Trastuzumab Resistance: Role for Notch Signaling by Kinnari Mehta, Clodia Osipo

“…Overexpression of ErbB-2 predicts for aggressive tumor behavior, resistance to some cytotoxic and antihormonal therapies, and poor overall survival. …”
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Tau-Reactive Endogenous Antibodies: Origin, Functionality, and Implications for the Pathophysiology of Alzheimer’s Disease by Lenka Hromadkova, Saak Victor Ovsepian

“…Multiple anti-tau antibodies inhibiting the formation and propagation of cytotoxic tau or promoting its clearance and degradation have been tested in clinical trials, albeit with the inconclusive outcome. …”
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Anti-CD20 Treatment of Autoimmune Hemolytic Anemia Refractory to Corticosteroids and Azathioprine: A Pediatric Case Report and Mini Review by Alexandros Makis, Zoi Kanta, Dimitrios Kalogeropoulos, Nikoloaos Chaliasos

“…Refractory cases are treated with immunosuppressive drugs, cytotoxic agents, androgens, or splenectomy, with various side effects and questionable efficacy. …”
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ASSOCIATION BETWEEN PR PROTEINS WITH RIBONUCLEASE ACTIVITY AND PLANT RESISTANCE AGAINST PATHOGENIC FUNGI by E. A. Filipenko, A. V. Kochetov, Y. Kanayama, V. I. Malinovsky, V. K. Shumny

“…This paper presents current data on molecular mechanisms governing the antifungal activity of PR-ribonucleases connected both with their direct cytotoxic impact on pathogen cells and with possible participation in induction of plant cell apoptosis and development of the hypersensitive reaction (HR).…”
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Novel Thioethers of Dihydroartemisinin Exhibiting Their Biological Activities by Ngoc Hung Truong, Thi Hong Ha Tran, Kim Chi Hoang, Duc Bao Ninh, Viet Duc Le, Duc Anh Le, Van Chinh Luu

“…Screening in vitro biological activities revealed that most of the synthesized conjugates showed good cytotoxic and anti-inflammatory activity, while three of them displayed α-glucosidase inhibitory activity. …”
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From prescription to pollution: The ecological consequences of NSAIDs in aquatic ecosystems by Divya Lakshmi S, Vijaya Geetha B, Vibha Murali

“…NSAIDs can enter aquatic ecosystems through wastewater discharge as it is very difficult to extract NSAIDs by conventional wastewater treatment, thus affecting aquatic life. These drugs induce cytotoxic and genotoxic effects, affect the functioning of endocrine systems, influence behavioural changes, and impair reproduction in fish and other aquatic organisms. …”
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TiO2 – do we have to worry about it? One of the important aetiological factors in inflammatory bowel disease by Sara Jarmakiewicz-Czaja, Aneta Sokal, Jacek Tabarkiewicz, Rafał Filip

“…It may have pro-inflammatory, cytotoxic, and genotoxic effects. A change in the composition of the host’s intestinal microflora is also observed after exposure to high doses of TiO2. …”
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Autophagy in Macrophages: Impacting Inflammation and Bacterial Infection by Ali Vural, John H. Kehrl

“…Innate immune responses include the rapid induction of transcriptional networks that trigger the production of cytokines, chemokines, and cytotoxic molecules; the mobilization of cells including neutrophils and other leukocytes; the engulfment of pathogens by phagocytosis and their delivery to lysosome for degradation; and the induction of autophagy. …”
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Quercetin nanoparticles as a therapeutic approach: pharmacological actions and potential applications in therapy by Reham Farouk El-Sayed Baiomy

“…Furthermore, these nanoparticles have been scientifically documented to possess antioxidant, anticarcinogenic, hepatoprotective, and cytotoxic activities. This comprehensive review aims to explore the pharmacokinetics and biological activities associated with quercetin nanoparticles. …”
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Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival by Gil-Ran Kim, Kyung-Ho Nam, Je-Min Choi

