Impact of the Timing of Enzyme Replacement Therapy Initiation and Cognitive Impairment Status on Outcomes for Patients with Mucopolysaccharidosis II (MPS II) in the United States:... by Karen S. Yee, David Alexanderian, Yidie Feng, Xiaowei Ren, Bernd Schweikert, Olulade Ayodele

“…**Results:** In patients initiating ERT before 3 years of age, there was a trend toward lower symptom burden and HRU compared with patients who initiated ERT at an older age. Evaluation of developmental and behavioral signs and symptoms in the full study population showed that communication delay (70.0% of patients), cognitive delay (62.1%), behavioral problems (52.9%), and toileting delay (50.0%) were particularly common; earliest documented signs and symptoms were motor delay (median [range] age at first documentation: 4.2 [0.9-18.7] years) and behavioral problems (4.4 [0.6-13.7] years). …”
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In Vitro Anthelmintic Activity and Phytochemical Screening of Crude Extracts of Three Medicinal Plants against Haemonchus Contortus in Sheep at Haramaya Municipal Abattoir, Eastern... by Hassen Shamil Mumed, Dereje Regassa Nigussie, Kedir Sali Musa, Abdallahi Abdurahman Demissie

“…Hence, the current study revealed that the extracts from three plants have potential anthelmintic effect, and we recommend further study on fractionating each component separately and validating the materials using other parasite developmental stages are warranted.…”
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Development of an m6A-Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low-Grade Glioma Patients by Dahua Xu, Peihu Li, Chunrui Zhang, Yutong Shen, Jiale Cai, Qingchen Wei, Meng Cao, Zhizhou Xu, Deng Wu, Hong Wang, Xiaoman Bi, Bo Wang, Kongning Li

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Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening by Cuili Ma, Hwanwook Seong, Xiaowei Li, Xiao Yu, Shunliang Xu, Yujing Li

“…Undoubtedly, animal models have made a significant contribution to gaining insight into the developmental and pathophysiological understanding of human diseases. …”
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Representing and Quantifying Conformational Changes of Kinases and Phosphatases Using the TSR-Based Algorithm by Tarikul I. Milon, Krishna Rauniyar, Sara Furman, Khairum H. Orthi, Yingchun Wang, Vijay Raghavan, Wu Xu

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Should you hold onto the treadmill handrails or not? Cortical evidence at different walking speeds by Monica Biggio, Costanza Iester, Davide Cattaneo, Simone Cutini, Ambra Bisio, Ludovico Pedullà, Alessandro Torchio, Marco Bove, Laura Bonzano

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Nuclear mRNA export by Chen Suli, Jiang Qingyi, Fan Jing, Cheng Hong

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Improvement of survival and development of Pacific white shrimp Litopenaeus vannamei larvae by feeding taurine enriched rotifers by Dedi Jusadi, Syarifah Ruchyani, Ing Mokoginta, Julie Ekasari

“…The experimental results also concluded that a concentration of 50 mg/L is the most optimum taurine enrichment concentration of rotifers for the improvement of white shrimp larval survival and developmental stage. Keywords: taurine, rotifer, white shrimp, enrichment ABSTRAK Penelitian ini bertujuan untuk mengkaji konsentrasi optimum taurin melalui pengayaan pada rotifera terhadap tingkat kelangsungan hidup dan perkembangan stadia larva udang vaname Litopenaeus vannamei. …”
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Neuropeptides SP and CGRP Diminish the Moraxella catarrhalis Outer Membrane Vesicle- (OMV-) Triggered Inflammatory Response of Human A549 Epithelial Cells and Neutrophils by Daria Augustyniak, Justyna Roszkowiak, Izabela Wiśniewska, Jacek Skała, Daiva Gorczyca, Zuzanna Drulis-Kawa

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Artificial Intelligence in Pediatric Epilepsy Detection: Balancing Effectiveness With Ethical Considerations for Welfare by Marina Ramzy Mourid, Hamza Irfan, Malik Olatunde Oduoye

