Direct ring fluorination of 3-substituted 5-(1,3-dioxane) acetal isoxazoles: application to the formal synthesis of a bioactive fluorinated isoxazole by Bacheley, Lucas, Guillamot, Gérard, Phansavath, Phannarath, Ratovelomanana-Vidal, Virginie

“…This method was transposed to gram-scale and has been applied to the formal synthesis of a bioactive compound that increases CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) activity.…”
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Extensive Mycobacterium abscessus Pneumonia in an Immunocompetent Infant with No Underlying Lung Pathology by Morouge M. Alramadhan, James R. Murphy, Michael L. Chang

“…Pulmonary infection due to Mycobacterium abscessus occurs in patients with cystic fibrosis, but rarely in immunocompetent children without underlying lung pathology. …”
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PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases by Yongchun Shen, Lei Chen, Tao Wang, Fuqiang Wen

“…Airway mucus hypersecretion (AMH) is a key pathophysiological feature of chronic airway inflammatory diseases such as bronchial asthma, cystic fibrosis, and chronic obstructive pulmonary disease. …”
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Diretrizes para desenvolvimento da competência em informação para pessoas com fibrose cística by Eliane Rodrigues Mota Orelo, Elizete Vieira Vitorino

“…A Coleta de dados se deu no acervo da Biblioteca Universitária da UFSC, no portal Scielo Brasil, no Portal Capes, nas bases de dados Ebsco e Web Of Science e, nas revistas nacionais de Biblioteconomia e Ciência da Informação, os termos de busca foram: “Information Literacy”, “Competência em Informação” “Cystic Fibrosis” e “Fibrose Cística”. Realizou-se entrevistas semiestruturadas via plataforma “google meet”, com pessoas com Fibrose Cística, acima de 18 anos de idade, residentes no estado de SC. …”
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Mycobacterium avium Infection of Multinucleated Giant Cells Reveals Association of Bacterial Survival to Autophagy and Cholesterol Utilization by Jayanthi J. Joseph, Amy Leestemaker-Palmer, Soheila Kazemi, Lia Danelishvili, Luiz E. Bermudez

“…Mycobacterium avium subsp. hominissuis (M. avium) is an opportunistic environmental pathogen that typically infects patients with existing lung conditions such as cystic fibrosis or COPD. Pulmonary M. avium infection generates peribronchial granulomas that contain infected macrophages and multinucleated giant cells (MGCs). …”
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Polymorphonuclear Leukocytes or Hydrogen Peroxide Enhance Biofilm Development of Mucoid Pseudomonas aeruginosa by Qi Tan, Qing Ai, Qi Xu, Fang Li, Jialin Yu

“…P. aeruginosa cells usually undergo mucoid conversion during chronic lung infection in patients with cystic fibrosis (CF) and resist destruction by polymorphonuclear leukocytes (PMNs), which release free oxygen radicals (ROS), such as H2O2. …”
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Azole-Induced Myositis after Combined Lung-Liver Transplantation by Sofie Happaerts, Michiel Wieërs, Ward Vander Mijnsbrugge, Laurent Godinas, Dirk Van Raemdonck, Laurens J. Ceulemans, Robin Vos, Geert M. Verleden

“…Our patient was a 38-year-old man who received a single sequential lung transplantation and liver transplantation because of end-stage cystic fibrosis. He presented to our emergency room with acute pain in both forearms at 3 weeks after voriconazole was initiated for invasive pulmonary aspergillosis infection. …”
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Treatment of Cytomegalovirus Infection with Cidofovir and CMV Immune Globulin in a Lung Transplant Recipient by Heinrike Wilkens, Martina Sester

“…A CMV-seronegative 42-year-old man with cystic fibrosis received a lung from a CMV-seropositive donor. …”
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Montelukast: More than a Cysteinyl Leukotriene Receptor Antagonist? by Gregory R. Tintinger, Charles Feldman, Annette J. Theron, Ronald Anderson

“…If so, montelukast is potentially useful in the chemotherapy of intermittent asthma, chronic obstructive pulmonary disease, cystic fibrosis, and viral bronchiolitis, which, to a large extent, involve airway epithelial cell/neutrophil interactions. …”
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Effectiveness of Palivizumab in Preventing RSV Hospitalization in High Risk Children: A Real-World Perspective by Nusrat Homaira, William Rawlinson, Thomas L. Snelling, Adam Jaffe

“…Data are limited to allow commenting on the protective effect of palivizumab among other high risk children, including those with Down syndrome, cystic fibrosis, and haematological malignancy, indicating further research is warranted in these groups.…”
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Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism by Joseph H. Sisson, Todd A. Wyatt, Jacqueline A. Pavlik, Pawanjit S. Sarna, Peter J. Murphy

