Drug discovery: a multifactorial ecosystem by Fernando Albericio

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RNA Editing and Drug Discovery for Cancer Therapy by Wei-Hsuan Huang, Chao-Neng Tseng, Jen-Yang Tang, Cheng-Hong Yang, Shih-Shin Liang, Hsueh-Wei Chang

“…Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. …”
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A guide for active learning in synergistic drug discovery by Shuhui Wang, Alexandre Allauzen, Philippe Nghe, Vaitea Opuu

“…Abstract Synergistic drug combination screening is a promising strategy in drug discovery, but it involves navigating a costly and complex search space. …”
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New strategies to enhance the efficiency and precision of drug discovery by Qi An, Liang Huang, Chuan Wang, Dongmei Wang, Yalan Tu

Subjects: “…drug discovery…”
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Super-resolution microscopy as a drug discovery tool by Lauren Toms, Lorna FitzPatrick, Philip Auckland

“…Now, after nearly two decades, super-resolution microscopy has begun to address previously unmet challenges in the study of human disease and is poised to become a pivotal tool in drug discovery.…”
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Linking machine learning and biophysical structural features in drug discovery by Armin Ahmadi, Shivangi Gupta, Vineetha Menon, Jerome Baudry

Subjects: “…drug discovery…”
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Unleashing the Power of Artificial Intelligence-Driven Drug Discovery in Streptomyces by Wei-Shan Ang, Jodi Woan-Fei Law, Yatinesh Kumari, Vengadesh Letchumanan, Loh Teng-Hern Tan

“…Graphical abstract: The role of machine learning in drug discovery from Streptomyces. …”
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Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery by Leonel Pereira, Ana Valado

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Malaysia’s Breakthrough in Modern Actinobacteria (MOD-ACTINO) Drug Discovery Research by Angel Yun-Kuan Thye, Vengadesh Letchumanan, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Learn-Han Lee

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Caution when using network partners for target identification in drug discovery by Dandan Tan, Yiheng Chen, Yann Ilboudo, Kevin Y.H. Liang, Guillaume Butler-Laporte, J. Brent Richards

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Novel 4-aminoquinazoline derivatives as new leads for anticancer drug discovery by Ghorab Mostafa M., Alsaid Mansour S.

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Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach by Amir Taherkhani, Parita Khodadadi, Lida Samie, Zahra Azadian, Zeynab Bayat

“…Methods. A computational drug discovery approach was performed using the AutoDock tool to identify potential MAPK3 inhibitors from 46 plant-based flavonoids. …”
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3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment by Aida Rodriguez-Garcia, Jacqueline Oliva-Ramirez, Claudia Bautista-Flores, Samira Hosseini

“…Organ-on-chip devices, including in vitro modelling of 3D organoids, 3D microfabrication, and 3D bioprinted platforms, play an essential role in drug discovery, testing, and assessment. In this article, a thorough review is provided of the latest advancements in the area of organ-on-chip devices targeting liver, kidney, lung, gut, heart, skin, and brain mimicry devices for drug discovery, development, and/or assessment. …”
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Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…Abstract Background Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activity of drugs as well as to the genomic effects of drugs in multiple disease contexts. …”
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Exploring Fragment Adding Strategies to Enhance Molecule Pretraining in AI-Driven Drug Discovery by Zhaoxu Meng, Cheng Chen, Xuan Zhang, Wei Zhao, Xuefeng Cui

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Implementing enclosed sterile integrated robotic platforms to improve cell-based screening for drug discovery by Alice Rockliffe, Lauren Wheeler, Kiran Lidhar, Arun Dhar, Michelle Pemberton, Richard Kasprowicz, Ceridwen Hopely, Jo Francis, Shane Marine, David Brierley, Lorna Suckling

“…We offer perspective on the advantages of such custom integrated systems and their limitations in cellular screening for early drug discovery.…”
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Peroxisome Proliferator-Activated Receptor δ: A Target with a Broad Therapeutic Potential for Drug Discovery by Francine M. Gregoire

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Miniaturization and characterization of patient derived hepatocellular carcinoma tumor organoid cultures for cancer drug discovery applications by David A. Close, Paul A. Johnston

“…The ability to efficiently generate, expand, and biobank PDTOs has the potential to make the clinical diversity of cancer accessible for personalized medicine assay guided therapeutic drug selection and drug discovery. We describe the miniaturization and growth in 96- and 384-well formats of a single non-tumor liver and two Hepatocellular carcinoma (HCC) organoids derived from cryopreserved PDTO cells and the application of high content imaging (HCI) to characterize the models and enhance drug sensitivity testing. …”
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Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

“…Targeting more variable allosteric sites, which are spatially different from the highly conserved orthosteric sites, represents a novel approach in biased GPCR drug discovery, leading to innovative strategies for targeting GPCRs. …”
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Enhancing drug discovery and patient care through advanced analytics with the power of NLP and machine learning in pharmaceutical data interpretation by Nagalakshmi R, Surbhi Bhatia Khan, Ananthoju Vijay kumar, Mahesh T R, Mohammad Alojail, Saurabh Raj Sangwan, Mo Saraee

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