Cost-Effectiveness of the CNIC-Polypill Strategy Compared With Separate Monocomponents in Secondary Prevention of Cardiovascular and Cerebrovascular Disease in Portugal: The MERCUR... by Carlos Aguiar, Francisco Araujo, Gabriel Rubio-Mercade, David Carcedo, Silvia Paz, Jose María Castellano, Valentín Fuster

“…The incremental cost of the CNIC-Polypill strategy emerges slightly above the comparator, but willingness-to-pay estimates and sensitivity analyses indicate that the CNIC-Polypill strategy is consistently cost-effective compared with monocomponents and remains within acceptable affordability margins. …”
Get full text

Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis by Xiaoxue Wang, Longhao Cheng, Aijun Liu, Lihong Liu, Lili Gong, Guolin Shen

“…Notably, a panel of circulating plasma metabolite biomarkers, including lactic acid and leucine, has emerged not only as diagnostic indicators but also as valuable tools for tumor surveillance, aiding in the assessment of disease stage and prognostic evaluation. …”
Get full text

Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…Further, %inhibition of platelet aggregation from AT-10 treatment in poor metaboliser group was significantly higher than the clopidogrel treatments in extensive metaboliser group.Overall pharmacokinetic comparison in all subjects indicates that AT-10 gives greater exposure to active Metabolite H4 than clopidogrel.Conclusion AT-10 showed better inhibition of platelet aggregation in poor metabolizers as compared to Clopidogrel. AT-10 may emerge as a potential alternative to Clopidogrel as an anti-platelet drug. …”
Get full text

Using a Two-Steps Clustering and PCA Analysis for Stratified Chronic Non-Cancer Pain Care: A Retrospective Cross-Sectional Study by Peiró AM, Barrachina J, Escorial M, Aguado I, Margarit C, Grimby-Ekman A

“…A clustering analysis was performed according to: 1) pain intensity and relief; 2) quality of life; 3) number of adverse events; and 4) emergency department visits. A retrospective study was developed (n = 120) following the stratified analysis.Results: From a principal component analysis, cut-off points were defined to discriminate between the six clusters and three groups of different pain intervention requirements. …”
Get full text

Matching-Adjusted Indirect Comparison of the Efficacy and Safety of Erdafitinib vs Enfortumab Vedotin in Patients with Locally Advanced Metastatic Urothelial Carcinoma by Suzy Van Sanden, Ayman Youssef, Simona Baculea, Keith Stubbs, Spyros Triantos, Zijiao Yuan, Caitlin Daly

“…For safety, MAIC-yielded risk ratios of 1.09 (0.99, 1.21) for any treatment-related adverse events, 0.86 (0.57, 1.28) for grade 3+ TRAEs, and 1.02 (0.98, 1.06) for any treatment-emergent adverse events. **Conclusion:** The MAIC indicates comparable efficacy of erdafitinib vs EV for overall survival and progression-free survival, with erdafitinib showing a higher probability of achieving deep responses. …”
Get full text

Nonlinear relationship between hepatic steatosis index and reversion to normal glucose regulation in Chinese adults with prediabetes by Haiyong Zeng, Fei Yu, Haofei Hu, Yong Han, Ruixue Ye, Changchun Cao

Get full text

New method for cytological evaluation using direct nipple discharge without aspiration by Jiang Zhu, Han Cong, Xiaotong Zhang, Xiaoya Dong, Song Zhao, Chaolu Hu, Jude Ranchu Maimo, Yawen Wang, Kai Zhang, Jianli Wang, Pengyu Li, Rong Ma

Get full text

KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA by Xiaowei Lu, Kui Hu, Dandan Zhang, Xuefeng Yin, Jifeng Nie, Kai Zhao

Get full text

Flexible Dual Fe-based Catalyst: MIL-53(Fe) Loaded with Deep Eutectic Solvent for Discontinuous Selective Oxidation of H2S by Fengke Wang, Chaofan Li, Weizhen Kong, Shucan Qin, Qianqian Peng, Lihua Zang, Yunqian Ma, Yi Nie, Guihuan Yan

Get full text

Neonatal Bacterial Meningitis: Single Reference Center Experience and Review of Current Literature: A Retrospective Cohort Study by Alper Aykanat, Hasan Tolga Celik, Gulsen Hazirolan, Sule Yigit, Murat Yurdakok

“… OBJECTIVE: Despite improvements in neonatal care, neonatal bacterial meningitis is still an emerging problem worldwide with high rates of mortality. …”
Get full text

