LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

“…In contrast to the finding that TCF1 controls epigenetic and transcriptional reprogramming in tumor-infiltrating stem-like T cells, little is known about the regulation of TCF1. Emerging data show that elevated body mass index is associated with outcomes of immunotherapy. …”
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Analysis of drought and extreme precipitation events in Thailand: trends, climate modeling, and implications for climate change adaptation by José Francisco de Oliveira-Júnior, David Mendes, Helder Dutra Porto, Kelvy Rosalvo Alencar Cardoso, José Augusto Ferreira Neto, Emannuel Bezerra Cavalcante da Silva, Marlúcia de Aquino Pereira, Monica Cristina Damião Mendes, Bernardo Bruno Dias Baracho, Punyawi Jamjareegulgarn

“…In the R4.5 scenario, a meridional pattern emerged in CDD, increasing from east (E) to west (W). …”
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Unfolding insights about resilience and its coping strategies by medical academics and healthcare professionals at their workplaces: a thematic qualitative analysis by Salman Yousuf Guraya, Jacqueline Maria Dias, Mohamed Ahmed Eladl, Ayah Mohammad Rajai Rustom, Fatima Audi Saleem Alalawi, Majid Hassan Saleh Alhammadi, Yusra Ahmed Mohammed Ahmed, Amna Ali Omran Taryam Al Shamsi, Sarah Juman Bilalaga, Alfred Nicholson, Hani Malik, Shaista Salman Guraya

“…Through an inductive thematic analysis, three overarching themes with sub-themes emerged; cognitive mastery (cognitive appraisal and problem-solving abilities), affective well-being (gratification from professional efficacy and social support), and conative efficiency (proactive approaches and introspection and reflection). …”
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Anthropometric measurements as markers of elevated blood pressure among Portuguese children and adolescents by Edmar Mendes, Paulo Farinatti, Alynne Andaki, Susana Vale, Andreia Pizarro, Maria Paula Santos, Clarice Martins, Jorge Mota

“…As indicated by ROC curves, BMI emerged as the most accurate predictor of elevated BP (AUC = 0.584–0.724, p < 0.05). …”
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Estudio psicométrico del cuestionario de intenciones emprendedoras en jóvenes mexicanos - Psychometric study of the entrepreneurial intentions questionnaire in Mexican youth by Ignacio Norambuena, Felipe Quintano, Leonor Riquelme, José Sepúlveda, Cristina Tavera, Selene Pérez, Crisóforo Álvarez, Roque López

“…ABSTRACT: Introduction/Objective: entrepreneurship has emerged as a key driver for personal growth and economic development across various fields. …”
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uN2CpolyG-mediated p65 nuclear sequestration suppresses the NF-κB-NLRP3 pathway in neuronal intranuclear inclusion disease by Yu Shen, Kaiyan Jiang, Dandan Tan, Min Zhu, Yusen Qiu, Pencheng Huang, Wenquan Zou, Jianwen Deng, Zhaoxia Wang, Ying Xiong, Daojun Hong

“…Abstract Background Neuronal intranuclear inclusion disease (NIID) is genetically linked to CGG repeat expansion in the 5’-untranslated region of the NOTCH2NLC gene, with nascent polyglycine-containing protein (uN2CpolyG) identified as a primary pathogenic factor. Emerging clinical evidence suggests that inflammation contributes to NIID pathogenesis, yet the underlying molecular mechanisms remain elusive. …”
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Risk factors for the delayed discharge from anesthesia intensive care unit: a single-center retrospective study by Yue Qian, Jing Hao, Wei Zhu, Yan Yang, Zhuan-yun Zhang, Lu-yang Zhou, Xiao-ping Gu, Zheng-liang Ma, Yu-e Sun

“…Binary multivariate logistic regression analysis showed that younger than 18 years or older than 64 years, the American Society of Anesthesiologists physical status of class III-IV, body mass index of less than 18 kg/m2 or greater than 25 kg/m2, preoperative complications, emergency surgeries and intraoperative massive hemorrhage were risk factors for the delayed discharge from an AICU. …”
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Post-vaccination campaign evaluation of systemic and mucosal immunity of trivalent oral poliovirus vaccine in Karachi, Pakistan (2020–2021): a cross-sectional studyResearch in cont... by Ali Faisal Saleem, Visalakshi Jeyaseelan, Zaubina Kazi, Mahjabeen Zehra, Muhammad Masroor Alam, Grace Macklin, Rocio Lopez Cavestany, Sajid Muhammad, Najeeb Rehman, Ondrej Mach

“…Summary: Background: The transmission of wild poliovirus (WPV1) and circulating vaccine-derived poliovirus (cVDPV) continues to be a major Public Health Emergency of International Concern. Currently, only Afghanistan and Pakistan remain polio-endemic for WPV1. …”
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One-step diagnosis of infection and lung cancer using metagenomic sequencing by Shaoqiang Li, Yangqing Zhan, Yan Wang, Weilong Li, Xidong Wang, Haoru Wang, Wenjun Sun, Xuefang Cao, Zhengtu Li, Feng Ye

“…Abstract Background Traditional detection methods face challenges in meeting the diverse clinical needs for diagnosing both lung cancer and infections within a single test. Onco-mNGS has emerged as a promising solution capable of accurately identifying infectious pathogens and tumors simultaneously. …”
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Assessing the comparative effectiveness of ECHO and coaching implementation strategies in a jail/provider MOUD implementation trial by Todd Molfenter, Jessica Vechinski, Jee-Seon Kim, Jingru Zhang, Lionel Meng, Jessica Tveit, Lynn Madden, Faye S. Taxman

