Integrin-Linked Kinase: A Multi-functional Regulator Modulating Extracellular Pressure-Stimulated Cancer Cell Adhesion through Focal Adhesion Kinase and AKT by Shouye Wang, Marc D. Basson

“…Malignant cells in cancer patients may be exposed to physical forces such as extracellular pressure and shear, that stimulate their adhesion to matrix proteins, endothelium and surgical wounds. Pressure induces phosphorylation of AKT and focal adhesion kinase (FAK), which are required for pressure-stimulated cancer cell adhesion, but what mediates this effect is unknown. …”
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A Case Report Illustrating the Postoperative Course of Descemetorhexis without Endothelial Keratoplasty with Topical Netarsudil Therapy by Pimpiroon Ploysangam, Sangita P. Patel

“…DSO circumvents the challenges associated with cadaveric donor corneal transplantation by tapping into the potential of the patient’s own corneal endothelium to repair defects. Outcomes have been variable with emerging knowledge on predictive factors for success. …”
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COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells by Carla Longo de Freitas, Priscilla Yuri Okochi Alves da silva, Maria do Carmo Pinho Franco, Danilo Candido de Almeida

“…Hence, elucidate whether virus target the endothelium is a crucial step to understand COVID-19 pathogenesis. …”
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The Mechanism of Acupuncture in Treating Essential Hypertension: A Narrative Review by Juan Li, Mingsheng Sun, Jing Ye, Yuxi Li, Rongjiang Jin, Hui Zheng, Fanrong Liang

“…We found that the mechanism whereby acupuncture lowers blood pressure is related to the regulation of renin-angiotensin-aldosterone system, vascular endothelium, oxidative stress, neuroendocrine system, and so on. …”
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Fatal Basilar Thrombosis Possibly Related to Minor Cervical Trauma: A Case Report by Elmaz Shaqiri, Gentian Vyshka, Admir Sinamati, Besim Ymaj, Zija Ismaili

“…Pontine arteries showed extensive alterations, mainly in the form of severed endothelium, which suggested a thrombotic-traumatic mechanism as the main etiological factor. …”
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The Role of Inflammation in the Pathogenesis of Preeclampsia by Michał Michalczyk, Aleksander Celewicz, Marta Celewicz, Paula Woźniakowska-Gondek, Rafał Rzepka

“…Preeclampsia is characterized by excessive and progressive activation of the immune system along with an increase in proinflammatory cytokines and antiangiogenic factors in fetoplacental unit as well as in vascular endothelium in pregnant women. A single, major underlying mechanism of preeclampsia is yet to be identified. …”
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Role of Extracellular Hemoglobin in Thrombosis and Vascular Occlusion in Patients with Sickle Cell Anemia by Zhou Zhou, Molly Behymer, Prasenjit Guchhait

“…ECHb and its degradation product, heme, are known to cause oxidative damage to the vessel wall and stimulate the expression of adhesive protein ligands on vascular endothelium. Our study shows that ECHb binds potently to VWF—largest multimeric glycoprotein in circulation—through the A2-domain, and significantly inhibits its cleavage by the metalloprotease ADAMTS13. …”
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The Role of the TGF-β Coreceptor Endoglin in Cancer by Eduardo Pérez-Gómez, Gaelle del Castillo, Juan Francisco Santibáñez, Jose Miguel Lêpez-Novoa, Carmelo Bernabéu, Miguel Quintanilla

“…Endoglin is overexpressed in the tumor-associated vascular endothelium, where it modulates angiogenesis. This feature makes endoglin a promising target for antiangiogenic cancer therapy. …”
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COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells by Carla Longo de Freitas, Priscilla Yuri Okochi Alves da silva, Maria do Carmo Pinho Franco, Danilo Candido de Almeida

“…Hence, elucidate whether virus target the endothelium is a crucial step to understand COVID-19 pathogenesis. …”
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Microvascular angina in postmenopausal women. by Alexander Valdés Martín, Sherien Sixto Fernández

“…<strong><br />Conclusions:</strong> Stress-induced ischemia is associated with a post-stress reduction in left ventricular ejection fraction and an abnormal endothelium-dependent vasodilation.…”
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An Update on Corneal Biomechanics and Architecture in Diabetes by María A. del Buey, Paula Casas, Constanza Caramello, Nuria López, Marisa de la Rica, Ana B. Subirón, Elena Lanchares, Valentín Huerva, Andrzej Grzybowski, Francisco J. Ascaso

