Focal therapy of prostate cancer: Use of artificial intelligence to define tumour volume and predict treatment outcomes by Wayne G. Brisbane, Alan M. Priester, Anissa V. Nguyen, Mark Topoozian, Sakina Mota, Merdie K. Delfin, Samantha Gonzalez, Kyla P. Grunden, Shannon Richardson, Shyam Natarajan, Leonard S. Marks

“…Receiver operating curves and multivariate analysis were used to determine significance. Results A successful primary outcome was observed in 77.7% of patients. …”
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Impaction bone grafting for acetabular bone defects replacement in revision hip arthroplasty: biomechanical aspects by Vadim N. Golnik, Natalia V. Fedorova, Alexey Y. Larichkin, Svetlana V. Boyko, Andrey A. Panchenko, Alexandr M. Kosinov, Vladimir A. Peleganchuk, Vitaliy V. Pavlov

“…The aim of the study is to explore the mechanical properties of osteoplastic material and determine the potential impact of cyclic loads on dynamic changes in the position of the acetabular component after revision hip arthroplasty using impaction bone grafting. …”
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Analysis of Nucleotide Alterations in the E6 Genomic Region of Human Papillomavirus Types 6 and 11 in Condyloma Acuminatum Samples from Brazil by Marina Carrara Dias, Bruna Stuqui, Paola Jocelan Scarin Provazzi, Cíntia Bittar, Natália Maria Candido, Renata Prandini Adum de Matos, Rodolfo Miglioli Badial, Caroline Measso do Bonfim, Patricia Pereira dos Santos Melli, Silvana Maria Quintana, José Antônio Cordeiro, Paula Rahal, Marilia de Freitas Calmon

“…Therefore, the aims of this study were to detect variants and nucleotide alterations present in the E6 regions of HPV types 6 and 11 found in CA samples, to correlate the HPV presence with the clinical-pathological data of the patients, and to determine phylogenetic relationships with variants from other places in the world. …”
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Estimated cumulative incidence of intervention by children's social care services to age 18: a whole-of-England administrative data cohort study using the child in need census by Matthew A Jay, Patricio Troncoso, Andy Bilson, Dave Thomson, Richard Dorsett, Rachel Pearson, Bianca De Stavola, Ruth Gilbert

“…Government should monitor the cumulative incidence of ever receiving CSC support with a view to addressing upstream health and social determinants. …”
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Causal associations between osteoporosis and HBV infection across Asian and European populations: evidence from Mendelian randomization and colocalization analysis by Zhengnan Li, Jiarui Cao, Ke Li, Yixin Wu, Zhanpeng Luo, Rui Cao, Zhiheng Cheng, Zhendong Tian, Yiyang Han, Yuping Lai, Bangqi Wang, Shen Chen

“…However, the causal relationship between HBV infection and osteoporosis remains to be determined.MethodsWe investigated whether HBV infection is causally associated with osteoporosis using Mendelian randomization (MR) in East Asian and European populations, respectively. …”
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Multidrug-Resistant Tuberculosis and Its Association with Adrenal Insufficiency: Assessment with the Low-Dose ACTH Stimulation Test by René Rodríguez-Gutiérrez, Adrian Rendon, Maximiliano Barrera-Sánchez, Kevin Erick Gabriel Carlos-Reyna, Neri Alejandro Álvarez-Villalobos, Gloria González-Saldivar, José Gerardo González-González

“…A spike in TB incidence and a lack of evidence of this association in patients with MDR-TB call for reassessment of an illness (adrenal dysfunction) that if not diagnosed could seriously jeopardize patients’ health. Objective. To determine the prevalence of adrenocortical insufficiency in patients with MDR-TB using the low-dose (1 μg) ACTH stimulation test at baseline and at 6–12 months of follow-up after antituberculosis treatment and culture conversion. …”
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Optogenetic control of horizontally acquired genes prevent stuck fermentations in yeast by David Figueroa, Diego Ruiz, Nicolò Tellini, Matteo De Chiara, Eduardo I. Kessi-Pérez, Claudio Martínez, Gianni Liti, Amparo Querol, José M. Guillamón, Francisco Salinas

