Proteomics integrated with metabolomics: Analysis of the internal mechanism underlying changes in meat quality in different muscles from bactrian camels by Rendalai Si, Liang Ming, Xueyan Yun, Jing He, Li Yi, Qin Na, Rimutu Ji, Tungalag Dong

“…Proteomic analysis unveiled significant differences in metabolic enzymes and binding proteins among different muscles. …”
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Giant Water Bugs, Electric Light Bugs, Lethocerus, Abedus, Belostoma (Insecta: Heteroptera: Belostomatidae) by Paul M. Choate

“…Individuals prey on aquatic insects, small fish, frogs, tadpoles, small birds, and other organisms they are able to capture. Powerful enzymes are injected into prey to kill them. Adults of Lethocerus are considered a delicacy in Asia, and are eaten both fresh and cooked. …”
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Bile Acids and Their Value for Central Nervous System by Yu. O. Shulpekova, P. E. Tkachenko, E. N. Shirokova, I. V. Damulin

“…The presence in CNS of various bile acid synthesis-related receptors and enzymes indicates their value in brain functioning and warrants research into their metabolism.…”
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Role of mitochondrial and lysosomal dysfunction in acute pancreatitis pathogenesis by Yuliya V Yevsyutina, V. T. Ivashkin, E. Z. Abgadzhava

“…Hyperamilasemia, premature intralobular activation of digestive enzymes, accumulation of large vacuoles in acinar cells, activation of proinflammatory mediators, apoptosis and necrosis of acinar cells are the basic pathomorphological signs of AP. …”
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Strategies to improve the quality of wheat flour in baking: a review by Mariana de Paula Kraüss Ferreira, Vitor Anselmo da Guia Ribeiro, Jefferson Henrique Tiago Barros, Caroline Joy Steel

“…Focusing on gluten, which is crucial for the technological quality of the flour, we explored strategies involving additives (oxidizing agents, emulsifiers, and hydrocolloids), processing aids (enzymes), and the ingredient vital wheat gluten. We also evaluated the regulatory aspects governing the use of these enhancers in various countries.…”
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Prenatal exposure to bisphenol A causes reproductive damage in F1 male rabbits due to inflammation and oxidative stress by Qianhui Zhao, Jialu Pan, Yongzhan Bao, Xiao Wang, Wanyu Shi

“…By modulation of the Nrf2 and NF-κB axes, BPA could influence the expression of antioxidant enzymes and inflammatory mediators in the rabbit reproductive system, leading to cell apoptosis and tissue damage. …”
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Prokaryotic cellulase gene clusters derived from 2,305 metagenomes by Bing Song, Fernando D. K. Tria, Josip Skejo

“…They do it by producing cellulases, the various enzymes which break beta-glycosidic bonds in the cellulose. …”
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Pantoprazole – safety in drug-drug interaction by E. V. Shikh, D. A. Sychev

“…Pantoprazole is metabolized by CYP2C19 and CYP3A4, however, it has the lowest affinity to these enzymes of all PPIs. The primary metabolite of pantoprazole (the CYP system product 4-hydroxypantoprazole) enters next cytosolic phase of biotransformation i.e. conjugation to sulfate. …”
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Giant Water Bugs, Electric Light Bugs, Lethocerus, Abedus, Belostoma (Insecta: Heteroptera: Belostomatidae) by Paul M. Choate

“…Individuals prey on aquatic insects, small fish, frogs, tadpoles, small birds, and other organisms they are able to capture. Powerful enzymes are injected into prey to kill them. Adults of Lethocerus are considered a delicacy in Asia, and are eaten both fresh and cooked. …”
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Unraveling the metabolic landscape of Exophiala spinifera strain FM: Model reconstruction, insights into biodesulfurization and beyond. by Hamta Babaei Naeij, Zahra Etemadifar, John Kilbane, Mohammad Hossein Karimi-Jafari, Sepideh Mofidifar

“…However, the specific pathway and enzymes involved in this process remain unclear due to limited genome sequencing and metabolic understanding of E. spinifera. …”
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Research Progress on Enzymatic Preparation and Functional Properties of Bioactive Peptides in Hairtail by Yuanyuan WU, Kewei ZHENG, Wenzhu LI, Cheng LI, Xiaojun YAN, Qingbao MA, Wei JIANG