“…The different corneal structures (epithelium, stroma, and endothelium) are affected by specific complications of diabetes. …”
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Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan by Maryse Delehedde, Lucie Devenyns, Claude-Alain Maurage, Romain R. Vivès

“…Consequently, Endocan expression has been associated with a growing number of pathological conditions where endothelium gets challenged and notably in highly vascularized cancers. …”
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Circulating Endothelial Microparticles: A Key Hallmark of Atherosclerosis Progression by Keshav Raj Paudel, Nisha Panth, Dong-Wook Kim

“…The prominent MPs present in blood are endothelial microparticles (EMPs) described as complex submicron (0.1 to 1.0 μm) vesicles like structure, released in response to endothelium cell activation or apoptosis. EMPs possess both physiological and pathological effects and may promote oxidative stress and vascular inflammation. …”
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COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells by Carla Longo de Freitas, Priscilla Yuri Okochi Alves da silva, Maria do Carmo Pinho Franco, Danilo Candido de Almeida

“…Hence, elucidate whether virus target the endothelium is a crucial step to understand COVID-19 pathogenesis. …”
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Gastric Cytoprotection as Basis of Gastrointestinal Mucosa Protection and Repair in Erosive Ulcerative Lesions of Various Aetiologies by K. V. Ivashkin, E. A. Izatullaev, V. R. Korneeva

“…SH-containing endogenous substances (L-cysteine, D,L-methionine, GSH) and exogenous molecules (methylmethionine-sulfonium chloride (MMSC), N-acetylcysteine) prevent damage due to the ability to absorb/neutralise free radicals released in xenobiotic-triggered cell damage, inhibit TNF-α expression, reduce the aspirin-induced leukocyte-endothelium adhesion and stimulate mucin release. In experiment, MMSC prevented the ethanol-induced GM damage, stimulated mucin release and its redistribution on the GM surface; in clinical trials, MMSC effectively facilitated remission in duodenal ulcer.Conclusion. …”
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Glycyrrhizin Attenuates Toll Like Receptor-2, -4 and Experimental Vasospasm in a Rat Model by Chih-Zen Chang, Shu-Chuan Wu, Aij-Lie Kwan

“…Morphologically, deformed endothelium, tortuous elastic lamina, and smooth muscle necrosis were observed in the SAH rats, but were absent in the glycyrrhizin pretreatment group. …”
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Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes by Arpeeta Sharma, Pascal N. Bernatchez, Judy B. de Haan

“…Overwhelming evidence from clinical and laboratory investigations have demonstrated that these cardiovascular complications are initiated by a dysfunctional vascular endothelium. Indeed, endothelial dysfunction is one of the key events that occur during diabetes, leading to the acceleration of cardiovascular mortality and morbidity. …”
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Alterations of the Erythrocyte Membrane during Sepsis by Yasmina Serroukh, Sarah Djebara, Christophe Lelubre, Karim Zouaoui Boudjeltia, Patrick Biston, Michael Piagnerelli

“…This membrane is a complex unit with multiple interactions between the extracellular and intracellular compartments: blood stream, endothelium, and other blood cells on the one hand, and the intracytoplasmic compartment with possible rapid adaptation of erythrocyte metabolism on the other. …”
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Effect of Lower Extremity Bypass Surgery on Inflammatory Reaction and Endothelial Dysfunction in Type 2 Diabetic Patients by Pei-Hsuan Tsai, Jun-Jen Liu, Szu-Yuan Chou, Yao-Chung Chang, Sung-Ling Yeh

“…This study investigated the alteration of inflammatory and endothelium dysfunction markers before and after LEBS in DM patients. …”
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Effects of Combinations of Ophthalmic Viscosurgical Devices and Suction Flow Rates on the Corneal Endothelial Cell Damage Incurred during Phacoemulsification by Tomoyuki Kunishige, Hiroshi Takahashi

“…We examined the effects of different ophthalmic viscosurgical devices (OVDs) and suction flow rates during phacoemulsification on the amount of ultrasound power used and damage to the corneal endothelium. In total, 48 eyes of 24 patients who underwent phacoemulsification and intraocular lens insertion with different OVD settings in the left and right eye between February and August 2018 were examined retrospectively from medical records. …”
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