Alkaloids extracted from Dendrobium officinale grown in diverse environments exhibited robust antioxidative and antiaging activity by Yichen Liu, Arome Solomon Odiba, Qi Yu, Jin Xie, Nkwachukwu Oziamara Okoro, Guiyan Liao, Xinchen Zhu, Bin He, Cheng Jin, Wenxia Fang, Bin Wang

“…Antioxidants play a vital role in mitigating the adverse conditions associated with aging. In this study, we investigated the impact of Dendrobium officinale alkaloids (DOA) cultivated in diverse environments on antioxidative and anti-aging responses in Caenorhabditis elegans. …”
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Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts by Kelley Weinfurtner, David Tischfield, George McClung, Jennifer Crainic, John Gordan, Jing Jiao, Emma E. Furth, Wuyan Li, Erena Tuzneen Supan, Gregory J. Nadolski, Stephen J. Hunt, David E. Kaplan, Terence P.F. Gade

“…Material and Methods: NOG (NOD/Shi-scid/IL-2Rγnull) and NOG-EXL (huGM-CSF/huIL-3 NOG) mice conditioned with busulfan underwent i.v. injection of human CD34+ cells. …”
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Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo... by Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

“…We additionally provided a hierarchical organization of determinants of long-term benefit through a conditional inference tree analysis.Results The study included 1050 patients from 61 institutions across 14 countries, with a median follow-up of 70.3 months. …”
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Spatial heterogeneity determines the gastrointestinal microbiome signatures and ecological processes that govern bacterial community assembly in sheep by Yukun Zhang, Jiangbo Cheng, Changchun Lin, Fadi Li, Xiaoxue Zhang, Chong Li, Deyin Zhang, Xiaobin Yang, Dan Xu, Yuan Zhao, Liming Zhao, Xiaolong Li, Huibin Tian, Xiuxiu Weng, Weimin Wang

“…We explored the microbial community composition, community types (enterotypes), bacterial interactions, and ecological processes in 10 gastrointestinal regions of 36 six-month-old Hu sheep raised under same diets and environmental conditions. Our findings revealed a unique U-shaped pattern of bacterial diversity from the rumen to the rectum, with the lowest diversity in the jejunum. …”
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Impact de l’évaluation de la sédation sur la durée de ventilation mécanique en réanimation pédiatrique [Impact of sedation assessment on duration of mechanical ventilation in pedia... by Zakaria Zoheir Addou, Nabil Tabet Aoul, Abdessamad DALI ALI Dali-Ali

“…Results-We included 71 children in the study "after" implementation of sedation scale and 41Children "before". The conditions for which sedation was indicated were traumatic (32%) and Neurological (30%).The average number of CB assessments per day was 11.8±5 "after". …”
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Editorial by Lindsay B. Flynn

“…The pandemic comes on top of an already bad set of conditions: expensive housing and stagnant wages, potential for intergenerational conflict due to the privatisation of risk and the different needs of cohorts at different life stages, and increasing income and wealth inequality that continues to limit the varying opportunities of young people as they try to establish themselves in the housing market. …”
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Normative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case–Control Study by Lianne Mobbs, Vinuja Fernando, R. Dineth Fonseka, Pragadesh Natarajan, Monish Maharaj, Ralph J. Mobbs

“…By doing so, we aim to enhance the clinical utility of gait analysis in diagnosing and managing health conditions. Methods: We conducted an observational case–control study involving 313 healthy participants. …”
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The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…PPOs catalyze the oxidation of phenol to quinone, creating unfavorable conditions for pathogen development. It induces resistance in potassium phosphite treatment, leading to increased quinone production and creating a toxic environment for the pathogen. …”
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Études comportementales pour la conservation du singe laineux de Poeppig (Lagothrix l. poeppigii) by Justine Philippon

“…Nous tenterons également de mettre à jour les facteurs intrinsèques (âge, sexe, rang social) et extrinsèques (âge de la capture, temps passé en captivité, conditions de captivité) à l’individu, influant sur le temps nécessaire à une totale réhabilitation. …”
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Altérations comportementales et fonctionnelles de la préhension au cours du vieillissement chez un primate non-humain : le microcèbe murin by Marie Le Brazidec, Emmanuelle Pouydebat, Anthony Herrel, Fabienne Aujard

“…Grâce aux améliorations des conditions de vie et de santé ces dernières décennies, nous connaissons une augmentation de l’espérance de vie. …”
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Les orangs-outans aiment-ils peindre ? Étude préliminaire des variations du stress en captivité par dosage du cortisol et observation comportementale lors de l'enrichissement du mi... by Baptiste Sadoughi, Victor Narat, Morgane Debuigne, Michel Saint Jalme, Sabrina Krief

