Influence of ethnicity on cyclin-dependent kinase inhibitor efficacy and toxicity: A systematic review and meta-analysis by Roberto Buonaiuto, Aldo Caltavituro, Margherita Tafuro, Alessandra Longobardi, Giuliana Pavone, Pierluigi De Santis, Roberta Caputo, Carmine De Angelis, Lucia Del Mastro, Fabio Puglisi, Mario Giuliano, Grazia Arpino, Martina Pagliuca, Michelino De Laurentiis

“…Although the magnitude of benefit appears to be independent of ethnicity, future clinical trials should devise a standardized method for stratifying patients by ethnicity to more effectively assess potential differences in treatment benefits. …”
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MECHANISMS AND CLINICAL PERSPECTIVES OF ALLERGEN-SPECIFIC IMMUNOTHERAPY by Leila Akhvlediani, Marina Izmailovich, Meruyert Gazaliyeva, Anna Skvortsova, Kanan Tanriverdiev

“…Vitamin D, particularly 25(OH)D, plays a pivotal immunomodulatory role, supporting Treg and Breg cell function, and mitigating allergic inflammation. Clinical trials demonstrate that vitamin D supplementation enhances ASIT outcomes, especially in pediatric patients. …”
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Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review by Adekunle Babajide Rowaiye, Lorretha Chinonye Emenyonu, Ezinne Janefrances Nwonu, Okiemute Ajiroghene Okpalefe, Joseph Akwoba Ogugua, Victor Oluwatoyin Akinseye, Gordon Chukwuma Ibeanu

“…Both in vivo and in vitro experiments, and human clinical trials have proven a marked efficacy of these bioactive molecules in suppressing the key enzyme biomarkers that modulate T2D pathogenesis. …”
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The Taking Charge After Stroke (TaCAS) study protocol: a multicentre, investigator-blinded, randomised controlled trial comparing the effect of a single Take Charge session, two Ta... by Mark Weatherall, Harry McNaughton, Vivian Wai Yin Fu

“…Results will be published and presented at relevant stroke meetings within New Zealand and internationally, informing the use of a self-management intervention after stroke.Trial registration Australia and New Zealand Clinical Trials Registry ACTRN12615001163594. Date registered 02-11-2015. …”
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Evaluation of a Low-threshold Exercise And Protein supplementation intervention for Women (LEAP-W) experiencing homelessness and addiction: Protocol for a single-arm mixed methods... by Fiona Kennedy, Deirdre Murray, Clíona Ní Cheallaigh, Roman Romero-Ortuno, Julie Broderick

“…The findings of this research will help narrow the research gap and will guide clinicians and policy makers to implement unique gender-based treatment strategies for this population. (300).<h4>Clinical trials.gov number</h4>NCT05700305.…”
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Aortic intimal sarcoma with abdominal metastasis: case report and management approach by Gongji Yao, Gongji Yao, Jianwei Xu, Jianwei Xu

“…This case highlights the potential effectiveness of combined surgical and chemotherapeutic approaches for managing abdominal metastasis of aortic intimal sarcoma and provides a foundation for future clinical trials.…”
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A Systematic Literature Review of Three Stenting Strategies for Bifurcation Lesions in Coronary Artery Disease by Larragem Parsley-Raines, Dominique M. Brandt, Dillon L. Carr, Sabrina Uhry, Eileen S. Alexander, Stephanie A. Donauer, Peter J. Mallow

“…**Methods:** Literature searches in Medline, Cochrane Library, Web of Science and Embase were conducted to identify prospective clinical trials from January 2007-July 2017. **Results:** 602 articles were identified. …”
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Treatment Interruption and Regimen Change in Firstgeneration versus Second-generation Tyrosine Kinase Inhibitors used as First-line Therapy for Chronic Myeloid Leukemia by Melea A. Ward, Gang Fang, Kristy L. Richards, Christine M. Walko, Stephanie R. Earnshaw, Laura E. Happe, Susan J. Blalock

“…**Background:** Research has shown that treatment interruptions are associated with worse failure-free survival in chronic myeloid leukemia (CML); however they are commonly used in clinical trials to manage adverse events. **Objectives:** This study assessed the comparative rates of treatment interruption and regimen change between patients initiating first-line therapy with a first-generation tyrosine kinase inhibitor (1GTKI) imatinib versus second-generation TKI (2GTKI), dasatinib or nilotinib, for the treatment of CML in clinical practice. …”
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Beliefs about HIV cure: A qualitative study of people living with HIV in Soweto, South Africa by Fatima Laher, Naledi Mahlangu, Mbalenhle Sibiya

