Biological significance of soluble IL-2 receptor by Calogero Caruso, Giuseppina Candore, Diego Cigna, Antonio Tobia Colucci, Maria Assunta Modica

“…Since many conditions may influence sIL-2R production, little diagnostic use may result from these measurements. However, since blood sIL-2R levels may correlate with disease progression and/or response to therapy, their measurement may be a useful index of activity and extent of disease. …”
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Performance evaluation of nine reference centers and comparison of DNA extraction protocols for effective surveillance of Leishmania-infected Phlebotomine sand flies: Basis for tec... by Jorian Prudhomme, Aymeric Delabarre, Bulent Alten, Umut Berberoglu, Eduardo Berriatua, Gioia Bongiorno, José Manuel Cristovao, Maya Davidovich-Cohen, Trentina Di Muccio, Ozge Erisoz Kasap, Eleonora Fiorentino, Oscar D Kirstein, Edwin Kniha, Carla Maia, Mesut Mungan, Clara Muñoz-Hernández, Muhammed Nalçaci, Gizem Oguz Kaskan, Yusuf Ozbel, Seray Ozensoy Toz, Ricardo Parreira, Katharina Platzgummer, Ceylan Polat, José Risueño, Liora Studentsky, Gamze Varol, Julia Walochnik, Kardelen Yetişmiş, Florence Robert-Gangneux

“…All but one center detected all concentrations, demonstrating strong diagnostic proficiency. The ability to detect low concentrations highlighted the robustness of the qPCR assay used, though variations in Cq values indicated differences in sensitivity related to technical capabilities or DNA extraction kit performance. …”
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Chromothripsis in Treatment Resistance in Multiple Myeloma by Kyoung Joo Lee, Ki Hong Lee, Kyong-Ah Yoon, Ji Yeon Sohn, Eunyoung Lee, Hyewon Lee, Hyeon-Seok Eom, Sun-Young Kong

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Therapeutic Drug Monitoring-Guided Linezolid Therapy for the Treatment of Multiple Staphylococcal Brain Abscesses in a 3-Month-Old Infant by Anna Cascone, Maia De Luca, Raffaele Simeoli, Bianca Maria Goffredo, Laura Cursi, Costanza Tripiciano, Lorenza Romani, Stefania Mercadante, Martina Di Giuseppe, Francesca Ippolita Calo Carducci, Davide Luglietto, Paola Bernaschi, Laura Lancella

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The interrelation of students’ ideas about fatherhood with gender, age and structure of valuable orientations by S. V. Merzlyakova, M. G. Golubeva, N. V. Bibarsova

“…The research methods involve theoretical-methodological literature analysis, questionnaire method, psycho-diagnostic methods, and mathematical and statistical data processing methods.Results. …”
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Evaluation of the Frequency of HLA-DQ2/DQ8 Genes Among Patients with Celiac Disease and Those on a Gluten-Free Diet by Marek K. Kowalski, Danuta Domżał-Magrowska, Ewa Małecka-Wojciesko

“…Background: Celiac disease (CD) is a chronic, permanent, gluten-dependent disease that manifests itself with inflammation of the small intestine and malabsorption in genetically predisposed individuals with HLA-DQ2 and -DQ8 (human leukocyte antigen) histocompatibility antigens. Objective: The diagnostic criteria for celiac disease have undergone numerous modifications over the years. …”
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Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency by Nanis S. Marzuki, Firman P. Idris, Hannie D. Kartapradja, Alida R. Harahap, Jose R. L. Batubara

“…These results serve to inform the development of improved clinical and molecular 5ARD2 diagnostic approaches, specifically in Indonesian patients.…”
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Whole Exome Sequencing Reveals Compound Heterozygosity for Ethnically Distinct PEX7 Mutations Responsible for Rhizomelic Chondrodysplasia Punctata, Type 1 by Jessie C. Jacobsen, Emma Glamuzina, Juliet Taylor, Brendan Swan, Shona Handisides, Callum Wilson, Michael Fietz, Tessa van Dijk, Bart Appelhof, Rosamund Hill, Rosemary Marks, Donald R. Love, Stephen P. Robertson, Russell G. Snell, Klaus Lehnert

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A Machine Learning Algorithm to Predict Medical Device Recall by the Food and Drug Administration by Victor Barbosa Slivinskis, Isabela Agi Maluli, Joshua Seth Broder

“…The study adhered to relevant items of the Standards for Reporting Diagnostic accuracy studies (STARD) guidelines. Results: Using a rounding threshold of 0.5, sensitivities for T-3, T-6, and T-12 were 89% (95% confidence interval [CI] 69–97), 90% (95% CI 70–97), and 75% (95% CI 53–89). …”
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Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents by Lian Tock, Ana R. Dâmaso, Aline de Piano, June Carnier, Priscila L. Sanches, Henrique Manoel Lederman, Regina M. Y. Ernandes, Marco Túlio de Mello, Sérgio Tufik

