Patient experience and burden of haemolytic disease of the foetus and newborn: a systematic review by P. Maurice, J. McCallion, M. Fitzgibbon, J. N. Barthelmes, W. Karmous, E. J. Hardy, S. A. Mitchell, C. R. Mitchell, J. Lee, W. Noel, Andras Borsi, J. M. Jouannic

“…This systematic review (SR) aimed to identify and summarise real-world evidence (RWE) related to the patient burden/experience and economic burden of HDFN. Methods Electronic database searches supplemented by handsearching of grey literature, were conducted to identify studies that reported the clinical patient burden/experience, and economic burden of HDFN in Europe, the Middle East, and Africa (EMEA). …”
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Caution when using network partners for target identification in drug discovery by Dandan Tan, Yiheng Chen, Yann Ilboudo, Kevin Y.H. Liang, Guillaume Butler-Laporte, J. Brent Richards

“…To address this, we tested the approach on a list of robust positive control genes. We used the IntAct database to find physically interacting proteins of genes identified by exome-wide association studies (ExWASs), genome-wide association studies (GWASs) combined with a locus-to-gene mapping algorithm called the Effector Index, and Genetic Priority Score (GPS), which integrated eight genetic features with drug indications from the Open Targets and SIDER databases. …”
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Efficacy of electroacupuncture for insomnia in cancer patients: a systematic review and meta-analysis by Xiaodong Liu, Ning Xu, Shangpei Wang, Qingjun Jia

“…Electroacupuncture (EA) has been widely applied in managing sleep disorders, particularly in cancer patients or those experiencing insomnia.ObjectivesThis meta-analysis aims to evaluate the efficacy and safety of electroacupuncture for treating cancer-related insomnia.MethodsTwo independent reviewers conducted comprehensive searches across multiple databases, including EMBASE, Web of Science, PubMed, the Cochrane Library, Wanfang Digital Journals, China National Knowledge Infrastructure (CNKI), and the VIP Database for Chinese Technical Periodicals. …”
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Clinical outcomes after immune checkpoint inhibitor-associated acute kidney injury: a cohort study by Vin-Cent Wu, Ting-Ya Yang, Min-Hsiang Chuang, Hong-Min Lin, Heng-Chih Pan, Yun Chou, Jui-Yi Chen

“…Kaplan-Meier analyses coupled with log-rank tests were conducted to estimate the survival probabilities.Setting Data were sourced from the TriNetX database spanning records from 25 March 2011 to 5 April 2024.Participants Patients with cancer aged ≥18 years treated with ICPi with or without AKI occurrence.Primary and secondary outcome measures The primary outcome was all-cause mortality, and secondary outcomes included major adverse kidney events (MAKE), major adverse cardiovascular events (MACE), the composite of MAKE or MACE with death, and end-stage renal disease.Results The study identified 926 patients with cancer who developed ICPi-AKI (mean age, 67.1±11.8 years; 57.4% men). …”
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Adverse health effects after breast cancer up to 14 years after diagnosis by Marianne J. Heins, Kelly M. de Ligt, Janneke Verloop, Sabine Siesling, Joke C. Korevaar, Annette Berendsen, Daan Brandenbarg, Anneriet Dassen, Agnes Jager, Jacqueline Hugtenburg, Gerda van der Weele

“…Methods: We retrieved data on 11,495 women diagnosed with breast cancer in 2000–2016 and 23,242 age and sex matched controls from the PSCCR-Breast Cancer, a database containing data about cancer diagnosis, treatment and primary healthcare. …”
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Early Outcomes With Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement in Patients With Atrial Fibrillation by Shashank Shekhar, MD, Amar Krishnaswamy, MD, Grant Reed, MD, MSc, James Yun, MD, Rishi Puri, MD, PhD, Samir Kapadia, MD

