Discrepancies in safety reporting for chronic back pain clinical trials: an observational study from ClinicalTrials.gov and publications by Nick Boyne, Alison Duke, Jack Rea, Adam Khan, Alec Young, Jared Van Vleet, Matt Vassar

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Open challenges for the automatic synthesis of clinical trials by Olivia Sanchez-Graillet, David M. Schmidt, Christian Kullik, Philipp Cimiano

Subjects: “…Clinical trial synthesis…”
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Randomization and placebo effects in clinical trials of major depressive disorder by James A. Rogers, Stephen Senn

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A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda by Keneth Iceland, Kasozi, Anne, Laudisoit, Lawrence Obado, Osuwat, Gaber El-Saber, Batiha, Naif E. Al, Omairi, Eric, Aigbogun, Herbert Izo, Ninsiima, Ibe Michael, Usman, Lisa M., DeTora, Ewan Thomas, MacLeod, Halima, Nalugo, Francis P., Crawley, Barbara E., Bierer, Daniel Chans, Mwandah, Charles Drago, Kato, Kenedy, Kiyimba, Emmanuel Tiyo, Ayikobua, Linda, Lillian, Kevin, Matama, Shui Ching, Nelly Mak, David, Onanyang, Theophilus, Pius, Linda, Lillian, Kevin, Matama, Shui Ching, Nelly Mak, David, Onanyang, Theophilus, Pius, David Paul, Nalumenya, Robinson, Ssebuufu, Nina Olivia, Rugambwa, Grace Henry, Musoke, Kevin, Bardosh, Juma John, Ochieng, Fred, Ssempijja, Patrick, Kyamanywa, Gabriel, Tumwine, Khalid J., Alzahrani, Susan Christina, Welburn

Subjects: “…COVID-19 clinical trials in resource poor countries…”
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Proposal and Strategy for Nursing-Led Research: Protocol for an Unfunded Clinical Trial by Leticia Carmen Simón-López, Ismael Ortuño-Soriano, Raquel Luengo-González, Paloma Posada-Moreno, Ignacio Zaragoza-García, Rubén Sánchez-Gómez

“… BackgroundClinical trials are known to provide cause-and-effect results and data with low levels of bias. …”
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Correction: Relevance of tumor boards for the inclusion of patients in oncological clinical trials by Hendrik Dapper, Maurice Dantes, Peter Herschbach, Hana Algül, Volker Heinemann

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Enhancing vaccine clinical trials participation among elderly: challenges and strategies by Paul Gillard, Samer Nakhle, Darin Brimhall, Ouzama Henry, Narcisa Mesaros

“…In fact, recent megatrials enrolling more than 30,000 elderly participants demonstrated the feasibility of large-scale clinical trials involving this very specific population. …”
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An analysis of controlled human infection studies registered on ClinicalTrials.gov by James Wilkinson, Joshua Osowicki, Euzebiusz Jamrozik, Ian J Saldanha, Meta Roestenberg, Danny Toomey, Jupiter Adams-Phipps, John Pietro, Jake Littman, Steffen Kamenicek, Daniel Kaufman

“…We hypothesised that data may be more easily aggregated using a clinical trial registry such as ClinicalTrals.gov, the largest publicly accessible registry of clinical trial data. …”
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Sociodemographic factors associated with acceptance of COVID-19 vaccine and clinical trials in Uganda: a cross-sectional study in western Uganda by Isaac, Echoru, Patricia, Decanar Ajambo, Emmanuel, Keirania, Edmund E. M, Bukenya

Subjects: “…COVID-19, vaccine, Acceptance, Clinical trials, Western Uganda…”
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Color Stability of Orthodontic Elastomeric Ligatures in the Oral Environment: A Clinical Trial by Marzieh Mazhari, Mehdi Yaghoubi Ashrafi, Sara Gholamian, Mehrnaz Moradinejad

“…Materials and Methods: This clinical trial was conducted on 67 patients. After applying the exclusion criteria, 11 participants were excluded, and 56 remained. …”
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The Holy Grail: highlighting the need for equitable access to dementia treatments and clinical trials by Rebekah M. Ahmed, Olivier Piguet, Catherine J. Mummery, Sharon L. Naismith, Muireann Irish

“…This viewpoint discusses the barriers to access to early treatments and clinical trials for patients with dementia and offers a potential framework to address these including provision of infrastructure, regulatory change and patient education.…”
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Introducing youth to clinical research: Development and pilot implementation of a children’s activity book by Renee Cadzow, Andy Strohmeier, Erin Carnes, Teresa Quattrin

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Validation of the Food Safe Zone questionnaire for families of individuals with Prader-Willi syndrome by Elisabeth M. Dykens, Elizabeth Roof, Hailee Hunt-Hawkins, Theresa V. Strong

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Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments by Miao M, Yan J, Sun Y, Liu J, Guo S

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A descriptive-multivariate analysis of community knowledge, confidence, and trust in COVID-19 clinical trials amongst Ugandans working in healthcare settings. by Keneth Iceland, Kasozi, Lawrence Obado, Osuwat

Subjects: “…COVID-19 clinical trials in resource poor countries; COVID-19 vaccines; Clinical trials in Africa; COVID-19 and medical workers; vaccines, Oxford-AstraZeneca.…”
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A Criterion-based Approach for the Systematic and Transparent Extrapolation of Clinical Trial Survival Data by Gabriel Tremblay, Patrick Haines, Andrew Briggs

“…Often, significant survival effects are found beyond the time period observed in clinical trials, thus, extrapolation of trial results is required for health economic and HTA evaluations. …”
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Incorporating health literacy principles into the adaptation of a methods motivational interviewing approach for enrolling black adults in a pilot randomized trial by Olayinka O. Shiyanbola, Meng-Jung Wen, Martha A. Maurer

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“Common sense is hard work” but benefits from persistent collaboration: Lessons learnt from the development of The Collaborative Network for European Clinical Trials for Children (c4c) to support the conduct of paediatric clinical trials of medicines by Sabah Attar, Carla Peacock, Mandy Wan, Erin Halil, Chloe Bickerstaff, Lionel Tan, Hafsah Bhatti, Ricardo M. Fernandes, Regis Hankard, Mark A. Turner

“…Contemporary Clinical Trials Communications…”
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The roadmap to integrate diversity, equity, and inclusion in hematology clinical trials: an American Society of Hematology initiative by Alice Kuaban, Alysha K. Croker, Jeffrey Keefer, Leonard A. Valentino, Barbara E. Bierer, Stephen Boateng, Donna DiMichele, Patrick Fogarty, C. Michael Gibson, Anna M. Hood, Lloryn Hubbard, Antonella Isgrò, Karin Knobe, Leslie Lake, Iman Martin, Michel Reid, Jonathan C. Roberts, Wendy Tomlinson, Lanre Tunji-Ajayi, Harriette G.C. Van Spall, Caroline Voltz-Girolt, Allison P. Wheeler, Alan E. Mast, Stephanie Seremetis

“…Abstract: Clinical trial design for classical hematologic diseases is difficult because samples sizes are often small and not representative of the disease population. …”
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CAR-T therapy for endocrine neoplasms: novel targets and combination of therapies by Fang Wang, Ruiqi Zhang, Zhaokai Zhou, Run Shi, Fu Peng, Yudi Xu, Shuai Yang, Zhan Wang, Pengpeng Zhang, Rui Tu, Chun Zhang, Xingchen Liu, Jun Cai

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