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Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer by Sinem İnan, Semra Bilaçeroğlu, Burcu Uludağ Artun

“…There is a need for much larger, randomized studies to obtain evidence for the potential role of NT-proBNP as a helpful diagnostic biomarker for lung cancer. Clinical suspicion of malignancy may be posed if high NT-proBNP levels cannot be explained by all other risk factors and disorders or diseases. …”
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A Framework for Early Detection of Acute Lymphoblastic Leukemia and Its Subtypes From Peripheral Blood Smear Images Using Deep Ensemble Learning Technique by Sajida Perveen, Abdullah Alourani, Muhammad Shahbaz, M. Usman Ashraf, Isma Hamid

“…A definitive diagnosis often demands highly invasive diagnostic procedures thereby proving time-consuming and expensive. …”
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A Case of Primary Lung Adenocarcinoma With Recurrent Brain Metastasis due to Transformation to Small Cell Carcinoma During Adjuvant Atezolizumab Therapy by Nao Kobayashi, Noriaki Sunaga, Masakiyo Yatomi, Ikuo Wakamatsu, Sohei Muto, Hayato Ikota, Rei Yamaguchi, Yoichi Ohtaki, Toshiteru Nagashima, Nobuteru Kubo, Tomomi Masuda, Yosuke Miura, Hiroaki Tsurumaki, Reiko Sakurai, Yasuhiko Koga, Takeshi Hisada, Toshitaka Maeno

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Application of the 2021 AAPOS Guidelines in Clinics with Revision and Validation of SPOT Referral Criteria by Li R, Yan Q, Lin X, Wu Z, Zhu H, Guo W, Zhang P, Zuo F, Wu Z, Liu H, Huang D

“…These results were compared to the age-based 2021 AAPOS diagnostic thresholds. Additionally, this study validated previously reported referral criteria within its population.Results: The study involved 1103 children (347 below four years; 756 aged four years and above). …”
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Late-onset first epileptic seizure and cerebral small vessel disease: role of juxtacortical white matter lesions by Adrian Nasca, Adrian Nasca, Leo Sokolovič, Leo Sokolovič, Oliver Koprda, Patrick Haage, Patrick Haage, Thorsten Schmidt, Juraj Kukolja, Juraj Kukolja

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Hiperurisemia pada Pra Diabetes by Ellyza Nasrul, Sofitri .

“…<br />Hyperuricemia is a state in the blood uric acid levels over 7.0 mg / dL.Pre-diabetes is a subject which has a plasma<br />glucose level will rise but the increase is still not reached the minimum value for the diagnostic criteria for diabetes<br />mellitus (DM). …”
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Targeting Liver Biopsies For Optimal Biopsy Site In Diffused Liver Disease Using Real-Time Shear Wave Elastography: A Prospective, Single Center Study by Naushaba Malik, Shahbakht Aftab, Rida Noor, Noor Aftab, Rizwan, Rehan

“… Objective: The study aimed to pinpoint the precise site for liver biopsy using ultrasound and elastography guidance and to assess and compare the diagnostic accuracy of shear wave elastography (SWE) and transient elastography (TE) through histopathological correlation. …”
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Effects of orally administered clioquinol on the fecal microbiome of horses by Mikaila Z. Smith, Mary York, Kile S. Townsend, Lynn M. Martin, Tamara Gull, Lyndon M. Coghill, Aaron C. Ericsson, Philip J. Johnson

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Clinical diagnosis of seasonal influenza by physicians: a retrospective observational study by Hiroyuki Kato, Tadashi Kobayashi, Hiroki Maita, Takashi Akimoto, Fumihiko Matsuoka, Shigeki Funakoshi, Hiroshi Osawa

“…Objective To elucidate the diagnostic accuracy of pretest probability of influenza (%) by physicians and the factors affecting the clinical diagnosis.Design Retrospective, single-centre observational study.Setting A community primary care clinic in Japan.Participants The participants were recruited from a database of studies conducted during the influenza season from December 2017 to April 2019.Primary outcome measure Sensitivity and specificity of the physician’s clinical diagnosis of influenza recorded in the medical record as pretest probability.Results A total of 335 patients (median age, 31 years; male, 66.6%) were analysed in this study. …”
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Assessment of Biosecurity Status in Commercial Chicken Farms Found in Bishoftu Town, Oromia Regional State, Ethiopia by Abdulbari Ismael, Adem Abdella, Shihun Shimelis, Asamenew Tesfaye, Yimer Muktar

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