Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation by O. V. Goloshchapov, A. V. Beynarovich, A. B. Chukhlovin, R. V. Klementeva, A. A. Shcherbakov, E. A. Bakin, I. K. Golubovskaya, N. D. Ventslovayte, O. S. Yudintseva, M. V. Gorchakova, V. E. Karev, M. A. Kucher, M. A. Suvorova, E. V. Svetkina, G. G. Rodionov, V. V. Gostev, S. V. Sidorenko, I. S. Moiseev, A. D. Kulagin

“…Due to early viral/bacterial colitis post-transplant associated with a multidrug-resistant strain of K. pneumoniae and herpes virus type 6, FMT was performed on days 46 and 47 after allo-HSCT. …”
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Which scoring systems are useful for predicting the prognosis of lower gastrointestinal bleeding? Old and new by Ku Bean Jeong, Hee Seok Moon, Kyung Ryun In, Sun Hyung Kang, Jae kyu Sung, Hyun Yong Jeong

“…The primary etiologies of lower gastrointestinal bleeding were identified as ischemic colitis and diverticular bleeding, accounting for 18.8% and 18.5% of cases, respectively. …”
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Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis by Alexandra Noble, Rodrigo Motta, Silvia Cabras, Belen Moron Flores, Jan Nowak, Aleksandra Glapa-Nowak, Alessandra Geremia, Jack Satsangi, Emma Culver

“…Results Whole blood DNA methylation profiling and genotyping was performed in 264 individuals; 47 with IgG4-SC, 65 with PSC, 64 with ulcerative colitis (UC), and 88 healthy controls. We identified 19 significant methylation differences between IgG4-SC and controls and 38 between PSC and controls. …”
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High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD by Alberto J. León, Emma Gómez, Jose A. Garrote, David Bernardo, Asterio Barrera, Jose L. Marcos, Luis Fernández-Salazar, Benito Velayos, Alfredo Blanco-Quirós, Eduardo Arranz

“…Biopsy specimens from patients with ulcerative colitis (UC) and Crohn's disease (CD), from both affected and unaffected areas, and also from a group of colonic biopsies from healthy controls, were included in our study. …”
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Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase by Keiichi Mitsuyama, Nobuo Tomiyasu, Kosuke Takaki, Junya Masuda, Hiroshi Yamasaki, Kotaro Kuwaki, Teiko Takeda, Shigehiko Kitazaki, Osamu Tsuruta, Michio Sata

“…Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. …”
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Clostridium difficile Peritonitis: An Emerging Infection in Peritoneal Dialysis Patients by Saira Chaughtai, Bhavika Gandhi, Zeeshan Chaughtai, Dana Tarina, Mohammad A. Hossain, Arif Asif

“…In this article, we present a case of peritoneal dialysis (PD)-related peritonitis caused by C. difficile-associated diarrhea and colitis. In this patient, the peritonitis was caused by transmural translocation of the enteric bacteria. …”
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The Frequency of Clinic Visits Was Not Associated with Medication Adherence or Outcome in Children with Inflammatory Bowel Diseases by Cheryl Kluthe, Jenkin Tsui, Donald Spady, Matthew Carroll, Eytan Wine, Hien Quoc Huynh

“…Results. 127 patients were reviewed with 82 patients diagnosed with Crohn’s disease (CD) and 46 with ulcerative colitis (UC) which included one IBD-Unclassified. …”
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Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches by Lucia Centanni, Clelia Cicerone, Fabrizio Fanizzi, Ferdinando D’Amico, Federica Furfaro, Alessandra Zilli, Tommaso Lorenzo Parigi, Laurent Peyrin-Biroulet, Silvio Danese, Mariangela Allocca

“…Inflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic, relapsing conditions characterized by dysregulated immune responses and persistent intestinal inflammation. …”
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High Intestinal and Systemic Levels of Interleukin-23/T-Helper 17 Pathway in Chinese Patients with Inflammatory Bowel Disease by Lu Song, Rui Zhou, Sha Huang, Feng Zhou, Shufang Xu, Wei Wang, Fengming Yi, Xiaobing Wang, Bing Xia

“…Our results indicated that the mRNA levels of IL-12p40 and TL1A were increased in ulcerative colitis (UC) patients. Furthermore, serum IL-12p40 and TL1A levels were higher in active UC patients, especially in patients with disease course less than 1.25 years or initial onset. …”
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Investigation of potential Shiga toxin producing Escherichia coli (STEC) associated with a local foodborne outbreak using multidisciplinary approaches by Kristen A. Lozinak, Niketa Jani, Jayanthi Gangiredla, Isha Patel, Christopher A. Elkins, Zonglin Hu, Prince A. Kassim, Robert A. Myers, Pongpan Laksanalamai