“…Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. …”
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Protocol for functional screening of CFTR-targeted genetic therapies in patient-derived organoids using DETECTOR deep-learning-based analysis by Mattijs Bulcaen, Ronald B. Liu, Kasper Gryspeert, Sam Thierie, Anabela S. Ramalho, François Vermeulen, Xavier Casadevall I Solvas, Marianne S. Carlon

“…Summary: Here, we present a protocol for the rapid functional screening of gene editing and addition strategies in patient-derived organoids using the deep-learning-based tool DETECTOR (detection of targeted editing of cystic fibrosis transmembrane conductance regulator [CFTR] in organoids). …”
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Diabetic Muscle Infarction: A Rare Cause of Acute Limb Pain in Dialysis Patients by G. De Vlieger, B. Bammens, F. Claus, R. Vos, K. Claes

“…In the current paper, we present two diabetic patients with cystic fibrosis, who are treated with automated peritoneal dialysis and suffered from episodic lower limb infarction. …”
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Insights into the diverse roles of the terminal oxidases in Burkholderia cenocepacia H111 by Sarah Paszti, Olivier Biner, Yilei Liu, Kim Bolli, Sarah Dorothy Jeggli, Gabriella Pessi, Leo Eberl

“…Abstract Burkholderia cenocepacia H111 is an obligate aerobic bacterium which has been isolated from a cystic fibrosis (CF) patient. In CF lungs the environment is considered micro-oxic or even oxygen-depleted due to bacterial activities and limited oxygen diffusion in the mucus layer. …”
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Qualitative study exploring the views and perceptions of parents/carers of young children with CF regarding the introduction of CFTR modulator therapy (The REVEAL study; PaRents pE... by Kevin W Southern, Sioned Haf Davies, Faye Wade, Heather Fogg, Adam Walsh

“…Background Cystic fibrosis (CF) is associated with a historically high treatment burden which causes anxiety and exhaustion for parents of children with CF, especially in the early years of a child’s life. …”
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Awareness and attitudes of pregnant women concerning genetic disorders and pregnancy termination in northeastern Iran by Nafiseh Todarbary, Abouzar Irandegani, Mojtaba Meshkat, Aida Gholoobi, Tayebeh Hamzehloei

“…Education level was associated with abortion agreement for various conditions, including cleft lip or palate, Alzheimer’s disease, Turner syndrome, cystic fibrosis, phenylketonuria, Huntington’s disease, autism, fragile X syndrome, and epilepsy. …”
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Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy by Xingren Liu, Xin Wang, Xue Wu, Shuhua Zhan, Yan Yang, Caiyu Jiang

“…Airway BSCs, which are strongly capable of self-renewal and multi-lineage differentiation, can effectively attenuate airway epithelial injury caused by environmental factors or genetic disorders, such as cystic fibrosis. This review comprehensively explores the efficacy and action mechanisms of airway BSCs across various lung disease models and describes potential strategies for inducing pluripotent stem cells to differentiate into pulmonary epithelial lineages on the basis of the original research findings. …”
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Hypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms by Romina A. Tobares, Román A. Martino, Claudia A. Colque, Gaston L. Castillo Moro, Alejandro J. Moyano, Andrea G. Albarracín Orio, Andrea M. Smania

“…Abstract Biofilms are critical in the persistence of Pseudomonas aeruginosa infections, particularly in cystic fibrosis patients. This study explores the adaptive mechanisms behind the phenotypic switching between Small Colony Variants (SCVs) and revertant states in P. aeruginosa biofilms, emphasizing hypermutability due to Mismatch Repair System (MRS) deficiencies. …”
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Factors Associated With Multi-Drug Resistant Organisms Among Bronchiectasis Patients: A Retrospective Study of Bronchiectasis Patients in Jordan by Al Oweidat K, Toubasi AA, Khraisat FA, Al-Sayegh TN, Al-Harasis LM, Albtoosh AS

“…The diagnosis of bronchiectasis was established through lung Computerized Tomography (CT) scans and clinical symptom assessment.Results: The study encompassed 235 patients, revealing a notably higher occurrence of MDROs among non-cystic fibrosis patients compared to their counterparts (P-value=0.001). …”
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Fetoplacental Discrepancy with Normal Karyotype in Amniotic Fluid and Two Different Cell Lines in Placenta by Veronica Ortega, Christina Mendiola, Eric Williamson, Kenneth Higby, Gopalrao V. N. Velagaleti

“…Mother was a carrier for the Cystic Fibrosis (delta F508), Factor V Leiden mutations, HbD-Los Angeles and HbQ-India variants. …”
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