CAR-T cells: prospective genetic engineering approach to orchestrate solid tumor in lung cancer by Angeline Felisca Tanujaya, Dhea Anggraini, Ahmad Dzulfikri Nurhan

“…Introduction: Various strategies, starting with surgery, systemic radiation therapy with cytotoxic chemotherapy, and immunotherapy, have been carried out to address mortality from lung cancer. …”
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Trial watch: local anesthetics in cancer therapy by Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer, Lucillia Bezu

“…Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic as well as indirect immunemediated effects that together reduce the proliferative, invasive and migratory potential of malignant cells. …”
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Biological Evaluation of Garcinia kola Heckel by Abdulrahman Mahmoud Dogara, Saber W. Hamad, Harmand A. Hama, Sarwan W. Bradosty, Soran Kayfi, Sawsan S. Al-Rawi, Abubakar Abdullahi Lema

“…Antioxidant, antimicrobial, antidiabetic, antibacterial, medications, antiviral, traditional medicine, ethnopharmacology, toxicity, cytotoxic action, chemical composition, mineral elements, GCMS analysis, and any other related phrases were used as filters to find studies. …”
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Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines by Burcu Saygıdeğer Demir, Tuğba Keleş, Osman Serindağ

“…The results of this research showed that all three metal complexes indicated dose-dependent cytotoxicity on A549 and K562 cell lines and that the complexes inhibited different percentages of the TrxR, GPx, and Cat enzymes of these tumor cells.…”
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The Story of CD4+CD28− T Cells Revisited: Solved or Still Ongoing? by Kathrin Maly, Michael Schirmer

“…The proinflammatory and cytotoxic capacities of these cells indicate an involvement in progression and maintenance of chronic immune-mediated disease. …”
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Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani by Sudipta Chakraborty, Kaushik Bhar, Sandip Saha, Rajarshi Chakrabarti, Anjali Pal, Anirban Siddhanta

“…Moreover, this antileishmanial activity has comparatively less cytotoxic effect on the mouse macrophage cell line. …”
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Chemotherapy and cognitive function: comprehensive review on methotrexate‐induced chemobrain by Nadine C. Sabry, Haidy E. Michel, Esther T. Menze

“…This review is deliberated to highlight the mechanisms behind the pathophysiology of chemobrain, with concentration on the cytotoxic agent ‘’methotrexate’’(MTX), which has been revealed to be involved in arduous neurotoxicity. …”
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The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFα and a TNFα 36–62 Peptide by Ø. Rekdal, Z. Konopski, J. S. Svendsen, J.-O. Winberg, T. Espevik, B. Østerud

“…In contrast to TNFα, the peptide did not show a cytotoxic activity against WEHI 164 flbrosarcoma cells. …”
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Repetitive Noninvasive Monitoring of HSV1-tk-Expressing T Cells Intravenously Infused into Nonhuman Primates Using Positron Emission Tomography and Computed Tomography with F-FEAU by Gianpietro Dotti, Mei Tian, Barbara Savoldo, Amer Najjar, Laurence J.N. Cooper, James Jackson, Amanda Smith, Osama Mawlawi, Rajesh Uthamanthil, Agatha Borne, David Brammer, Vincenzo Paolillo, Mian Alauddin, Carlos Gonzalez, David Steiner, William K. Decker, Frank Marini, Steven Kornblau, Catherine M. Bollard, Elizabeth J. Shpall, Juri G. Gelovani

“…Adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTLs) has been successfully used to treat patients with different types of cancer. …”
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Designing and immunomolecular analysis of a new broad-spectrum multiepitope vaccine against divergent human papillomavirus types. by Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz

“…Immunodominant B cell, cytotoxic T cell (CTL), and helper T cell (HTL) epitopes were predicted using bioinformatics tools These epitopes were subsequently analyzed using various immunoinformatics tools, and those that exhibited high antigenicity, immunogenicity, non-allergenicity, non-toxicity, and excellent conservation were selected. …”
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Harnessing light-activated gallium porphyrins to combat intracellular Staphylococcus aureus using an in vitro keratinocyte infection model by Klaudia Szymczak, Michał Rychłowski, Lei Zhang, Joanna Nakonieczna

