IL-2 and IL-15 augment HBV therapeutic vaccination and PD1 blockade for functional cure in the AAV-HBV mouse model by Gavin Lewis, Kirsten Malo, Thomas Rowland, Jenaya Hooks, Hao Yuan Liu, Sonam Popli, George Kukolj, Craig S. Pace

“…Research into a cure has focused on finite combinatorial interventions that aim to reduce HBV surface antigen (HBsAg), suppress virus specific immune tolerance, and induce an adaptive response that functionally controls the virus.MethodsIn C57BL/6 mice transduced with adeno-associated virus encoding the HBV genome, which replicate HBV and persistently express HBsAg at 104 IU/mL or higher, a combination of small interfering RNA (siRNA) knockdown of HBsAg expression followed by immunization with a self amplifying RNA therapeutic HBV vaccine failed to establish HBV control. …”
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Combinatorial phenethyl isothiocyanate and withaferin A targets multiple epigenetics pathways to inhibit MCF-7 and MDA-MB-231 human breast cancer cells by Mohammad Mijanur Rahman, Trygve O. Tollefsbol

“…In this regard, combinatorial interventions enable simultaneously targeting various neoplastic pathways to eradicate multiple tumorigenic clones. …”
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Swimming combined with corn peptide counteracts high-fat diet-induced obesity through rescuing imbalanced gut flora by Qiuyue Wu, Ya Liu, Jinxiu Li, Tong Wu

“…Therefore, the combinatorial intervention of swimming and corn peptide can at least partially ameliorate HFD-induced gut microbiota dysbiosis and corresponding metabolic changes, promote energy metabolism, and contribute to body weight control and lipid-lowering effects in obese mice.…”
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