Bupropion Mediated Effects on Depression, Attention Deficit Hyperactivity Disorder, and Smoking Cessation by Austin Clark, Brendan Tate, Bretton Urban, Ryan Schroeder, Sonja Gennuso, Shahab Ahmadzadeh, David McGregor, Brook Girma, Sahar Shekoohi, Alan D. Kaye

“…In the case of ADHD, the evidence for efficacy is mixed with poorly conducted randomized clinical trials, small sample sizes, and a lack of long-term assessments. …”
Get full text

Real-world pharmacovigilance analysis unveils the toxicity profile of amivantamab targeting EGFR exon 20 insertion mutations in non-small cell lung cancer by Jing Zhang, Wenjie Li

“…Abstract Background While clinical trials have demonstrated enduring responses to amivantamab among advanced non-small cell lung cancer (NSCLC) patients bearing EGFR exon 20 insertion mutations, the associated toxicity profile in real-world scenarios remains elusive. …”
Get full text

The Effect of Transobturator Tape Surgery on Female Sexual Functions: A Systematic Review by Engin Yildirim, Nuriye Buyukkayaci Duman, Umit Gorkem, Ozgur Kan

“…Results: A total of 24 clinical trials were evaluated. The most frequently administered scales were the female sexual function index and The Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire -12. …”
Get full text

Bibliometrics of NIHR HTA monographs and their related journal articles by Norman Waugh, Pamela Royle

Get full text

Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects by Yufei Wang, Guangliang Li, Hanying Wang, Quan Qi, Xian Wang, Haiqi Lu

“…Nectin-4-targeted approaches, such as ADCs, oncolytic viruses, photothermal therapy and immunotherapy, have shown promising results in early-phase clinical trials. These therapies offer novel strategies for delivering targeted treatments to Nectin-4-expressing cancer cells, enhancing treatment efficacy and minimizing off-target effects. …”
Get full text

Exploiting question-answer framework with multi-GRU to detect adverse drug reaction on social media by Jiao-huang Luo, Ai-hua Yang

“…The dilemma arises from the inherent impossibility of conducting a comprehensive evaluation of a drug before its market release, constrained by the limitations in scale and duration of clinical trials. Therefore, the post-marketing detection of ADRs in a timely and accurate manner becomes imperative. …”
Get full text

Anti-Inflammatory and Antimicrobial Effects of Herbal Formulation Called Apo-Taat Using Extended-Spectrum ß-Lactamase-Producing Escherichia coli Isolates by Thanakan Kitnithiprapha, Sumalee Panthong, Intouch Sakpakdeejaroen, Sumalee Kondo

“…Furthermore, safety and clinical trials should be conducted in the future.…”
Get full text

Neonatal Surgery Intensive Care Unit: Hacettepe University Experience by Umit Ayse Tandircioglu, Hasan Tolga Celik, Sule Yigit, Murat Yurdakok

“…The protocol was registered with Clinical Trials.gov identifier NCT04734002. RESULTS: The total number of newborns admitted to the neonatal intensive care unit was 5442. …”
Get full text

Phytoconstituent analysis, bioactivity, and safety evaluation of various colors of Chrysanthemum morifolium flower extracts for cosmetic application by Angsana Neatpatiparn, Varaporn Buraphacheep Junyaprasert, Krit Thirapanmethee, Veerawat Teeranachaideekul

“…However, further studies, including human clinical trials, are needed to confirm these biological activities and safety profiles.…”
Get full text

The effect of azithromycin treatment on respiratory morbidity in children with down syndrome by Inbal Golan-Tripto, Omer Dor, Noga Arwas, Itai Hazan, Guy Hazan, Aviv Goldbart

“…Conclusion The significant reduction in respiratory LOS suggests the potential benefits of Azithromycin in children with DS, and emphasizes the need for larger clinical trials to determine optimal use and long-term effects in this vulnerable population.…”
Get full text

Mindfulness-based (non-contact) boxing therapy (MBBT) for depression and anxiety: A feasibility study. by Johny Bozdarov, Brett D M Jones, Madeha Umer, Daniel M Blumberger, Ishrat M Husain

