Pegilated interferon alpha 2b «Pegaltevir» chronic hepatitis C treatment (randomized clinical trial) by Marina V. Mayevskaya, Ye. N. Bessonova, P. O. Bogomolov, N. I. Geyvandova, K. V. Zhdanov, V. G. Morozov, V. D. Pasechnikov, I. Yu. Khomenko, A. V. Yagoda, V. T. Ivashkin

“…These qualities formed the basis for development of the Russian pegilated interferon-alpha 2b (Pegaltevir®, LLC «FARMAPARK», Russia) and carrying out doublestaged randomized open clinical trial: study of safety, tolerability and pharmacokinetics of Pegaltevir® at single injection of increasing doses in various groups of healthy volunteers - the I stage; studying of efficacy and safety of Pegaltevir® in comparison to PegIntron® (Schering-Plough, USA) at CHC as a part of double antiviral therapy with ribavirin (Rebetol®, Schering-Plough, USA) - the II stage. …”
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Advantages and disadvantages of coronary drug-eluting stent: a 23-year journey of randomized clinical trials by Alfredo E. Rodriguez, Juan Mieres, Juan M. Rokos

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Metformin versus insulin in glycemic control in pregnancy (MevIP): a randomized clinical trial protocol by Carolina Freitas Alves Amaral-Moreira, Daiane Sofia Morais Paulino, Belmiro G. Pereira, Patricia Moretti Rehder, Fernanda G. Surita

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Evaluation of in-office tooth whitening treatment with violet LED: protocol for a randomised controlled clinical trial by Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Maria Fernanda Setúbal Destro Rodrigues, Ana Eliza Castanho Garrini dos Santos, Marcelo Mendes Pinto, Dácio Antonio Pantano Junior, Aldo Brugnera Jr, Fátima Antonia Aparecida Zanin

“…This study describes a protocol for the first randomised controlled clinical trial to compare the effects of the two methods.Methods and analysis Eighty patients will be divided into four groups: G1 violet LED; G2 violet LED +35% carbamide peroxide; G3 35% H2O2 and G4 violet LED +gingivoplasty. …”
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Multicenter Randomized Clinical Trial of Brief Psychotherapy versus Usual Treatment for Common Mental Disorders in Adults by Marco A. Luengo-Castro, Javier Fernández-Méndez, José M. García-Montes, Pedro J. Caunedo-Riesco, Juan M. García-Haro, Begoña Braña-Menéndez, Dolores González-Díaz, Andrés Cabero-Álvarez, Marcelino Cuesta-Izquierdo

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Impact of telephone follow-up on COPD outcomes in pulmonary rehabilitation patients: A randomized clinical trial by Stefanie Tonguino Rosero, Juan Carlos Ávila Valencia, Jhonatan Betancourt Peña

“… # Methods Double-blind randomized controlled clinical trial in patients with COPD in a PR program in Cali-Colombia, allocation by randomization tables. …”
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Comparative effects of gong’s mobilization and mobilization with movement in patients with adhesive capsulitis: a randomized clinical trial by Fareeha Amjad, Hasha Asghar

“…The mainstay of this clinical trial is a comprehensive comparative evaluation of MWM with Gong’s Mobilization as it remains insufficiently explored. …”
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SHoes for Adolescent PatEllofemoral pain: study protocol for the SHAPE Australian community-based, randomised clinical trial by Kim L Bennell, Kade L Paterson, Rana S Hinman, Jo-Anne Manski-Nankervis, Adam Bryant, Karen Elaine Lamb, Peixuan Li, Sam Shearer, Anurika P De Silva

“…Guidelines recommend exercise and foot orthoses based on clinical trials in adults; however, these approaches have been found to be ineffective and have poor adherence in adolescents. …”
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Photobiomodulation preconditioning for oral mucositis prevention and quality of life improvement in chemotherapy patients: a randomized clinical trial by Marwa Khalil, Omar Hamadah, Maher Saifo

“…Materials and methods This is a prospective, randomized, double-blind clinical trial including 45 patients divided into three age- and sex-matched groups. …”
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Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial by Sitthiphong Suwannaphisit, Nitiphoom Sinnathakorn, Pormes Suwanno, Warangkana Fongsri, Boonsin Tangtrakulwanich