“…This study is the first to analyze aPDI toxicity in real time within an infection model, demonstrating that this method is neither cytotoxic nor phototoxic.…”
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Application of Immuno-PET in Antibody–Drug Conjugate Development by Kendra S. Carmon PhD, Ali Azhdarinia PhD

“…Antibody–drug conjugates (ADCs) combine the high affinity and specificity of mAbs with the potency of cytotoxic drugs to target tumor-expressing antigen and destroy cancer cells. …”
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Advancing cancer immunotherapy through emerging intratumoral delivery and biomedical imaging technologies by Eunseo Choi, Alexander Bagley, Sakib Haque, Celeste Winters, Conroy Sun

“…Intratumoral delivery of cytotoxic or immunomodulating compounds is a promising approach for cancer therapy. …”
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9,10-Dioxoanthracenyldithiocarbamates effectively inhibit the proliferation of non-small cell lung cancer by targeting multiple protein tyrosine kinases by Mateusz Olszewski, Maryna Stasevych, Viktor Zvarych, Natalia Maciejewska

“…The compounds were subjected to a range of tests to assess their cytotoxic and apoptotic properties, ability to inhibit colony formation, pro-DNA damage functions, and capacity to inhibit the activity of tyrosine kinase proteins (PTKs). …”
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Whole genome sequence of Streptomyces colonosanans strain MUSC 93JT isolated from mangrove forest in Malaysia by Hooi-Leng Ser, Jodi Woan-Fei Law, Wen-Si Tan, Wai-Fong Yin, Kok-Gan Chan

“…The strain exhibited potent antioxidant activities and cytotoxic activity against several human cancer cell lines. …”
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EPIDEMIOLOGY OF THERAPY-RELATED MYELOID NEOPLASMS IN THE NORDIC COUNTRIES by Kjeld Schmiegelow

“…In 524 patients we determined the erythrocyte activity of thiopurine methyltransferase (TPMT), which methylates 6MP and its metabolites, and thus reduces cellular levels of cytotoxic 6-thioguanine nucleotides. The TPMT activity was significantly lower in those that did compared to those that did not develop an SMN (Median: 12.1 vs 18.1 IU/ml; p=0.02). …”
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Immunomodulatory insights of monoterpene glycosides in endometriosis: immune infiltration and target pathways analysis by Jin Zhan, Jiajie Wu

“…Significant differences in immune cell infiltration were observed, with increased CD8 T cells, cytotoxic cells, and others in endometriosis. Differential expression analysis identified 43 potential targets. …”
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Trichosanthes dioica Roxb.: A vegetable with diverse pharmacological properties by Mahia Khandaker, Saleha Akter, Mohammad Zafar Imam

“…Studies have found promising antihyperglycemic, antihyperlipidemic, antitumor, cytotoxic, arsenic poisoning ameliorative, anti-inflammatory, antidiarrheal, and varieties of pharmacological activities of T. dioica. …”
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T-cell agonists in cancer immunotherapy by Gennaro Ciliberto, Aung Naing, Joud Hajjar, Cara L Haymaker, Yeonjoo Choi, Yaoyao Shi

“…In addition, researchers are conducting trials of combinations of such immune modulators with checkpoint blockade, radiotherapy and cytotoxic chemotherapeutic drugs in patients with advanced tumors. …”
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Severe Myositis, Myocarditis, and Myasthenia Gravis with Elevated Anti-Striated Muscle Antibody following Single Dose of Ipilimumab-Nivolumab Therapy in a Patient with Metastatic M... by Mahdieh Fazel, Patrick M. Jedlowski

“…Immune checkpoint inhibitors targeting programmed cell death protein 1 and cytotoxic T-lymphocyte associated protein 4 have improved survival in patients with metastatic melanoma, especially in combination (i.e., ipilimumab-nivolumab). …”
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