“…Methods: Data on adult TAVR patients with a concomitant diagnosis of AF was obtained from the 2017-2020 National Readmissions Database. Stroke, major stroke, in-hospital mortality, and 30-day readmission rates were compared between the CPD and no-CPD cohorts in a propensity score matched analysis. …”
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Categorising implementation determinants and strategies within the US HIV implementation literature: a systematic review protocol by Justin D Smith, Brian Mustanski, Virginia McKay, James Lorenz Merle, Dennis Li, Brennan Keiser, Alithia Zamantakis, Artur Queiroz, Carlos G Gallo, Juan A Villamar, Juan Pablo Zapata, Nanette Benbow

“…Between November 2020 and January 2022, a broad database search strategy of Ovid MEDLINE, PsycINFO and Web of Science was conducted to capture implementation-related studies along the HIV prevention and care continuum. …”
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Contrast quality control for segmentation task based on deep learning models—Application to stroke lesion in CT imaging by Juliette Moreau, Juliette Moreau, Laura Mechtouff, Laura Mechtouff, David Rousseau, Omer Faruk Eker, Omer Faruk Eker, Yves Berthezene, Yves Berthezene, Tae-Hee Cho, Tae-Hee Cho, Carole Frindel, Carole Frindel

“…Moreover, the model trained without the low-contrast images performed equally well with all images when tested on another database.DiscussionThis study opens discussion with clinicians concerning the limitations, areas for improvement, and strategies for enhancing datasets and training models. …”
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Clinical outcome analysis for surgical fixation versus conservative treatment on rib fractures: a systematic evaluation and meta-analysis by Penglong Zhao, Qiyue Ge, Haotian Zheng, Jing Luo, Xiaobin Song, Liwen Hu

“…Methods We searched six online databases (PubMed, Web of Science, Embase, Cochrane Library, and the Sino-American Clinical Trials Database) for literature published between June 2004 and June 2024. …”
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Comprehensive Overview - Outcomes and Challenges of Bariatric Surgery - Physical, Psychological and Nutritional Considerations by Katarzyna Doman, Dawid Komada, Kamil Hermanowicz, Daria Oleksy, Agnieszka Najdek, Urszula Kaczmarska, Aleksandra Woźniak, Marcin Mycyk, Julia Nowak, Michał Jakub Cioch

“…Materials and methods The article is a result of the review of the scientific literature searched by keywords “bariatric surgery”, “negative outcomes”, “obesity’’ available in Pubmed database. This overview does not cover all possible postoperative complications in bariatric surgery, but focuses on selected issues important for a comprehensive strategy for managing obesity. …”
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Center-Related Variation in Hospitalization Cost for Patients Undergoing Percutaneous Left Atrial Appendage Occlusion by Shivaraj Patil, MD, Chaitanya Rojulpote, MD, Abhijit Bhattaru, BS, Avica Atri, MD, Krishna Vamsi Rojulpote, BS, Ola Khraisha, MD, Viha Atri, MD, William Frick, MD, Tarek Nafee, MD, Kishore Harjai, MD, Sumeet Mainigi, MD, Chien-Jung Lin, PhD, MD

“…Methods: All adults undergoing elective left atrial appendage occlusion with Watchman were identified in the 2016-2018 National Inpatient Database. Mixed models were used to evaluate the impact of center on total hospital costs, adjusting for patient and center characteristics and length of stay. …”
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Global trends and research frontiers on machine learning in sustainable animal production in times of climate change: Bibliometric analysis aimed at insights and orientations for t... by Robson Mateus Freitas Silveira, Concepta Mcmanus, Iran José Oliveira da Siva

“…In total, 1082 documents published in the last 70 years, in Scopus Database, were selected for the study. The annual growth rate recorded for publications in this field reached 3.78% per year, with 31.52% international contribution and 22.2 citations per document. …”
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Bergapten alleviates senescence of chondrocytes in osteoarthritis by YE Yuanlan, LIU Kaiwen, PAN Yiming

“…The obtained targets were intersected with Venny2.1.0, protein-protein interaction (PPI) analysis was performed using the STRING database, and molecular docking was conducted by AutoDock Vina. …”
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A novel approach for unveiling co-occurrence patterns of UV filter mixtures in sunscreens: Prioritization for hazard and risk assessment by Ah-Reum Jo, Ba Reum Kwon, Inae Lee, Jieun Min, Sohyeon Choi, Na-Youn Park, Younglim Kho, Jeongim Park, Ho Kim, Kyungho Choi

