Nomogram based on the neutrophil-to-lymphocyte ratio and MR diffusion quantitative parameters for predicting Ki67 expression in hepatocellular carcinoma from a prospective study by Yu-chen Wei, Liang yun, Yan-ling Liang, Robert Grimm, Chongze Yang, Yuan-fang Tao, Sheng-chen Jiang, Jin-yuan Liao

“…Univariate and multivariate logistic regression analyses were conducted using the training set data to construct a model, which was internally validated. …”
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The Effects of Exercise on Inhibitory Function Interventions for Patients With Major Depressive Disorder (MDD): A Systematic Review and Meta‐Analysis by Zhihui Xu, Cong Liu, Peng Wang, Xing Wang, Yuzhang Li

“…Conclusion Based on the International Classification of Diseases (ICD) and the Diagnostic and Statistical Manual of Mental Disorders (DSM) classification systems, a research framework for exercise interventions on executive function in MDD patients was constructed, demonstrating that exercise can improve inhibitory function in MDD with high evidence quality. …”
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Il luogo e il senso: creazione e significazione degli spazi nel mondo globale by Gambardella, Fabiana, Amodio, Paolo

“…The “Sapiens 2.0” continues to construct his world as a place of signification and habitability, modelling his own “surroundings” in a way that is once again unprecedented, due to the transformations that he produces and which, in a circular and recursive process, continue to renew his features As plastic, versatile and changing entities, we exist in a global world, we easily move between semantically relevant places – home, neighbourhood, square, café – and the so-called “non-places”, spaces of transit, from airports and shopping malls to the web, which has now became the sapiens’ second home, the home within the home, or rather the ubiquitous home, in which we spend most of our time. …”
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Exploring dental students' knowledge on oral cancer prevention: a cross-sectional study in Moldova, Armenia, and Belarus by Olga Golburean, Diana Uncuta, Gayane Manrikyan, Natalia Shakavets, Izabella Vardanyan, Marina Markaryan, Ferda Özkaya, Daniela-Elena Costea, Tarig Al-Hadi Osman

“…A knowledge score ranging from 0–14 was constructed from the obtained data. Differences in the knowledge score between different groups of students was investigated using either student`s t-test whenever comparing two groups, or One-way ANOVA with Bonferroni`s correction for three or more groups. …”
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The development and application of a risk prediction model for cardiac arrest in ICU patients with mechanical ventilation (ICU机械通气患者心脏骤停风险预测模型的构建及应用研究)... by SHAO Qianqian (邵茜茜), GUO Linlin (郭林林), JIANG Tingting (蒋婷婷)

“…Results The study finally included arrhythmia, hypoxemia, acid-base imbalance, septic shock, history of cardiac arrest, multiple organ dysfunction syndrome to construct the risk prediction model. This model’s area under curve of receiver operating characteristic was 0. 909. …”
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Design and implementation of adaptive mimic voting device oriented to persistent connection by Dacheng ZHOU, Hongchang CHEN, Guozhen CHENG, Weizhen HE, Ke SHANG, Hongchao HU

“…Methods: The proposed mimic voter adaptively divides the chunked-transfer-encoded data arriving at the voter successively from the heterogeneous redundant executives,dynamically votes, and then outputs the data in the form of a sliding window during the continuous data transmission process.Gradually releasing the data of the voted blocks can reduce the memory consumption of the mimic voter and lower the voting processing time while maintaining the continuity of data transmission of the persistent connection.On the one hand,a voting algorithm selection strategy set is constructed to keep the voting accuracy by analyzing the data characteristics in the sliding window.On the other hand,an inventory model of the data voting process of the adaptive mimic voter is established,and an adaptive voting window control strategy is proposed based on the cost optimization of the inventory model to provide the best adaptive segmentation scheme for the data to be voted. …”
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The Clinical Value of the Combined Detection of Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Prognostic Nutritional Index (PNI) in Ear... by Zheng J, Zheng L, Wang X, Mao X, Wang Q, Yang Y, Mo D

“…Univariate and multivariate logistic regression analyses were utilized to verify independent risk factors for patients, and constructed the nomograms. The correlation between hematological indicators and tumor-node-metastasis (TNM) stage was assessed through Spearman’s analysis.Results: Eligible patients and healthy controls were grouped by gender. …”
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COMPETENZE CHIAVE PER IL CURRICOLO VERTICALE: L’OPINIONE DEGLI INSEGNANTI E I MATERIALI DIDATTICI by Matteo La Grassa, Monica Barni

“…However, it also emerges that a ‘vertical’ approach is very complex to implement for logistical and organisational reasons and due to the lack of specific training that can foster constructive dialogue between groups of teachers with different competences and disciplinary objectives. …”
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Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments by Ding B, Li M, Zhang J, Zhang X, Gao H, Gao J, Shen C, Zhou Y, Li F, Liu A

