Ginseng-derived Nanoparticles Inhibit Lung Cancer Cell Growth by Promoting Macrophage M1 Polarization by Liangliang FAN, Limei REN, Song YANG, Wenjing LI, Yueming ZHAO, Ronghua ZHAO, Daqing ZHAO, Jiawen WANG

“…Simultaneously, GDNPs-CM promoted the expression levels of inflammation-related proteins, such as TLR4, MyD88, NF-κB, iNOS, and COX-2 in A549 cells (P<0.05, P<0.01). Conclusion: GDNPs induce apoptosis in lung cancer cells by stimulating M1 polarization of macrophages, inhibiting the proliferation of A549 cells, regulating the A549 cell cycle, and activating the TLR4/MyD88/NF-κB signaling pathway to promote the expression levels of inflammatory factors.…”
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Characterization of the bioaccumulation and toxicity of copper pyrithione, an antifouling compound, on juveniles of rainbow trout by Bourdon, Charlotte, Cachot, Jérôme, Gonzalez, Patrice, Couture, Patrice

“…The expression of genes involved in the antioxidant response (sod1, sod2, gpx), detoxification (cyp1a, mt1x, mt2x), Cu transport (ctr1, ctr2, slc11a2), energy metabolism (AcoAc, cox, 12S) and cell cycle regulation (bax) strongly decreased at Day 8 in the gills and at Day 16 in the liver of CuPT-exposed fish in comparison to controls at the same time point. …”
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Survival in patients with CKD 3–5 after 12 months of exercise training – a post-hoc analysis of the RENEXC trial by Sara Denguir, Matthias Hellberg, Martin Almquist, Naomi Clyne

“…Univariate and multivariate Cox regression analyses were used and adjusted for age, sex, comorbidity, time on dialysis and time with a kidney transplant. …”
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Behavioral risk factors and socioeconomic inequalities in ischemic heart disease mortality in the United States: A causal mediation analysis using record linkage data. by Yachen Zhu, Laura Llamosas-Falcón, William C Kerr, Jürgen Rehm, Charlotte Probst

“…Counterfactual-based causal mediation analyses with Cox proportional hazards models were performed to quantify the contributions of 4 BRFs (smoking, alcohol use, physical inactivity, and BMI) to socioeconomic inequalities in IHD mortality. …”
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Association between lifestyle risk factors and mortality in the Mexico City prospective study by Paloma Ferrero-Hernández, Gary O’Donovan, Fanny Petermann-Rocha, Diego G. D. Christofaro, Carlos Cristi-Montero, Adilson Marques, Marcelo de Maio Nascimento, Claudio Farías-Valenzuela, Leandro F. M. Rezende, Gerson Ferrari

“…Lifestyle risk factors assessment was based on five modifiable lifestyle risk factors and their respective cut-off points according to current health recommendations, including obesity, physical inactivity, tobacco, alcohol consumption and fruits and vegetables intake. Multivariable Cox regression models were used to estimate the associations of lifestyle risk factor score (ranging from 0 to 5) with all-cause and cause-specific mortality (cardiovascular disease, renal or hepatobiliary diseases, diabetes, respiratory diseases, cancer and all-cause mortality). …”
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Risk of SARS-CoV-2 infection before and after the Omicron wave in a cohort of healthcare workers in Ontario, Canada by Jorge L. Martinez-Cajas, Ann Jolly, Yanping Gong, Gerald Evans, Santiago Perez-Patrigeon, Bradley Stoner, T. Hugh Guan, Beatriz Alvarado

“…We employed Poisson regression for period #1 and Cox regression for period #2 to examine associations of demographic factors (age, sex, ethnicity, migration status, income insufficiency), health factors (chronic conditions, smoking history, SARS-CoV-2 vaccination status), household factors (exposure to COVID-19), occupational factors (work role, exposure to COVID-19 patients, personal protective equipment access, aerosol-generating procedures) and community exposures (use of masks, distance, hand-washing) with SARS-CoV-2 infection. …”
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How intravitreal anti-vascular endothelial growth factor initial dosing impacts patient outcomes in diabetic macular oedema by Rishi P. Singh, David Tabano, Blanche L. Kuo, Andrew LaPrise, Theodore Leng, Eunice Kim, Meghan Hatfield, Vincent Garmo

“…Characteristics and outcomes for eyes with initial doses (three injections within 100 days of index date) were compared with those without. Multivariate Cox Proportional Hazards modelling estimated predictors for treatment discontinuation, re-initiation, or switch; Generalized Estimating Equations-adjusted modelling estimated characteristics associated with receiving initial doses. …”
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Real-world outcomes in patients with melanoma brain metastasis: a US multisite retrospective chart review study of systemic treatments by Ning Ning, Sunandana Chandra, Andriy Moshyk, Divya Patel, Isabella C Glitza Oliva, Jennell Palaia, Leon A Sakkal, Natalia Han, Shardul Odak, Jordana K Schmier