“…Further well-designed randomized clinical trials are warranted to confirm the clinical benefits of MBBT.…”
Get full text

Antisecretory factor in severe traumatic brain injury (AFISTBI): protocol for an exploratory randomized placebo-controlled trial by Linus Réen, David Cederberg, Niklas Marklund, Edward Visse, Peter Siesjö

“…Trial registration ClinicalTrials.gov NCT04117672. Registered on September 17, 2017. …”
Get full text

Design and Preparing a Topical Semi-solid Formulation of a Combination of Plantago ovata seeds and Rosehip oil to Provide an Analgesic and Anti-inflammatory Medicine by Amirhossein Zamani, Aida Alipour, Mohammad M. Zarshenas, Hajar Ashrafi

“…After passing the clinical trials, the mentioned product can be effective as a product derived from herbal compounds for pain control.…”
Get full text

The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (H... by Darshan Hullon, Ghasaq K. Subeh, Yelizaveta Volkova, Karolina Janiec, Adam Trach, Ruslan Mnevets

“…GLP-1R agonists, including semaglutide and liraglutide, have demonstrated significant cardioprotective effects, such as improving vascular endothelial function, reducing inflammation, and preventing atherosclerosis. Clinical trials, such as the STEP-HFpEF trial, have shown positive results in reducing symptoms and physical restrictions in HFpEF patients. …”
Get full text

ErbB- and MUC1-targeted CAR-T cell immunotherapy of oral squamous cell carcinoma by Saffron E. Summers, Saffron E. Summers, Vehid Salih, Andrew D. Foey

“…Currently, there are few clinical trials investigating the use of CAR-T cells in HNSCC/OSCC; however, results from trials investigating similar solid tumours, such as breast cancer, can be adopted to help evaluate the use of CAR-T in this cancer. …”
Get full text

Microbubble dynamics in brain microvessels. by James H Bezer, Paul Prentice, William Lim Kee Chang, Sophie V Morse, Kirsten Christensen-Jeffries, Christopher J Rowlands, Andriy S Kozlov, James J Choi

“…Focused ultrasound stimulation of microbubbles is being tested in clinical trials for its ability to deliver drugs across the blood-brain barrier (BBB). …”
Get full text

Effects of distant biofield energy healing on adults associated with psychological and mental health-related symptoms: a randomized, placebo-controlled, double-blind study by Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Sambhu Mondal, Snehasis Jana

“…However, due to insufficient scientific studies on biofield therapies, authors planned this clinical trial to examine the safety and effectiveness of biofield therapy in treating symptoms of psychological and mental health and to explore parameters for its effectiveness…”
Get full text

Metabolomic profile and its association with the diagnosis of prostate cancer: a systematic review by Angela Patricia Salinas Pita, Mildrey Mosquera Escudero, Eliecer Jiménez-Charris, Herney Andrés García-Perdomo

“…Methods We conducted a search strategy in MEDLINE (OVID), EMBASE, LILACS, and the Cochrane Central Register of Controlled Trials (CENTRAL) from 2008 to the present. We included Clinical trials and analytical and descriptive observational studies that reported metabolite results and metabolite profiles in serum, tissue, urine, and seminal fluid. …”
Get full text

Effect of vortioxetine versus venlafaxine on cognitive functions in adults with major depressive disorder: A randomized-controlled trial by Chayan K. Manna, Rajeev Ranjan, Pankaj Kumar, Shamshad Ahmad, Santanu Nath

“…Conclusion: Our study findings suggest that improvement in cognitive scores is significantly higher with vortioxetine than venlafaxine over the eight weeks of monotherapy. Clinical Trial registration number: CTRI/2020/07/026819 (Registered with Clinical Trials Registry- India).…”
Get full text

Vascular endothelial growth factor A: friend or foe in the pathogenesis of HIV and SARS-CoV-2 infections? by Mieke A. van der Mescht, Helen C. Steel, Ronald Anderson, Theresa M. Rossouw

“…In this context, a few clinical trials have described a diminished requirement for oxygen therapy during anti-VEGF treatment of SARS-CoV-2 infection. …”
Get full text