In this Issue by Editorial Board

“…The civiliarchic community and the UN have not yet found answers to these threats, since the task of ensuring complex multi-stage security in the conditions of modern global resilience urgently requires scientific understanding, political analysis of the tasks associated with ensuring global security in the broad sense and human security as the most important component of international, regional and national security. …”
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Analysis and synthesis of intelligent automatic control systems with type-1 fuzzy regulator by Yu. A. Bykovtsev, V. M. Lokhin

“…A procedure proposed for synthesizing the parameters of the type-1 fuzzy regulator is aimed at ensuring complex requirements for the quality of the control system according to the degree of stability, the degree of oscillation, and steady-state mode accuracy. …”
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Protein Ligases: Nature’s Gift for Protein/Peptide Synthesis by Yvonne Ritsema, Huapeng Li, Qingfei Zheng

“…Proteins are structurally and functionally diverse biomacromolecules that serve a variety of essential activities to ensure complex biological homeostasis. The desire to elucidate and enhance these biological functions has been at the forefront of research for many decades. …”
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CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly by Hanna Schwaemmle, Hadrien Soldati, Nikolaos M. R. Lykoskoufis, Mylène Docquier, Alexandre Hainard, Simon M. G. Braun

“…However, the molecular mechanisms regulating SWI/SNF subunit dosage to ensure complex assembly remain largely unexplored. We performed a CRISPR KO screen, using epigenome editing in mouse embryonic stem cells, and identified Mlf2 and Rbm15 as regulators of SWI/SNF complex activity. …”
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