A Review on Current Knowledge of Medicinal Properties of Garcinia quaesita by Sivasinthujah Srikokulan, A. S. Nirubini

“…It provides information on its botanical descriptions, phyto-constituents, antioxidant, antibacterial, anti-hyperglycemic, anti-inflammatory, cytotoxic and anticancer activities. There have been few studies that reported the medicinal properties of the leaf, fruit rind and fruit. …”
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Combining CRISPR-Cas9 and TCR exchange to generate a safe and efficient cord blood-derived T cell product for pediatric relapsed AML by Zsolt Sebestyen, Jürgen Kuball, Maud Plantinga, Anja Krippner-Heidenreich, S Nierkens, Ester Dunnebach, Vania Lo Presti, Olaf T Heidenreich, Angelo Meringa, Alice van Velzen, Aida Valera Moreira, Ronald W Stam, Rishi S Kotecha, Annelisa Cornel, Niek P van Til

“…WT1-TCR-engineered T cells lacking the expression of their eTCR (eTCR−/− WT1-TCR) showed increased cell surface expression of the rTCR and production of cytotoxic cytokines, such as granzyme A and B, perforin, interferon-γ (IFNγ), and tumor necrosis factor-α (TNFα), on antigen recognition when compared with WT1-TCR-engineered T cells still expressing their eTCR (eTCR+/+ WT1-TCR). …”
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CD8+CD57+ T cells exhibit distinct features in human non-small cell lung cancer by Wei Sun, Rong Liu, Bing Huang, Peiliang Wang, Zhiwei Yuan, Jianjian Yang, Hui Xiong, Ni Zhang, Qi Huang, Xiangning Fu, Lequn Li

“…CD8+CD57+ T cells exhibited enhanced cytotoxic potencies and impaired proliferative capability. …”
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Immunogenicity of the CoronaVac vaccine in children: a real-world study by Wbeimar Aguilar-Jimenez, Ana Lucia Rodriguez-Perea, Mateo Chvatal-Medina, Paula A. Velilla, Wildeman Zapata-Builes, Wildeman Zapata-Builes, Laura M. Monsalve-Escudero, Maria I. Zapata-Cardona, Jorge Humberto Tabares-Guevara, Daniel S. Rincón, Juan C. Hernandez, Juan C. Hernandez, Yulied Tabares, Liliana Lopez-Carvajal, Maria T. Rugeles

“…T-cells were stimulated with wild-type and Omicron peptide pools to analyze activation-induced markers, memory phenotype, cytotoxic molecules, and cytokine production by flow cytometry.FindingsCoronaVac was well tolerated, with only 7.8% infection incidence in both Exposed and Non-Exposed groups. …”
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Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in Acinetobacter baumannii by Maria Romano, Federico Falchi, Federico Falchi, Eliana De Gregorio, Maria Stabile, Antonella Migliaccio, Alessia Ruggiero, Valeria Napolitano, Ida Autiero, Flavia Squeglia, Rita Berisio

“…Finally, we checked that the identified compound was not cytotoxic at the used concentrations by haemolysis assays.ResultsWe successfully produced PmrC PetN transferase membrane protein in high yields and showed that PmrC is a stable α-β protein, with melting temperature Tm = 60°C. …”
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Exploiting the immunogenic potential of standard of care radiation or cisplatin therapy in preclinical models of HPV-associated malignancies by James W Hodge, Michelle R Padget, Kellsye P Fabian, Joshua T Kowalczyk, Diana C Lopez, Austin TK Hoke, Clint T Allen, Mario Hermsen, Nyall R London

“…Background While radiation and chemotherapy are primarily purposed for their cytotoxic effects, a growing body of preclinical and clinical evidence demonstrates an immunogenic potential for these standard therapies. …”
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Study on the Regulated Cell Death of Hypertrophic H9c2 Cells Induced by Au:Ag Nanoparticles by Galindo-Padrón AG, Lorenzo-Anota HY, Rueda-Munguía M, García-Carrasco A, Gaitán López M, Vázquez-Garza E, Campos-González E, Lozano O, Cholula-Díaz JL

“…In particular, whether they could cause an exacerbated cytotoxic response in susceptible tissues due to damage or disease, such as the heart, liver, spleen, or kidneys. …”
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Unlocking the pharmacological potential of Brennnesselwurzel (Urtica dioica L.): an in-depth study on multifaceted biological activities by Amr Elkelish, Abdelghafar M. Abu-Elsaoud, Alaa M. Alqahtani, Mohammad El-Nablaway, Norah Al harthi, Najwa Al harthi, Sulaiman Lakoh, Essa M. Saied, Mai Labib

“…Among the cells examined, the BWE extract exhibited significant cytotoxic activity toward HCT-116, A-549, MDA-MB-231 cells with IC50 of 15.11, 15.32, 15.79 µg/mL, respectively, while it possessed no significant cytotoxic activity towards WI-38 cells (IC50 119.62 µg/mL). …”
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Patterns of immune evasion in triple-negative breast cancer and new potential therapeutic targets: a review by Lucía Serrano García, Beatriz Jávega, Antonio Llombart Cussac, Antonio Llombart Cussac, Antonio Llombart Cussac, María Gión, José Manuel Pérez-García, José Manuel Pérez-García, Javier Cortés, Javier Cortés, Javier Cortés, María Leonor Fernández-Murga