“…To do this, we first sequenced the genome of the wine yeast strain using long-read sequencing and determined that region A is present in a single copy. …”
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Changes on the Development of Rigor Mortis in Cultured Tilapia (Oreochromis niloticus) Fed with a Mixture of Plant Proteins by Nathaly Montoya Camacho, Enrique Márquez Ríos, Francisco Javier Castillo Yáñez, Saúl Ruíz Cruz, Aldo Alejandro Arvizu Flores, Wilfrido Torres Arreola, Jose Luis Cárdenas López, Santiago Valdéz Hurtado, Víctor Manuel Ocaño Higuera

“…The chemical composition of experimental diets and muscle were determined. The glycogen, adenosine 5′-triphosphate (ATP) and related compounds, pH, shear force, and rigor index (RI%) were monitored during storage on ice for 48 h. …”
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Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar s... by Efstratios Koutroumpakis, Mohamed A. Naser, Abdallah Sherif Radwan Mohamed, Salman A. Eraj, Andrea Jarre, Jay C. Shiao, Mona Kamal, Subha Perni, Jack P. Phan, William H. Morrison, Steven J. Frank, G.Brandon Gunn, Adam S. Garden, Anita Deswal, Jun-ichi Abe, David I. Rosenthal, Elie Mouhayar, Clifton D. Fuller

“…Aim: This study leveraged standard-of-care CT scans of patients receiving unilateral radiotherapy (RT) for early tonsillar cancer to detect volumetric changes in the carotid arteries, and determine whether there is a dose–response relationship. …”
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Lactoferrin Modulates Radiation Response Under Hypoxic Conditions, Possibly Through the Regulation of ROS Production in a Cell Type-Specific Manner by Daitoku Murakami, Takahiro Fukazawa, Michihito Kyo, Mutsumi Miyauchi, Shigehiro Ono, Tomonao Aikawa, Nobuyuki Hirohashi, Keiji Tanimoto

“…However, the effects of LF and its mechanisms in anticancer therapies, especially in radiotherapy against cancer cells under hypoxic conditions, are not well-determined. In this study, we focused on the molecular mechanisms of LF functions in cells under hypoxic conditions. …”
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Severity Assessment of COVID-19 Using a CT-Based Radiomics Model by Zhigao Xu, Lili Zhao, Guoqiang Yang, Ying Ren, Jinlong Wu, Yuwei Xia, Xuhong Yang, Milan Cao, Guojiang Zhang, Taisong Peng, Jiafeng Zhao, Hui Yang, Jinfeng Hu, Jiangfeng Du

“…Receiver operating characteristic (ROC) curves were generated to determine the diagnostic performance of various models. …”
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Ruxolitinib synergizes with regulatory T cells to improve inflammation but has no added benefits in decreasing albuminuria in SLE by Mi-Ae Lyu, Ximing Tang, Maria Gabriela Raso, Meixian Huang, Ke Zeng, Tara Sadeghi, Christopher R. Flowers, Simrit Parmar

“…We hypothesize that the addition of ruxolitinib to UCB-Tregs may improve SLE outcomes.MethodsIn vitro cell suppression, phenotype change, IL-10 secretion, and cytokine levels in coculture supernatants were determined to quantify the impact of adding ruxolitinib to UCB-Tregs. …”
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Ecological risk assessment of future suitable areas for Piper kadsura under the background of climate change by Shimeng Li, Yuanxin Li, Mingli Hu, Mingli Hu, Yankun Li, Yankun Li, Mingrong Yang, Shi Wang, Shi Wang, Wei Yu, Wei Yu, Chunsong Cheng, Qiqing Cheng, Qiqing Cheng

“…Especially in the SSP585 scenario, the total suitable area and the highly suitable area will be significantly reduced by 89.26% and 87.95% compared with the present during the 2090s.DiscussionOverall, these findings can provide useful references for the suitable areas’ determination of wild resources, optimization of artificial cultivation and scientific selection of high quality medicinal materials on P. kadsura.…”
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Effect of Bacille Calmette–Guérin vaccination on immune responses to SARS‐CoV‐2 and COVID‐19 vaccination by Nicole L Messina, Susie Germano, Amy W Chung, Carolien E van deSandt, Natalie E Stevens, Lilith F Allen, Rhian Bonnici, Julio Croda, Claudio Counoupas, Branka Grubor‐Bauk, Ebene R Haycroft, Katherine Kedzierska, Ellie McDonald, Rebecca McElroy, Mihai G Netea, Boris Novakovic, Kirsten P Perrett, Laure F Pittet, Ruth A Purcell, Kanta Subbarao, James A Triccas, David J Lynn, Nigel Curtis, the BRACE Trial Consortium Group

