Tumor-Induced Local and Systemic Impact on Blood Vessel Function by J. Cedervall, A. Dimberg, A-K. Olsson

“…In addition, leukocytes, such as cytotoxic T-cells, have to travel across the vessel wall to enter the tumor tissue where they contribute to killing of cancer cells. …”
Get full text

Modulation of nitric oxide synthase activity in macrophages by P. G. Jorens, K. E. Matthys, H. Bult

“…NO is a major effector molecule of the anti-microbial and cytotoxic activity of rodent macrophages against certain micro-organisms and tumour cells, respectively. …”
Get full text

Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease: An Immunohistochemical Investigation by Taku Fujimura, Sadanori Furudate, Yumi Kambayashi, Setsuya Aiba

“…In this study, we employed immunohistochemical staining for immunosuppressive macrophages and cytotoxic T cells in the lesional skin of patients with noninvasive EMPD and those with invasive EMPD.…”
Get full text

Alpha-Hemoglobin-Stabilizing Protein: An Erythroid Molecular Chaperone by Maria Emília Favero, Fernando Ferreira Costa

“…Evidence strongly suggests that AHSP participates in hemoglobin synthesis and may act to neutralize the cytotoxic effects of excess free alpha-globin subunits that accumulate both in normal and beta-thalassemic erythroid precursor cells. …”
Get full text

Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10 by Bernard A Fox, Cristina Bergamaschi, George N Pavlakis, Antonio Valentin, Jenifer Bear, Barbara K Felber, Shawn M Jensen, Hrishikesh Pandit, Bethany A Nagy, Dimitris Stellas, Maggie Cam

“…Background Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8+ T and natural killer (NK) cells. Bioactive IL-15 is produced in the body as a heterodimeric cytokine, comprising the IL-15 and IL-15 receptor alpha chains (hetIL-15). …”
Get full text

Oncolytic influenza virus enhances killing effect of gemcitabine against pancreatic cancer cells by MENG Zihe, MENG Zihe, XU Yongru, DENG Zhaoda

“…At the cellular level， the viruses demonstrated a significant selective cytotoxic effect on Panc02， PANC-1， SW1990， and BxPC-3 cells under the conditions of 48 h post-infection and MOI=3.0， when compared to 48 h post-infection and MOI=0 （P<0.01）. …”
Get full text

Poor clinical outcomes and immunoevasive contexture in CD161+CD8+ T cells barren human pancreatic cancer by Jun Yu, Liang Liu, Hanlin Yin, Qiangda Chen, Siyao Liu, Wenchuan Wu, Ning Pu, Wenhui Lou, Zhenlai Jiang, Taochen He, Yuqi Xie, Weilin Mao, Jiande Han, Joseph R Habib

“…Finally, we identified tumor-infiltrating CD161+CD8+ T cells as a unique subtype of responsive CD8+ T cells characterized by increased levels of cytotoxic cytokines and immune checkpoint molecules.Conclusion CD161+CD8+ T cells exhibit elevated levels of both cytotoxic and immune-checkpoint molecules, indicating as a potential and attractive target for immunotherapy. …”
Get full text

Using Poly(amidoamine) PAMAM-βCD Dendrimer for Controlled and Prolonged Delivery of Doxorubicin as Alternative System for Cancer Treatment by Kendra Sorroza-Martínez, Ignacio González-Sánchez, Raúl Villamil-Ramos, Marco Cerbón, Jorge Antonio Guerrero-Álvarez, Cristina Coronel-Cruz, Ernesto Rivera, Israel González-Méndez

“…<b>Results:</b> The PAMAM-βCD/Ad-h-Dox assembly was adequately characterized, and the cytotoxic activity results demonstrate that the nanocarrier alone and its hydrolysis product are innocuous compared to the PAMAM-βCD/Ad-h-Dox nanocarrier that showed cytotoxicity equivalent to free Dox in the tested cancer cell lines. …”
Get full text

Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and n... by Lucas A. Horn, Hanne Lind, Kristen Fousek, Haiyan Qin, Nika Rajabian, Shantel Angstadt, Nicole Hsiao-Sanchez, Miriam M. Medina-Enriquez, Marcus D. Kelly, Clint T. Allen, Sarah M. Hammoudeh, Roberto Weigert, Dean Y. Maeda, John A. Zebala, Claudia Palena

“…Treatment of HPV-negative HNSCC cell lines in vitro with SX-682 sensitized the tumor cells to the cytotoxic activity of docetaxel. In vivo, treatment of HNSCC xenograft models with the combination of SX-682 plus docetaxel led to strong anti-tumor control resulting in tumor cures. …”
Get full text

Human head and neck cancer cell lines response to cold atmospheric plasma activated media is affected by the chemistry of culture media by Viviana di Giacomo, Marwa Balaha, Asia Pece, Ilaria Cela, Gianluca Fulgenzi, Giovanna Orsini, Tatiana Spadoni, Tirtha Raj Acharya, Nagendra Kumar Kaushik, Eun Ha Choi, Monica Rapino, Mariangela Mazzone, Gabriella Mincione, Gianluca Sala, Eloisa Sardella, Vittoria Perrotti