“…Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method and compared between treatments in a univariate Cox proportional hazards model.Results In total, 472 patients with MBM who received first-line nivolumab plus ipilimumab (n=246), anti-PD-1 monotherapy (n=112) or BRAF/MEK inhibitors (n=114) were identified. …”
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The Impact of COVID-19 Pandemic on the Diagnosis, Treatment, and Outcomes of Colorectal Cancer in Singapore by Hui Lionel Raphael Chen, Piea Peng Lee, Yun Zhao, Wei Hao Caleb Ng, Jiashen Zhao, Yu En Christopher Tan, Bo Jie Sean Loh, Kah-Hoe Pierce Chow, Hiang Khoon Tan, Kwong-Wei Emile Tan

“…The study was divided into the pre-COVID-19 (January 2019–January 2020), early COVID-19 (February–May 2020), recovery (June–December 2020), and heightened alert (January–December 2021) periods. Cox regression was used to model the waiting time to colonoscopy. …”
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RNA结合蛋白PTBP1与磷酸化-AXL共表达在骨肉瘤中的临床意义 by 李湘湘, 徐雯莉, 卢正宇, 何安芳, 王震, 刘妮, 乐雨婷, 彭挺生

“…免疫组化结果显示PTBP1和p-AXL蛋白的表达在骨肉瘤组织中显著高于非恶性骨组织；p-AXL阳性表达率与肺转移相关（<italic>P</italic>=0.025）；Kaplan-Meier分析发现肺转移、复发、PTBP1表达及PTBP1/p-AXL共表达等因素与骨肉瘤患者不良总生存期相关；且多变量Cox回归分析显示肺转移（<italic>P</italic>&lt;0.000 1）、PTBP1表达阳性（<italic>P</italic>=0.041）是骨肉瘤患者总生存期（OS）独立危险因素；PTBP1/p-AXL共表达患者的OS（<italic>P</italic>=0.017）和PFS（<italic>P</italic>=0.043）均低于非PTBP1/p-AXL共表达患者。…”
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Long-Term Analysis of Recurrence Beyond Milan Criteria Following Ablation of Solitary Early-Stage Hepatocellular Carcinoma &le;3 cm in Potentially Transplantable Patients: A Over 1... by Chen S, Qi H, Tan H, Cao F, Xie L, Huang T, Wu Y, Wen C, Wang Y, Shen L, Fan W

“…Shuanggang Chen,1,2,&ast; Han Qi,1,2,&ast; Hongtong Tan,1,2,&ast; Fei Cao,1,2 Lin Xie,1,2 Tao Huang,1,2 Ying Wu,3 Chunyong Wen,1,2 Yujia Wang,1,2 Lujun Shen,1,2 Weijun Fan1,2 1Department of Minimally Invasive Interventional Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Department of Interventional Therapy, Shenzhen second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Weijun Fan, Email fanwj@sysucc.org.cn; Lujun Shen, Email shenlj@sysucc.org.cnBackground: Salvage liver transplantation is promising for hepatocellular carcinoma(HCC) recurrence post-ablation but is significantly affected by recurrence beyond Milan Criteria (RBM).Materials and Methods: A retrospective cohort study of potentially transplantable HCC patients undergoing ablation between 2007 and 2017 assessed median time to recurrence beyond Milan Criteria(TRBM) via Kaplan-Meier curves and predictive capacity of recurrence and RBM for overall survival(OS) via Receiver Operating Characteristic Curves, and identified independent risk factors for TRBM and RBM via Cox and binary logistic regression models.Results: We enrolled 191 potentially transplantable patients with early-stage HBV-related HCC ≤ 3 cm who underwent ablation. …”
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Association between triglyceride-glucose (TyG) related indices and cardiovascular diseases and mortality among individuals with metabolic dysfunction-associated steatotic liver dis... by Yanan Qiao, Yue Wang, Cheng Chen, Yueqing Huang, Chunhua Zhao

“…The TyG index, along with its combination with adiposity parameters (i.e. body mass index [BMI], waist circumference [WC], and waist-to-height ratio [WHtR]), were calculated. Cox proportional hazards models and restricted cubic spline (RCS) were performed to evaluate the associations between TyG-related indices and the risk of overall CVD, coronary heart disease (CHD), stroke, all-cause mortality, and cardiovascular mortality. …”
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Impaired pulmonary function increases the risk of gout: evidence from a large cohort study in the UK Biobank by Zijian Kang, Jianzheng Zhang, Chen Zhu, Ying Zhu, Hanlei Jiang, Qiang Tong, Sheng-Ming Dai