“…Conclusions Coaching emerged as a more effective implementation strategy than ECHO for increasing buprenorphine use in jail settings. …”
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Presenting a Multi-objective Mathematical Model for Smart Grids Considering Load Response Programs by Mohammad Hossein Tahari-Mehrjardi, Aliyeh Kazemi, Hamed Shakouri Ganjavi

“…In response to these challenges, smart grids have emerged and offer several advantages. Effective management of electricity demand is critical in the context of smart grids, and the implementation of demand-response techniques plays an instrumental role in achieving this objective. …”
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Exploring the Impact of Homophily Attitude, Physical, and Social Attractiveness on Purchase Intentions by Honya Ghasemi, Ramin Bashir Khodaparasti, Hooshmand Bagheri Garbollagh

“…Given the omnipresence of smartphones today and customers' responsiveness to new technologies, there is an increasing focus on studying consumer behavior towards emerging technologies. Augmented reality has appeared as a new technology available to retailers for customer interaction. …”
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Using the WHO building blocks to examine cross-border public health surveillance in MENA by Laura Buback, Shayanne Martin, Esbeydy Pardo, Farah Massoud, Jesus Formigo, Atousa Bonyani, Noha H. Farag, Zayid K. Almayahi, Kenta Ishii, Susie Welty, Dana Schneider

“…Abstract The introduction of the Sustainable Development Goals by the United Nations has set a global target for achieving Universal Health Coverage, requiring resilient health systems capable of addressing public health emergencies and ensuring health security. Public health surveillance, crucial for detecting and responding to infectious disease outbreaks, is key to building health system resilience. …”
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Incident prescriptions for common cardiovascular medications: comparison of recent versus pre-2020 medication adherence and discontinuation in three universal health care systems by Candace D. McNaughton, Peter C. Austin, Cynthia A. Jackevicius, Anna Chu, Jessalyn K. Holodinsky, Michael D. Hill, Colleen M. Norris, Mukesh Kumar, Noreen Kamal, Douglas S. Lee, Nadia Khan, Manav V. Vyas, Raed A. Joundi, Moira K. Kapral, Amy Y. X. Yu

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Optimizing Obstructive Sleep Apnea Risk Assessment in Hypertension: Development of a Predictive Nomogram in China by Yang Y, Sun X, Liang J, Liao WF, Ye W, Zheng Z, Du L, Chen M, Zhang Y, Lin W, Huang J, Yao W, Chen R

“…Yitian Yang,1,&ast; Xishi Sun,2,&ast; Jinhua Liang,1,&ast; Wei Feng Liao,1,&ast; Weilong Ye,1 Zhenzhen Zheng,1 Lianfang Du,1 Mingdi Chen,1 Yuan Zhang,3 Wenjia Lin,2 Jinyu Huang,2 Weimin Yao,1 Riken Chen1,4 1The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524003, People’s Republic of China; 2Emergency Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 3The First Clinical School of Medicine, Guangdong Medical University, Zhanjiang, Guangdong, 524003, People’s Republic of China; 4State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Riken Chen; Weimin Yao, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524003, People’s Republic of China, Tel +13560244631 ; +13822521722, Email chenriken@126.com; 490296443@qq.comPurpose: Obstructive sleep apnea (OSA) is common in patients with hypertension. …”
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Toxicity of Low-dose Graphene Oxide Nanoparticles in an in-vivo Wild Type of Caenorhabditis elegans Model by Ming-Hsien Tsai, How-Ran Chao, Jheng-Jie Jiang, Yu-Hsieh Su, Mariene-syne P. Cortez, Lemmuel L. Tayo, I-Cheng Lu, Hao Hsieh, Chih-Chung Lin, Sheng-Lun Lin, Wan Nurdiyana Wan Mansor, Ching-Kai Su, Sen-Ting Huang, Wen-Li Hsu

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Overlying strata movement law and rockburst prevention & control for fully mechanized top coal caving face in extra-thick coal seams by Hai Rong, Longyue He, Yadi Wang, Xiangzhi Wei, Shilong Wei, Suihan Yang, Jincheng Li, Linlin Chen

“…When the working face advances 20–30 m, a distinct pressure accumulation area emerges in the middle of the working face and is regularly distributed as the working face advances. …”
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Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…HMGB1, particularly platelet-derived HMGB1, emerges as a key mediator to this process. Therefore, targeting NETosis through modulation of HMGB1 presents a promising multipotent therapeutic strategy for mitigating ischemic brain damage.…”
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Positional embeddings and zero-shot learning using BERT for molecular-property prediction by Medard Edmund Mswahili, JunHa Hwang, Jagath C. Rajapakse, Kyuri Jo, Young-Seob Jeong

“…Integrating position information within transformer architectures has emerged as a promising approach. This encoding mechanism provides essential supervision for modeling dependencies among elements situated at different positions within a given sequence. …”
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The impact of energy drinks on health of children and young adults - review of latest research by Klaudia Kożuchowska, Dawid Pilarz, Marcelina Szewczyk, Maria Morawska, Aleksandra Tomczyk, Julia Ufnal, Dominika Lewandowska, Dominika Rosińska-Lewandoska, Klaudia Drewko, Kinga Jarosz

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