Patient-Centric Structural Determinants of Adherence Rates Among Asthma Populations: Exploring the Potential of Patient Activation and Encouragement Tool TRUSTR to Improve Adherenc... by Asim Zia, Arthur Brassart, Sheila Thomas, Fen Ye, Judith J. Stephenson, C. Daniel Mullins, Christopher A. Jones

“…**Methods:** The patient population (N = 37 359) consists of commercially insured patients with asthma who have been identified from administrative claims in the HealthCore Integrated Research Database (HIRD) between April 1, 2018 and March 31, 2019. …”
Get full text

Meta-analysis examining the association between low platelet monoamine oxidase levels and Zuckerman's sensation seeking scale in a sex dependent manner by Jordan Winfield, Ian A. Mendez, Gabriel A. Frietze

“…To identify studies to include in this meta-analysis, a preliminary database was produced by searching PsycInfo, Medline, PubMed, ProQuest, and ScienceDirect, from the time period of January 01, 1970 through August 01, 2022. …”
Get full text

Economic Burden of HIV in a Commercially Insured Population in the United States by Cindy Y. Chen, Prina Donga, Alicia K. Campbell, Babafemi Taiwo

“…**Methods:** This retrospective observational study utilized data from the IBM MarketScan® Commercial Claims and Encounters database. Adults with newly diagnosed HIV-1 or those initiated with PrEP were included (index date was the first HIV diagnosis or PrEP prescription, respectively, between January 1, 2016, and April 30, 2021). …”
Get full text

Harnessing Internet Search Data as a Potential Tool for Medical Diagnosis: Literature Review by Gregory J Downing, Lucas M Tramontozzi, Jackson Garcia, Emma Villanueva

“…We searched for published peer-reviewed literature on the PubMed database between October and December 2023. …”
Get full text

Real-world Bleeding Outcomes and Costs Following Vascular Graft Anastomosis Using PROLENE Sutures with HEMO-SEAL Technology in Patients Undergoing Abdominal Aortic Aneurysm Repair by Nadia Y. Sutton, Niels-Derrek Schmitz

“…**Methods:** AAA repair procedures using hemostats and either HEMO-SEAL sutures or standard PROLENE sutures were identified from 2009 to 2013 using the Premier Healthcare Database. The primary outcome was the number and cost of hemostat units. …”
Get full text

Economic Outcomes and Incidence of Postsurgical Hypotension With Liposomal Bupivacaine vs Epidural Analgesia in Abdominal Surgeries by Margaret Holtz, Nick Liao, Jennifer H. Lin, Carl V. Asche

“…**Methods:** This retrospective analysis identified records of adults who underwent abdominal surgeries between January 2016 and September 2019 with either LB administration or traditional epidural analgesia using the Premier Healthcare Database. Economic outcomes included length of stay, hospital costs, rates of discharge to home, and 30-day hospital readmissions. …”
Get full text

Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study by Chunyan Zhou, Yanyu Zhang, Xiaoyi Liu, Chenyu He, Shiyang Li, Shiyang Li

“…This study aimed to explore the association between the metabolic score for insulin resistance (METS-IR) and the incidence of CMM.MethodsThis study included 6,977 individuals in the CHARLS database. We used multiple cox proportional hazards regression and restricted cubic splines (RCS) analysis to evaluate the association between METS-IR and CMM. …”
Get full text

Nonlinear effect of body mass index on postoperative survival following isolated heart transplantation by Reid Dale, PhD, Nataliya Bahatyrevich, MD, MS, Matthew Leipzig, BSc, Maria Elizabeth Currie, MD, PhD

“…Methods: A total of 30,787 patients were analyzed from the United Network for Organ Sharing (UNOS) database. Patients receiving an isolated heart transplant ages 18 and older since 2010 were included. …”
Get full text

Widening access to isotretinoin in primary care: an evaluation of New Zealand national dispensing data for isotretinoin for acne, 2008–2023 by Bruce Arroll, Diarmuid Quinlan, Peter Moodie, Rachel Petronella Roskvist, Jason Arnold

“…Objectives To identify what changes in the prescribing of isotretinoin have occurred since funded prescriber access was widened in 2009 from ‘dermatologist only’ prescribing to include ‘general practitioners (GPs) and nurse practitioners working within their scope of practice’.Design Evaluation of isotretinoin dispensing data from 2008 to 2023 using the national annual prescribing data obtained from the New Zealand Pharmaceutical National Collection database.Setting All New Zealand citizens prescribed and dispensed funded isotretinoin for acne from 2008 to 2023 were included.Main outcome measures The prescribing data were analysed to identify the total number of prescriptions per year by prescribing clinician type, patient ethnicity and deprivation levels.Results In 2008, nearly 100% (26 897) of dispensed prescriptions were written by a dermatologist, while in 2023, 79% (39 432) were written by primary care clinicians. …”
Get full text

Using the modified frailty index as a predictor of complications in adults undergoing transforaminal interbody lumbar fusion by Momin M. Mohis, Simon G. Ammanuel, Cuong P. Luu, James A. Stadler

“…Methods: Using the American College of Surgeons National Surgical Quality Improvement (ACS-NSQIP) database, all patients who underwent TLIF in 2015–2020 were filtered for their demographics, operative characteristics, and 30-day complication outcomes. …”
Get full text

A Bibliometric Analysis of Medullary Thyroid Carcinoma From 2000 to 2022 by TAN Meijuan, YANG Shijie, XU Xiequn

“…ObjectiveTo review the state of research on medullary thyroid carcinoma (MTC) over the past two decades, so as to offer a quick reference for understanding the current state and future trends in this field.MethodsA computer was employed to search the Web of Science Core Collection database for MTC-related literature (types: articles and reviews) published between 2000 and 2022. …”
Get full text