“…This study utilized a public database, “Hwahae”, and analyzed 2183 sunscreen products marketed in South Korea as of 2019, using an association rule mining (ARM) to elucidate their co-occurrence patterns. …”
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Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease by Yue Xu, Yue Xu, Durong Chen, Meiqi Dong, Yun Zhang, Yun Zhang, Hongmei Yu, Hongmei Yu, Hongmei Yu, Yanqing Han, Yanqing Han, Yanqing Han

“…ObjectiveTo investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients and explore the mediating role of cognitive function over time.MethodsData from 892 PD patients from the Parkinson’s Progression Markers Initiative (PPMI) database were included in this study, and depression, cognitive function, and ADL were measured using the Geriatric Depression Scale (GDS-15), Montreal Cognitive Assessment Scale (MoCA), and Unified Parkinson’s Disease Rating Scale, Part II (UPDRS II) respectively. …”
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Comparison of Survival Outcomes of Lymphovascular Space Invasion-Negative and Lymphovascular Space Invasion - Positive Women with Stage IIIC Endometrioid Endometrial Cancer: A Case... by Zeliha Firat Cuylan, Mehmet Mutlu Meydanli, Murat Öz, Ahmet Taner Turan, Ozgur Akbayir, Murat Dede, Ali Ayhan

“…Study Design: A multicenter, retrospective, department database review was performed to identify lymphovascular space invasion-negative and lymphovascular space invasion-positive stage IIIC endometrioid endometrial cancer at five gynecological oncology centers in Turkey. …”
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Course of COVID-19 in Patients with Inflammatory Bowel Disease: Regional Experience by L. M. Kupkenova, E. N. Belousova, E. S. Bodryagina, D. D. Mukhametova, A. Kh. Odintsova, D. G. Iskhakova, D. I. Abdulganieva

“…In a comparative analysis of patients with IBD and COVID-19 from the SECURE-IBD database and own data, it was found that the average age of patients was comparable (42.7 vs 41.0). …”
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Outcomes, Healthcare Resource Utilization, and Costs of Overall, Community-Acquired, and Hospital-Acquired Acute Kidney Injury in COVID-19 Patients by Jay L. Koyner, Rachel H. Mackey, Ning A. Rosenthal, Leslie A. Carabuena, J. Patrick Kampf, Paul McPherson, Toni Rodriguez, Aarti Sanghani, Julien Textoris

“…**Methods:** This retrospective cohort study included inpatients with COVID-19 discharged from US hospitals in the Premier PINC AI™ Healthcare Database April 1–October 31, 2020, categorized as AKI, CA-AKI, HA-AKI, or no AKI by ICD-10-CM diagnosis codes. …”
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Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…This study evaluates upadacitinib-related adverse events (AEs) utilizing data from the US Food and Drug Administration Adverse Event Reporting System (FAERS).MethodsWe employed disproportionality analyses, including the proportional reporting ratio (PRR), reporting odds ratio (ROR), Bayesian confidence propagation neural network (BCPNN), and empirical Bayesian geometric mean (EBGM) algorithms to identify signals of upadacitinib-associated AEs for treating inflammatory bowel disease (IBD).ResultsFrom a total of 7,037,004 adverse event reports sourced from the FAERS database, 37,822 identified upadacitinib as the primary suspect drug in adverse drug events (ADEs), including 1,917 reports specifically related to the treatment of inflammatory bowel disease (IBD). …”
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Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis by Lingling Zhao, Cheng Xu, Jiewen Deng, Yang Ni

“…This meta-analysis aims to assess whether the integration of HAIC with lenvatinib and PD-1 inhibitors (referred to as the HAIC-L-P group) leads to better treatment effectiveness and security compared to lenvatinib and PD-1 inhibitors alone (L-P group) in uHCC.MethodsAn exhaustive search of the literature was conducted, including PubMed, the Cochrane Library, Embase, ClinicalTrials.gov, and Web of Science, from the start of each database until September 2024, to ensure a thorough and up-to-date compilation of relevant studies. …”
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