“…Propensity score matching (PSM) created balanced groups, while Cox regression gauged the risk association between reduced lung capacity and gout compared with normal function. …”
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Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study by Xiao S, Ou J, Qiu W, Ye C, Li N, Chen S, Lai Y, Deng Z, Wu F, Shen Y

“…Normal spirometry was defined as a prebronchodilator FEV1/FVC≥ 0.70 and FEV1≥ 80% predicted. We used Cox proportional hazards regression models to compare all-cause mortality between the groups. …”
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18 F-FDG PET/CT体积代谢参数在局限期小细胞肺癌预后的预测价值 by 林晓平, 梁培炎, 胡莹莹

“…采用Kaplan-Meier法进行生存分析比较，Cox模型分析预后因素。 【结果】本组 18 F-FDG 代谢参数结果：pSUV max 中位数为 11.4（1.7 ~ 24.6），SUV max 中位数为 13.92（2.61 ~ 43.28），SUV mean 中位 数为 8.31（1.71 ~ 26.85），SUV peak 中位数为 10.51（1.49 ~ 27.48）。…”
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An Update of the Appropriate Treatment Strategies in Anaplastic Thyroid Cancer: A Population-Based Study of 735 Patients by Nai-si Huang, Xiao Shi, Bo-wen Lei, Wen-jun Wei, Zhong-wu Lu, Peng-cheng Yu, Yu Wang, Qing-hai Ji, Yu-long Wang

“…By directly comparing eight treatment modalities, we found that surgery+radiotherapy RT±chemotherapy was the most effective treatment strategy. surgery+chemotherapy and RT+chemotherapy had comparable results (hazard ratio HR=1.461, 95% confidential interval (CI): 0.843-2.531, P=0.177). Multivariate Cox regression analysis also showed increased mortality risk in patients with increased age (HR=1.022, P<0.001), tumor extension to adjacent structures (HR=1.649, P=0.013), and distant metastasis (HR=2.041, P<0.001), while surgery+RT (HR=0.600, P=0.004) and chemotherapy (HR=0.692, P=0.010) were independently associated with improved OS. …”
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Characterization of adult T-cell leukemia/lymphoma patients with specific skin lesions in a tertiary dermatological service in Brazil by Mariana Valente, José Antonio Sanches, Youko Nukui, Jade Cury-Martins, Bruno Castro Souza, Juliana Pereira, Denis Miyashiro

“…Survival curves using the Kaplan–Meier method were analyzed with log-rank test, univariate and multivariate analyses were performed with the Cox proportional hazards model.ResultsForty-four patients were studied, 24 females (54.5%), and 20 males (45.5%). …”
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Associations of modifiable dementia risk factors with dementia and cognitive decline: evidence from three prospective cohorts by Mengzhao Wang, Changming Fan, Yanbai Han, Yifei Wang, Hejia Cai, Wanying Zhong, Xin Yang, Zhenshan Wang, Hongli Wang, Yiming Han

“…After adjusting for confounding factors, multivariable logistic regression was utilized to analyze the relationship between modifiable dementia risk factors and dementia, while multivariable linear regression was employed to examine the relationship between these risk factors and cognitive decline. Additionally, the Cox proportional hazards model was used to assess the relationship between the number of risk factor events, clusters, and dementia risk.ResultsA total of 30,113 participants from HRS, CHARLS, and ELSA were included (44.6% male, mean age 66.04 years), with an average follow-up period of 7.29 years. …”
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Oxidative balance score and its association with chronic inflammatory airway diseases and mortality: a population-based study by Zhuanbo Luo, Shiyu Chen, Peixu Chen, Feng Qiu, Weina Huang, Chao Cao

“…In prospective cohort studies, cumulative survival rates were determined using the Kaplan–Meier method and compared with log-rank tests. Multiple COX regressions were conducted to evaluate the relationship between OBS and all-cause as well as respiratory diseases mortality among participants with CIAD.ResultsA total of 12,458 adults were enrolled in this study. …”
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输注陈旧红细胞对肝细胞癌切除术后病人预后的影响 by 薛瑞峰, 赵崇希, 王培宗, 陈东泰, 陈晓辉, 曾维安, 李强

“…Kaplan–Meier生存分析显示输血组的总生存时间，肝内无复发生存时间，肝外无转移生存时间都更差（<italic>P</italic>&lt;0.001），Cox多因素回归分析进一步提示输注陈旧红细胞是总生存时间（HR<italic>=</italic>1.417， <italic>P</italic>=0.049）和肝内无复发生存时间（HR<italic>=</italic>1.519， <italic>P</italic>=0.013）的独立影响因素，新鲜红细胞却不是。…”
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