“…Shiga toxin producing Escherichia coli (STEC) outbreak is a public health concern as it can potentially cause a variety of clinical manifestations including diarrhea, hemorrhagic colitis and hemolytic uremic syndrome (HUS). However E. coli are generally innocuous commensal organisms, and there is a need to discriminate pathogenic from non-pathogenic isolates rapidly and accurately. …”
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GastroFuse-Net: an ensemble deep learning framework designed for gastrointestinal abnormality detection in endoscopic images by Sonam Aggarwal, Isha Gupta, Ashok Kumar, Sandeep Kautish, Abdulaziz S. Almazyad, Ali Wagdy Mohamed, Frank Werner, Mohammad Shokouhifar

“…This dataset contained images that were classified according to structures (cecum, z-line, pylorus), diseases (ulcerative colitis, esophagitis, polyps), or surgical operations (dyed resection margins, dyed lifted polyps). …”
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Intestinal Permeability Measured by Urinary Sucrose Excretion Correlates with Serum Zonulin and Faecal Calprotectin Concentrations in UC Patients in Remission by C. A. M. Wegh, N. M. de Roos, R. Hovenier, J. Meijerink, I. Besseling-van der Vaart, S. van Hemert, B. J. M. Witteman

“…Background and Aims. Ulcerative colitis (UC) is associated with an increased intestinal permeability, possibly through a dysbiosis of intestinal bacteria. …”
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Allicin Alleviates Inflammation of Trinitrobenzenesulfonic Acid-Induced Rats and Suppresses P38 and JNK Pathways in Caco-2 Cells by Chen Li, Weijian Lun, Xinmei Zhao, Shan Lei, Yandong Guo, Jiayi Ma, Fachao Zhi

“…To evaluate the effects and investigate the mechanism of allicin on trinitrobenzenesulfonic acid-induced colitis, specifically with mesalazine or sulfasalazine. …”
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Chronic inflammatory bowel diseases: the course and treatment methods in Russian Federation (Results of multicenter population-based one-stage observational study) by L. . Khalif, M. V. Shapina, A. O. Golovenko, Ye. A. Belousova, Ye. Yu. Chashkova, A. V. Lakhin, O. V. Knyazev, A. Yu. Baranovsky, N. N. Nikolayeva, A. V. Tkachev

“…To evaluate the prevalence of clinical manifestations and variants of progression for ulcerative colitis (UC) and Crohn’s disease (CD) in population of the Russian Federation. …”
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The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease by Yi-Han Chen, Li Wang, Shu-Yi Feng, Wei-Min Cai, Xiao-Fu Chen, Zhi-Ming Huang

“…A total of 876 IBD patients, composed of 275 patients with ulcerative colitis (UC) and 601 patients with Crohn’s disease (CD), were included in this retrospective study, and the serum C-reactive protein (CRP), albumin (ALB), erythrocyte sedimentation rate (ESR), and CBC parameters were measured. …”
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The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World by Peter C. Church, Jeffrey Hyams, Frank Ruemmele, Lissy de Ridder, Dan Turner, Anne M. Griffiths

“…Physicians were surveyed about anti-TNF use in Crohn’s disease (CD) and ulcerative colitis (UC). Chi-squared, independent samples Mann–Whitney U, or related samples Wilcoxon signed rank tests were used to compare groups. …”
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Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand by Tomoko Hayashi, Shiyin Yao, Brian Crain, Michael Chan, Howard B. Cottam, Fitzgerald Lao, Dennis A. Carson, Maripat Corr

“…The proinflammatory potency of Tolerimod1 was 10-fold less than the unconjugated TLR7 ligand, and Tolerimod1 reduced neutrophil recruitment in chemically induced peritonitis and colitis. The effects of Tolerimod1 were mediated by the radioresistant cells in radiation chimeric mice and by mast cells in reconstituted mast cell-deficient mice (KitW-sh). …”
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Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis by Xinxin Zhou, Mengting Ren, Jinpu Yang, Hanghai Pan, Mosang Yu, Feng Ji

“…Although some studies have reported the therapeutic effects of curcumin on ulcerative colitis (UC), the specific mechanism remains unclear. …”
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Significance of immune factors in Crohn's disease development by D. S. Stavtsev, T. A. Astrelina, O. V. Knyazev, T. V. Pukhlikova

“…Associations with clinical forms of disease was found, in particular in Italy presence of DRB1*0304, DRB1*0305, DRB1*0307, DRB1*0309 is linked to total involvement of the large intestine, in Spain presence of HLA-DRB1*07 — with terminal ileitis at CD, HLA-DRB1*0103 — with colitis. It has been demonstrated, that certain HLA-haplotypes have stronger association with Crohn's disease. …”
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Case Report of Gastrointestinal Bleeding in an Adult with Chronic Visceral Acid Sphingomyelinase Deficiency by David Cassiman, Louis Libbrecht, Wouter Meersseman, Alexander Wilmer

“…At age 64 they had multiple hospital admissions for hematochezia (originally diagnosed as ischemic colitis) accompanied by hypotension (blood pressure 91/45 mmHg), anemia (hemoglobin 8.5g/dL, ref 12-16; INR 1.4, ref ≤1.2), and mild renal insufficiency (creatinine 1.33mg/dL, ref 0.51-0.95). …”
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