“…The antioxidative activity of enzymatic hydrolysates is extensively studied, with alkaline protease and papain being the most commonly used enzymes. However, research on the specific peptide sequences responsible for bioactivity and their underlying mechanisms remains limited. …”
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Association between microplastics and the functionalities of human gut microbiome by Bei Gao, Lixia Chen, Lizhi Wu, Shirui Zhang, Sunan Zhao, Zhe Mo, Zhijian Chen, Pengcheng Tu

“…Associations were found between microplastics and microbial species, as well as microbial genes encoding invasion-related virulence factors, quorum sensing, autoinducer and transporter system, and microplastic biodegradation enzymes. The findings are of significance to improve the understanding of functional changes in the gut microbiome associated with microplastic exposure, as well as raising awareness regarding the health risks of microplastics in the human population.…”
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An integrated microbiome- and metabolome-genome-wide association study reveals the role of heritable ruminal microbial carbohydrate metabolism in lactation performance in Holstein... by Chenguang Zhang, Huifeng Liu, Xingwei Jiang, Zhihong Zhang, Xinfeng Hou, Yue Wang, Dangdang Wang, Zongjun Li, Yangchun Cao, Shengru Wu, Sharon A. Huws, Junhu Yao

“…_E13-27, which have the oligosaccharide-degradation enzymes genes, including the GH10, GH13, GH43, GH95, and GH115 families. …”
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Allelopathic and auto-toxic effects of aqueous extracts of Codonopsis pilosula root secretions. by Daiyu Qiu, Xue Wang, Fengbin Xu, Qian Li, Fengying Ren, Kan Jiang

“…Our findings revealed that the inhibitory effects on seed germination, seedling growth, and the activity of antioxidant enzymes-collectively referred to as a comprehensive effect-intensified progressively with increasing concentrations of the aqueous extracts from C. pilosula root exudates. …”
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Potential Azo-8-hydroxyquinoline derivatives as multi-target lead candidates for Alzheimer's disease: An in-depth in silico study of monoamine oxidase and cholinesterase inhibitors... by Fatima Zahra Guerguer, Bouchra Rossafi, Oussama Abchir, Yasir S Raouf, Dhabya Bakhit Albalushi, Abdelouahid Samadi, Samir Chtita

“…Cognitive dysfunction in Alzheimer's disease results from a complex interplay of various pathological processes, including the dysregulation of key enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidase B (MAO-B). …”
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Guards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity. by Haleema Sadia Malik, James B Bliska

“…For example, virulent bacterial pathogens have proteins called effectors that are typically enzymes and are secreted into host cells. To detect and respond to the activities of effectors, diverse phyla of host organisms evolved effector-triggered immunity (ETI). …”
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Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease by Roger F. Butterworth, Ali Canbay

“…L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6–9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios. …”
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Understanding the impact of triazoles on female fertility and embryo development: Mechanisms and implications by Sonal Sharma, Geeta Pandey

“…The findings suggest that triazoles might negatively affect female fertility and embryonic development through multiple mechanisms including inhibition or interference with key enzymes such as CYP17A1 and CYP19A1 (aromatase) involved in steroid hormone synthesis, endocrine disruption, oxidative stress, disruption of signaling pathways, and apoptosis. …”
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Application of iron on improving antimony tolerance in Salvia spinosa by Shakiba Rajabpoor, Soghra Kiani, Shokoofeh Hajihashemi

“…The limitation of H2O2 generation in response to co-application of Fe with Sb was followed by counterbalancing the antioxidant enzymes (e.g. catalase, superoxide dismutase and ascorbate peroxidase), phenols, flavonoids, lipid membrane preservation, and increase of the carbohydrates and proteins contents, which altogether improved growth in Sb-stressed plants. …”
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Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism by Jie An, Inna Astapova, Guofang Zhang, Andrew L. Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J. Muehlbauer, Tabitha George, Joseph Brozinick, Mark A. Herman, Christopher B. Newgard

“…In addition, expression of multiple anaplerotic enzymes is decreased by GalNac-siChREBP treatment, affecting TCA cycle intermediates. …”
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