CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation by Donghua Cai, Chuling Li, Yingyuan Zhang, Sisi He, Yihai Guo, Wangjun Liao, Yulin Liao, Jianping Bin, Xiang He

“…Conclusions CircHipk3 serves a dual role in augmenting macrophage pyroptosis by interaction with Stat3, increase the NLRP3 level, and by binding Snd1 to promote Ptbp1 mRNA degradation to inhibit autophagy, thereby inducing aneurysm formation and progression. …”
Get full text

Angel or devil: the dual roles of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in the development of liver injury based on integrating pharmacological techniques: a systematic review by Jiajie Jiang, Jiajie Jiang, Qixiu Wang, Qiang Wu, Bobin Deng, Cui Guo, Jie Chen, Jinhao Zeng, Yaoguang Guo, Xiao Ma

Get full text

Probing the Dual Role of Ca²⁺ in the <i>Allochromatium tepidum</i> LH1–RC Complex by Constructing and Analyzing Ca²⁺-Bound and Ca²⁺-Free LH1 Complexes by Mei-Juan Zou, Shuai Sun, Guang-Lei Wang, Yi-Hao Yan, Wei Ji, Zheng-Yu Wang-Otomo, Michael T. Madigan, Long-Jiang Yu

Get full text

Praxéologie du droit de la copropriété au Maroc : Radiographie ethno-méthodologique d’une résidence à Tanger by Stéphane Gignoux

“…This contribution; based on our dual role of trustee and researcher in the city of Tangiers; proposes a questioning on the relationship between law and regulation in Moroccan context of co-ownership. …”
Get full text

An Anti-Racist reading of the notion of 'fundamental British values' by Ümit Yıldız

“…The compulsory promotion of the notion of ‘fundamental British values (FBVs)’ is a mechanism within this production line. ‘FBVs’ play a dual role, firstly as a tool to identify the signs of ‘radicalisation’ and ‘extremism’ amongst young, predominantly Muslim people. …”
Get full text

Translocality, Remittances, and Food Security in the Ghana-Qatar Migration Corridor by Bernard Owusu, Jonathan Crush

“…The study underscores the dual role of remittances in supporting household food security while imposing financial constraints on migrants and calls for policies that address the needs of both remitters and recipients. …”
Get full text

Neutrophils in Tuberculosis: Heterogeneity Shapes the Way? by Irina V. Lyadova

“…Accordingly, during M. tuberculosis infection, they play a dual role. Particularly, they contribute to the generation of effector T cells, participate in the formation of granuloma, and are directly involved in tissue necrosis, destruction, and infection dissemination. …”
Get full text

Researching as a Commoner: Affect and the Lives of Underprivileged Mobile Youth in Greece by Stelios Pantazidis, Yannis Pechtelidis

“…Using qualitative ethnographic methods, the research investigates the role of convivial spaces and the ambiance of the commons in creating meaningful connections and emotional resilience, enabling the participants to articulate aspirations and reclaim agency. The dual role of the researcher as an advocate and observer raised questions about representation and power dynamics. …”
Get full text

The Redox System in C. elegans, a Phylogenetic Approach by Andrew D. Johnston, Paul R. Ebert

“…The “Redox Hypothesis" has been proposed to emphasize a dual role of ROS. This hypothesis suggests that the primary effect of changes to the redox state is modified cellular signalling rather than simply oxidative damage. …”
Get full text

From hypoxic pockets to daily routines: linking brain oxygenation and cognitive resilience by Dian Jiao

“…The discovery of hypoxic pockets within the cortical regions has transformed the understanding of cerebral oxygen dynamics, revealing their dual role as both contributors to neuronal adaptation and potential precursors to dysfunction. …”
Get full text

Memes and Their Role in the 2019 Romanian Presidential Elections: An Exploratory Analysis by Andreea Stancea, Iulia Călin, Cecilia Ciocîrlan

“…Focusing on memes related to candidates Klaus Iohannis and Viorica Dãncilã, the article highlights the dual role of memes: as entertainment and as tools for framing political narratives in a biased manner. …”
Get full text

Lessons from Cancer Immunoediting in Cutaneous Melanoma by Mariana Aris, María Marcela Barrio, José Mordoh

“…We will revisit the dual role of the immune system in controlling and enabling tumor progression, known as cancer immunoediting. …”
Get full text

Understanding game data work by Heikki Tyni, Olli Sotamaa, Taina Myöhänen

“…Complicating the previous game studio hierarchy is the data analyst's dual role as both a subservient support function and a central broker of data. …”
Get full text

Les interventions japonaises au jardin Albert-Kahn dans la deuxième moitié du xxe siècle : vitrine et laboratoire de nouvelles conceptions du jardin japonais by Hiromi Matsugi

“…This approach seeks to highlight the diversity of views regarding what a Japanese garden should be and the dual role played by the garden as both a test ground and a showcase for these ideas. …”
Get full text

Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription Complex by Nikolay L. Manuylov, Sergei G. Tevosian

“…., myocardial, endocardial, or epicardial cells) remains to be understood. Although a dual role (both as an activator and a repressor) for the GATA4-FOG2 transcriptional complex has been put forward, the specific genes under GATA4-FOG2 control in the developing heart have remained largely elusive. …”
Get full text

The Challenges of Conducting a Nurse-Led Intervention in a Randomized Controlled Trial with Vulnerable Participants by Tanya Park, Kim Usher, Kim Foster

“…These included managing the need of participants to tell their story and be heard, reluctance of participants to remain in allocated groups, participant literacy, dual role of the nurse nurse-researcher, and reporting the benefits of nonstatistical results of a quantitative research project. …”
Get full text

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy by Naths Grazia Sukubo, Paolo Bigini, Annalisa Morelli

“…In this review, we will explore the dual role of macrophages in NC delivery, highlighting their physiological functions, the challenges posed by the mononuclear phagocyte system, and innovative strategies to exploit macrophage interactions for therapeutic advantage. …”
Get full text

PPARs in Alveolar Macrophage Biology by Monica R. Smith, Theodore J. Standiford, Raju C. Reddy

“…In this review, we describe the dual role of the alveolar macrophage as both a first-line defender through its phagocytotic activity and a regulator of the immune response. …”
Get full text

cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values by Danyang Zhang, Bingxue Zhang

“…The cGAS/STING signaling pathway, a pivotal mechanism in innate immunity, detects cytosolic DNA from pathogens or cellular damage, triggering immune responses via type I interferons and inflammatory cytokines. This pathway’s dual role in gynecological cancers, either promoting antitumor immunity or facilitating tumor immune evasion, makes it a compelling target for innovative therapies. …”
Get full text

Microbial diversity and food safety in duck meat preservation: effects of nanoemulsion nutmeg seed extract with focus on proteobacteria and lactococcus by Supamri Supamri, Lilik Eka Radiati, Agus Susilo

“…Amplicon analysis of 16S rRNA revealed NEp5’s dual role in suppressing harmful Proteobacteria (e.g. …”
Get full text