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PARP inhibitors as therapy for small cell lung carcinoma: A systematic review and meta-analysis of clinical trials by Samuel Pratama, Lowilius Wiyono, Martien Silviandy Setiawan, Brigitta Cindy Lauren

“…Results: Five randomized controlled clinical trials with 451 interventional patients and 308 control patients with SCLC were included. …”
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Challenges for funders in monitoring compliance with policies on clinical trials registration and reporting: analysis of funding and registry data in the UK by Rachel L Knowles, Frances Rawle, Kam Pou Ha, Julia Mueller, Rosa Parker

“…Objectives To evaluate compliance by researchers with funder requirements on clinical trial transparency, including identifying key areas for improvement; to assess the completeness, accuracy and suitability for annual compliance monitoring of the data routinely collected by a research funding body.Design Descriptive analysis of clinical trials funded between February 2011 and January 2017 against funder policy requirements.Setting Public medical research funding body in the UK.Data sources Relevant clinical trials were identified from grant application details, post-award grant monitoring systems and the International Standard Randomised Controlled Trial Number (ISRCTN) registry.Main outcome measure The proportion of all Medical Research Council (MRC)-funded clinical trials that were (a) registered in a clinical trial registry and (b) publicly reported summary results within 2 years of completion.Results There were 175 grants awarded that included a clinical trial and all trials were registered in a public trials registry. …”
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Comparing the Effect of Intrathecal Injection of Pethidine with That of Bupivacaine on Hemodynamics in Hip Surgery: A Double Blinded Clinical Trial by Seyed Babak Mojaveraghili, Sina Hassannasab, Mansour Deylami, Tahereh Chavoshi, Avasadat Mirkatouli, Nasser Behnampour

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Perceptions of Cardiovascular Healthcare Professionals Regarding Clinical Trials: A Survey-Based Study from the Middle East by Zainab Atiyah Dakhil, Hasan Ali Farhan, Mohammed Dheyaa Marsool, Mohammed Saad Qasim, Michele Peters, Jose Leal

“…There is a lack of data on insights of cardiologists in these countries regarding conducting and participating in clinical trials. We sought the views of cardiovascular healthcare professionals in Iraq on participation in clinical trials. …”
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Post-rectectomy choice of preventive intestinal stoma formation method: prospective multicenter randomized clinical trial protocol by P. V. Tsarkov, I. A. Tulina, P. B. Tsugulya, V. S. Kochetkov, S. V. Khmelik

“…To justify and present the protocol of the prospective, multicenter randomized clinical trial for evaluation of the choice of preventive intestinal stoma formation method after rectectomy. …”
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Effects of hydrogen water and psychological treatment in a sample of women with panic disorder: a randomized and controlled clinical trial by Ana Belén Fernández-Serrano, Francisco José Moya-Faz, Cesar Augusto Giner Alegría, Juan Carlos Fernández Rodríguez, Jose Francisco Soriano Guilabert, Martín del Toro Mellado

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A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients by Shayma Ghazi, Dilyar Ahmed Baban, Saif Monem Aziz

“…Patients and Methods: A randomized controlled clinical trial on 45 (T2DM) patients, both sexes with moderate gingivitis, age 40-55 years, (Hb1Ac) < 7%. …”
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Clinical trials since 2020 of rapid anti-suicidal ideation effects of ketamine and its enantiomers: a systematic review by Sumra Sajid, J. John Mann, Michael F. Grunebaum

“…Methods We conducted a systematic review of clinical trials (CT) since 2020 of racemic ketamine or one of its enantiomers’ (R/S) potential to reduce suicidal ideation or behavior (SIB). …”
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Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis by Agnieszka Starzyk, Piotr Charzewski

“…Materials and Methods: This study combined a literature review with clinical trial analysis to evaluate the role of selenium and vitamin D in HT. …”
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Analysis of quality of life and periodontal health with an eight-unit maxillary fixed retainer through a prospective clinical trial by Mohamed H. Abbas, Essam M. Abdalla, Nadia M. El Harouni, Eiman S. Marzouk

“…A single-arm prospective clinical trial with only twenty-eight test group patients (6 males, 22 females) who finished active orthodontic treatment were recruited. …”
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