“…Les dosages de cortisol nous permettent de comparer les taux obtenus en conditions normales et ceux en cas d'isolement - a priori stressant - avec ou sans enrichissement. …”
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Life Cycle Assessment (LCA) of Carbon Emission of Garden Pavement by Peiyong WANG, Ruixing LU

“…Among the 25 types of pavements, granular pavement of graded gravel surface without cementation performs best in environmental adaption, environmental protection and low carbon, and thus can be vigorously promoted for use under appropriate conditions.…”
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Biosynthesis inhibition of miR-142-5p in a N 6-methyladenosine-dependent manner induces neuropathic pain through CDK5/TRPV1 signaling by Jinshi Li, Yang Guo, Chen Zhu, Dongxu Wang, Yuan Li, Xiaotong Hao, Linyan Cao, Yiting Fan, Bo Fang

“…Abstract Background Neuropathic pain (NP) represents a debilitating and refractory condition. However, the understanding of NP and the current treatment approaches available for its management are limited. …”
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Componentes y Dinámica Natural del Ambiente - Ciudad de Neuquén- by Olga Capua, Elsie Marcela Jurio

“…Under the prevailing climatic conditions, soil pedogenic processes are weak or allowing the initial processes of weathering or weathering, act directly on the rocky outcrops influencing modeling. …”
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Poverty Dynamics and the Fundamental Root Causes in Iran by Zahra Azari, Parviz Mohamadzadeh, Davoud Behboudi

“…Production structure: the elements related to the production structure that were extracted from coding are: false beliefs due to unfavorable conditions, weakness in production culture, non-guaranteeing of property rights, political isolation, erosion of social capital, elimination of comparative advantage in production, corrupt monetary and banking system, presence of institutions subordinate to power in the economy, lack of written program in production, centralization in the center of the country and the environment of rentier economy. …”
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Development of a comprehensive model to predict stock prices in the stock market with an interpretive structural modeling approach by Shiva Rezaeyan, Mohammad Taleghani, Azita Sherej Sharifi

“…Multiple factors, such as market dynamics, industry trends, company performance, economic conditions, political events, and globalization, exert influence on stock markets. …”
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“Restoration of the Past Scenery-Realm”: A Research on the Scenery-Realm Restoration of Jiang’s Fu Garden During Qing Dynasty in the Historical Revolution of the Humble Administrat... by Qian BIAN

“…By identifying and correlating the content of the images, the potential and limitations of schematic layout recovery of the Fu Garden are elucidated, and the distinctive significance of a core scenic area named Yuanxiang Hall within the garden for understanding the value orientation of the Fu Garden’s restoration is highlighted, as well as the feasible conditions for its research. Based on the above macroscopic understanding of textual and image materials, a further step is to conduct a close reading and analysis of key historical materials in order to answer the key questions.Results1) In response to the question of what had been restored, it can be said that there are two aspects to consider: The construction of scenery and the experience of realm. …”
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Urban monitoring, evaluation and application of COVID-19 listed vaccine effectiveness: a health code blockchain study by Tao Wang, Hongyan Li, Chaoqun Li, Zheheng Li

“…In the simulation of urban listed vaccination involving six regions, programmes 1 and 5 have the best protective effect among the eight vaccination programmes, and the optimal vaccination order is 3-5-2-4-6-1. (2) In the presence of asymptomatic conditions, the basic reproduction number, namely R0*(1-VR*VE), does not accurately reflect the effect of herd immunity, but the comprehensive basic reproduction number (R) should be used. …”
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Cross-sectional study of the perceived wellbeing of children in palliative care by Daniel Toro-Pérez, Ester Camprodon-Rosanas, Catalina Bolancé, Montserrat Guillen, Sergi Navarro Vilarrubí, Joaquin T. Limonero

“…Objective: To describe the perceived wellbeing (pWB) and the psychological characteristics of young people with life-limiting and life-threatening conditions (LLTCs). Methods: We conducted a cross-sectional study in young people aged 8 years or older with collection of data on demographic and disease-related variables from the health records. …”
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Case Reports: The core of practice-based evidence by Antonio Villa

“…Nevertheless, medicine must often satisfy the patient that could be affected by a condition for which no study or guidelines can support the clinical decision more than the practical experience of the same medical doctor and/or the preferences given by the patient. …”
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