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Coelomocytes: Biology and Possible Immune Functions in Invertebrates with Special Remarks on Nematodes
Published 2009-01-01“…The model nematode, C. elegans lacks an adaptive immune system and the coelomocytes are capable of endocytosis, but their involvement in phagocytosis of bacteria seems unlikely. …”
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22
Features of Human Herpesvirus-6A and -6B Entry
Published 2012-01-01“…The process of herpesvirus entry into target cells is complicated, and in the case of HHV-6A and HHV-6B, the detailed mechanism remains to be elucidated, although both viruses are known to enter cells via endocytosis. In this paper, (1) findings about the cellular receptor and its ligand for HHV-6A and HHV-6B are summarized, and (2) a schematic model of HHV-6A’s replication cycle, including its entry, is presented. …”
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23
Palmitoylation as a Functional Regulator of Neurotransmitter Receptors
Published 2018-01-01“…From the functional point of view, palmitoylation affects a wide span of neurotransmitter receptors activities including their trafficking, sorting, stability, residence lifetime at the cell surface, endocytosis, recycling, and synaptic clustering. This review summarizes the current knowledge on the palmitoylation of neurotransmitter receptors and its role in the regulation of receptors functions as well as in the control of different kinds of physiological and pathological behavior.…”
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24
The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways
Published 2020-01-01“…Early endosome marker Rab5 GTPase, a key member of the Rab family, plays a crucial role in endocytosis and membrane transport. The activated-state Rab5 recruits its effectors and regulates the internalization and trafficking of membrane receptors by regulating vesicle fusion and receptor sorting in the early endosomes. …”
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25
The Precapillary Segment of the Blood-Brain Barrier and Its Relation to Perivascular Drainage in Alzheimer's Disease and Small Vessel Disease.
Published 2009-01-01“…At capillaries protein transport is possible via receptor-mediated endocytosis through endothelial cells. At the arteries and veins the BBB is thicker and there is, under physiological conditions, no direct transport from the brain tissue to the blood or vice versa. …”
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Binding of Host Factors Influences Internalization and Intracellular Trafficking of Streptococcus uberis in Bovine Mammary Epithelial Cells
Published 2010-01-01“…We showed that internalization of Streptococcus uberis into bovine mammary epithelial cells occurred through receptor- (RME) and caveolae-mediated endocytosis (CME). We reported also that treatment of S. uberis with host proteins including lactoferrin (LF) enhanced its internalization into host cells. …”
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27
Antibody Mediated Transduction of Therapeutic Proteins into Living Cells
Published 2005-01-01“…Current techniques for delivering proteins across cell membranes include taking advantage of receptor-mediated endocytosis or using protein transduction domains that penetrate directly into cells. …”
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28
Imaging Early Steps of Sindbis Virus Infection by Total Internal Reflection Fluorescence Microscopy
Published 2011-01-01“…Moreover, dual color TIRFM of GFP-Rab5 and SINV suggested that the virus was targeted to the early endosomes after endocytosis. These findings demonstrate the utility of quantum dot labeling in studying the early steps and behavior of SINV infection.…”
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29
Galectin-3 Is a Potential Mediator for Atherosclerosis
Published 2020-01-01“…Gal-3 has been demonstrated in recent years to be a novel inflammatory factor participating in the process of intravascular inflammation, lipid endocytosis, macrophage activation, cellular proliferation, monocyte chemotaxis, and cell adhesion. …”
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30
Identification of a guanine nucleotide exchange factor for Arf3, the yeast orthologue of mammalian Arf6.
Published 2007-09-01“…One of the most well characterised of these G proteins is mammalian Arf6, a protein that participates in many cellular processes including endocytosis, actin remodelling and cell adhesion. Exchange of GDP for GTP on Arf6 is performed by a variety of guanine nucleotide exchange factors (GEFs), principally of the cytohesin (PSCD) and EFA6 (PSD) families. …”
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31
Resveratrol-loaded metal-organic framework for mitochondria-targeted amplified CO gas therapy
Published 2025-01-01“…In this work, we provide a facile method to design ROS-responsive and mitochondrial targeting CO-delivery nanoplatform, based on the thiol-functionalized metal-organic framework (MOF), abbreviated as UiO-66-SH, incorporating the drug resveratrol (RES) for combined tumor therapy. After endocytosis by tumor cells and localization within the mitochondria, UiO@FeCO@RES was decomposed by ATP to release RES and generate CO gas via a Fenton-like reaction between hydroxyl radicals (·OH) and FeCO. …”
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32
The intestinal microbiome as a separate organ
Published 2014-12-01“…Interaction of bacteria with the «host» reminds cooperation of usual cells and can be carried out due to receptor binding, paracrine and humoral pathways, as well as due to phagocytosis and endocytosis. Microbes produce hormone-like substances, analogues of growth factors and neurotransmitters that determine two-way interaction of microflora with the central nervous system and its active metabolic role. …”
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Productive Entry Pathways of Human Rhinoviruses
Published 2012-01-01“…At least all A and B type viruses depend on receptor-mediated endocytosis for infection. In HeLa cells, they are internalized mainly by a clathrin- and dynamin-dependent mechanism. …”
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A Systemic Network Triggered by Human Cytomegalovirus Entry
Published 2011-01-01“…The up-regulated network contains various functional modules, such as cell surface receptors, skeletal development, endocytosis, ion transport, and chromatin remodeling. …”
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Traffic Control of Bacteria-Derived Molecules: A New System of Host-Bacterial Crosstalk
Published 2013-01-01“…It is noteworthy that such bacteria-derived molecules are taken into the intestinal epithelia through a transport or endocytosis system, thereafter exhibiting their beneficial effects. …”
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36
BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex
Published 2014-01-01“…There is accumulating evidence that activity-dependent immediate early gene Arc is an activity “sensor,” which acts upstream of Aβ production and triggers AMPA receptor endocytosis to homeostatically downregulate the strength of excitatory synaptic transmission. …”
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Acetylation Modification Improves Immunoregulatory Effect of Polysaccharide from Seeds of Plantago asiatica L.
Published 2018-01-01“…The results showed that Ac-PLCPs with degree of substitution (DS) from 0.06 to 0.1 could not only stimulate the expression of surface molecules major histocompatibility complex class II (MHC II), cluster of differentiation 86 (CD86), and CD80 on DCs (P<0.01) but also increase the secretion of cytokine IL-12p70 (P<0.01). The endocytosis activity of DCs was attenuated by Ac-PLCPs treatment (P<0.01), while the mRNA expressions of chemokine receptors CCR7 and CXCR4 in DCs were significantly increased (P<0.01). …”
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Protein Ubiquitylation in Pancreatic Cancer
Published 2010-01-01“…Indeed, despite its role in promoting protein degradation through the proteasome, ubiquitylation is now known to regulate diverse cellular processes, such as membrane protein endocytosis and intracellular trafficking, assembly of protein complexes, gene transcription, and activation or inactivation of enzymes. …”
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Mechanisms and roles of membrane-anchored ATG8s
Published 2025-01-01“…However, recent studies have identified non-canonical roles for lipidated ATG8 in processes such as LC3-associated phagocytosis (LAP), LC3-associated endocytosis (LANDO), and lipidated ATG8-mediated secretory autophagy. …”
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Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties
Published 2025-01-01“…Intracellular trafficking supports all cell functions maintaining the exchange of material between membrane-bound organelles and the plasma membrane during endocytosis, cargo sorting, and exocytosis/secretion. …”
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