Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle by Vishnu Kumarasamy, Jianxin Wang, Michelle Roti, Yin Wan, Adam P. Dommer, Hanna Rosenheck, Sivasankar Putta, Alec Trub, John Bisi, Jay Strum, Patrick Roberts, Seth M. Rubin, Costakis Frangou, Karen McLean, Agnieszka K. Witkiewicz, Erik S. Knudsen

“…Abstract Cyclin dependent kinase 2 (CDK2) regulates cell cycle and is an emerging target for cancer therapy. There are relatively small numbers of tumor models that exhibit strong dependence on CDK2 and undergo G1 cell cycle arrest following CDK2 inhibition. …”
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Drivers in the conservation of urban green space depletion: A case study of Wa Municipality, Ghana by Sabastian Batasuma, Wei Cao, Nathan Awelama Atigah, Emefa Acorlor Garnet, Joshua Kojo Bonzo, Justice Gyimah

“…In rapidly developing regions, especially in emerging economies like Ghana, the decline of greenery is an urgent concern. …”
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Comprehensive Analysis of Word Embedding Models and Design of Effective Feature Vector for Classification of Amazon Product Reviews by B. Priya Kamath, M. Geetha, U. Dinesh Acharya, Dipesh Singh, Ayush Rao, Shwetha Rai, Roopashri Shetty

“…Sentiment Analysis (SA) is a well-known and emerging research field in the area of Natural Language Processing (NLP) and text classification. …”
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Occurrence of macrolides resistance in Legionella pneumophila ST188: Results of the Belgian epidemiology and resistome investigation of clinical isolates by Charlotte Michel, Fedoua Echahidi, Geraldine De Muylder, Max Sewell, Ian Boostrom, Olivier Denis, Owen B. Spiller, Denis Pierard

“…Although Legionella pneumophila is known as pathogenic, systematic investigations into antibiotic resistance are scarce, and reports of resistance in isolates are recently emerging. Methods: Clinical cases and metadata reported to the Belgian National Reference Centre between 2011 and 2022 were retrospectively analyzed. …”
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Design Optimization of a 3-PUU Parallel Machine for Friction Stir Welding Robots by Eka Marliana, Latifah Nurahmi, Arif Wahjudi, I. Made Londen Batan, Guowu Wei

“…Friction Stir Welding (FSW) has recently emerged as an effective solid-state joining technique for welding high-strength aluminum alloys and light metals, particularly in the railway industry. …”
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Systematic literature review on the theory of Social Embeddedness of Thriving at Work by Listya Istiningtyas, Debora E. Purba, Elizabeth K. Poerwandari, Bagus Takwin, Mirra N. Milla

“…Motivation for the study: The findings guide future research to refine the SEMTW model and address emerging challenges in the modern work environment. …”
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UAV With the Ability to Control with Sign Language and Hand by Image Processing by Hediyeh Hojaji, Alireza Delisnav, Mohammad Hossein Ghafouri Moghaddam, Fariba Ghorbani, Shadi Shafaghi, Masoud Shafaghi

“…These findings underscore the potential of AI-driven drones to engage in natural conversational interactions with humans, thereby providing vital information to assist decision-making processes during emergencies. In conclusion, our approach promises to revolutionize the efficacy of rescue operations by facilitating rapid and accurate communication of critical information to rescue teams. …”
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Leveraging an Enhanced CodeBERT-Based Model for Multiclass Software Defect Prediction via Defect Classification by Rida Ghafoor Hussain, Kin-Choong Yow, Marco Gori

“…Automated testing has emerged as the most practical approach to achieving bug-free and efficient code. …”
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The Impact of Nurses' Disaster Preparedness Competencies on Public Health Center Resilience in Disaster-Prone Areas: A cross-sectional study by Moh Ikram Dg Sirua, Balqis Balqis, Muhammad Alwy Arifin, Indar Indar, Syamsuar Manyullei

“… Background: Disaster-prone areas need resilient health centers to ensure effective health management services and emergency response during earthquakes and tsunamis. …”
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Identification and Quantification of Emission Hotspots of Air Pollutants over Bhubaneswar: A Smart City in Eastern India by Saroj Kumar Sahu, Pallavi Sahoo, Poonam Mangaraj, Gufran Beig, Bhishma Tyagi, Basanta Samal, Ashirbad Mishra, Ravi Yadav

“…Windblown road dust, transport sector, and residential cooking activities emerged as the dominating sources. Emissions of CO, NOx, SO2, VOC, PM2.5, PM10, BC, and OC are estimated to be 112 Gg yr−1, 44 Gg yr−1, 11 Gg yr−1, 73 Gg yr−1, 9 Gg yr−1, 17 Gg yr−1, 5 Gg yr−1 and 0.8 Gg yr−1 respectively. …”
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Topical steroids as alternative to systemic hormonal treatment for inflammatory bowel diseases in pediatric practice by E. N. Fedulova, O. V. Shumilova, O. V. Fedorova, O. A. Tutina, G. V. Medyantseva