A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline by Amit Garg, Jun Xu, Mario Fioravanti, Taku Nakashima

“…Objective To evaluate the safety profile of nicergoline compared with placebo and other active agents from published randomised controlled trials.Design Systematic review and meta-analysis of nicergoline compared with placebo and other active agents across various indications.Data sources MEDLINE, Medline-in-process, Cochrane, EMBASE, EMBASE alerts, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR) and Cochrane Methodology Register (CMR) for all the randomised controlled trials, open-label or blinded, in adults treated with nicergoline. …”
Get full text

Effects of removing reimbursement restrictions on targeted therapy accessibility for non-small cell lung cancer treatment in Taiwan: an interrupted time series study by Jason C Hsu, Chen-Fang Wei, Szu-Chun Yang

“…Another targeted therapy, erlotinib, was initially approved as a third-line therapy in 2007, and it became a second-line therapy in 2008.Objectives This study is aimed towards an exploration of the impacts of the Taiwan NHI reimbursement policies (removing reimbursement restrictions) related to accessibility of targeted therapies.Setting We retrieved 2004–2013 claims data for all patients with lung cancer diagnoses from the NHI Research Database.Design and outcome measures Using an interrupted time series design and segmented regression, we estimated changes in the monthly prescribing rate by patient number and market shares by cost following each modification of the reimbursement policy for gefitinib and erlotinib for NSCLC treatment.Results Totally 92 220 patients with NSCLC were identified. …”
Get full text

Exploring the Mediating Role of Multiple Organ Dysfunction in Sepsis-Induced Disseminated Intravascular Coagulation and Its Impact on Worsening Prognosis by Guangjie Wang MD, Chenxiao Hao MD, Sun Yao MD, Yiqin Wang PHD, Zongtao Xu MD, Huiying Zhao MD, Youzhong An MD

“…Using data from the Peking University People's Hospital Investigation on Sepsis-Induced Coagulopathy database, we categorized patients into DIC and non-DIC groups based on DIC scores within 24 h of ICU admission (< 5 cutoff). …”
Get full text

Resetting the Hsc70-mediated lysosomal degradation of PD-L1 via a supramolecular meso peptide for the restoration of acquired anti-tumor T cell immunity by Yujia Zhao, Dan Liu, Wenguang Yang, Wangxiao He, Jin Yan, Leiqing Yao

“…Furthermore, based on bioinformatics analysis of mRNA expression data from 30 types of tumors obtained from TCGA database, malignant melanoma was identified as the most suitable indication for CTAC-PDL1 due to its specific characteristics of tumor immune. …”
Get full text

Surgical Treatment Patterns, Healthcare Resource Utilization, and Economic Burden in Patients with Tenosynovial Giant Cell Tumor Who Underwent Joint Surgery in the United States by Feng Lin, Winghan J. Kwong, Sherry Shi, Irina Pivneva, Eric Q. Wu, John A. Abraham

“…**Methods:** Patients newly diagnosed with TGCT, aged 18-64 years, who underwent joint surgery post-TGCT diagnosis were identified from the OptumHealth Care Solutions, Inc database (Q1/1999-Q1/2017). Patients were required to be continuously enrolled for ≥1 year before and ≥3 years after the first TGCT diagnosis (index date). …”
Get full text

Trends, gender, and racial disparities in patients with mortality due to paroxysmal tachycardia: A nationwide analysis from 1999-2020. by Aman Goyal, Humza Saeed, Saif Yamin, Abdullah, Wania Sultan, Muhammad Khubaib Arshad, Samia Aziz Sulaiman, Mah I Kan Changez, Gauranga Mahalwar

“…<h4>Methods</h4>Our study examined death certificates from 1999 to 2020 using the CDC WONDER Database to identify deaths caused by paroxysmal tachycardia in individuals aged 25 and older, using the ICD-10 code I47. …”
Get full text

Outcomes for Dostarlimab and Real-World Treatments in Post-platinum Patients With Advanced/Recurrent Endometrial Cancer: The GARNET Trial Versus a US Electronic Health Record-Based... by Scott Goulden, Qin Shen, Robert L. Coleman, Cara Mathews, Matthias Hunger, Ankit Pahwa, Rene Schade

“…**Objectives:** The objective of this study was to compare overall survival (OS) and describe time to treatment discontinuation (TTD) for dostarlimab (GARNET Cohort A1 safety population) with an equivalent real-world external control arm receiving non-anti-programmed death (PD)-1/PD-ligand (L)1/2 treatments (constructed using data from a nationwide electronic health record–derived de-identified database and applied GARNET eligibility criteria). …”
Get full text

Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD) by John R Hurst, Jennifer K Quint, Hana Müllerova, Liam Smeeth, Harriet Forbes, Susan Eaton, Rachael L DiSantostefano, Kourtney Davis

“…We assessed the accuracy of different approaches using the Clinical Practice Research Datalink, a UK electronic health record database.Setting 951 participants registered with a CPRD practice in the UK between 1 January 2004 and 31 December 2012. …”
Get full text

Cost Effectiveness of Insulin Glargine versus Neutral Protamin Hagedorn Insulin in the Treatment of Type 2 Diabetes Patients in Turkey by Ilhan Satman, Hayley Bennett, Candeger Yilmaz, Sazi Imamoglu, Goksun Ayvaz, Abdurrahman Comlekci, Demet Ozkaya, Toros Sahin

“…Improvements in glycaemic control have been incorporated using data from The Health Improvement Network (THIN) database in the United Kingdom, combined with meta-regression results describing the relationship between hypoglycaemia and glycaemic control. …”
Get full text