A retrospective cohort study: do patients with graves’ disease need to be euthyroid prior to surgery? by Abrar Al Jassim, Tim Wallace, Sarah Bouhabel, Agnieszka Majdan, Michael Hier, Veronique-Isabelle Forest, Richard Payne

“…Abstract Background The 2016 American Thyroid Association guidelines indicate that patients with Graves’ disease who undergo a thyroidectomy should be rendered euthyroid through the use of antithyroid drugs (ATD) prior to surgery to avoid complications such as a thyroid storm. …”
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Secondary hyperoxaluria: Cause and consequence of chronic kidney disease by Loreto Mariscal de Gante, Laura Salanova, Mariel Valdivia Mazeyra, Rosario Serrano Pardo, Borja Quiroga

“…Different immunomodulatory drugs, microbiome modifiers and SGLT2 inhibitors could constitute new therapeutic targets. …”
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Establishment and validation of HPLC methods for the determination of folic acid and parabens antimicrobial agents on folic acid oral solution by Wenhong Wu, Ying Liang, Renbang Zhao, Yude Shi, Jiahui Hou, Jiumei Peng, Jiadi Pan, Xiaoyi Li, Jingjing Zhou

“…Abstract Background As the common antibacterial drugs in folic acid oral liquid, parabens are listed as mandatory substances in the quality standard. …”
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Assessing hemorrhagic risks in combination therapy: implications of angiogenesis inhibitors and immune checkpoint inhibitors by Yuhui Yang, Yuhui Yang, Yuhui Yang, Pingping Long, Pingping Long, Ying Tuo, Ying Tuo, Xiaoxiao Wang

“…In the combination group, esophageal variceal hemorrhage (ROR 40.72, PRR 2344.72) and tumor hemorrhage (ROR 19.31, PRR 1056.63) exhibited significantly increased risks Additive and multiplicative models indicated that the excess risk (RDAB = 0.01025, P<0.001) and relative risk (RRAB = 1.99277, P<0.001) of combination therapy were significantly higher than those of monotherapy, suggesting a positive interaction between the drugs that further increases the risk of hemorrhage.ConclusionOur study demonstrates that the combination of AGIs and ICIs significantly raises the risk of hemorrhage, underscoring the urgent need for enhanced monitoring protocols in clinical practice to improve treatment efficacy and safety.…”
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In Vitro Acaricidal Activity of Selected Medicinal Plants Traditionally Used against Ticks in Eastern Ethiopia by Jelalu Kemal, Tesfaheywet Zerihun, Sisay Alemu, Kedir Sali, Musa Nasir, Ashebr Abraha, Teka Feyera

“…Thus, all the tested plants could be used against Rhipicephalus (Boophilus) decoloratus and Rhipicephalus pulchellus as a potential alternative to substitute commercially available drugs. We recommend further study on fractionating each component separately and validating the materials.…”
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Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study by Ming-Ju Wu, Chew-Teng Kor, Chia-Chu Chang, Shuo-Chun Weng, Chia-Lin Wu, Ping-Fang Chiu, Der-Cherng Tarng

“…The interaction between migraine and comorbidities was not significant; age, male gender and long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) were independent risk factors for CKD in subjects with migraine.Conclusion Migraine may be an independent risk factor for CKD. …”
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Exosomes Derived from CXCR4-Overexpressing BMSC Promoted Activation of Microvascular Endothelial Cells in Cerebral Ischemia/Reperfusion Injury by Xutong Li, Ye Zhang, Yong Wang, Dan Zhao, Chengcheng Sun, Shaoting Zhou, Dongsheng Xu, Jing Zhao

“…However, due to the lack of effective neuroprotective drugs, most stroke patients have varying degrees of long-term disability. …”
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Rechallenge therapy versus tyrosine kinase inhibitor (TKI) for advanced metastatic colorectal cancer: a retrospective study by Chenming Liu, Jintao Chen, Yuxing Liu

“…Abstract Currently, the standard third-line treatment options for advanced metastatic colorectal cancer (mCRC) include regorafenib, fruquintinib, and trifluridine/tipiracil (TAS-102), but these drugs have limited clinical efficacy. This study aims to evaluate the efficacy and survival outcomes of tyrosine kinase inhibitor (TKI) versus chemotherapy rechallenge in third-line treatment for advanced mCRC patients. …”
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Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024 by Congxu Zhu, Jingjing Yang, Lumei Liu, Bonan Li, Tiansong Sun, Wen Sheng, Qinghu He

“…Glycolysis has also demonstrated significant clinical value in the diagnosis and prognosis of PCa. Moreover, drugs targeting glycolytic inhibitors and natural products have exhibited therapeutic potential against this disease. …”
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Hubungan Pengetahuan dan Dukungan Keluarga dengan Kepatuhan Minum Obat Anti Tuberkulosis di Puskesmas Andalas Kota Padang by Ivan Putra Siswanto, Yanwirasti , Elly Usman

“…The objective of this study was to determine the relationship between knowledge of pulmonary TB patients and family support to adherence of anti-tuberculosis drugs at the health center patients Andalas Padang. …”
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Sexual maturity staging and affecting immune-hormonal factors in children aged 6-18 years living with HIV: experience from tertiary care center in North India by Ashwini Shivannavar, Alok Hemal, Hema Gupta Mittal