“…Belatacept, a modified version of cytotoxic T lymphocyte antigen-4 immunoglobulin with increased binding affinity for its ligand, has emerged as a viable alternative to traditional CNIs due to its lower toxicity profile. …”
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Conventional Medicinal Uses, Phytoconstituents, and Biological Activities of Euphorbia officinarum L.: A Systematic Review by Imane Chamkhi, Mohamed Hnini, Jamal Aurag

“…Plants in the genus Euphorbia are well known for the chemical diversity of their diterpenoids and isoprenoid constituents, which perform many activities such as cytotoxic, antimicrobial, and anti-inflammatory activities, as well as different biological properties, that cannot be overlooked. …”
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CD8+ T cell exhaustion in the tumor microenvironment of breast cancer by Hanghang Xie, Xiaowei Xi, Ting Lei, Hongli Liu, Zhijia Xia

“…CD8+ T cells are crucial cytotoxic components of the tumor immune system. In chronic inflammation, they become low-responsive, a state known as T cell exhaustion (TEX). …”
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Treatment of Decompensated Alcoholic Liver Disease by John Menachery, Ajay Duseja

“…The rationale for using glucocorticoids is to block cytotoxic and inflammatory pathways in patients with severe alcoholic hepatitis. …”
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Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants by Emily E. Miller, Leigh Christopher Reardon

“…Although NE does not typically affect solid organ transplant patients, this patient had a variety of risk factors that may have predisposed her to development of NE such as severe neutropenia, supratherapeutic tacrolimus level, immunosuppression with cytotoxic agents, and elevated Epstein-Barr viral load. …”
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Plant-Derived Triterpenoid Functionalization: Synthesis of α-Acyloxycarboxamides by Fidel Rodriguez-Lopez, Edgar G. Rodríguez-García, Hugo A. García-Gutiérrez, Rocío Gámez-Montaño

“…Triterpenoids and their derivatives are an important class of natural products of interest in medicinal chemistry due to their potential applications as antibacterial, antifungal, and cytotoxic agents. Herein, we describe the use of ethanol as a solvent in the Passerini reaction for the functionalization of masticadienonic acid isolated from fruits and peduncles of <i>P. mexicana</i>. …”
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Investigation of probiotic properties of Lactiplantibacillus plantarum isolated from hawthorn vinegar by Irmak Icen Taskin

“…Additionally, it demonstrates a high adhesion capacity to HCT116 cells (96.63%) and exhibits cytotoxic effects on these cells.…”
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CHRONIC MYELOPROLIFERATIVE NEOPLASMS: A COLLABORATIVE APPROACH by Paola Guglielmelli, Lisa Pieri, Alessandro Maria Vannucchi

“…Therapy aims at reducing the rate of thrombosis without increasing the risk of hematologic transformation which could be caused by exposure to cytotoxic drugs. On the other hand, survival is significantly reduced in primary myelofibrosis, and the clinical manifestations may be disabling. …”
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Effects of Various Flavonoids on the α-Synuclein Fibrillation Process by Xiaoyun Meng, Larissa A. Munishkina, Anthony L. Fink, Vladimir N. Uversky

“…Currently, there is no approved therapeutic agent directed toward preventing the protein aggregation, which has been recently shown to have a key role in the cytotoxic nature of amyloidogenic proteins. Flavonoids, known as plant pigments, belong to a broad family of polyphenolic compounds. …”
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Different Patterns of Platelet Count Fluctuation in Response to Various Anticancer Chemotherapies among Patient with Bladder Cancer by Ayako Watanabe, Yu Ogawa, Misa Saeki, Takuya Nagata, Masashi Morita, Kenji Momo

“…It may include thrombocytopenia caused by bone marrow suppression due to cytotoxic anticancer agents and thrombocytosis due to rebound during recovery. …”
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Lepidium meyenii biological activity and future perspectives by Zoya Dzhakova, Diana Karcheva-Bahchevanska, Stanislava Ivanova

“…The main compounds in the underground part of the plant are glucosinolates, thiohydantoins, isothiocyanates, macamides, macaene, fatty acids, polysaccharides, alkaloids, fiber, lipids and proteins, which are responsible for various biological activities including antimicrobial, antioxidant, cytotoxic, anti-inflammatory and immunomodulatory activities. …”
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