“…Etiopathogenesis of IBD represents the cascade of self-maintaining pathophysiological reactions: adaptive microcirculational, hypoxicmetabolic, autoimmune inflammatory and dysbiotic disorders emerging on a background of genetic features of the body under the effect of unfavorable environmental factors. …”
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REPAIR OF SCIATIC NERVE LESION AUGMENTED WITH AMNION MEMBRANE COMPOSITE AND MESENCHYMAL STEM CELL by Heri Suroto, R. Taufan Mulyo Wibisono

“…The patient underwent emergency surgery to repair the right Femoral artery and the Sciatic nerve. …”
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Research trends and hotspots in post-stroke speech rehabilitation: A bibliometric analysis by Nan Huang, Kang Zou, Fang Liu, Zhen Su, Long Chen, Yanbiao Zhong, Yun Luo, Maoyuan Wang, Li Xiao

“…Key trends included “communication disorders,” “functional connectivity,” and “melodic intonation therapy,” with “stroke” and “aphasia” emerging as central keywords. Conclusion: Research in post-stroke speech rehabilitation is increasing, with significant contributions from the United States and key institutions. …”
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Randomised feasibility study of an intestinal adsorbent in acute diarrhoea in The Gambia by Elena Markaryan, Matthew Dodd, Stephen Allen, Carol Howell, Angela Allen, Paul Rahden, Abdoulie Fatty, Momodou Lamin Jobarteh, Abdoulwahab Sallah, Ebrahim Jaiteh, Doreen Umoh, Fanta Bass, Radovan Hnatič

“…An intestinal adsorbent may reduce diarrhoea duration and severity.Methods Randomised controlled feasibility trial with two phases: phase 1 (0–4 hours and double-blind) and phase 2 (up to 5 days and open-label). 50 children aged 6–59 months with acute diarrhoea presenting with no or some dehydration to the emergency paediatric unit and outpatient clinic at Edward Francis Small Teaching Hospital, Banjul, The Gambia were randomised to either standard treatment (oral rehydration fluid and zinc) or standard treatment with polymethylsiloxane polyhydrate for up to 5 days.Results Recruitment was completed in 7 months. …”
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DockCADD: A streamlined in silico pipeline for the identification of potent ribosomal S6 Kinase 2 (RSK2) inhibitors by El Mehdi Karim, Meriem Khedraoui, Abdelkbir Errougui, Yasir S. Raouf, Abdelouahid Samadi, Samir Chtita

“…Ribosomal S6 Kinase 2 (RSK2), a serine/threonine kinase, has emerged as a promising target for cancer therapy because it is implicated in oncogenic signaling. …”
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Evaluation of the quality of standing trees using an Arbotom acoustic stress tomograph by Michajlová Katarína, Gejdoš Miloš, Gergeľ Tomáš, Gretsch Dominik

“…Acoustic equipment utilizing excited stress acoustic waves has emerged as a valuable tool for evaluating the internal structure of standing trees. …”
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Online Banking and Business Sustainability of SACCOs in Rubanda Town Council Rubanda District. by Biira, Emily

“…The study findings on the contributions of automated teller machines on business sustainability of SACCOs in Rubanda Town Council were; convenient deposit options, employee salary disbursement, flexibility in fund transfer, improved cash flow management, and easy emergency access to funds. The study recommended that SACCOs should regularly update and upgrade the online platform to enhance accessibility, incorporate new features, and adapt to changing technological trends to enhance the business sustainability of SACCOs and SACCOs should offer responsive customer support channels, including chat, phone, or email, to assist members with any queries or concerns related to online banking because this can contribute to their confidence and satisfaction with the service.…”
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Information and Communication Technology Application and the Provision of Reference Services in Selected University Libraries in Western Uganda. by Nabukenya, Judith

“…Inadequate power supply is the most significant challenge, reported by 71% (37 respondents).The study recommended that, given less used platforms like Myspace, web forms and RSS libraries should focus on providing continuous training and support for these and other emerging ICT platforms. Keywords: Information and Communication Technology, Reference services, Universities, Western Uganda, ICT platforms, ICT services.…”
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Assessing the Effect of Saturation Variations on the Factor of Safety of Slopes in Elgon Sub-Region. by Muboki, Peterson

“…This underscores the importance of considering saturation variations when evaluating slope stability. The findings also emerge from direct shear tests, which highlight potential weaknesses at specific depths likely attributable to the interplay between saturation and soil properties. …”
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Comparison of Concrete Strength Development Using Different Brands of Cement of N32.5 in Uganda . by Beinamani, Edidia

“…On the other hand, offered a compelling balance of cost and strength, emerging as the most cost-effective option for general construction needs. …”
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