“…No statistically significant association was observed with CD4 categories (p = 0.3), viral load categories (p = 0.2), age at ART initiation, and BMI categories with pubertal stages. Among antiretroviral drugs, less than 50% of children on abacavir, zidovudine, and lopinavir/ritonavir had attained pubertal onset (in girls, breast stage ≥ 2; in boys, testicular volume (TV) stage ≥ 2). …”
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Benefits of a Juvenile Arthritis Support Program (JASP-1) for children recently diagnosed with Juvenile Idiopathic Arthritis and their parents by Karina Mördrup, Johanna Granhagen Jungner, Eva Broström, Karin Palmblad, Cecilia Bartholdson

“…Abstract Background Medical treatment for children with Juvenile Idiopathic Arthritis (JIA) has improved radically since the development of biological disease-modifying antirheumatic drugs. However, children suffer from pain and anxiety, and parents often experience loneliness and lack of support. …”
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Comparing the effects of Mycozin and Clotrimazole 1% creams on vaginal candidiasis: a triple-blinded randomized controlled trial by Khadije Hajizadeh, Zahra Alivand, Vahideh Rahmani, Leila Mehrannia, Sanam Nami, Behrooz Shokouhi, Mojgan Mirghafourvand

“…The resistance to azole compounds, and the side effects of chemical drugs have been reported following azole therapy. …”
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Artrosis: ¿cambios degenerativos o cambios adaptativos? Consejos educativos breves en la consulta de atención primaria by Gema Izquierdo Enríquez, María Victoria García Espinosa, Isabel Prieto Checa, María Fernández de Paúl, Patricia Moreno Carrero, Silvia Fernanda García Vila

“…Moreover, there are no disease-modifying drugs or curative treatment at present; the basic or first-line treatment is non-pharmacological, based on education and physical exercise.The presence of degenerative changes in imaging tests is present in a high percentage of the general asymptomatic population, i.e. in those who have no pain or functional limitation, and this percentage increases progressively with age. …”
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How to publish a new fungal species, or name, version 3.0 by M. Catherine Aime, Andrew N. Miller, Takayuki Aoki, Konstanze Bensch, Lei Cai, Pedro W. Crous, David L. Hawksworth, Kevin D. Hyde, Paul M. Kirk, Robert Lücking, Tom W. May, Elaine Malosso, Scott A. Redhead, Amy Y. Rossman, Marc Stadler, Marco Thines, Andrey M. Yurkov, Ning Zhang, Conrad L. Schoch

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Single-vehicle injury crashes on rural roads in Iceland: contribution of unforgiving roadsides to fatal and serious injuries of vehicle occupants by Audur Thora Arnadottir, Gudmundur F. Ulfarsson, Sungyop Kim

“…Not a single foreign tourist driver in this data was noted as being under the influence of alcohol or illegal drugs. To strengthen the analysis of the contribution of roadside elements to the severity of run-off-road crashes and to monitor the effects of improvements in the future, it is recommended that additional information on roadside elements be coded and added to the standard police record crash data. …”
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Comprehensive Analysis and Functional Characteristics of Differential Expression of N6-Methyladenosine Methylation Modification in the Whole Transcriptome of Rheumatoid Arthritis by Lei Wan, Jian Liu, Chuanbing Huang, Ziheng Zhu, Kun Wang, Guanghan Sun, Lei Zhu, Zhongxiang Hu

“…The discovery of m6A methylation-modifying genes in this study may provide a fresh perspective on the development of drugs for RA treatment. High-throughput sequencing combined with methylated RNA immunoprecipitation (MeRIP-seq) and RNA sequencing were used to assess whole-transcriptome m6A modifications in the synovium of patients with RA. …”
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Efficacy and prognosis of dapagliflozin in the treatment of patients with acute myocardial infarction complicated with type 2 diabetes in Xining area by Jinping Chai, Delian Li, Yanmin Liu, Xiaoling Su

“…There were no significant differences in the number of coronary artery lesions, treatment regimens, cardiovascular and hypoglycemic drugs between the two groups (P > 0.05). However, up to dapagliflozin group of patients after discharge significantly lower than the control group, the incidence of cardiovascular adverse events at dapagliflozin group of 4 cases of heart failure and cardiovascular death in 1 case and control group in heart failure 13 cases, 10 cases of cardiovascular death, cerebral hemorrhage 2 cases died. …”
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miRNA Expression Profile and Effect of Wenxin Granule in Rats with Ligation-Induced Myocardial Infarction by Aiming Wu, Lixia Lou, Jianying Zhai, Dongmei Zhang, Limin Chai, Bo Nie, Haiyan Zhu, Yonghong Gao, Hongcai Shang, Mingjing Zhao

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Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing by Sasa Vasilijic, Richard Seist, Zhenzhen Yin, Lei Xu, Konstantina M. Stankovic

“…The mechanisms underlying this SNHL are incompletely understood and currently, there are no drugs FDA approved specifically for VS. This knowledge gap significantly limits the development of effective treatments aimed at preventing, stabilizing, or reversing VS-induced SNHL. …”
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