“…Standard treatment for TNBC primarily relies on cytotoxic agents, such as taxanes, anthracyclines, and platinum compounds for both early and advanced stages of the disease. …”
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β-caryophyllene sensitizes hepatocellular carcinoma cells to chemotherapeutics and inhibits cell malignancy through targeting MAPK signaling pathway by Irum Basheer, Hai Wang, Guangyue Li, Shah Jehan, Ali Raza, Chentao Du, Najeeb Ullah, Dangdang Li, Guangchao Sui

“…In combinatorial treatments, BCP synergistically enhanced cytotoxicity of DOX and DDP in HCC cells but this effect was markedly reduced in HL-7702 cells. …”
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Therapeutic inhibition of monocyte recruitment prevents checkpoint inhibitor-induced hepatitis by Nick Powell, Mark R Thursz, Kevin J Woollard, James Larkin, Samra Turajlic, Stephen R Atkinson, Robert D Goldin, Evangelos Triantafyllou, Lucia A Possamai, Charalambos G Antoniades, Cathrin L C Gudd, Eoin Mitchell, Marie-Anne Mawhin

“…However, their liver recruitment, clustering, and cytotoxic activity is dependent on the presence of CCR2+ monocytes. …”
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Efficient One-Pot Synthesis of Novel Caffeic Acid Derivatives as Potential Antimalarials by Katarzyna Sidoryk, Silvia Parapini, Nicoletta Basilico, Magdalena Zaremba-Czogalla, Marek Kubiszewski, Marcin Cybulski, Jerzy Gubernator, Agnieszka Zagórska, Anna Jaromin

“…The compounds have been evaluated against chloroquine-sensitive and chloroquine-resistant P. falciparum strains. Their cytotoxicity to normal human dermal fibroblasts and their propensity to induce hemolysis have been also determined. …”
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5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell by Senthil Kumar Chinnaiyan, Agnes Mary Soloman, Ramesh Kannan Perumal, Arun Gopinath, Madhan Balaraman

“…In this study, 5‐FU‐G‐AuNPs exhibited potential cytotoxic and apoptotic effects on (MiaPaCa‐2) cell line.…”
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Computational analysis of degree-based hyper invariants for supramolecular chain by Zhang Xiujun, Amjad Muhammad, Jamil Muhammad Kamran, Saleem Umair, Ali Haider, Waheed Muhammad

“…N-salicylidene-l-valine is getting attention in recent research due to its distinct structure and elevated catalytic and cytotoxic activity. To understand more about this structure and its characteristics in topological indices, we investigate the chain of supramolecular dialkyltin N-salicylidene-l-valine complexes-2, 3, and 4. …”
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T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer by A. E. Albers, L. Strauss, T. Liao, T. K. Hoffmann, A. M. Kaufmann

“…Immunosurveillance is exerted mostly by cytotoxic T-lymphocytes (CTLs) while specific immune suppression is associated with tumor malignancy and progression. …”
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Integral manifolds for impulsive HCV conformable neural network models by Martin Bohner, Ivanka Stamova, Gani Stamov, Cvetelina Spirova

“…In this paper, we offer a new modelling approach for hepatitis C virus (HCV) infection models with cytotoxic T lymphocytes (CTL) immune responses. The standard neural network models with reaction-diffusion terms are generalized to the discontinuous case considering impulsive controllers. …”
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Rethinking Immune Check Point Inhibitors Use in Liver Transplantation: Implications and ResistanceSummary by Vivian Ortiz, Emilien Loeuillard

“…ICI therapy aims to heighten cytotoxic T lymphocytes response against tumors. However, tumor recurrence is common owing to tumor immune response escape involving ablation of CTL response by interfering with antigen presentation, triggering CLT apoptosis and inducing epigenetic changes that promote ICI therapy resistance. …”
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The Effects of TLR Activation on T-Cell Development and Differentiation by Bo Jin, Tao Sun, Xiao-Hong Yu, Ying-Xiang Yang, Anthony E. T. Yeo

“…T cells consist of various subsets, that is, Th1, Th2, Th17, T follicular helper (Tfh), cytotoxic T lymphocytes (CTLs), regulatory T cells (Treg) and these originate from thymic progenitor thymocytes. …”
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Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker by K. Earlam, C. A. Souza, R. Glikstein, M. M. Gomes, S. Pakhalé

“…Treatment includes smoking cessation and the potential use of glucocorticoids or cytotoxic agents depending on the severity of disease and multisystem involvement.…”
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Primary T-Cell Non-Hodgkin Lymphoma of the Vagina by J. L. Herraiz, A. Llueca, Y. Maazouzi, D. Piquer, A. Palmeiro, E. Calpe

“…The results of the immunohistological studies of the mass revealed the presence of a cytotoxic T-cell non-Hodgkin lymphoma, which is the least common subtype.…”
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