Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model by Sean P. Kessler, Dana R. Obery, Carol de la Motte

“…In this study, we tested the progression of inflammation in mice null for the hyaluronan synthase genes (HAS1, HAS3, or both HAS1 and HAS3) in the DSS-colitis model. Our data demonstrate that both the HAS1/HAS3 double and the HAS3 null mice are protected from colitis, compared to wild-type and HAS1 null mice, as determined by measurement of weight loss, disease activity, serum IL-6 levels, histologic scoring, and immunohistochemistry. …”
Get full text

Correction: Genomic characterization of Escherichia coli with a polyketide synthase (pks) island isolated from ulcerative colitis patients by Chao Lv, Mohd Abdullah, Chun-Li Su, Weiye Chen, Nan Zhou, Zile Cheng, Yiwen Chen, Min Li, Kenneth W. Simpson, Ahmed Elsaadi, Yongzhang Zhu, Steven M. Lipkin, Yung-Fu Chang

Get full text

Short-term results of ileal pouch anastomosis in early and late terms after urgent surgery for complicated ulcerative colitis by Yu. E. Kitsenko, S. K. Yefetov, I. A. Tulina, P. V. Tsarkov

“…To estimate short-term results of ileal pouch anastomosis after urgent colon surgery at complicated ulcerative colitis. Material and methods. Two peer groups including 26 patients each after multi-stage surgical treatment were analyzed. …”
Get full text

Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway by Dacheng Wu, Keyan Wu, Qingtian Zhu, Weiming Xiao, Qing Shan, Zhigang Yan, Jian Wu, Bin Deng, Yan Xue, Weijuan Gong, Guotao Lu, Yanbing Ding

“…In this present study, we aimed to explore the protective effects of formononetin on dextran sulfate sodium- (DSS-) induced acute colitis. By intraperitoneal injection of formononetin in mice, the disease severity of colitis was attenuated in a dose-dependent manner, mainly manifesting as relieved clinical symptoms of colitis, mitigated colonic epithelial cell injury, and upregulations of colonic tight junction proteins levels (ZO-1, claudin-1, and occludin). …”
Get full text

Effect of sodium alginate-based hydrogel loaded with lutein on gut microbiota and inflammatory response in DSS-induced colitis mice by Pengxiang Xu, Shuwei Luo, Jiangfeng Song, Zhuqing Dai, Dajing Li, Cai’e Wu

Subjects: Get full text

The short-term and long-term results of three-stage surgical treatment of ulcerative colitis with formation of ileal J-pouch by P. V. Tsarkov, A. Yu. Kravchenko, I. A. Tulina, Yury Ye. Kitsenko

“…The three-stage surgery for ulcerative colitis is an optimum management approach in the presence of complicated ulcerative colitis. …”
Get full text

Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis–A preclinical systematic review and meta-analysis by Jinchen Chong, Zepeng Chen, Jiaze Ma, Linhai He, Yijia Zhu, Zhihua Lu, Zhengxi Qiu, Chen Chen, Yugen Chen, Feng Jiang

Subjects: Get full text

Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPARα by Bianca Knoch, Matthew P. G. Barnett, Janine Cooney, Warren C. McNabb, Diane Barraclough, William Laing, Shuotun Zhu, Zaneta A. Park, Paul MacLean, Scott O. Knowles, Nicole C. Roy

“…Bacterial inoculation resulted in severe colitis in Il10-/- mice from 10 to 12 weeks of age. …”
Get full text

Enhanced precise therapy of ROS-sensitive dual-layer shell nanoparticles loading quercetin on DSS-induced ulcerative colitis mice by Yang Bai, Danling Jiang, Boda Wu, Jiao Peng, Ji Wang, Yuhui Chen, Xi Li

“…Ulcerative colitis (UC) is an intestinal condition, involving inflammatory response, apoptosis, and associated processes. …”
Get full text

Adapting to ulcerative colitis to try to live a ‘normal’ life: a qualitative study of patients’ experiences in the Midlands region of England by Rachel Cooney, Christel McMullan, Dmitri Nepogodiev, Laura Magill, Thomas D Pinkney, Jonathan M Mathers, Laura L Jones, Shri Pathmakanthan

“…Objective To provide a framework that is able to categorise whether patients are able to adapt to and lead a ‘normal’ life with ulcerative colitis (UC) and to detail the factors that influence this.Design Qualitative research study using in-depth semi-structured interviews.Setting Four clinical sites in the West and East Midlands regions of England.Participants 28 adult patients diagnosed with UC for years between 1 and 22.Results Medication was rarely sufficient for patients to adapt to UC and live as ‘normal’ a life as possible. …”
Get full text

Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions by Yuanyuan Liu, Zerong Zhang, Xiaoyan Li, Qinghong Hu, Zhangyu Jiang, Jia Lv, Jiayi Xue, Dongyu Wang, Jianxiong Cao, Lingyu Li, Xiaowen Ou, Lijun Zhu, Zhongqiu Liu, Tao Su

Subjects: Get full text

Golden berry fruit modulates inflammation in LPS-stimulated RAW 264.7 macrophages and the DSS-induced acute colitis model by Jenny Castro, Guillermo Lopez-Lluch, Juan Carlos Rodríguez, Rocío de la Puerta, Lía Barrios, Rubén Salas, Luis Franco

Subjects: “…Dextran sodium sulphate-induced acute colitis…”
Get full text

Systemic immune-inflammation index: Unveiling the diagnostic potential in ulcerative colitis through a comprehensive systematic review and meta-analysis by Anas Elgenidy, Omar Alomari, Tasbih Emad, Sara K. Kamal, Islam E. Al Ghanam, Aya Sherif, Mohammed Al-mahdi Al-kurdi, Abdallah A. Helal, Yusof Mohamed Omar, Mohamed Rafiek Ramadan

Subjects: “…Ulcerative colitis…”
Get full text

The intervention effects of Lactobacillus casei LC2W on Escherichia coli O157:H7 -induced mouse colitis by Guangqiang Wang, Hongyu Tang, Ying Zhang, Xiang Xiao, Yongjun Xia, Lianzhong Ai

“…Results showed that the administration of L. casei LC2W was able to alleviate the symptoms of colitis induced by E. coli O157:H7, exhibiting lower weight loss as well as more intact colon tissue. …”
Get full text

Atractylenolide III Improves Mitochondrial Function and Protects Against Ulcerative Colitis by Activating AMPK/SIRT1/PGC-1α by Jieru Han, Wenhao Li, Guangyu Shi, Yunlei Huang, Xutao Sun, Na Sun, Deyou Jiang

“…Ulcerative colitis (UC) is a complex inflammatory bowel disease (IBD) associated with mitochondrial function. …”
Get full text

Perinuclear Antineutrophil Cytoplasmic Autoantibodies and Anti-Saccharomyces Cerevisiae Antibodies as Serological Markers Are Not Specific in the Identification of Crohn’s Disease and Ulcerative Colitis by Vishal Anand, Anthony S Russell, Ross Tsuyuki, Richard Fedorak

“…OBJECTIVE: To evaluate the diagnostic accuracy of perinuclear antineutrophil cytoplasmic autoantibodies (pANCAs) and anti-Saccharomyces cerevisiae antibodies (ASCAs), as single agents and in combination, for the diagnosis of Crohn’s disease (CD) and ulcerative colitis (UC), including in cases of indeterminate colitis (IC).…”
Get full text

Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats by Pei-Ran Lv, Yang-Shuai Su, Wei He, Xiao-Yu Wang, Hong Shi, Xiao-Ning Zhang, Bing Zhu, Yu Kan, Li-Zhen Chen, Qiao-Feng Wu, Shu-Guang Yu, Xiang-Hong Jing

“…Although referred pain or hypersensitivity has been repeatedly reported in irritable bowel syndrome (IBS) patients and experimental colitis rodents, little is known about the neural mechanisms. …”
Get full text

Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-κB/MLCK pathway by Tong Li, Guiqiu Hu, Shoupeng Fu, Di Qin, Zheyu Song

“…However, the precise impact of PHY on colitis induced by dextran sodium sulfate (DSS) and its mechanism remain elusive. …”
Get full text

IL-33 Aggravates DSS-Induced Acute Colitis in Mouse Colon Lamina Propria by Enhancing Th2 Cell Responses by Junfeng Zhu, Fangli Yang, Lixuan Sang, Jingbo Zhai, Xiaoqing Zhang, Dan Yue, Shengjun Li, Yan Li, Changlong Lu, Xun Sun

“…We investigated the role of interleukin- (IL-) 33 in dextran sulphate sodium- (DSS-) induced acute colitis in mice using recombinant mouse IL-33 protein (rIL-33). …”
Get full text

Could Total Colectomy with Ileorectal Anastomosis Be an Alternative to Total Proctocolectomy with Ileal Pouch-Anal Anastomosis in Selected Ulcerative Colitis Patients? by Francesco Tonelli, Carmela Di Martino, Francesco Giudici

“…To evaluate ileorectal anastomosis (IRA) in selected ulcerative colitis patients. Methods. Early and late complications after IRA and IPAA were investigated. …”
Get full text