“…Background: Rare cases of HIV cure exist. Clinical trials of HIV cure are also underway. However, little is documented about how potential cures are perceived by African people living with HIV, although they are key stakeholders. …”
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Psychometric validation of the continuum beliefs of mental illness scale (CB-MIS) and its associations with stigma by Lina-Jolien Peter, Thomas McLaren, Samuel Tomczyk, Holger Muehlan, Silke Schmidt, Georg Schomerus

“…Trial registration German Clinical Trials Register: DRKS00023557. Registered 11/12/2020. …”
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Functional MRI-guided microsurgery of intracranial arteriovenous malformations: study protocol for a randomised controlled trial by Shuo Wang, Yuanli Zhao, Jun Wu, Bing Zhao, Yong Cao

“…Study findings will be disseminated in the printed media.Trial registration number ClinicalTrials.gov NCT01758211.…”
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What are the perceived influences on asthma self-management at the workplace? A qualitative study by Adrian Loerbroks, Katherina Heinrichs, Patricia Vu-Eickmann, Stefan Hummel, Jalal Gholami

“…Support by colleagues, line managers, and the employer, for example, practical, emotional, or structural support, was perceived to exert effects on symptom prevention, acute symptom management, and communication (ie, self-disclosure of one’s condition).Conclusions Perceived JDL and social support were experienced as influencing successful implementation of asthma SMB at the workplace.Trial registration number German Clinical Trials Register no: DRKS00011309.…”
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Infant outcomes after exposure to Tdap vaccine in pregnancy: an observational study by Helen Petousis-Harris, Tony Walls, Patricia Graham, Nicola Austin, Linda Hill

“…We have not found any adverse events attributable to vaccine exposure.Conclusions These data add to the growing pool of evidence that the administration of Tdap vaccine during pregnancy is an appropriate strategy for reducing the burden of pertussis in infants.Clinical trial registration Australia New Zealand Clinical Trials Registry ACTRN12613001045707.…”
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Measles neutralising antibody levels in patients receiving intravenous immunoglobulin treatment - a sub-analysis of a randomized, cross-over bioequivalence trial. by Vatsala Rajendram, Martyn Paddick, John More

“…<h4>Trial registration</h4>ClinicalTrials.gov NCT01963143.…”
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ASA score is an independent predictor of 1-year outcome after moderate-to-severe traumatic brain injury by Olivia Kiwanuka, Philipp Lassarén, Alexander Fletcher-Sandersjöö, Charles Tatter, Jonathan Tjerkaski, David W. Nelson, Eric P. Thelin

“…Logistic regression evaluated the contribution of ASA score to the International Mission for Prognosis and Clinical Trials in Traumatic Brain Injury (IMPACT) core + CT outcome prediction model incorporating age, admission GCS, pupillary reactivity, Marshall CT classification, hypoxia, hypotension, epidural hematoma, and subarachnoid hemorrhage. …”
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State of the art progress of Evolvulus alsinoides in pharmacological activity and plant tissue culture: A potent Chinese medicinal plant by Collince Omondi Awere, Valentine Chikaodili Anadebe, Rakkammal Kasinathan, Pandiyan Muthuramalingam, Ramesh Manikandan

“…Nevertheless, thorough clinical trials and translational research are required to bridge the gap between conventional knowledge and current medical uses. …”
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The Impact of Antibiotics on the Development of Colorectal Cancer – A Review of Current Insights and Directions for Future Research by Karol Zagórski, Mateusz Kozik, Nina Skalska-Dziobek, Weronika Małagocka, Karolina Chybowska, Maria Naruszewicz, Przemysław Cetnarowski

“…Systematic reviews, meta-analyses, clinical trials and observational studies were included if they were relevant and provided data on the influence of antibiotics on CRC.   …”
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The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study by Xiangqian Huang, Xiaoming Zhang, Jiahao Song, Duo Lan, Mengqi Wang, Xunming Ji, Da Zhou, Ran Meng

“…Abstract Background and purpose Although Ginkgo biloba extract (GBE) has been shown to be effective in treating acute ischemic stroke (AIS) in several clinical trials, concerns regarding adverse events, such as bleeding, have been raised. …”
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Patient experiences of an ankle fracture and the most important factors in their recovery: a qualitative interview study by Rebecca Samantha Kearney, Rebecca McKeown, David R Ellard, Zi Heng Liew

“…Thematic content analysis was used to identify themes in the data.Setting Individuals were recruited from a sample of participants of a UK-based clinical trial of immobilisation methods for ankle fracture (ISRCTN15537280 at the pre-results stage at time of writing). …”
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Methods to address functional unblinding of raters in CNS trials by Steven D. Targum, William P. Horan, Vicki G. Davis, Alan Breier, Stephen K. Brannan

“…These methods may have utility across all clinical trials.…”
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