“…This study developed a promising strategy for tumor-targeted co-delivery of Dacarbazine (DTIC) and miRNA 34a-loaded PHRD micelles (Co-PHRD) for combination treatment of MM.Methods: To construct the dual drug-loaded delivery system Co-PHRD, poly (L-arginine)-poly (L-histidine)-polylactic acid (PLA) was employed as a building block. …”
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Accurate phenotype-to-genotype mapping of high-diversity yeast libraries by heat-shock-electroporation (HEEL) by Marcus Wäneskog, Emma Elise Hoch-Schneider, Shilpa Garg, Christian Kronborg Cantalapiedra, Elena Schäfer, Michael Krogh Jensen, Emil Damgaard Jensen

“…HEEL should enable highly accurate phenotype-to-genotype measurements going forward, which could be used to construct better computer-based models.…”
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The clinical features and risk factors of coagulopathy associated with cefoperazone/sulbactam: a nomogram prediction model by Changjing Xu, Junlong Zhu, Kun Tu, Hui Tang, Xinxin Zhou, Qiuyu Li, Kun Chen, Xuping Yang, Yilan Huang

“…A nomogram model was constructed from the multivariate logistic regression analysis and internally validated for model discrimination and calibration. …”
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Place of retinoprotective therapy in modern ophthalmologic practice by E.A. Egorov, D.A. Dorofeev

“…For the analysis of the most significant predictors of prescribing retinoprotective therapy for glaucoma, a model of binomial logistic regression was constructed which included all the questions of the questionnaire, then the variance analysis was used to identify the significant predictors.…”
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Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA by Paolo Peruzzo, Natascha Bergamin, Martina Bon, Sara Cappelli, Alessandra Longo, Elisa Goina, Cristiana Stuani, Emanuele Buratti, Andrea Dardis

“….-32-13T>G and other GAA exon 2-skipping mutations. Methods A set of constructs expressing 5 different engineered U1 snRNAs was generated. …”
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ApoB/ApoA-Ι is associated with major cardiovascular events and readmission risk of patients after percutaneous coronary intervention in one year by Jie Zhang, Mengyu Liu, Ju Gao, Xiaowen Tian, Yaru Song, Haibei Zhang, Peng Zhao

“…Predictive nomograms were constructed to forecast MACEs and readmission, with the accuracy of the nomograms assessed using the concordance index. …”
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Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma by Malcolm K Brenner, Challice Bonifant, Norihiro Watanabe, Mary K McKenna, Daniel Brenner, Ada Ozcan, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, David M Markovitz

“…Here, we tested the efficacy of our novel H84T CAR in models of pancreatic ductal adenocarcinoma (PDAC), intractable tumors with aberrant glycosylation and characterized by desmoplastic stroma largely contributed by pancreatic stellate cells (PSCs).Methods We transduced human T cells with a second-generation retroviral construct expressing the H84T BanLec chimeric receptor, measured T-cell expansion, characterized T-cell phenotype, and tested their efficacy against PDAC tumor cells lines by flow cytometry quantification. …”
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Searching for new genes associated with the familial hypercholesterolemia phenotype using whole-genome sequencing and machine learning by D. E. Ivanoshchuk, A. B. Kolker, O. V. Timoshchenko, S. E. Semaev, E. V. Shakhtshneider

“…On the basis of a group of patients with familial hypercholesterolemia (enrolled according to the Dutch Lipid Clinic Network Criteria and including cases confirmed by molecular genetic analysis), decision trees were constructed, which made it possible to identify cases in the study population that require additional molecular genetic analysis. …”
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MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress by Huang Z, Chen J, Liu S, Xiang X, Long Y, Tan P, Fu W

“…However, the role of membrane-associated protein 17 (MAP17) in NASH remains unclear, which prompted this study to explore its relationship with immune infiltration and its regulatory mechanisms.Methods: We employed weighted correlation network analysis (WGCNA) to construct a gene co-expression network aimed at identifying key genes associated with NASH progression. …”
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Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus by Rui Zhao, Jun Li, Yingtian Li, Xujuan Pei, Jingyi Di, Zhoujie Xie, Hao Liu, Weixia Gao

“…Consequently, an endogenous expression component library for S. zooepidemicus was constructed, comprising 32 constitutive and 4 inducible expression elements. …”
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CYFIP2: potential pancreatic cancer biomarker and immunotherapeutic target by Cong Xiao, Xiaojuan Zhang, Bobo Hou, Ping Wan, Zhenjun Cao, Xuefeng Rao

“…Pancreatic cancer cell lines were constructed with the specific expression of CYFIP2 mRNA, and their invasive and metastatic abilities were analysed using scratch and transwell assays. …”
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Mortality Prediction Using SaO2/FiO2 Ratio Based on eICU Database Analysis by Sharad Patel, Gurkeerat Singh, Samson Zarbiv, Kia Ghiassi, Jean-Sebastien Rachoin

“…Feature importance was assessed using SHAP, ELI5 (permutation importance), and a built-in XGBoost feature importance method. We constructed partial dependence plots to illustrate the relationship between mortality probability and S/F values. …”
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