“…This study aimed to determine the immunomodulatory effects of BCG vaccination on immune responses to vaccines against SARS‐CoV‐2. …”
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Retrospective cohort study on diseases and risk factors associated with death in hospitalized neonatal foals by Donatienne L. Castelain, Alexander Dufourni, Mathilde L. Pas, Jade Bokma, Eva deBruijn, Ellen Paulussen, Laurence Lefère, Gunther vanLoon, Bart Pardon

“…Prediction of risk of death upon admission is often difficult but might support decision‐making. Objectives To determine diseases and risk factors associated with death in neonatal hospitalized foals. …”
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Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes by Shuai Zhang, Ruixue Wang, Kun Luo, Shipeng Gu, Xinyu Liu, Junhan Wang, Ludan Zhang, Lin Sun

“…RNA m6A modification in Drosophila has proven to be involved in sex determination regulated by Sxl and may affect X chromosome expression through the MSL complex. …”
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Platinum drugs upregulate CXCR4 and PD‐L1 expression via ROS‐dependent pathways, with implications for novel combined treatment in gastric cancer by Xiaoyu Kang, Lin Zhang, Shushang Liu, Fei Wang, Haiming Liu, Fenli Zhou, Fei Wu, Haohao Zhang, Daiming Fan, Yongzhan Nie, Zhangqian Chen

“…Immunohistochemistry, western blot, and RT‐qPCR were performed to determine the expression pattern of CXCR4 and PD‐L1 in GC. …”
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Artificial Intelligence–Related Dental Research: Bibliometric and Altmetric Analysis by Wei Lu, Xueqian Yu, Yueyang Li, Yi Cao, Yanning Chen, Fang Hua

“…R package Bibliometrix was employed to automatically calculate scientific impacts, determining the core authors and journals. Altmetric data were described narratively and supplemented with Spearman correlation analysis. …”
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Genotype Distribution of CNDP1 Polymorphisms in the Healthy Chinese Han Population: Association with HbA1c and Fasting Blood Glucose by Shiqi Zhang, Juan Xu, Di Cui, Shujuan Jiang, Xin Xu, Yi Zhang, Dongchun Zhu, Li Xia, Benito Yard, Yonggui Wu, Qiu Zhang

“…To this end, the (CTG)n allele distribution along with 5 relevant SNPs in the CNDP1 gene, previously reported to be associated with DN in non (CTG)5 carriers of Afro-American ethnicity, were determined in 663 healthy individuals. The (CTG)6 homozygous genotype was the most prevalent (84.5%) genotype in the Chinese Han population. …”
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Functional Improvement Trajectories After Surgery (FIT After Surgery) study: protocol for a multicentre prospective cohort study to evaluate significant new disability after major... by E Jacobsohn, Duminda N Wijeysundera, Gerald Lebovic, M Davis, Martine T E Puts, Shabbir M H Alibhai, Karim S Ladha, C Wong, Daniel I McIsaac, C Hanley, T Barnes, G Lorello, N Siddiqui, P Serrano, Tyler R Chesney, S Choi, J Van Vlymen, D Sussman, D Macdonald, P Jüni, Emily Hladkowicz, C David Mazer, M Bosch, CD Mazer, A Jerath, J Pazmino-Canizares, E Kennedy, R Spence, V Lyon, Alice C Wei, Julian F Daza, Sahar Ehtesham, Janet M van Vlymen, DN Wijeysundera, KS Ladha, JF Daza, G Mattina, E Hladkowicz, M Tessier, S Ehtesham, S Nnorom, SMH Alibhai, M Puts, G Lebovic, TR Chesney, AC Wei, S Drozdz, M Louridas, RH Breau, M Lalu, S Abdellatif, S Gagne, E Duceppe, K Zarnke, D Dumerton, M Karizhenskaia, H El Beheiry, F Bonazza, A Zahavich, M Thorleifson, S L Russell, H Bagry, SY MacDonell, J Dale-Gandar, L Kaustov, A Fleet, E Al Azazi, M Parotto, S A McCluskey, H Poonawala, D Dillane, Di McIsaac, S Avramescu, S Shabeen

“…We will use multivariable logistic regression models to determine the association of preoperative characteristics and surgery type with outcomes, joint modelling to characterise longitudinal time trends in WHODAS scores over 12 months after surgery, and longitudinal latent class mixture models to identify clusters following similar trajectories of disability.Ethics and dissemination The FIT After Surgery study has received research ethics board approval at all sites. …”
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