Communicating with Deaf Patients in the Clinical Environment through Deaf-Hearing Teams: Lessons Learned from a Virtual Patient Panel [version 2; peer review: 2 approved] by Dimitrios Papanagnou, Natalie P. Snyder, Rosemary Frasso, Benedicta O. Olonilua, Julia Croce

Get full text

IL-6–174 G/C transversion might decrease male infertility risk: A case-control study by Tayyebeh Zamani-Badi, Mohammad Karimian, Javad Amini Mahabadi, Atieh Rafatmanesh, Hossein Nikzad

“…Among the many genes related to male reproductive function, interleukin 6 (IL-6) has emerged as a key player. Despite the growing recognition of genetic factors in male infertility, the specific association between the IL-6–174 G/C genetic polymorphism and male infertility remains an area that needs further investigation. …”
Get full text

Acceptability of telemedicine for early surgical site infection diagnosis after cesarean delivery in rural Rwanda: a qualitative study by Laban Bikorimana, Eve Hiyori Estrada, Anne Niyigena, Robert Riviello, Fredrick Kateera, Bethany Hedt-Gauthier, Vincent K. Cubaka

“…Women and CHWs reported perceived faster healing associated with the intervention, enhanced access to postoperative care from home, and cost savings as notable benefits of the telemedicine program. Trust in CHWs emerged as a critical factor for community acceptance. …”
Get full text

Validation and assessment of the arabic psychological first aid scale among physicians, nurses, and counselors in Jordan by Basma Eid Alshareef, Othman A. Alfuqaha, Ibraheem B. Maali, Khaled Amer

“…The results highlight the emergent need to provide knowledge, skills, and attitudes of PFA interventions among medical professionals, particularly for physicians and nurses. …”
Get full text

Sustainable pectin extraction from Riang husk using ultrasound-assisted extraction with deep eutectic solvents and its potential in antipollution products by Manee Saelee, Hla Myo, Nuntawat Khat-udomkiri

“…., commonly known as Riang, has emerged as a promising source for developing antipollution products due to its characteristics. …”
Get full text

Do the Street Sweeping and Washing Work for Reducing the Near-ground Levels of Fine Particulate Matter and Related Pollutants? by Sheng-Lun Lin, Yunzhou Deng, Ming-Yeng Lin, Shih-Wei Huang

Get full text

Healthcare Resource Utilization and Cost Comparisons of High-Protein Enteral Nutrition Formulas Used in Critically Ill Patients by Matthew C. Bozeman, Laura L. Schott, Amarsinh M. Desai, Mary K. Miranowski, Dorothy L. Baumer, Cynthia C. Lowen, Zhun Cao, Krysmaru Araujo Torres

“…Among the enteral nutrition products studied, IP emerged as the most cost-saving option, with lower adjusted hospital cost per day than PC or StdHP. …”
Get full text

Supply chain performance in the age of Industry 4.0 by Tahsina Khan, Md Mehedi Hasan Emon

“…Social implications: By highlighting the benefits of digital supply chain integration, the study contributes to broader societal goals of economic development and industrial competitiveness in emerging markets. Originality/value: This study is among the first to empirically examine the impact of Industry 4.0 adoption on supply chain performance in Bangladesh, providing valuable insights for both practitioners and researchers. …”
Get full text

Point-of-care lung ultrasound in detecting pneumonia: A systematic review by Iqra Abid, Nadia Qureshi, Nicola Lategan, Simon Williams, Sidra Shahid

“…Since it overcomes most of the limitations of CXR and other diagnostic modalities, it can be utilized as a diagnostic tool for pneumonia for all age groups as it is a safe, readily available, and cost-effective modality that can be utilized in an emergency department, intensive care units, wards, and clinics by trained respiratory care professionals.…”
Get full text

Healthcare Resource Utilization and Costs Among Patients With Gastroesophageal Reflux Disease, Barrett’s Esophagus, and Barrett’s Esophagus-Related Neoplasia in the United States... by Prateek Sharma, Gary W. Falk, Menaka Bhor, A. Burak Ozbay, Dominick Latremouille-Viau, Annie Guerin, Sherry Shi, Margaret M. Elvekrog, Paul Limburg

“…Disease-related annual mean number of inpatient admissions, office visits, and emergency department visits by cohort were 0.09, 1.45, and 0.19 for GERD; 0.08, 1.55, and 0.10 for NDBE; 0.10, 1.92, and 0.13 for IND; 0.09, 2.05, and 0.10 for LGD; 0.12, 2.16, and 0.14 for HGD; and 1.43, 6.27, and 0.87 for EAC. …”
Get full text