“…It profoundly impacts both developmental progress and quality of life in affected children. …”
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X-Linked Autism Type 9 Caused by a Hemizygote Pathogenic Variant in the TMLHE Gene: Etiological Diagnosis in an Adult Male with Moderate Intellectual Disability by Verhoeven WM, Pfundt R, Engelke UF, Kluijtmans LA, Egger JI

“…Lack of TMLH enzyme activity is associated with developmental delay and autistic behaviours described as X-linked recessive autism, type 6 (OMIM#300872).Patient and Methods: Here, an institutionalized adult male patient with intellectual disability, autism, and challenging behaviours is presented in whom genetic analysis disclosed a novel pathogenic variant in the TMLHE gene. …”
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Postnatal cytomegalovirus infection and its effect on hearing and neurodevelopmental outcomes among infants aged 3-10 months: A cohort study in Eastern Uganda. by Noela Regina Akwi Okalany, David Mukunya, Peter Olupot-Olupot, Martin Chebet, Francis Okello, Andrew D Weeks, Fred Bisso, Thorkild Tylleskär, Kathy Burgoine, Ingunn Marie Stadskleiv Engebretsen

“…Clinical assessments included neurodevelopmental evaluation using the Malawi Developmental Assessment Tool, the Hammersmith Infant Neurological Examination, and hearing screening using Otoacoustic Emission testing (Otoport Lite, Otodynamics Limited). …”
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Cytokinin B-Mo-based Product Influences the Source-to-sink Dynamics and Nonstructural Carbohydrate Contents in Hydroponic Lettuce Plants by Mayra A. Toro-Herrera, Rosa E. Raudales

“…Variations in growth rates and carbon pools across individual leaves or groups of leaves at similar developmental stages allow us to comprehend plant strategies of carbon allocation and partitioning. …”
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The Role of Immersive Experience in Anxiety Reduction: Evidence from Virtual Reality Sessions by Dominika Wilczyńska, Tamara Walczak-Kozłowska, David Alarcón, María José Arenilla, Jose Carlos Jaenes, Marcelina Hejła, Mariusz Lipowski, Joanna Nestorowicz, Henryk Olszewski

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Exosomes Derived from Stem Cells from the Apical Papilla Promote Dentine-Pulp Complex Regeneration by Inducing Specific Dentinogenesis by Xueying Zhuang, Lingli Ji, Huan Jiang, Yao Liu, Xuemei Liu, Jing Bi, Weidong Zhao, Zhenjiang Ding, Xu Chen

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The language use Inventory-Persian: report of the psychometric properties by Mahbubeh Nakhshab, Ali Asgary, Akram Ahmadi

“…Concurrent validity was also established by a moderate and positive value of the correlation between total scores of the LUI-Persian and Newsha developmental scale (r = 0.54, p = 0.01). Exploratory factor analysis (EFA) indicated that the Language Use Inventory-Persian had 2 factors of verbal and nonverbal use of language. …”
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Spatiotemporal simulation of blue-green space pattern evolution and carbon storage under different SSP-RCP scenarios in Wuhan by Guiyuan Li, Wangzhen Wang, Bowen Li, Zhongyuan Duan, Liang Hu, Jingwen Liu

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Effect of Linear Alkylbenzene Sulfonate on Mortality, Hatching Rate of Eggs and Abnormality of Catfish (Pangasius hypophthalmus Sauvage) Larvae by E. Supriyono, L. Lisnawati, D. Djokosetiyanto

“… Linear alkylbenzene sulfonate (LAS) surfactant in the water can affecting fish in all developmental stages.  This study was aimed to observe the effect of LAS on mortality, hatching rate of eggs, and abnormality of patin catfish (Pangasius hypophthalmus Sauvage) larvae.   …”
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Evaluation of Commercial Disinfectants against Staphylococcus lentus and Micrococcus spp. of Poultry Origin by Otun Saha, Nadira Naznin Rakhi, Arif Istiaq, Israt Islam, Munawar Sultana, M. Anwar Hossain, Md. Mizanur Rahaman

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Data from Emergency Medical Service Activities: A Novel Approach to Monitoring COVID-19 and Other Infectious Diseases by Daniele del Re, Luigi Palla, Paolo Meridiani, Livia Soffi, Michele Tancredi Loiudice, Martina Antinozzi, Maria Sofia Cattaruzza

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