“…In addition, cytotoxic effects were also observed on HNC, two bladder cancer models and one breast cancer cell line when considering PTL, paving the way for their application into a clinical setting.…”
Get full text

Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch by Judith Wienke, S Nierkens, Miranda P Dierselhuis, Jan J Molenaar, Annelisa M Cornel, Ester Dunnebach, Damon A Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Josephine G M Strijker, Denise A M H van den Beemt, Anke H W Essing, Bianca Koopmans, Sem A G Engels, Vania Lo Presti, Celina S Szanto, Rani E George, Sebastiaan van Heesch

“…Moreover, MICA and MICB, important in NK cell cytotoxicity, were also increased by entinostat exposure. …”
Get full text

Understanding the Molecular Mechanisms of Incomptine A in Treating Non-Hodgkin Lymphoma Associated with U-937 Cells: Bioinformatics Approaches, Part I by Fernando Calzada, Normand García-Hernández, Elihú Bautista, José Manuel Sánchez-López, Miguel Valdes, Claudia Velázquez, Elizabeth Barbosa

“…<b>Background</b>: Incomptine A (<b>IA</b>) has been reported to have cytotoxic activity in non-Hodgkin lymphoma cancer cell lines and have effects on U-937 cells, including the induction of apoptosis, the production of reactive oxygen species, and the inhibition of glycolytic enzymes. …”
Get full text

Synthesis, characterization, and evaluation of copper-doped zinc oxide nanoparticles anticancer effects: in vitro and in vivo experiments by Habib Ghaznavi, Mohammad Reza Hajinezhad, Zahra Hesari, Milad Shirvaliloo, Saman Sargazi, Sheida Shahraki, Eshagh Ali Saberi, Roghayeh Sheervalilou, Somayeh Jafarinejad

“…This study aims to synthesize zinc oxide nanoparticles and copper-doped zinc oxide nanoparticles to harness the combined cytotoxic and anticancer effects of them in vitro and in vivo studies. …”
Get full text

Co-exposure of ferruginous components of subway particles with lipopolysaccharide impairs vascular function: A comparative study with ambient particulate matter by Oluwatoyin Hannah Owokoniran, Akiko Honda, Takamichi Ichinose, Raga Ishikawa, Megumi Nagao, Natsuko Miyasaka, Zaoshi Wang, Satsuki Takai, Issei Omori, Kerui Zhang, Wei Liu, Yuya Higaki, Takayuki Kameda, Tomonari Matsuda, Taku Fujiwara, Tomoaki Okuda, Hirohisa Takano

“…While VEP and UA induced an increase in interleukin (IL)-6 production, iron oxides, particularly Fe3O4, increased IL-8 production at slightly toxic and non-cytotoxic concentrations. In addition, co-exposure of all particles and LPS at non-cytotoxic concentrations promoted pro-inflammatory cytokine (IL-6 and IL-8) production relative to exposure to the particles alone. …”
Get full text

Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…Both 125I-HLX58 and 131I-HLX58-Der exhibited significant binding affinity for the CLDN18.2-positive cancer cell line. The cytotoxic effect of 131I-HLX58-Der was observed in the CLDN18.2-positive cell line, with an IC50 of 11.28 ng/mL. …”
Get full text

Persistence of activated anti‐mesothelin hYP218 chimeric antigen receptor T cells in the tumour is associated with efficacy in gastric and colorectal carcinomas by Sameer Mir, Abhilash Venugopalan, Jingli Zhang, Nishanth Ulhas Nair, Manjistha Sengupta, Manakamana Khanal, Chaido Stathopoulou, Qun Jiang, Raffit Hassan

“…Activated hYP218 CAR T cells persist in the tumour microenvironment and retain their cytotoxic activity. Addition of pembrolizumab in larger tumours enhance CAR T cell efficacy.…”
Get full text

Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Abstract In malignant glioma, cytotoxic drugs are often inhibited from accessing the tumor site due to the blood-tumor barrier (BTB). …”
Get full text

Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2 by Shaoyi Cao, Huaqiu Li, Xiaoyan Ye, Xinxing Xing, Yonghuan Xie, Xiangfeng Zeng, Hongjiao Liu, Xing Zhong, Xinyi Yang, Wenxiu Xing, Cairong Zhu, Xiaoping Wu

“…Results Shikonin was identified as a potent cytotoxic compound against EGFR-T790M-mutant NSCLC cells. …”
Get full text

Bioassay Guided Fractionation Protocol for Determining Novel Active Compounds in Selected Australian Flora by Janice Mani, Joel Johnson, Holly Hosking, Beatriz E. Hoyos, Kerry B. Walsh, Paul Neilsen, Mani Naiker

“…A high occurrence of t-ferulic acid in the GGL extracts was found which may explain the cytotoxic activity of GGL extracts. Peaks in KPS and KPF extracts were tentatively identified as gallic acid, protocatechuic acid, 4-hydroxybenzoic acid and syringic acid and possibly ellagic acid. …”
Get full text

PPARγ as a Novel Therapeutic Target in Lung Cancer by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…This review of the current literature highlights the potential of PPARγ agonists as novel therapeutic modalities in lung cancer, either as monotherapy or in combination with standard cytotoxic chemotherapy.…”
Get full text