Trehalose-loaded LNPs enhance mRNA stability and bridge in vitro in vivo efficacy gap by Xu-Han Liu, Hui-Ping Song, Ling-Ling Tao, Zhe Zhai, Jin-Xing Huang, Yong-Xian Cheng

“…This strategy enables trehalose to externally form a vitrified matrix that preserves LNP colloidal integrity, while internally stabilizing mRNA through hydrogen bonding, markedly reducing chemical degradation during storage compared to LNP relying solely on externally added trehalose. …”
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