, Yanting Liu, Fang Liu, Kaiyu Guo, Runhua Tang, Jingwei Ye, Li Xue, Zhipeng Su, Zhe Bao Wu

“…In this study, we analyzed the expression of deubiquitinating enzymes in functioning ACTH PitNETs from both male and female subjects using RNA sequencing and identified USP11 as a potential susceptibility factor contributing to the higher prevalence of these PitNETs in females. …”
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Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…The regulation of fatty acid metabolism involves enzymes desaturase (FADS1, FADS2) and elongase (ELOVL2 and ELOVL5) fatty acids. …”
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Growth profile of Bacteroidetes strains under low molecular weight alginate fractions produced by non-thermal processing techniques by Pedro Rivero-Ramos, Pedro J. Fernandez-Julia, Dolores Rodrigo, María Benlloch-Tinoco, Jose Munoz-Munoz

“…Finally, D. mossii DSMZ22836 was found to employ three enzymes (Aly, GH88, GH92) to degrade the low Mw alginate fractions. …”
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Systematic analysis of the pharmacogenomics landscape towards clinical implementation of precision therapeutics in Greece by George P. Patrinos, Kariofyllis Karamperis, Margarita-Ioanna Koufaki, Maria Skokou, Zoe Kordou, Eirini Sparaki, Margarita Skaraki, Christina Mitropoulou

“…Abstract Pharmacogenomics (PGx) aims to delineate a patient’s genetic profile with differences in drug efficacy and/or toxicity, particularly focusing on genes encoding for drug-metabolizing enzymes and transporters. Clinical implementation of PGx is a complex undertaking involving a multidisciplinary approach that includes, among others, a thorough understanding of a country’s preparedness to adopt this modern discipline and a detailed knowledge of PGx biomarkers allelic spectrum at a population level. …”
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Black rice (Oryza sativa L.) and its anthocyanins: mechanisms, food applications, and clinical insights for postprandial glycemic and lipid regulation by Thavaree Thilavech, Tanyawan Suantawee, Charoonsri Chusak, Phim On Suklaew, Sirichai Adisakwattana

“…Based on in vitro studies, black rice anthocyanins exhibit a variety of mechanisms, including the inhibition of carbohydrate and fat digestive enzymes, binding to bile acids, interference with cholesterol micellization, and the inhibition of glucose and cholesterol uptake in enterocytes. …”
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Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics by Seyede Sara Pakdaman Kolour, Saeide Nematollahi, Masoud Dehbozorgi, Farnaz Fattahi, Fatemeh Movahed, Neda Esfandiari, Mohammad Saeed Kahrizi, Nima Ghavamikia, Bahareh Salmanian Hajiagha

“…Dysregulated miRNAs upregulate the synthesis of enzymes that degrade cartilage, downregulate the expression of components in the cartilage matrix, promote the production of proinflammatory cytokines, induce programmed cell death in chondrocytes, inhibit the process of autophagy in chondrocytes, and participate in pathways related to pain. …”
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Structural basis of SIRT7 nucleosome engagement and substrate specificity by Carlos Moreno-Yruela, Babatunde E. Ekundayo, Polina N. Foteva, Dongchun Ni, Esther Calvino-Sanles, Henning Stahlberg, Beat Fierz

“…Abstract Chromatin-modifying enzymes target distinct residues within histones to finetune gene expression profiles. …”
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Effect of Cannabis seeds on Some biomedical parameters in male rats by Karwan Anwar Hassan

“…Alkaline Phosphatase, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase (ALP, GPT, and GOT), creatinine and uric acid was done for estimating the effect of cannabis seeds on renal and liver function. Enzymes Alkaline phosphatase, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase (ALP, GPT, and GOT) as well as creatinine, uric acid and very low-density lipoprotein (VLDL) were not significantly (p<0.05) different in both groups. …”
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Monosodium glutamate (MSG) exposure induced oxidative stress and disrupted testicular hormonal regulation, exacerbating reproductive dysfunction in male WISTAR rats by Adesua Emmanuel Ogunmokunwa, Babatunde Oluwaseun Ibitoye

“…Conversely, the activities of antioxidant enzymes (SOD, CAT, GSH, GPx) were significantly diminished, reflecting impaired antioxidant defences. …”
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Effect of Cannabis seeds on Some biomedical parameters in male rats by Karwan Anwar Hassan

“…Alkaline Phosphatase, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase (ALP, GPT, and GOT), creatinine and uric acid was done for estimating the effect of cannabis seeds on renal and liver function. Enzymes Alkaline phosphatase, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase (ALP, GPT, and GOT) as well as creatinine, uric acid and very low-density lipoprotein (VLDL) were not significantly (p<0.05) different in both groups. …”
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Effect of Cannabis seeds on Some biomedical parameters in male rats by Karwan Anwar Hassan

“…Alkaline Phosphatase, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase (ALP, GPT, and GOT), creatinine and uric acid was done for estimating the effect of cannabis seeds on renal and liver function. Enzymes Alkaline phosphatase, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase (ALP, GPT, and GOT) as well as creatinine, uric acid and very low-density lipoprotein (VLDL) were not significantly (p<0.05) different in both groups. …”
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Effect of Dietary Inclusion of Chitosan on Survival and Selected Cellular Antioxidants in <i>Drosophila melanogaster</i> by O.G. Igharo, L.I. Abadaike, J.O. Osunbor, I.C. Owie, A.I. Aruomaren, E.L. Igharo, K.I. Ikeke

“…These results have shown that dietary inclusions of chitosan in various concentrations increased the survival rate of the flies than in control which contained only water and also increase some antioxidant enzymes in the flies than in control. Reduced antioxidant levels have been linked to accelerated aging and conditions leading to death like cancer. …”
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Applying Machine Learning Techniques to Identify Undiagnosed Patients with Exocrine Pancreatic Insufficiency by Bruce Pyenson, Maggie Alston, Jeffrey Gomberg, Feng Han, Nikhil Khandelwal, Motoharu Dei, Monica Son, Jaime Vora

“…**Background:** Exocrine pancreatic insufficiency (EPI) is a serious condition characterized by a lack of functional exocrine pancreatic enzymes and the resultant inability to properly digest nutrients. …”
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Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats by Fouziyeh Siahpour, Hosein Sadeghi, Esmaeel Panahi kokhdan, Mohammad Khoshnoud

“…Drugs like sildenafil, which inhibits phosphodiesterase enzymes, are used to treat pulmonary arterial hypertension. …”
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