Ethnopharmacology of Psychotria: Potential Use of P. malayana Jack Leaves as Antidiabetic Agent by Sharifah Nurul Akilah Syed Mohamad, Alfi Khatib, Siti Zaiton Mat Soád, Qamar Uddin Ahmed, Zalikha Ibrahim

“…The review discusses the pharmacologically active compounds unique to these species, which are of considerable interest for drug development in diabetes treatment. A summary of these studies and their implications is presented. …”
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A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation by Jyotirmoy Sarker, Pritha Das, Sabarni Sarker, Apurba Kumar Roy, A. Z. M. Ruhul Momen

“…These findings provide valid reasons for the assumption that inhibiting TMPRSS2 can have a beneficial effect in reducing the cellular entry of the virus, ultimately affecting the infection rate and case severity. Several drug development studies are going on to develop potential inhibitors of the protease, using both conventional and computational approaches. …”
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Identification of therapeutic targets for Alzheimer’s Disease Treatment using bioinformatics and machine learning by ZhanQiang Xie, YongLi Situ, Li Deng, Meng Liang, Hang Ding, Zhen Guo, QinYing Xu, Zhu Liang, Zheng Shao

“…This research provides a comprehensive and reliable method for the discovery of AD therapeutic targets and the construction of diagnostic models, offering important insights and directions for future AD treatment strategies and drug development.…”
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Investigation of catechin’s anti-inflammatory activity: A bioinformatics and molecular docking study by Nisa Yulianti Suprahman, Bulan Rosita Sari, Riri Fauziyya, Fatimah

“…As a country with rich biodiversity, Indonesia offers numerous phytochemicals with potential for drug development, including catechin, a natural compound with anti-inflammatory properties. …”
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General Approach to Identifying Potential Targets for Cancer Imaging by Integrated Bioinformatics Analysis of Publicly Available Genomic Profiles by Yongliang Yang, S. James Adelstein, Amin I. Kassis

“…Molecular imaging has moved to the forefront of drug development and biomedical research. The identification of appropriate imaging targets has become the touchstone for the accurate diagnosis and prognosis of human cancer. …”
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Ligand-Based Pharmacophore Modeling and Virtual Screening of RAD9 Inhibitors by Nirmal K. Prasad, Vishnupriya Kanakaveti, Siddhartha Eadlapalli, Ramakrishna Vadde, Angamba Potshangbam Meetei, Vaibhav Vindal

“…The bioactive molecules of natural origin act as excellent leads for new drug development. Thus, in the present study, we used the compounds of natural origin like camptothecin, ascididemin, and Dolastatin and also compared them with synthetic molecule NSC15520. …”
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Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents by Ajani Olayinka O., Nlebemuo Martins T., Adekoya Joseph A., Ogunniran Kehinde O., Siyanbola Tolutope O., Ajanaku Christiana O.

“…Hence, this review highlights the current versatile routes to accessing functionalized quinoxaline motifs and harnessing their documented therapeutic potentials for anticancer drug development.…”
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Differentially Expressed Genes Study Shown Potential for BCG Stimulation in Reducing the Severity of COVID-19 by Irandi Putra Pratomo, Aryo Tedjo, Dimas R Noor, Wisnu Ananta Kusuma

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VDAC1: A Key Player in the Mitochondrial Landscape of Neurodegeneration by Shirel Argueti-Ostrovsky, Shir Barel, Joy Kahn, Adrian Israelson

“…By unraveling the complex involvement of VDAC1 in neurodegenerative processes, this review highlights potential avenues for future research and drug development aimed at alleviating mitochondrial-related neurodegeneration.…”
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Investigating Pb2 CAP-binding domain inhibitors from marine bacteria for targeting the influenza A H5N1. by Taha A Kumosani, Aymn T Abbas, Balogun Basheer, Ahmed M Hassan, Soonham S Yaghmoor, Areej H Alyahiby, Amer H Asseri, Vivek Dhar Dwivedi, Esam I Azhar

“…A promising strategy for antiviral drug development involves targeting the RNA-dependent RNA polymerase, specifically the PB2-cap binding domain of Influenza A H5N1. …”
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Identifying natural inhibitors against FUS protein in dementia through machine learning, molecular docking, and dynamics simulation by Darwin Li

“…Originating from medicinal plants, these compounds are not only structurally compatible with the target protein but also adhere to pharmacokinetic profiles suitable for drug development, including optimal molecular weight and LogP values conducive to blood-brain barrier penetration. …”
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Synthesis, characterization, and in silico studies of substituted 2,3-dihydro-1,3,4-thiadiazole derivatives by Yasser H. Zaki, Sobhi M. Gomha, Basant Farag, Magdi E.A. Zaki, Ahmed M. Hussein

“…This research advances the understanding of heterocyclic chemistry and underscores the potential for developing new compounds, providing promising opportunities for drug development.…”
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IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials by Jihan K. Zaki, Jakub Tomasik, Sabine Bahn

“…Overall, the evolving drug repurposing landscape illustrates a significant shift in the rationale for schizophrenia drug development, highlighting the potential of in silico strategies, biomarker-based patient stratification, and personalized treatments that align with underlying pathophysiological processes.…”
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Impact of Domain Knowledge and Multi-Modality on Intelligent Molecular Property Prediction: A Systematic Survey by Taojie Kuang, Pengfei Liu, Zhixiang Ren

“…The precise prediction of molecular properties is essential for advancements in drug development, particularly in virtual screening and compound optimization. …”
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Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex by Maxine Bi, Xudong Wang, Jinan Wang, Jun Xu, Wenkai Sun, Victor Ayo Adediwura, Yinglong Miao, Yifan Cheng, Libin Ye

“…Abstract Unraveling the signaling roles of intermediate complexes is pivotal for G protein-coupled receptor (GPCR) drug development. Despite hundreds of GPCR-Gαβγ structures, these snapshots primarily capture the fully activated complex. …”
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Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium by Cassady E. Rupert, Tae Yun Kim, Bum-Rak Choi, Kareen L. K. Coulombe

“…Cardiac tissue engineering using hiPSC-derived cardiomyocytes is a promising avenue for cardiovascular regeneration, pharmaceutical drug development, cardiotoxicity evaluation, and disease modeling. …”
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The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease by Yang Xu, Ji Zhang, Lingsong Ma, Shoucai Zhao, Shizun Li, Tingting Huang, Zhaohu Chu

“…Multiple inhibitors of RIPK1 and MLKL have been developed to block the cascade of signal pathways for procedural necrosis and represent potential leads for drug development. In this review, we highlight recent progress in the study of roles for necroptosis in cerebral ischemic disease and discuss how these modifications delicately control necroptosis.…”
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Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications by Devan Buchanan, Shogo Mori, Ahmed Chadli, Siva S. Panda

“…These advancements can potentially address complex diseases and advance the broader field of biological drug development.…”
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Development of a novel, high-throughput imaged capillary isoelectric focusing-Western method to characterize charge heterogeneity of monoclonal antibody heavy and light chains by Gangadhar Dhulipala, Alanna Broszeit, Kun Lu, Nisha Palackal, Erica Pyles

“…Further, the developed method can be applied in different aspects of drug development, such as comparability, release or stability testing given its ability to provide identity, as well as qualitative and quantitative comparative analysis.…”
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Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…However, challenges such as the complexity of drug development and metabolic interactions must be overcome. …”
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